PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.


:PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5'-UTRs. Most studies of human PDCD4 have employed tumor cell lines, possibly resulting in a biased picture of its role in normal cells. Here, we have studied the function of PDCD4 in a telomerase-immortalized human epithelial cell line. We show for the first time that PDCD4 is required for the G1/S-transition, demonstrating its crucial role in the cell cycle. Inhibition of p53-dependent activation of p21WAF1/CIP1 overrides the requirement for PDCD4 for the G1/S-transition, suggesting that PDCD4 counteracts basal p53 activity to prevent activation of the G1/S checkpoint by p53. Transcriptome and ribosome profiling data show that silencing of PDCD4 changes the expression levels and translation of many mRNAs, providing an unbiased view of the cellular processes that are affected by PDCD4 in an epithelial cell line. Our data identify PDCD4 as a key regulator of cell cycle- and DNA-related functions that are inhibited when it is silenced, suggesting that decreased expression of PDCD4 might contribute to tumor development by compromising genomic integrity.


Sci Rep


Scientific reports


Haas A,Nilges BS,Leidel SA,Klempnauer KH




Has Abstract


2020-02-17 00:00:00












  • Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange.

    abstract::Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

    更新日期:2013-01-01 00:00:00

  • Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum Crispum and Apium Graveolens against Experimental Hyperuricemia.

    abstract::Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood. It is the cause of gout, manifested by inflammatory arthritis, pain and disability. This study examined the possible ameliorative impacts of parsley (PAR) and celery (CEL) as hypouricemic agents at biochemic...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Soliman MM,Nassan MA,Aldhahrani A,Althobaiti F,Mohamed WA

    更新日期:2020-06-11 00:00:00

  • Dynamical Analysis of Standing Balance Control on Sloped Surfaces in Individuals with Lumbar Disc Herniation.

    abstract::The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li J,Zhang Y,Song S,Hou Y,Hong Y,Yue S,Li K

    更新日期:2020-02-03 00:00:00

  • The effect of refractive error on optokinetic nystagmus.

    abstract::Subjective refraction is the gold-standard for prescribing refractive correction, but its accuracy is limited by patient's subjective judgment about their clarity of vision. We asked if an involuntary eye movement, optokinetic nystagmus (OKN), could serve as an objective measure of visual-clarity, specifically measuri...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Doustkouhi SM,Turnbull PRK,Dakin SC

    更新日期:2020-11-18 00:00:00

  • Scaling and correlation properties of RR and QT intervals at the cellular level.

    abstract::We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim J,Shah D,Potapov I,Latukka J,Aalto-Setälä K,Räsänen E

    更新日期:2019-03-06 00:00:00

  • Predicting county-scale maize yields with publicly available data.

    abstract::Maize (corn) is the dominant grain grown in the world. Total maize production in 2018 equaled 1.12 billion tons. Maize is used primarily as an animal feed in the production of eggs, dairy, pork and chicken. The US produces 32% of the world's maize followed by China at 22% and Brazil at 9% ( https://apps.fas.usda.gov/p...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jiang Z,Liu C,Ganapathysubramanian B,Hayes DJ,Sarkar S

    更新日期:2020-09-11 00:00:00

  • Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells.

    abstract::Daily sunlight exposure damages the epidermal basement membrane (BM) and disrupts epidermal homeostasis. Inter-follicular epidermal stem cells (IFE-SCs) regulate epidermal proliferation and differentiation, which supports epidermal homeostasis. Here, we examine how photoaging affects the function of IFE-SCs and we ide...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Iriyama S,Yasuda M,Nishikawa S,Takai E,Hosoi J,Amano S

    更新日期:2020-07-28 00:00:00

  • The Anopheles coluzzii microbiome and its interaction with the intracellular parasite Wolbachia.

    abstract::Wolbachia, an endosymbiotic alpha-proteobacterium commonly found in insects, can inhibit the transmission of human pathogens by mosquitoes. Biocontrol programs are underway using Aedes aegypti mosquitoes trans-infected with a non-natural Wolbachia strain to reduce dengue virus transmission. Less is known about the imp...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Straub TJ,Shaw WR,Marcenac P,Sawadogo SP,Dabiré RK,Diabaté A,Catteruccia F,Neafsey DE

    更新日期:2020-08-14 00:00:00

  • Linking landscape-scale conservation to regional and continental outcomes for a migratory species.

    abstract::Land-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply thi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mattsson BJ,Devries JH,Dubovsky JA,Semmens D,Thogmartin WE,Derbridge JJ,Lopez-Hoffman L

    更新日期:2020-03-18 00:00:00

  • Basin stability measure of different steady states in coupled oscillators.

    abstract::In this report, we investigate the stabilization of saddle fixed points in coupled oscillators where individual oscillators exhibit the saddle fixed points. The coupled oscillators may have two structurally different types of suppressed states, namely amplitude death and oscillation death. The stabilization of saddle ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rakshit S,Bera BK,Majhi S,Hens C,Ghosh D

    更新日期:2017-04-05 00:00:00

  • Modal characterization using principal component analysis: application to Bessel, higher-order Gaussian beams and their superposition.

    abstract::The modal characterization of various families of beams is a topic of current interest. We recently reported a new method for the simultaneous determination of both the azimuthal and radial mode indices for light fields possessing orbital angular momentum. The method is based upon probing the far-field diffraction pat...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mourka A,Mazilu M,Wright EM,Dholakia K

    更新日期:2013-01-01 00:00:00

  • In vitro Studies on The Inhibition of Replication of Zika and Chikungunya Viruses by Dolastane Isolated from Seaweed Canistrocarpus cervicornis.

    abstract::The lack of vaccines and antiviral treatment, along with the increasing number of cases of Zika virus (ZIKV) and Chikungunya virus (CHIKV) infections, emphasize the need for searching for new therapeutic strategies. In this context, the marine brown seaweed Canistrocarpus cervicornis has been proved to hold great anti...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cirne-Santos CC,de Souza Barros C,de Oliveira MC,Rabelo VW,Azevedo RC,Teixeira VL,Ferreira DF,de Palmer Paixão ICN

    更新日期:2020-05-19 00:00:00

  • Fast ion transport through ultrathin shells of metal sulfide hollow nanocolloids used for high-performance energy storage.

    abstract::Metal sulfide (MS, nickel sulfide/copper sulfide) hollow spheres with hierarchical, ultrathin shell structures have been constructed by a facile method. The as-formed MS hollow structures are shown to be uniform in sizes with hierarchical ultrathin shells, which could facilitate the transport of electrolyte ions. Elec...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen Z,Zhao M,Lv X,Zhou K,Jiang X,Ren X,Mei X

    更新日期:2018-01-08 00:00:00

  • Comparing passive measures of fatigue-like behavior in mice.

    abstract::Fatigue is a very common and costly symptom associated with various diseases and disorders. Nonetheless, understanding the pathobiology and developing of therapies for fatigue have been difficult, partly because of a lack of consensus on the measures to phenotype this behavior, both in clinical settings and in animal ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wolff BS,Raheem SA,Saligan LN

    更新日期:2018-09-24 00:00:00

  • Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy.

    abstract::High-precision radiotherapy (HPR) has established its important role in the treatment of tumors due to its precise dose distribution. Given its more complicated delivery process, HPR commonly requires more fraction delivery time (FDT). However, it is unknown whether it has an identical response of prolonged FDT on dif...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yao Q,Zheng R,Xie G,Liao G,Du S,Ren C,Li R,Lin X,Hu D,Yuan Y

    更新日期:2015-03-13 00:00:00

  • The globally invasive small Indian mongoose Urva auropunctata is likely to spread with climate change.

    abstract::Invasive alien species represent one of the major factors of global loss of biodiversity and disruption of natural ecosystems. The small Indian mongoose, Urva auropunctata, is considered one of the wild carnivore species with the greatest negative impact on global biodiversity. Understanding of the factors underpinnin...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Louppe V,Leroy B,Herrel A,Veron G

    更新日期:2020-05-04 00:00:00

  • Highly Tm(3+) doped germanate glass and its single mode fiber for 2.0 μm laser.

    abstract::Highly Tm(3+) doped optical fibers are urgently desirable for 2.0 μm compact single-frequency fiber laser and high-repetition-rate mode-locked fiber laser. Here, we systematically investigated the optical parameters, energy transfer processes and thermal properties of Tm(3+) doped barium gallo-germanate (BGG) glasses....

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wen X,Tang G,Yang Q,Chen X,Qian Q,Zhang Q,Yang Z

    更新日期:2016-02-01 00:00:00

  • Effectiveness of serum beta-2 microglobulin as a tool for evaluating donor kidney status for transplantation.

    abstract::Kidney transplantations using expanded criteria donors (ECD) are being increasingly adopted, but no consensus tools are available to evaluate donor kidney status. Beta-2 microglobulin (B2MG) is a marker of kidney function, and herein, we evaluate the usefulness of assessing B2MG to evaluate donor kidney status. Fifty-...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cha SW,Shin IS,Kim DG,Kim SH,Lee JY,Kim JS,Yang JW,Han BG,Choi SO

    更新日期:2020-05-15 00:00:00

  • Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses.

    abstract::Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kato S,Shirai Y,Sakamoto M,Mori S,Kodama T

    更新日期:2019-09-13 00:00:00

  • Association between secondary thrombocytosis and viral respiratory tract infections in children.

    abstract::Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and se...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zheng SY,Xiao QY,Xie XH,Deng Y,Ren L,Tian DY,Luo ZX,Luo J,Fu Z,Huang AL,Liu EM

    更新日期:2016-03-11 00:00:00

  • Biotic soil-plant interaction processes explain most of hysteric soil CO2 efflux response to temperature in cross-factorial mesocosm experiment.

    abstract::Ecosystem carbon flux partitioning is strongly influenced by poorly constrained soil CO2 efflux (Fsoil). Simple model applications (Arrhenius and Q10) do not account for observed diel hysteresis between Fsoil and soil temperature. How this hysteresis emerges and how it will respond to variation in vegetation or soil m...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dusza Y,Sanchez-Cañete EP,Galliard JL,Ferrière R,Chollet S,Massol F,Hansart A,Juarez S,Dontsova K,Haren JV,Troch P,Pavao-Zuckerman MA,Hamerlynck E,Barron-Gafford GA

    更新日期:2020-01-22 00:00:00

  • Spatial Abundance and Distribution of Potential Microbes and Functional Genes Associated with Anaerobic Mineralization of Pentachlorophenol in a Cylindrical Reactor.

    abstract::Functional interplays of microbial activity, genetic diversity and contaminant transformation are poorly understood in reactors for mineralizing halogenated aromatics anaerobically. Here, we investigated abundance and distribution of potential microbes and functional genes associated with pentachlorophenol (PCP) anaer...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li ZL,Nan J,Huang C,Liang B,Liu WZ,Cheng HY,Zhang C,Zhang D,Kong D,Kanamaru K,Kobayashi T,Wang AJ,Katayama A

    更新日期:2016-01-11 00:00:00

  • CdS quantum dots modified CuO inverse opal electrodes for ultrasensitive electrochemical and photoelectrochemical biosensor.

    abstract::The CuO inverse opal photonic crystals (IOPCs) were synthesized by the sol-gel method and modified with CdS quantum dots by successive ionic layer adsorption and reaction (SILAR). CdS QDs modified CuO IOPCs FTO electrodes of different SILAR cycles were fabricated and their electrochemical properties were studied by cy...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Xia L,Xu L,Song J,Xu R,Liu D,Dong B,Song H

    更新日期:2015-06-04 00:00:00

  • Methane excess in Arctic surface water-triggered by sea ice formation and melting.

    abstract::Arctic amplification of global warming has led to increased summer sea ice retreat, which influences gas exchange between the Arctic Ocean and the atmosphere where sea ice previously acted as a physical barrier. Indeed, recently observed enhanced atmospheric methane concentrations in Arctic regions with fractional sea...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Damm E,Rudels B,Schauer U,Mau S,Dieckmann G

    更新日期:2015-11-10 00:00:00

  • Novel concept for neutron detection: proportional counter filled with 10B nanoparticle aerosol.

    abstract::The high neutron detection efficiency, good gamma-ray discrimination and non-toxicity of 3He made of proportional counters filled with this gas the obvious choice for neutron detection, particularly in radiation portal monitors (RPM), used to control the illicit transport of nuclear material, of which neutron detector...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Amaro FD,Monteiro CM,Dos Santos JM,Antognini A

    更新日期:2017-02-09 00:00:00

  • A Flexible Electret Membrane with Persistent Electrostatic Effect and Resistance to Harsh Environment for Energy Harvesting.

    abstract::A novel flexible electret membrane, exhibiting persistent electrostatic effect, distinctive temperature stability and outstanding capability of resistance to harsh environment and fatigue, is demonstrated by experiment. Its excellent electret performance is correlated to the synergy of three factors, which are space c...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Huiming X,Gangjin C,Xumin C,Zhi C

    更新日期:2017-08-16 00:00:00

  • In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography.

    abstract::Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fib...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Coughlan CA,Chou LD,Jing JC,Chen JJ,Rangarajan S,Chang TH,Sharma GK,Cho K,Lee D,Goddard JA,Chen Z,Wong BJ

    更新日期:2016-03-10 00:00:00

  • Root canal configuration and root wall thickness of first maxillary premolars in an Israeli population. A Cone-beam computed tomography study.

    abstract::Anatomical features of first maxillary premolars may greatly affect endodontic and following restorative treatments. The aim of this study was to evaluate root canal configuration and root wall thickness of first maxillary premolars using a preexisting CBCT database. A CBCT database of 400 first maxillary premolar was...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kfir A,Mostinsky O,Elyzur O,Hertzeanu M,Metzger Z,Pawar AM

    更新日期:2020-01-16 00:00:00

  • Effects of short-term heat shock and physiological responses to heat stress in two Bradysia adults, Bradysia odoriphaga and Bradysia difformis.

    abstract::Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhu G,Xue M,Luo Y,Ji G,Liu F,Zhao H,Sun X

    更新日期:2017-10-17 00:00:00

  • SMRT sequencing of full-length transcriptome of seagrasses Zostera japonica.

    abstract::Seagrass meadows are among the four most productive marine ecosystems in the world. Zostera japonica (Z. japonica) is the most widely distributed species of seagrass in China. However, there is no reference genome or transcriptome available for Z. japonica, impeding progress in functional genomic and molecular ecology...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen S,Qiu G,Yang M

    更新日期:2019-10-10 00:00:00