Abstract：
:Recent studies have revealed the systematic altering of gene expression in human peripheral blood during the early stages of ischemic stroke, which suggests a new potential approach for the rapid diagnosis or prediction of stroke onset. Nevertheless, due to the difficulties of collecting human samples during proper disease stages, related studies are rather restricted. Many studies have instead been performed on manipulated animal models for investigating the regulation patterns of biomarkers during different stroke stages. An important inquiry is how well the findings of animal models can be replicated in human cases. Here, a method is proposed based on PageRank scores of miRNA-mRNA interaction network to select ischemic stroke biomarkers derived from rat brain samples, and biomarkers are validated with two human peripheral blood gene expression datasets. Hierarchical clustering results revealed that the achieved biomarkers clearly separate the blood gene expression of stroke patients and healthy people. Literature searches and functional analyses further validated the biological significance of these biomarkers. Compared to the traditional methods, such as differential expression, the proposed approach is more stable and accurate in detecting cross-species biomarkers with biological relevance, thereby suggesting an efficient approach of re-using gene biomarkers obtained from animal-model studies for human diseases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang Y,Cai Ydoi
10.1038/srep29693subject
Has Abstractpub_date
2016-07-13 00:00:00pages
29693issn
2045-2322pii
srep29693journal_volume
6pub_type
杂志文章abstract：:Survival of many species, from insects and birds to human and non-human mammals, requires synchronized activity. Among humans, synchrony occurs even at the level of autonomic functioning; people interacting often show mutual, simultaneous changes in activity of the sympathetic or parasympathetic branches of the autono...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44667-5
更新日期：2019-06-03 00:00:00
abstract：:N(1)-methyladenosine (m(1)A) is a prominent RNA modification involved in many biological processes. Accurate identification of m(1)A site is invaluable for better understanding the biological functions of m(1)A. However, limitations in experimental methods preclude the progress towards the identification of m(1)A site...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31080
更新日期：2016-08-11 00:00:00
abstract：:The pathways of protein post-translational modifications (PTMs) have been shown to play particularly important roles for almost any biological process. Identification of PTM substrates along with information on the exact sites is fundamental for fully understanding or controlling biological processes. Alternative comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25801
更新日期：2016-05-13 00:00:00
abstract：:Aneuploidy has been reported to occur at remarkably high levels in normal somatic tissues using Fluorescence In Situ Hybridization (FISH). Recently, these reports were contradicted by single-cell low-coverage whole genome sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46606-w
更新日期：2019-07-19 00:00:00
abstract：:In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40758-5
更新日期：2019-03-13 00:00:00
abstract：:The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23622
更新日期：2016-03-29 00:00:00
abstract：:Lead (Pb) toxicity is a major environmental concern affirming the need of proper mitigation strategies. In the present work, potential of combined treatment of 24-Epibrassinolide (24-EBL) and Salicylic acid (SA) against Pb toxicity to Brassica juncea L. seedlings were evaluated. Seedlings pre-imbibed in EBL (0.1 mM) a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39712-2
更新日期：2019-03-05 00:00:00
abstract：:Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26665
更新日期：2016-05-25 00:00:00
abstract：:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21247
更新日期：2016-02-16 00:00:00
abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/s41598-017-04214-6
更新日期：2017-06-23 00:00:00
abstract：:Epidemiological studies support a protective role of lycopene against stroke occurrence or mortality, but the results have been conflicting. We conducted a meta-analysis to assess the relationship between dietary or circulating lycopene and stroke risk (including stroke occurrence or mortality). Relevant papers were c...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep05031
更新日期：2014-05-22 00:00:00
abstract：:Nano/microfibrous structure can induce high cellular activities because of the topological similarity of the extracellular matrix, and thus, are widely used in various tissue regenerative materials. However, the fabrication of a bioceramic (high weight percent)-based 3D microfibrous structure is extremely difficult be...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03461-x
更新日期：2017-06-09 00:00:00
abstract：:Immunotherapies demand for predictive biomarkers to avoid unnecessary adverse effects and costs. Analytic morphomics is the technique to use body composition measures as imaging biomarkers for underlying pathophysiology to predict prognosis or outcome to therapy. We investigated different body composition measures to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46189-6
更新日期：2019-07-05 00:00:00
abstract：:Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09242
更新日期：2015-03-18 00:00:00
abstract：:Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-31266-z
更新日期：2018-08-28 00:00:00
abstract：:Organotypic, three-dimensional (3D) cancer models have enabled investigations of complex microtissues in increasingly realistic conditions. However, a drawback of these advanced models remains the poor biological relevance of cancer cell lines, while higher clinical significance would be obtainable with patient-derive...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06544-x
更新日期：2017-07-26 00:00:00
abstract：:This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42132-x
更新日期：2019-04-04 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-34064-9
更新日期：2018-10-18 00:00:00
abstract：:It is well established that topographical features modulate cell behaviour, including cell morphology, proliferation and differentiation. To define the effects of topography on human induced pluripotent stem cells (iPSC), we plated cells on a topographical library containing over 1000 different features in medium lack...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18948
更新日期：2016-01-13 00:00:00
abstract：:Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-017-08214-4
更新日期：2017-08-10 00:00:00
abstract：:Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form, CysC is released by cells in association with extracellular vesicles (EVs), including exosomes. We demonstrate that EVs containin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47524-7
更新日期：2019-07-31 00:00:00
abstract：:The distribution of carbon from a branch setting pod in alfalfa was investigated during the seed development of seeds to determine the relative contribution of pod and leaf photoassimilates to the total C balance and to investigate the partitioning of these photoassimilates to other plant organs. A 13Clabeling procedu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42026
更新日期：2017-02-07 00:00:00
abstract：:Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 nav...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30488
更新日期：2016-07-29 00:00:00
abstract：:The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient genome-editing, we optimized a workflow for the CRISPR/Cas9 system in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16932-y
更新日期：2017-11-30 00:00:00
abstract：:We tried to establish a reliable detrusor underactivity (DUA) rat model and to investigate pathophysiology of chronic bladder ischemia (CBI) on voiding behavior and bladder function. Adult male rats were divided into five groups. The arterial injury (AI) groups (AI-10, AI-20, AI-30) underwent vascular endothelial dama...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52811-4
更新日期：2019-11-08 00:00:00
abstract：:Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH deficiency on the dev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09023
更新日期：2015-03-17 00:00:00
abstract：:Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06189
更新日期：2014-08-26 00:00:00
abstract：:HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of the interaction, l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42096-y
更新日期：2019-04-05 00:00:00
abstract：:Solitons are of fundamental importance in photonics due to applications in optical data transmission and also as a tool for investigating novel phenomena ranging from light generation at new frequencies and wave-trapping to rogue waves. Solitons are also moving scatterers: they generate refractive index perturbations ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00932
更新日期：2012-01-01 00:00:00
abstract：:Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19074
更新日期：2016-01-08 00:00:00
