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"Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca(2+) fluoroimaging".

Abstract：

:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetics for voluntarily stimulating nerves, imaging to visualize neural activity, and a wearable micro-instrument for implantation into the brain could meet the abovementioned demand. To this end, a micro-device that can be applied to the brain less invasively and a system for controlling the device has been newly developed in this study. Since the novel implantable device has dual LEDs and a CMOS image sensor, photostimulation and fluorescence imaging can be performed simultaneously. The device enables bidirectional communication with the brain by means of light. In the present study, the device was evaluated in an in vitro experiment using a new on-chip 3D neuroculture with an extracellular matrix gel and an in vivo experiment involving regenerative medical transplantation and gene delivery to the brain by using both photosensitive channel and fluorescent Ca(2+) indicator. The device succeeded in activating cells locally by selective photostimulation, and the physiological Ca(2+) dynamics of neural cells were visualized simultaneously by fluorescence imaging.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kobayashi T,Haruta M,Sasagawa K,Matsumata M,Eizumi K,Kitsumoto C,Motoyama M,Maezawa Y,Ohta Y,Noda T,Tokuda T,Ishikawa Y,Ohta J

doi

10.1038/srep21247

subject

Has Abstract

pub_date

2016-02-16 00:00:00

pages

21247

issn

2045-2322

pii

srep21247

journal_volume

6

pub_type

杂志文章

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