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The network organization of protein interactions in the spliceosome is reproduced by the simple rules of food-web models.

Abstract：

:The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the interactions of less connected spliceosome proteins are nested subsets of the connections of the highly connected proteins. At the same time, the network has a modular structure with groups of proteins sharing similar interaction patterns. We then investigated the role of affinity and specificity in shaping the spliceosome network by adapting a probabilistic model originally designed to reproduce food webs. This food-web model was as successful in reproducing the structure of protein interactions as it is in reproducing interactions among species. The good performance of the model suggests affinity and specificity, partially determined by protein size and the timing of association to the complex, may be determining network structure. Moreover, because network models allow building ensembles of realistic networks while encompassing uncertainty they can be useful to examine the dynamics and vulnerability of intracelullar processes. Unraveling the mechanisms organizing the spliceosome interactions is important to characterize the role of individual proteins on splicing catalysis and regulation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pires MM,Cantor M,Guimarães PR,de Aguiar MA,Dos Reis SF,Coltri PP

doi

10.1038/srep14865

subject

Has Abstract

pub_date

2015-10-07 00:00:00

pages

14865

issn

2045-2322

pii

srep14865

journal_volume

5

pub_type

杂志文章

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