Screening Specific Biomarkers of Herbs Using a Metabolomics Approach: A Case Study of Panax ginseng.

abstract：:Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...

journal_title：Scientific reports

authors： Yamanashi T,Maki M,Kojima K,Shibukawa A,Tsukamoto T,Chowdhury S,Yamanaka A,Takagi S,Sudo Y

更新日期：2019-05-27 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. We retrospectively analysed the response to rituximab-containing therapy in CAD patients at our hospital. All patients received rituximab-containing therapy for a...

journal_title：Scientific reports

authors： Jia MN,Qiu Y,Wu YY,Cai H,Zhou DB,Cao XX,Li J

更新日期：2020-07-29 00:00:00

abstract：:The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent la...

journal_title：Scientific reports

authors： Vlakh EG,Grachova EV,Zhukovsky DD,Hubina AV,Mikhailova AS,Shakirova JR,Sharoyko VV,Tunik SP,Tennikova TB

更新日期：2017-02-03 00:00:00

abstract：:The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retro...

journal_title：Scientific reports

authors： Pennig L,Thiele F,Goertz L,Laukamp KR,Perkuhn M,Kabbasch C,Schlamann M,Fink GR,Borggrefe J

更新日期：2020-06-09 00:00:00

abstract：:A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently been linked with typical familial migraine with aura. We now report the functional characterisation of additional TRESK channel missense variants identified in unrelated patients. Several variants either had no apparent functional ef...

journal_title：Scientific reports

authors： Andres-Enguix I,Shang L,Stansfeld PJ,Morahan JM,Sansom MS,Lafrenière RG,Roy B,Griffiths LR,Rouleau GA,Ebers GC,Cader ZM,Tucker SJ

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common liver cancer, with a very poor prognosis. There is an urgent need for an effective therapy for HCC. Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined. Here, we treated human ...

journal_title：Scientific reports

authors： Yang Z,Zhao T,Liu H,Zhang L

更新日期：2016-01-19 00:00:00

abstract：:Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21(st) century. Conjugative DNA transfer is the most important mechanism for antibiotic resistance and virulence gene dissemination among bacteria and is mediated by a p...

journal_title：Scientific reports

authors： Fercher C,Probst I,Kohler V,Goessweiner-Mohr N,Arends K,Grohmann E,Zangger K,Meyer NH,Keller W

更新日期：2016-04-22 00:00:00

abstract：:Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, b...

journal_title：Scientific reports

authors： Liu X,Yu P,Cheng C,Potash JB,Han S

更新日期：2016-09-14 00:00:00

abstract：:A highly sensitive bismuth/silver nanoparticles/Nafion-modified screen-printed graphene electrode was fabricated and was utilized for the detection of trace lead (Pb) concentrations in river water samples prior to and after remediation using calamansi (Citrofortunella Microcarpa) rinds in different forms viz., ground ...

journal_title：Scientific reports

authors： Palisoc ST,Vitto RIM,Noel MG,Palisoc KT,Natividad MT

更新日期：2021-01-14 00:00:00

abstract：:Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...

journal_title：Scientific reports

authors： Luo KL,Yang YH,Lin YT,Hu YC,Yu HH,Wang LC,Chiang BL,Lee JH

更新日期：2020-11-16 00:00:00

abstract：:CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...

journal_title：Scientific reports

authors： Okuma R,Ueta D,Kuniyoshi S,Fujisawa Y,Smith B,Hsu CH,Inagaki Y,Si W,Kawae T,Lin H,Chuang FC,Masuda T,Kobayashi R,Okada Y

更新日期：2020-09-17 00:00:00

abstract：:We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...

journal_title：Scientific reports

authors： Guazzini A,Stefanelli F,Imbimbo E,Vilone D,Bagnoli F,Levnajić Z

更新日期：2019-04-02 00:00:00

abstract：:Tumorigenesis is driven by genetic alterations that perturb the signaling networks regulating proliferation or cell death. In order to block tumor growth, one has to precisely know how these signaling pathways function and interplay. Here, we identified the transcription factor Ets21C as a pivotal regulator of tumor g...

journal_title：Scientific reports

authors： Toggweiler J,Willecke M,Basler K

更新日期：2016-10-07 00:00:00

abstract：:A crystal of emerging magnetic charges is expected in the phase diagram of the dipolar kagomé spin ice. An observation of charge crystallites in thermally demagnetized artificial spin ice arrays has been recently reported by S. Zhang and coworkers and explained through the thermodynamics of the system as it approaches...

journal_title：Scientific reports

authors： Montaigne F,Lacour D,Chioar IA,Rougemaille N,Louis D,Mc Murtry S,Riahi H,Burgos BS,Menteş TO,Locatelli A,Canals B,Hehn M

更新日期：2014-07-16 00:00:00

abstract：:Although macrophages are important players in the injury/repair processes in animal models of acute kidney injury (AKI), their roles in human AKI remains uncertain owing to a paucity of human biopsy studies. We investigated the role of macrophages in 72 cases of biopsy-proven acute tubular necrosis (ATN) and six cases...

journal_title：Scientific reports

authors： Kim MG,Lim K,Lee YJ,Yang J,Oh SW,Cho WY,Jo SK

更新日期：2020-02-07 00:00:00

abstract：:Angiogenesis is a key restorative process following stroke but has also been linked to increased vascular permeability and blood brain barrier (BBB) disruption. Previous pre-clinical approaches primarily focused on the administration of vascular endothelial growth factor (VEGF) to promote vascular repair after stroke....

journal_title：Scientific reports

authors： Rust R,Weber RZ,Grönnert L,Mulders G,Maurer MA,Hofer AS,Sartori AM,Schwab ME

更新日期：2019-12-27 00:00:00

abstract：:Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...

journal_title：Scientific reports

authors： Berthold T,Centler F,Hübschmann T,Remer R,Thullner M,Harms H,Wick LY

更新日期：2016-11-04 00:00:00

abstract：:An ultrasensitive DNA biosensor has been developed through in-situ labeling of electroactive melamine-Cu(2+) complex (Mel-Cu(2+)) on the end of hairpin-like probe using gold nanoparticles (AuNPs) as the signal amplification platform. The 3'-thiolated hairpin-like probe was first immobilized to the gold electrode surfa...

journal_title：Scientific reports

authors： Wang Q,Gao F,Ni J,Liao X,Zhang X,Lin Z

更新日期：2016-03-02 00:00:00

abstract：:While nanowires and nanospheres have been utilized in the design of a diverse array of nanoscale devices, recent schemes frequently require nanoscale architectures of higher complexity. However, conventional techniques are largely unsatisfactory for the production of more intricate nanoscale shapes and patterns, and e...

journal_title：Scientific reports

authors： Khudiyev T,Tobail O,Bayindir M

更新日期：2014-05-06 00:00:00

abstract：:Late embryogenesis abundant (LEA) proteins are a large and highly diverse gene family present in a wide range of plant species. LEAs are proposed to play a role in various stress tolerance responses. Our study represents the first-ever survey of LEA proteins and their encoding genes in a widely distributed pine (Pinus...

journal_title：Scientific reports

authors： Gao J,Lan T

更新日期：2016-01-19 00:00:00

abstract：:Blockage of Delta-like 4 (DLL4)-directed Notch signaling induces excessive tip cell formation and endothelial proliferation resulting in dysfunctional angiogenesis in tumors. MMGZ01, as a murine anti-human DLL4 monoclonal antibody, specifically binds to human DLL4 and blocks Notch pathway. Here, the structure of MMGZ0...

journal_title：Scientific reports

authors： Jia X,Wang W,Xu Z,Wang S,Wang T,Wang M,Wu M

更新日期：2016-06-15 00:00:00

abstract：:The most consistent sex differences in cognition are found for spatial ability, in which males, on average, outperform females. Utilizing a twin design, two studies have shown that females with male co-twins perform better than females with female co-twins on a mental rotation task. According to the Twin Testosterone ...

journal_title：Scientific reports

authors： Toivainen T,Pannini G,Papageorgiou KA,Malanchini M,Rimfeld K,Shakeshaft N,Kovas Y

更新日期：2018-09-12 00:00:00

abstract：:Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

journal_title：Scientific reports

authors： Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

更新日期：2020-11-18 00:00:00

abstract：:The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR wit...

journal_title：Scientific reports

authors： Tanaka S,Ninomiya T,Taniguchi M,Tokumoto M,Masutani K,Ooboshi H,Kitazono T,Tsuruya K

更新日期：2017-11-02 00:00:00

abstract：:Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...

journal_title：Scientific reports

authors： Hashem YA,Amin HM,Essam TM,Yassin AS,Aziz RK

更新日期：2017-07-18 00:00:00

abstract：:Recombination is crucial for biological evolution, which provides many new combinations of genetic diversity. Accurate identification of recombination spots is useful for DNA function study. To improve the prediction accuracy, researchers have proposed several computational methods for recombination spot identificatio...

journal_title：Scientific reports

authors： Wang R,Xu Y,Liu B

更新日期：2016-03-31 00:00:00

abstract：:Influenza infection represents a major socio-economic burden worldwide. Novel delivery methods can render influenza vaccination easier and more acceptable by the public, and importantly confer protection equal or superior to that induced by conventional systemic administration. An attractive target for vaccine deliver...

journal_title：Scientific reports

authors： Koutsonanos DG,Vassilieva EV,Stavropoulou A,Zarnitsyn VG,Esser ES,Taherbhai MT,Prausnitz MR,Compans RW,Skountzou I

更新日期：2012-01-01 00:00:00

abstract：:A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX...

journal_title：Scientific reports

authors： Mo J,Eggers PK,Yuan ZX,Raston CL,Lim LY

更新日期：2016-03-24 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq® FGx™ Forensic Genomics System (I...

journal_title：Scientific reports

authors： Apaga DL,Dennis SE,Salvador JM,Calacal GC,De Ungria MC

更新日期：2017-03-24 00:00:00