Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration.

abstract：:This paper presents a digital elevation model (DEM) of the dunes found in the Lençóis Maranhenses National Park, an environmental protection area located in the Maranhão state (Brazil). The DEM supports the modeling studies of sand-dune evolution using multi-temporal satellite images and ground truth data, obtained th...

journal_title：Scientific reports

authors： Dos Santos ALS,Borges HP,Silva Junior CHL,Piedade Junior RN,da Silva Bezerra D

更新日期：2019-05-15 00:00:00

abstract：:MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patien...

journal_title：Scientific reports

authors： Lutz P,M Haimid M,Pohlmann A,Lehmann J,Jansen C,Schierwagen R,Klein S,Strassburg CP,Spengler U,Trebicka J

更新日期：2017-01-11 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chromatography were used t...

journal_title：Scientific reports

authors： Lu X,Machiesky LA,De Mel N,Du Q,Xu W,Washabaugh M,Jiang XR,Wang J

更新日期：2020-01-15 00:00:00

abstract：:Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotrichum sublineolum. An...

journal_title：Scientific reports

authors： Tugizimana F,Djami-Tchatchou AT,Fahrmann JF,Steenkamp PA,Piater LA,Dubery IA

更新日期：2019-03-01 00:00:00

abstract：:Climatic characteristics of Hengduan Mountains region were diverse, and Eothenomys miletus was a native species throughout this region. To investigate adaptive strategies of E. miletus to environmental factors in different locations in this region, five locations were selected, including Deqin (DQ), Xianggelila (XGLL)...

journal_title：Scientific reports

authors： Zhang HJ,Wang ZK,Zhu WL

更新日期：2019-10-17 00:00:00

abstract：:To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...

journal_title：Scientific reports

authors： Morand A,Tall ML,Kuete Yimagou E,Ngom II,Lo CI,Cornu F,Tsimaratos M,Lagier JC,Levasseur A,Raoult D,Fournier PE

更新日期：2021-01-29 00:00:00

abstract：:PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumo...

journal_title：Scientific reports

authors： Zou Y,Du F,Hu Q,Wang H

更新日期：2019-02-11 00:00:00

abstract：:Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 ad...

journal_title：Scientific reports

authors： Butkevich E,Härtig W,Nikolov M,Erck C,Grosche J,Urlaub H,Schmidt CF,Klopfenstein DR,Chua JJ

更新日期：2016-06-01 00:00:00

abstract：:The recent reaching of 20% of conversion efficiency by solar cells based on metal hybrid perovskites (MHP), e.g., the methylammonium (MA) lead iodide, CH3NH3PbI3 (MAPbI3), has excited the scientific community devoted to the photovoltaic materials. However, the toxicity of Pb is a hindrance for large scale commercial o...

journal_title：Scientific reports

authors： Guedes-Sobrinho D,Guilhon I,Marques M,Teles LK

更新日期：2019-07-30 00:00:00

abstract：:Water pollution is a serious concern for public health and environment in today's world; hence, there exists a strong demand to develop cost-effective, sustainable and eco-friendly membranes. Here, we produce a highly efficient molecular filter membrane based on bio-renewable material; cyclic oligosaccaharides known a...

journal_title：Scientific reports

authors： Celebioglu A,Yildiz ZI,Uyar T

更新日期：2017-08-07 00:00:00

abstract：:Immune cell infiltrates in melanoma have important prognostic value. Gene expression analysis may simultaneously quantify numbers and function of multiple immune cell subtypes in formalin-fixed paraffin-embedded (FFPE) tissues. Prior studies report single gene expression can represent individual immune cell subtypes, ...

journal_title：Scientific reports

authors： Kwak M,Erdag G,Slingluff CL Jr

更新日期：2020-10-27 00:00:00

abstract：:Molecular tests hold great potential for tuberculosis (TB) diagnosis, but are costly, time consuming, and HIV-infected patients are often sputum scarce. Therefore, alternative approaches are needed. We evaluated automated digital chest radiography (ACR) as a rapid and cheap pre-screen test prior to Xpert MTB/RIF (Xper...

journal_title：Scientific reports

authors： Philipsen RH,Sánchez CI,Maduskar P,Melendez J,Peters-Bax L,Peter JG,Dawson R,Theron G,Dheda K,van Ginneken B

更新日期：2015-07-27 00:00:00

abstract：:HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...

journal_title：Scientific reports

authors： Mohseni Ahooyi T,Shekarabi M,Torkzaban B,Langford TD,Burdo TH,Gordon J,Datta PK,Amini S,Khalili K

更新日期：2018-11-02 00:00:00

abstract：:Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-...

journal_title：Scientific reports

authors： Chen YF,Tang SC,Wu WC,Kao HL,Kuo YS,Yang SC

更新日期：2017-05-12 00:00:00

abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

journal_title：Scientific reports

authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

更新日期：2015-12-04 00:00:00

abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...

journal_title：Scientific reports

authors： Meng Q,Wang H,Yan P,Pan J,Lu D,Cui Z,Zhang F,Chen X

更新日期：2017-02-03 00:00:00

abstract：:The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that ...

journal_title：Scientific reports

authors： Min JS,Halder D,Yoon JY,Jeon SJ,Jun SY,Lee JR,Lee JJ,Choi MH,Jung CR,Lee D,Kim BJ,Kim NS

更新日期：2020-12-04 00:00:00

abstract：:PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5'-UTRs. Most studies of human PDCD4...

journal_title：Scientific reports

authors： Haas A,Nilges BS,Leidel SA,Klempnauer KH

更新日期：2020-02-17 00:00:00

abstract：:Recombinant Mycobacterium strains such as recombinant BCG (rBCG) have received considerable attention for the HIV-1 vaccine development. Recently, we described a temperature-sensitive Mycobacterium paragordonae (Mpg) strain as a novel live tuberculosis vaccine that is safer and showed an enhanced protective effect aga...

journal_title：Scientific reports

authors： Kim BJ,Kim BR,Kook YH,Kim BJ

更新日期：2019-10-29 00:00:00

abstract：:We here present the first detailed study of the specimen KNM-RU 18340 from Rusinga Island (Kenya), the only known complete early Miocene chameleon skull, using micro-CT. This specimen represents one of the oldest chameleon fossils ever recovered. For the first time, the skull bone internal surfaces, their sutures, and...

journal_title：Scientific reports

authors： Čerňanský A,Herrel A,Kibii JM,Anderson CV,Boistel R,Lehmann T

更新日期：2020-01-10 00:00:00

abstract：:The kynurenine pathway (KP) is dysregulated in neuroinflammatory diseases including Alzheimer's disease (AD), however has not been investigated in preclinical AD characterized by high neocortical amyloid-β load (NAL), prior to cognitive impairment. Serum KP metabolites were measured in the cognitively normal KARVIAH c...

journal_title：Scientific reports

authors： Chatterjee P,Goozee K,Lim CK,James I,Shen K,Jacobs KR,Sohrabi HR,Shah T,Asih PR,Dave P,ManYan C,Taddei K,Lovejoy DB,Chung R,Guillemin GJ,Martins RN

更新日期：2018-05-22 00:00:00

abstract：:We aimed to assess feasibility of a support vector machine (SVM) texture classifier to discriminate pathologic infiltration patterns from the normal bone marrows in MRI. This retrospective study included 467 cases, which were split into a training (n = 360) and a test set (n = 107). A sagittal T1-weighted lumbar spina...

journal_title：Scientific reports

authors： Hwang EJ,Jung JY,Lee SK,Lee SE,Jee WH

更新日期：2019-04-15 00:00:00

abstract：:The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the...

journal_title：Scientific reports

authors： Pires MM,Cantor M,Guimarães PR,de Aguiar MA,Dos Reis SF,Coltri PP

更新日期：2015-10-07 00:00:00

abstract：:Gut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes (T2DM). In this study, we used a high fat sucrose (HFS) diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyper...

journal_title：Scientific reports

authors： Zhang Y,Guo X,Guo J,He Q,Li H,Song Y,Zhang H

更新日期：2014-07-18 00:00:00

abstract：:Homogeneous target dose distribution in intensity-modulated radiotherapy (IMRT) for sinonasal cancer (SNC) is challenging to achieve. To solve this problem, we established and evaluated a basal-dose-compensation (BDC) optimization approach, in which the treatment plan is further optimized based on the initial plans. G...

journal_title：Scientific reports

authors： Lu JY,Zhang JY,Li M,Cheung ML,Li YK,Zheng J,Huang BT,Zhang WZ

更新日期：2015-10-26 00:00:00

abstract：:The plant selective autophagy cargo receptor neighbour of breast cancer 1 gene (NBR1) has been scarcely studied in the context of abiotic stress. We wanted to expand this knowledge by using Arabidopsis thaliana lines with constitutive ectopic overexpression of the AtNBR1 gene (OX lines) and the AtNBR1 Knock-Out (KO li...

journal_title：Scientific reports

authors： Tarnowski L,Rodriguez MC,Brzywczy J,Piecho-Kabacik M,Krčkova Z,Martinec J,Wawrzynska A,Sirko A

更新日期：2020-05-08 00:00:00

abstract：:Cytotoxic T lymphocyte-associated antigen 4 immunoglobulin fusion protein (CTLA4Ig, abatacept) is a B7/CD28 costimulation inhibitor that can ward off the immune response by preventing the activation of naïve T cells. This therapeutic agent is administered to patients with autoimmune diseases such as rheumatoid arthrit...

journal_title：Scientific reports

authors： Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH

更新日期：2014-11-06 00:00:00

abstract：:Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk [odds ratios (OR) ≤ 3] for (mostly peri- and post-menopausal) breast cancer. The majority of low/moderate-risk genes, particularly those with minor allele frequencie...

journal_title：Scientific reports

authors： Moslehi R,Tsao HS,Zeinomar N,Stagnar C,Fitzpatrick S,Dzutsev A

更新日期：2020-12-04 00:00:00

abstract：:Antigen-presenting cells including dendritic cells (DCs) express mannan receptors (MR) on their surface, which can be exploited in cancer therapy by designing immune-stimulatory viruses coated with mannan-modified capsids that then bind to DCs and initiate a potent immune response. Although the combination of anti-ang...

journal_title：Scientific reports

authors： Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

更新日期：2015-06-18 00:00:00

abstract：:This paper reports the application of anthracite particles of different sizes and coated with nine kinds of layered double hydroxides (LDHs) varying in M(II)-M(III) cations, as alternative substrates in the simulated vertical-flow constructed wetland columns. Effects of LDHs-coating and particle size of modified anthr...

journal_title：Scientific reports

authors： Zhang X,Guo L,Wang Y,Ruan C

更新日期：2015-10-12 00:00:00