Abstract:
:Pancreatic adenocarcinoma upregulated factor (PAUF) is a ligand of toll-like receptors (TLRs) and has been reported to be involved in pancreatic tumor development. However, the significance of PAUF expression in epithelial ovarian cancer remains unclear. We aimed to investigate the possible clinical significance of PAUF in epithelial ovarian cancer. We examined the link between PAUF and TLR4 in ovarian cancer cell lines. Recombinant PAUF induced cell activation and proliferation in ovarian cancer cell lines, whereas PAUF knockdown inhibited these properties. Subsequently, we assessed PAUF and TLR4 expression by immunohistochemistry on tissue microarray of 408 ovarian samples ranging from normal to metastatic. PAUF expression positively correlated with TLR4 expression. Overexpression of PAUF was associated with high-grade tumor (p = 0.014) and chemoresistant tumor (p = 0.017). Similarly, high expression of TLR4 correlated with advanced tumor stage (p = 0.002) and chemoresistant tumor (p = 0.001). Multivariate analysis indicated that PAUFhigh, TLR4high, and PAUFhigh/TLR4high expression are independent prognostic factor for progression-free survival, while TLR4high and PAUFhigh/TLR4high expression were independent prognostic factors for overall survival. Our results suggest that PAUF has a role in ovarian cancer progression and is a potential prognostic marker and novel chemotherapeutic target for ovarian cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi CH,Kang TH,Song JS,Kim YS,Chung EJ,Ylaya K,Kim S,Koh SS,Chung JY,Kim JH,Hewitt SMdoi
10.1038/s41598-018-30582-8subject
Has Abstractpub_date
2018-08-15 00:00:00pages
12161issue
1issn
2045-2322pii
10.1038/s41598-018-30582-8journal_volume
8pub_type
杂志文章abstract::Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47564-z
更新日期:2019-08-05 00:00:00
abstract::Previously reported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androgen load, and transgender identity have been inconsistent. The objectives of the present study were to provide additional original data and an updated meta-analysis concerning this association. In a study of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72486-6
更新日期:2020-11-09 00:00:00
abstract::We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02462
更新日期:2013-01-01 00:00:00
abstract::Although anxiety disorders (ADs) have been recognized as one of the most prevalent mental disorders in mainland China, the prevalence of ADs has not been reported until now. The lack of a consolidated and comparable review on the prevalence of ADs in mainland China necessitated this meta-analysis to measure the preval...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep28033
更新日期:2016-06-16 00:00:00
abstract::A new miniplate applied differently from conventional application method for bone fixation has been developed. The novel approach is the insertion of the screw into the bone before miniplate installation. This study aimed to assess the stress distribution of a newly designed Yang's Keyhole (YK)- plate for segmental-bo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27186-7
更新日期:2018-06-12 00:00:00
abstract::Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31367-9
更新日期:2018-09-04 00:00:00
abstract::Two Bidens species (Bidens pilosa and B. bipinnata) that originate from America have been introduced widely in pan-tropics, with the former regarded as a noxious invasive weed whereas the latter naturalized as a plant resource. Whether the two species exhibit different effects on the belowground system remains rarely ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11707-x
更新日期:2017-09-12 00:00:00
abstract::Ciliate Mesodinium species are commonly distributed in diverse aquatic systems worldwide. Among Mesodinium species, M. rubrum is closely associated with microbial food webs and red tide formation and is known to acquire chloroplasts from its cryptophyte prey for use in photosynthesis. For these reasons, Mesodinium has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50659-2
更新日期:2019-10-01 00:00:00
abstract::In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through headphones by recreating the sound pressure generated by the source at the listener's eardrums. This requires the acoustical features of the recordin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37342
更新日期:2016-11-17 00:00:00
abstract::Myodural bridges have been described in various species as connective tissue structures "bridging" small cranio-cervical muscles to the dura. Myodural bridges are thought to stabilize the dural sac during head and neck movements and promote cerebrospinal fluid motion; however, their role in neurological diseases has n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46444-w
更新日期:2019-07-10 00:00:00
abstract::In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08114-7
更新日期:2017-08-11 00:00:00
abstract::Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44619
更新日期:2017-03-20 00:00:00
abstract::Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell dea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09275
更新日期:2015-03-20 00:00:00
abstract::On-surface synthesis provides a route for the production of 1D and 2D covalently bonded polymeric structures. Such reactions are confined to the surface of a substrate and the catalytic properties of the substrate are often utilised to initiate the reaction. Recent studies have focused on the properties of various cry...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45359-w
更新日期:2019-06-27 00:00:00
abstract::Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26139-4
更新日期:2018-05-17 00:00:00
abstract::The spreading of cooperation in structured population is a challenging problem which can be observed at different scales of social and biological organization. Generally, the problem is studied by evaluating the chances that few initial invading cooperators, randomly appearing in a network, can lead to the spreading o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80770-8
更新日期:2021-01-13 00:00:00
abstract::The negatively charged nitrogen-vacancy ([Formula: see text]) center shows excellent spin properties and sensing capabilities on the nanoscale even at room temperature. Shallow implanted [Formula: see text] centers can effectively be protected from surface noise by chemical vapor deposition (CVD) diamond overgrowth, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79943-2
更新日期:2020-12-29 00:00:00
abstract::There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06903
更新日期:2014-11-11 00:00:00
abstract::Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35662
更新日期:2016-10-20 00:00:00
abstract::Dendritic spines are the postsynaptic sites of most excitatory synapses in the brain, and spine enlargement and shrinkage give rise to long-term potentiation and depression of synapses, respectively. Because spine structural plasticity is accompanied by remodeling of actin scaffolds, we hypothesized that the filamento...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32897
更新日期:2016-09-06 00:00:00
abstract::We demonstrate that the microstructural and mechanical properties of bacterial biofilms can be created through colloidal self-assembly of cells and polymers, and thereby link the complex material properties of biofilms to well understood colloidal and polymeric behaviors. This finding is applied to soften and disassem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13081
更新日期:2015-08-14 00:00:00
abstract::Adaptation of visual responses enhances visual information processing mainly by preserving the full dynamic range of neuronal responses during changing light conditions and is found throughout the whole visual system. Although adaptation in the primate superior colliculus neurons has received much attention little is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27331-2
更新日期:2018-06-12 00:00:00
abstract::The frontal lobes are essential for human volition and goal-directed behavior, yet their function remains unclear. While various models have highlighted working memory, reinforcement learning, and cognitive control as key functions, a single framework for interpreting the range of effects observed in prefrontal cortex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21407-9
更新日期:2018-03-01 00:00:00
abstract::Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18490-9
更新日期:2018-01-10 00:00:00
abstract::A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network connecting the electrocatalyst MnO nanoparticles together to facilitate good electrochemical performance. The electrocatalyst MnO shows favourable ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08012
更新日期:2015-01-30 00:00:00
abstract::Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in Cannabis, which is studied extensively for its medicinal value. A central gap in the science is the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profiles. Using a mass-spectrometry based metabolomic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46478-0
更新日期:2019-07-19 00:00:00
abstract::Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-an...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-24547-0
更新日期:2018-04-18 00:00:00
abstract::V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T cells, orthogonal to PD-1 and other checkpoints of the tumor-T cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71519-4
更新日期:2020-09-16 00:00:00
abstract::This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/srep38844
更新日期:2016-12-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69834-x
更新日期:2020-07-29 00:00:00