当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors.

The human HOXA9 protein uses paralog-specific residues of the homeodomain to interact with TALE-class cofactors.

Abstract：

:HOX proteins interact with PBX and MEIS cofactors, which belong to the TALE-class of homeodomain (HD)-containing transcription factors. Although the formation of HOX-PBX complexes depends on a unique conserved HOX motif called hexapeptide (HX), the additional presence of MEIS induces a remodeling of the interaction, leading to a global dispensability of the HX motif for trimeric complex formation in the large majority of HOX proteins. In addition, it was shown that the anterior HOXB3 and central HOXA7 and HOXC8 proteins could use different alternative TALE interaction motifs, with or without the HX motif, depending on the DNA-binding site and cell context. Here we dissected the molecular interaction properties of the human posterior HOXA9 protein with its TALE cofactors, PBX1 and MEIS1. Analysis was performed on different DNA-binding sites in vitro and by doing Bimolecular Fluorescence Complementation (BiFC) in different cell lines. Notably, we observed that the HOXA9-TALE interaction relies consistently on the redundant activity of the HX motif and two paralog-specific residues of the HOXA9 HD. Together with previous work, our results show that HOX proteins interact with their generic TALE cofactors through various modalities, ranging from unique and context-independent to versatile and context-dependent TALE binding interfaces.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dard A,Jia Y,Reboulet J,Bleicher F,Lavau C,Merabet S

doi

10.1038/s41598-019-42096-y

subject

Has Abstract

pub_date

2019-04-05 00:00:00

pages

5664

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42096-y

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Humans Use Predictive Gaze Strategies to Target Waypoints for Steering.

    abstract：:A major unresolved question in understanding visually guided locomotion in humans is whether actions are driven solely by the immediately available optical information (model-free online control mechanisms), or whether internal models have a role in anticipating the future path. We designed two experiments to investig...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44723-0

    authors： Tuhkanen S,Pekkanen J,Rinkkala P,Mole C,Wilkie RM,Lappi O

    更新日期：2019-06-06 00:00:00

  • Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods.

    abstract：:Light-inducible gene regulation has great potential for remote and noninvasive control of the fate and function of target cells. One method to achieve such control is delivery of heat shock protein (HSP) promoter-driven protein expression vectors and photothermal heaters into the cells, followed by activation by illum...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04912-1

    authors： Nakatsuji H,Kawabata Galbraith K,Kurisu J,Imahori H,Murakami T,Kengaku M

    更新日期：2017-07-05 00:00:00

  • Enhanced cytomegalovirus infection in human trabecular meshwork cells and its implication in glaucoma pathogenesis.

    abstract：:Cytomegalovirus (CMV) is one of the infectious causes of hypertensive anterior uveitis, which is characterized by recurrent episodes of elevated intraocular pressure (IOP) and mild anterior uveitis. Despite the potentially vision-threatening complications of this disease, the underlying mechanisms remain largely undef...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43349

    authors： Choi JA,Kim JE,Noh SJ,Kyoung Kim E,Park CK,Paik SY

    更新日期：2017-02-27 00:00:00

  • Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons.

    abstract：:We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification(TRAP). Here, we briefly report on the basic characterization of this mouse line including confirmation of expression of the transgene in midbrain dopamine neurons and validation of its effectiveness in capturin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08618-2

    authors： Dougherty JD

    更新日期：2017-08-14 00:00:00

  • Electrode-free visual prosthesis/exoskeleton control using augmented reality glasses in a first proof-of-technical-concept study.

    abstract：:In the field of neuroprosthetics, the current state-of-the-art method involves controlling the prosthesis with electromyography (EMG) or electrooculography/electroencephalography (EOG/EEG). However, these systems are both expensive and time consuming to calibrate, susceptible to interference, and require a lengthy lea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73250-6

    authors： Hazubski S,Hoppe H,Otte A

    更新日期：2020-10-01 00:00:00

  • A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition.

    abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10566

    authors： Tomsic J,He H,Akagi K,Liyanarachchi S,Pan Q,Bertani B,Nagy R,Symer DE,Blencowe BJ,de la Chapelle A

    更新日期：2015-07-02 00:00:00

  • SERS activity of hybrid nano/microstructures Ag-Fe3O4 based on Dimorphotheca ecklonis pollen grains as bio-template.

    abstract：:Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73615-x

    authors： Ávila-Avilés RD,Torres-Gómez N,Camacho-López MA,Vilchis-Nestor AR

    更新日期：2020-10-06 00:00:00

  • Electronic Excitation Dynamics in Liquid Water under Proton Irradiation.

    abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40379

    authors： Reeves KG,Kanai Y

    更新日期：2017-01-13 00:00:00

  • Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy.

    abstract：:Known susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35781

    authors： Zhou XJ,Nath SK,Qi YY,Sun C,Hou P,Zhang YM,Lv JC,Shi SF,Liu LJ,Chen R,Yang W,He KZ,Li Y,Zhang H

    更新日期：2016-11-02 00:00:00

  • Quality of non-expert citizen science data collected for habitat type conservation status assessment in Natura 2000 protected areas.

    abstract：:EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biod...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09316-9

    authors： Kallimanis AS,Panitsa M,Dimopoulos P

    更新日期：2017-08-21 00:00:00

  • Habitat fragmentation is associated to gut microbiota diversity of an endangered primate: implications for conservation.

    abstract：:The expansion of agriculture is shrinking pristine forest areas worldwide, jeopardizing the persistence of their wild inhabitants. The Udzungwa red colobus monkey (Procolobus gordonorum) is among the most threatened primate species in Africa. Primarily arboreal and highly sensitive to hunting and habitat destruction, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14862

    authors： Barelli C,Albanese D,Donati C,Pindo M,Dallago C,Rovero F,Cavalieri D,Tuohy KM,Hauffe HC,De Filippo C

    更新日期：2015-10-07 00:00:00

  • Hair follicle germs containing vascular endothelial cells for hair regenerative medicine.

    abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79722-z

    authors： Kageyama T,Chun YS,Fukuda J

    更新日期：2021-01-12 00:00:00

  • Endothelial dysfunction correlates with decompression bubbles in rats.

    abstract：:Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33390

    authors： Zhang K,Wang D,Jiang Z,Ning X,Buzzacott P,Xu W

    更新日期：2016-09-12 00:00:00

  • A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

    abstract：:Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80031-8

    authors： Raven KE,Girgis ST,Akram A,Blane B,Leek D,Brown N,Peacock SJ

    更新日期：2021-01-08 00:00:00

  • Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells.

    abstract：:Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. Plastic compression of collagen scaffolds seeded with MSC has been shown to enhance the osteogenic differentiation of MSC as it increases the collagen fibril...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38814

    authors： Chamieh F,Collignon AM,Coyac BR,Lesieur J,Ribes S,Sadoine J,Llorens A,Nicoletti A,Letourneur D,Colombier ML,Nazhat SN,Bouchard P,Chaussain C,Rochefort GY

    更新日期：2016-12-09 00:00:00

  • Quantitative comparison of tumor delivery for multiple targeted nanoparticles simultaneously by multiplex ICP-MS.

    abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05840

    authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

    更新日期：2014-07-28 00:00:00

  • Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.

    abstract：:Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of meth...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-19125-9

    authors： Wang Y,Zhang J,Qian Y,Tang X,Ling H,Chen K,Li Y,Gao P,Zhu D

    更新日期：2018-01-12 00:00:00

  • Controlled Deposition of Particles in Porous Media for Effective Aquifer Nanoremediation.

    abstract：:In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13423-y

    authors： Bianco C,Patiño Higuita JE,Tosco T,Tiraferri A,Sethi R

    更新日期：2017-10-11 00:00:00

  • Monti Sabatini and Colli Albani: the dormant twin volcanoes at the gates of Rome.

    abstract：:This multi-disciplinary work provides an updated assessment of possible future eruptive scenarios for the city of Rome. Seven new 40Ar/39Ar ages from selected products of the Monti Sabatini and Vulsini volcanic districts, along with a compilation of all the literature ages on the Colli Albani and Vico products, are us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65394-2

    authors： Marra F,Castellano C,Cucci L,Florindo F,Gaeta M,Jicha BR,Palladino DM,Sottili G,Tertulliani A,Tolomei C

    更新日期：2020-05-26 00:00:00

  • High performance organic-inorganic perovskite-optocoupler based on low-voltage and fast response perovskite compound photodetector.

    abstract：:Organic-inorganic hybrid photodetectors attract considerable attention because they can combine the advantages of both organic and inorganic systems. Here, a perovskite compound with a broad absorption spectrum and high power conversion efficiency is used as a photosensitive layer in an organic/inorganic hybrid hetero...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07902

    authors： Li D,Dong G,Li W,Wang L

    更新日期：2015-01-20 00:00:00

  • Effects of 8-week sensory electrical stimulation combined with motor training on EEG-EMG coherence and motor function in individuals with stroke.

    abstract：:The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand func...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-018-27553-4

    authors： Pan LH,Yang WW,Kao CL,Tsai MW,Wei SH,Fregni F,Chen VC,Chou LW

    更新日期：2018-06-15 00:00:00

  • Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model.

    abstract：:Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), an evolutionary mechanism that enables cells to cope with stressful co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57657-9

    authors： Maeyashiki C,Melhem H,Hering L,Baebler K,Cosin-Roger J,Schefer F,Weder B,Hausmann M,Scharl M,Rogler G,de Vallière C,Ruiz PA

    更新日期：2020-01-29 00:00:00

  • Different Effects of Thiazolidinediones on In-Stent Restenosis and Target Lesion Revascularization after PCI: A Meta-Analysis of Randomized Controlled Trials.

    abstract：:In-stent restenosis (ISR) remains the leading problem encountered after percutaneous coronary intervention (PCI). Thiazolidinediones (TZDs) has been shown to be associated with reduced ISR and target lesion revascularization (TLR); however, the results are inconsistent, especially between rosiglitazone and pioglitazon...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-14873-0

    authors： Zhou X,Chen S,Zhu M,Hua J,Dai J,Xu X,Qiu Y,Mao W

    更新日期：2017-10-31 00:00:00

  • Design of a Broadband Solar Thermal Absorber Using a Deep Neural Network and Experimental Demonstration of Its Performance.

    abstract：:In using nanostructures to design solar thermal absorbers, computational methods, such as rigorous coupled-wave analysis and the finite-difference time-domain method, are often employed to simulate light-structure interactions in the solar spectrum. However, those methods require heavy computational resources and CPU ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51407-2

    authors： Seo J,Jung PH,Kim M,Yang S,Lee I,Lee J,Lee H,Lee BJ

    更新日期：2019-10-21 00:00:00

  • Role of valence changes and nanoscale atomic displacements in BiS2-based superconductors.

    abstract：:Superconductivity within layered crystal structures has attracted sustained interest among condensed matter community, primarily due to their exotic superconducting properties. EuBiS2F is a newly discovered member in the BiS2-based superconducting family, which shows superconductivity at 0.3 K without extrinsic doping...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37394

    authors： Cheng J,Zhai H,Wang Y,Xu W,Liu S,Cao G

    更新日期：2016-11-22 00:00:00

  • Combining short and long read sequencing to characterize antimicrobial resistance genes on plasmids applied to an unauthorized genetically modified Bacillus.

    abstract：:Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data. This study aimed to improve the characterization,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61158-0

    authors： Berbers B,Saltykova A,Garcia-Graells C,Philipp P,Arella F,Marchal K,Winand R,Vanneste K,Roosens NHC,De Keersmaecker SCJ

    更新日期：2020-03-09 00:00:00

  • Organized Disassembly of Photosynthesis During Programmed Cell Death Mediated By Long Chain Bases.

    abstract：:In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65186-8

    authors： Zavafer A,González-Solís A,Palacios-Bahena S,Saucedo-García M,Tapia de Aquino C,Vázquez-Santana S,King-Díaz B,Gavilanes-Ruiz M

    更新日期：2020-06-25 00:00:00

  • Unraveling nonlinear electrophysiologic processes in the human visual system with full dimension spectral analysis.

    abstract：:Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53286-z

    authors： Nguyen KT,Liang WK,Lee V,Chang WS,Muggleton NG,Yeh JR,Huang NE,Juan CH

    更新日期：2019-11-15 00:00:00

  • Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors.

    abstract：:The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of whi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77726-3

    authors： Okimoto K,Maruoka D,Matsumura T,Tokunaga M,Kaneko T,Oura H,Akizue N,Ohta Y,Saito K,Arai M,Kato J,Kato N

    更新日期：2020-11-26 00:00:00

  • Light- induced electron transfer and ATP synthesis in a carotene synthesizing insect.

    abstract：:A singular adaptive phenotype of a parthenogenetic insect species (Acyrthosiphon pisum) was selected in cold conditions and is characterized by a remarkable apparition of a greenish colour. The aphid pigments involve carotenoid genes well defined in chloroplasts and cyanobacteria and amazingly present in the aphid gen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00579

    authors： Valmalette JC,Dombrovsky A,Brat P,Mertz C,Capovilla M,Robichon A

    更新日期：2012-01-01 00:00:00