Effect of Prior Local Treatment and Prostate-Specific Antigen Kinetics during Androgen-Deprivation Therapy on the Survival of Castration-Resistant Prostate Cancer.

abstract：:In many cancers, incidence, treatment efficacy and overall prognosis vary between geographic populations. Studies disentangling the contributing factors may help in both understanding cancer biology and tailoring therapeutic interventions. Ancestry estimation in such studies should preferably be driven by genomic data...

journal_title：Scientific reports

authors： Huang Q,Baudis M

更新日期：2020-03-16 00:00:00

abstract：:Understanding the response of the plant community to increasing nitrogen (N) deposition is helpful for improving pasture management in semi-arid areas. We implemented a 5-year N addition experiment in a Stipa krylovii steppe of Inner Mongolia, northern China. The aboveground biomass (AGB) and species richness were mea...

journal_title：Scientific reports

authors： He K,Qi Y,Huang Y,Chen H,Sheng Z,Xu X,Duan L

更新日期：2016-08-30 00:00:00

abstract：:Ethidium bromide (EB) and acridine orange (AO) bind to nucleic acids and are thus considered as potential mutagens. In this study, the effects of EB and AO on the germination behaviours of white, yellow, red, and purple maize seeds were investigated. The results indicate that low concentrations of EB (50 μg mL-1) and ...

journal_title：Scientific reports

authors： Zhang Y,Shi H,Deng B

更新日期：2018-09-19 00:00:00

abstract：:SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk b...

journal_title：Scientific reports

authors： Liu B,Lois LM,Reverter D

更新日期：2017-02-06 00:00:00

abstract：:The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to exa...

journal_title：Scientific reports

authors： Pan RY,Ma J,Wu HT,Liu QS,Qin XY,Cheng Y

更新日期：2017-08-23 00:00:00

abstract：:Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in so...

journal_title：Scientific reports

authors： Jin X,Jin C,Huang J,Min Y

更新日期：2017-02-21 00:00:00

abstract：:We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest. Immobilization of protein A on the spongy monolith enabled high-yield collection of imm...

journal_title：Scientific reports

authors： Kubota K,Kubo T,Tanigawa T,Naito T,Otsuka K

更新日期：2017-03-14 00:00:00

abstract：:Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...

journal_title：Scientific reports

authors： Ghosh S,Lim S

更新日期：2018-07-05 00:00:00

abstract：:Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or ...

journal_title：Scientific reports

authors： Cao H,Ma W

更新日期：2017-03-23 00:00:00

abstract：:Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the inf...

journal_title：Scientific reports

authors： Soares AR,Esteves M,Moreira PS,Cunha AM,Guimarães MR,Carvalho MM,Raposo-Lima C,Morgado P,Carvalho AF,Coimbra B,Melo A,Rodrigues AJ,Salgado AJ,Pêgo JM,Cerqueira JJ,Costa P,Sousa N,Almeida A,Leite-Almeida H

更新日期：2018-12-05 00:00:00

abstract：:The majority of oligomeric proteins form clusters which have rotational or dihedral symmetry. Despite the many advantages of symmetric packing, protein oligomers are only nearly symmetric, and the origin of this phenomenon is still in need to be fully explored. Here we apply near-symmetry analyses by the Continuous Sy...

journal_title：Scientific reports

authors： Bonjack M,Avnir D

更新日期：2020-05-20 00:00:00

abstract：:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...

journal_title：Scientific reports

authors： Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

更新日期：2016-07-14 00:00:00

abstract：:Quantum information technologies harness the intrinsic nature of quantum theory to beat the limitations of the classical methods for information processing and communication. Recently, the application of quantum features to metrology has attracted much attention. Quantum optical coherence tomography (QOCT), which util...

journal_title：Scientific reports

authors： Okano M,Lim HH,Okamoto R,Nishizawa N,Kurimura S,Takeuchi S

更新日期：2015-12-14 00:00:00

abstract：:Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...

journal_title：Scientific reports

authors： Yabuki H,Yonezawa S,Eguchi R,Takashiri M

更新日期：2020-10-12 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep23458. ...

journal_title：Scientific reports

authors： Sharma R,Aljayyoussi G,Tyrer HE,Gamble J,Hayward L,Guimaraes AF,Davies J,Waterhouse D,Cook DAN,Myhill LJ,Clare RH,Cassidy A,Steven A,Johnston KL,Ford L,Turner JD,Ward SA,Taylor MJ

更新日期：2018-01-08 00:00:00

abstract：:Most bacterial cells are stressed, and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress. In Escheric...

journal_title：Scientific reports

authors： Chowdhury N,Kwan BW,Wood TK

更新日期：2016-02-03 00:00:00

abstract：:A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb(3+), Tm(3+), Er(3+) and L...

journal_title：Scientific reports

authors： Lin H,Xu D,Li A,Teng D,Yang S,Zhang Y

更新日期：2016-06-16 00:00:00

abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...

journal_title：Scientific reports

authors： Petursdottir Maack H,Skalkidou A,Sjöholm A,Eurenius-Orre K,Mulic-Lutvica A,Wikström AK,Sundström Poromaa I

更新日期：2019-04-17 00:00:00

abstract：:In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS). Recent evidence reveals that gene expressi...

journal_title：Scientific reports

authors： Mannini L,C Lamaze F,Cucco F,Amato C,Quarantotti V,Rizzo IM,Krantz ID,Bilodeau S,Musio A

更新日期：2015-11-19 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...

journal_title：Scientific reports

authors： Inizan F,Hanna M,Stolyarchuk M,Chauvot de Beauchêne I,Tchertanov L

更新日期：2020-03-25 00:00:00

abstract：:This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content was determined by gas chromatography and expressed as mg of CHL in 100 g of fat (CHL_fat) or in 100 mg of milk (CHL_milk). GWAS was performed w...

journal_title：Scientific reports

authors： Do DN,Schenkel FS,Miglior F,Zhao X,Ibeagha-Awemu EM

更新日期：2018-09-05 00:00:00

abstract：:Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....

journal_title：Scientific reports

authors： Ginsberg MR,Rubin RA,Natowicz MR

更新日期：2013-01-01 00:00:00

abstract：:Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...

journal_title：Scientific reports

authors： Abdolali A,Kadri U,Kirby JT

更新日期：2019-11-14 00:00:00

abstract：:The development of efficient green light-emitting diodes (LEDs) is of paramount importance for the realization of colour-mixing white LEDs with a high luminous efficiency. While the insertion of an InGaN/GaN superlattice (SL) with a lower In content before the growth of InGaN/GaN multiple quantum wells (MQWs) is known...

journal_title：Scientific reports

authors： Zhou S,Liu X,Yan H,Gao Y,Xu H,Zhao J,Quan Z,Gui C,Liu S

更新日期：2018-07-23 00:00:00

abstract：:IgG is an indispensable biological experimental tool as well as a widely-used therapeutic protein. However, cell culture-based expression of monoclonal IgG is costly and time-consuming, making this process difficult to use for high-throughput screening in early-stage evaluation of biologics. With the goal of establish...

journal_title：Scientific reports

authors： Murakami S,Matsumoto R,Kanamori T

更新日期：2019-01-24 00:00:00

abstract：:This work demonstrates the dynamic through-silicon-via (TSV) filling process through staged electrodeposition experiments at different current densities. Different morphologies corresponding to TSV filling results can be obtained by controlling the applied current density. Specifically, a low current density (4 mA/cm2...

journal_title：Scientific reports

authors： Wang F,Zhao Z,Nie N,Wang F,Zhu W

更新日期：2017-04-19 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:When exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative processes. The development of robust strains therefore represents a pivotal challenge for the implementation of cost-effective bioprocesses. Altering ...

journal_title：Scientific reports

authors： Martani F,Marano F,Bertacchi S,Porro D,Branduardi P

更新日期：2015-12-14 00:00:00

abstract：:We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-...

journal_title：Scientific reports

authors： Ganesh T,Estrada M,Yeger H,Duffin J,Cheng HL

更新日期：2017-08-07 00:00:00

abstract：:Earthquakes are important natural events, yet their impacts on animal communities are poorly known. Understanding earthquake impacts on groundwater communities is essential to assess their resilience and hence to perform conservation actions. We investigated how a 6.3 Mw earthquake that occurred in 2009 altered the co...

journal_title：Scientific reports

authors： Fattorini S,Di Lorenzo T,Galassi DMP

更新日期：2018-01-24 00:00:00