当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.

PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.

Abstract：

:PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5'-UTRs. Most studies of human PDCD4 have employed tumor cell lines, possibly resulting in a biased picture of its role in normal cells. Here, we have studied the function of PDCD4 in a telomerase-immortalized human epithelial cell line. We show for the first time that PDCD4 is required for the G1/S-transition, demonstrating its crucial role in the cell cycle. Inhibition of p53-dependent activation of p21WAF1/CIP1 overrides the requirement for PDCD4 for the G1/S-transition, suggesting that PDCD4 counteracts basal p53 activity to prevent activation of the G1/S checkpoint by p53. Transcriptome and ribosome profiling data show that silencing of PDCD4 changes the expression levels and translation of many mRNAs, providing an unbiased view of the cellular processes that are affected by PDCD4 in an epithelial cell line. Our data identify PDCD4 as a key regulator of cell cycle- and DNA-related functions that are inhibited when it is silenced, suggesting that decreased expression of PDCD4 might contribute to tumor development by compromising genomic integrity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Haas A,Nilges BS,Leidel SA,Klempnauer KH

doi

10.1038/s41598-020-59678-w

subject

Has Abstract

pub_date

2020-02-17 00:00:00

pages

2758

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59678-w

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • GBA3: a polymorphic pseudogene in humans that experienced repeated gene loss during mammalian evolution.

    abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68106-y

    authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

    更新日期：2020-07-14 00:00:00

  • An aposymbiotic primary coral polyp counteracts acidification by active pH regulation.

    abstract：:Corals build their skeletons using extracellular calcifying fluid located in the tissue-skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40324

    authors： Ohno Y,Iguchi A,Shinzato C,Inoue M,Suzuki A,Sakai K,Nakamura T

    更新日期：2017-01-18 00:00:00

  • A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification.

    abstract：:Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43756-9

    authors： Moghieb A,Tesfay L,Nie S,Gritsenko M,Fillmore TL,Jacobs JM,Smith RD,Torti FM,Torti SV,Shi T,Ansong C

    更新日期：2019-05-13 00:00:00

  • Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

    abstract：:Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and ...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-019-39998-2

    authors： Pelusi S,Baselli G,Pietrelli A,Dongiovanni P,Donati B,McCain MV,Meroni M,Fracanzani AL,Romagnoli R,Petta S,Grieco A,Miele L,Soardo G,Bugianesi E,Fargion S,Aghemo A,D'Ambrosio R,Xing C,Romeo S,De Francesco R,Reeves

    更新日期：2019-03-06 00:00:00

  • Developing a routine lab test for absolute quantification of HER2 in FFPE breast cancer tissues using Quantitative Dot Blot (QDB) method.

    abstract：:Developing immunoassay for absolute quantitation of protein biomarkers in Formalin Fixed Paraffin Embedded (FFPE) samples promises improved objectivity, consistency and accuracy in daily clinical practice. The feasibility of Quantitative Dot Blot (QDB) method for this purpose was explored in this study. We were able t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69471-4

    authors： Yu G,Zhang W,Zhang Y,Lv J,Wu S,Sui X,Zhang J,Tang F

    更新日期：2020-07-27 00:00:00

  • Dyke apertures record stress accumulation during sustained volcanism.

    abstract：:The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74361-w

    authors： Thiele ST,Cruden AR,Micklethwaite S,Bunger AP,Köpping J

    更新日期：2020-10-15 00:00:00

  • Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus.

    abstract：:The peptidoglycan of Staphylococcus aureus is highly amidated. Amidation of α-D-isoglutamic acid in position 2 of the stem peptide plays a decisive role in the polymerization of cell wall building blocks. S. aureus mutants with a reduced degree of amidation are less viable and show increased susceptibility to methicil...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31098-x

    authors： Nöldeke ER,Muckenfuss LM,Niemann V,Müller A,Störk E,Zocher G,Schneider T,Stehle T

    更新日期：2018-08-28 00:00:00

  • Flower induction, microscope-aided cross-pollination, and seed production in the duckweed Lemna gibba with discovery of a male-sterile clone.

    abstract：:Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03240-8

    authors： Fu L,Huang M,Han B,Sun X,Sree KS,Appenroth KJ,Zhang J

    更新日期：2017-06-08 00:00:00

  • Loss of the six3/6 controlling pathways might have resulted in pinhole-eye evolution in Nautilus.

    abstract：:Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to explore the module of lens formation and its evolutionary mechanism. Here, we conducted an RNA-seq study of developing eyes of Nautilus and pygmy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01432

    authors： Ogura A,Yoshida MA,Moritaki T,Okuda Y,Sese J,Shimizu KK,Sousounis K,Tsonis PA

    更新日期：2013-01-01 00:00:00

  • GABA (γ-aminobutyric acid), as a thermo-protectant, to improve the reproductive function of heat-stressed mungbean plants.

    abstract：:Rising global temperatures are proving to be detrimental for the agriculture. Hence, strategies are needed to induce thermotolerance in food crops to sustain the food production. GABA (γ-aminobutyric acid), a non-protein amino acid, can partially protect plants from high-temperature stress. This study hypothesises tha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44163-w

    authors： Priya M,Sharma L,Kaur R,Bindumadhava H,Nair RM,Siddique KHM,Nayyar H

    更新日期：2019-05-24 00:00:00

  • Chronic kidney disease attenuates the impact of obesity on quality of life.

    abstract：:The impact of obesity on health-related quality of life (HRQoL) in chronic kidney disease (CKD) population has not been elucidated, despite the impairment of HRQoL in the obese among general population. We hypothesized that the impact of obesity on HRQoL might be confounded by impaired renal function in CKD population...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59382-9

    authors： Suh SH,Choi HS,Kim CS,Bae EH,Ma SK,Lee DH,Kim SW

    更新日期：2020-02-11 00:00:00

  • Brain activity in the right-frontal pole and lateral occipital cortex predicts successful post-operatory outcome after surgery for anterior glenoumeral instability.

    abstract：:Shoulder apprehension is more complex than a pure mechanical problem of the shoulder, creating a scar at the brain level that prevents the performance of specific movements. Surgery corrects for shoulder instability at the physical level, but a re-dislocation within the first year is rather common. Predicting which pa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00518-9

    authors： Zanchi D,Cunningham G,Lädermann A,Ozturk M,Hoffmeyer P,Haller S

    更新日期：2017-03-29 00:00:00

  • Lipid yield from the diatom Porosira glacialis is determined by solvent choice and number of extractions, independent of cell disruption.

    abstract：:Cell wall disruption is necessary to maximize lipid extraction yields in conventional species of mass-cultivated microalgae. This study investigated the effect of sonication, solvent choice and number of extractions on the lipid yield, lipid class composition and fatty acid composition of the diatom Porosira glacialis...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79269-z

    authors： Svenning JB,Dalheim L,Vasskog T,Matricon L,Vang B,Olsen RL

    更新日期：2020-12-17 00:00:00

  • MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.

    abstract：:Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular processes in liver diseases. However, the functional role of miRNAs in nonalcoholic fibrosing steatohepatitis is largely unclear. In this study, w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16163

    authors： Du J,Niu X,Wang Y,Kong L,Wang R,Zhang Y,Zhao S,Nan Y

    更新日期：2015-11-05 00:00:00

  • Cotinine concentration in serum correlates with tobacco smoke-induced emphysema in mice.

    abstract：:Secondhand smoke (SHS) has been associated with a variety of adverse health outcomes in nonsmokers, including emphysema (a chronic obstructive pulmonary disease). One way to detect SHS exposure is to measure the concentration of cotinine, the primary metabolite of nicotine, in bodily fluids. We have developed a method...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03864

    authors： Xu X,Su Y,Fan ZH

    更新日期：2014-01-27 00:00:00

  • In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.

    abstract：:The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41027

    authors： Hane FT,Li T,Smylie P,Pellizzari RM,Plata JA,DeBoef B,Albert MS

    更新日期：2017-01-20 00:00:00

  • CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.

    abstract：:CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune acti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00192-x

    authors： Joshi A,Punke EB,Sedano M,Beauchamp B,Patel R,Hossenlopp C,Alozie OK,Gupta J,Mukherjee D,Garg H

    更新日期：2017-03-22 00:00:00

  • Polarization conversion in plasmonic nanoantennas for metasurfaces using structural asymmetry and mode hybridization.

    abstract：:Polarization control using single plasmonic nanoantennas is of interest for subwavelength optical components in nano-optical circuits and metasurfaces. Here, we investigate the role of two mechanisms for polarization conversion by plasmonic antennas: Structural asymmetry and plasmon hybridization through strong coupli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40906

    authors： Wiecha PR,Black LJ,Wang Y,Paillard V,Girard C,Muskens OL,Arbouet A

    更新日期：2017-01-19 00:00:00

  • Maskless plasmonic lithography at 22 nm resolution.

    abstract：:Optical imaging and photolithography promise broad applications in nano-electronics, metrologies, and single-molecule biology. Light diffraction however sets a fundamental limit on optical resolution, and it poses a critical challenge to the down-scaling of nano-scale manufacturing. Surface plasmons have been used to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00175

    authors： Pan L,Park Y,Xiong Y,Ulin-Avila E,Wang Y,Zeng L,Xiong S,Rho J,Sun C,Bogy DB,Zhang X

    更新日期：2011-01-01 00:00:00

  • Effect of mechanically stimulated saliva on initial human dental biofilm formation.

    abstract：:This study evaluated the impact of mechanically stimulated saliva on initial bacterial colonization. Interaction between oral bacteria and both unstimulated and stimulated saliva was examined in vitro by laying labeled bacteria over SDS-PAGE-separated salivary proteins. The effects of chewing on in vivo biofilm, micro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48211-3

    authors： Inui T,Palmer RJ Jr,Shah N,Li W,Cisar JO,Wu CD

    更新日期：2019-08-14 00:00:00

  • A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy.

    abstract：:The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69740-2

    authors： He Y,Liu H,Wang S,Zhang J

    更新日期：2020-07-30 00:00:00

  • Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity.

    abstract：:TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 (A...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61972-6

    authors： Nakamura T,Hashikawa C,Okabe K,Yokote Y,Chirifu M,Toma-Fukai S,Nakamura N,Matsuo M,Kamikariya M,Okamoto Y,Gohda J,Akiyama T,Semba K,Ikemizu S,Otsuka M,Inoue JI,Yamagata Y

    更新日期：2020-03-20 00:00:00

  • Gaining new insights into nanoporous gold by mining and analysis of published images.

    abstract：:One way of expediting materials development is to decrease the need for new experiments by making greater use of published literature. Here, we use data mining and automated image analysis to gather new insights on nanoporous gold (NPG) without conducting additional experiments or simulations. NPG is a three-dimension...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25122-3

    authors： McCue I,Stuckner J,Murayama M,Demkowicz MJ

    更新日期：2018-04-30 00:00:00

  • Anisotropic characteristics and improved magnetic performance of Ca-La-Co-substituted strontium hexaferrite nanomagnets.

    abstract：:Recent studies on next-generation permanent magnets have focused on filling in the gap between rare-earth magnets and rare-earth-free magnets, taking into account both the cost-effectiveness and magnetic performance of the magnetic materials. As an improved rare-earth-free magnet candidate, here, Ca-substituted M-type...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72608-0

    authors： Lee J,Lee EJ,Hwang TY,Kim J,Choa YH

    更新日期：2020-09-28 00:00:00

  • Effect of ionic liquid treatment on the ultrastructural and topochemical features of compression wood in Japanese cedar (Cryptomeria japonica).

    abstract：:The morphological and topochemical changes in wood tissues in compression wood of Japanese cedar (Cryptomeria japonica) upon treated with two types of ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C2mim][Cl]) and 1-ethylpyridinium bromide ([EtPy][Br]) were investigated. Compression wood tracheids were swollen ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30147

    authors： Kanbayashi T,Miyafuji H

    更新日期：2016-07-18 00:00:00

  • Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation.

    abstract：:Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30534-2

    authors： Startek JB,Talavera K,Voets T,Alpizar YA

    更新日期：2018-08-13 00:00:00

  • Physical and mechanical properties of wood and their geographic variations in Larix sibirica trees naturally grown in Mongolia.

    abstract：:We examined the physical and mechanical properties of wood in Siberian larch (Larix sibirica) trees that grow naturally in five Mongolian provenances (Khentii, Arkhangai, Zavkhan, Khuvsgul, and Selenge) and the geographic variations between them. Five trees with stem diameters of 20 to 30 cm at 1.3 m above ground were...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69781-7

    authors： Tumenjargal B,Ishiguri F,Aiso H,Takahashi Y,Nezu I,Takashima Y,Baasan B,Chultem G,Ohshima J,Yokota S

    更新日期：2020-07-31 00:00:00

  • Impact of microscopic In fluctuations on the optical properties of InxGa1-xN blue light-emitting diodes assessed by low-energy X-ray fluorescence mapping using synchrotron radiation.

    abstract：:Among the III-nitride semiconductors, InxGa1-xN is a key material for visible optical devices such as light-emitting diodes (LEDs), laser diodes, and solar cells. Light emission is achieved via electron-hole recombination within the InxGa1-xN layer. When InxGa1-xN-based blue LEDs were first commercialized, the high pr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39086-5

    authors： Sakaki A,Funato M,Miyano M,Okazaki T,Kawakami Y

    更新日期：2019-03-06 00:00:00

  • The sensitivity of a radical pair compass magnetoreceptor can be significantly amplified by radical scavengers.

    abstract：:Birds have a remarkable ability to obtain navigational information from the Earth's magnetic field. The primary detection mechanism of this compass sense is uncertain but appears to involve the quantum spin dynamics of radical pairs formed transiently in cryptochrome proteins. We propose here a new version of the curr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09914-7

    authors： Kattnig DR,Hore PJ

    更新日期：2017-09-14 00:00:00

  • An early granulocyte colony-stimulating factor treatment attenuates neuropathic pain through activation of mu opioid receptors on the injured nerve.

    abstract：:Several studies have shown that the mu opioid receptor (MOR) located in the peripheral nerves can be activated after nerve injury and that it attenuates peripheral nociceptive signals to the spinal dorsal horn. Various cytokines and phosphorylated-p38 (p-p38) activation in the dorsal horn also play an important role i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25490

    authors： Liao MF,Yeh SR,Lo AL,Chao PK,Lee YL,Hung YH,Lu KT,Ro LS

    更新日期：2016-05-16 00:00:00