当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Different Effects of Thiazolidinediones on In-Stent Restenosis and Target Lesion Revascularization after PCI: A Meta-Analysis of Randomized Controlled Trials.

Different Effects of Thiazolidinediones on In-Stent Restenosis and Target Lesion Revascularization after PCI: A Meta-Analysis of Randomized Controlled Trials.

Abstract：

:In-stent restenosis (ISR) remains the leading problem encountered after percutaneous coronary intervention (PCI). Thiazolidinediones (TZDs) has been shown to be associated with reduced ISR and target lesion revascularization (TLR); however, the results are inconsistent, especially between rosiglitazone and pioglitazone. In this study, fourteen RCTs with a total of 1350 patients were finally included through a systematical literature search of Embase, Pubmed, the Cochrane Library, and ClinicalTrials.gov from inception to January 31, 2017. The follow-up duration of the included trials ranged from 6 months to 18 months. The results demonstrated that TZDs treatment is associated with significantly reduced risk of TLR (RR:0.45, 95%CI 0.30 to 0.67 for pioglitazone, RR:0.68, 95%CI 0.46 to 1.00 for rosiglitazone). Pioglitazone is associated with significantly reduced risks of ISR (RR:0.47, 95%CI 0.27 to 0.81), major adverse cardiac events (MACE) (RR:0.44, 95%CI 0.30 to 0.64) and neointimal area (SMD: -0.585, 95%CI -0.910 to -0.261). No significant relationship was observed between rosiglitazone and ISR (RR:0.91, 95%CI 0.39 to 2.12), MACE (RR:0.73, 95%CI 0.53 to 1.00) and neointimal area (SMD: -0.164, 95%CI -1.146 to 0.818). This meta-analysis demonstrated that TZDs treatment is associated with significant reduction in ISR, TLR and MACE for patients after PCI. Pioglitazone treatment seems to have more beneficial effects than rosiglitazone and no significantly increased cardiovascular risk was detected for both agents.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhou X,Chen S,Zhu M,Hua J,Dai J,Xu X,Qiu Y,Mao W

doi

10.1038/s41598-017-14873-0

subject

Has Abstract

pub_date

2017-10-31 00:00:00

pages

14464

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14873-0

journal_volume

7

pub_type

杂志文章,meta分析

相关文献

Scientific Reports文献大全
  • Global identification of a marine diatom long noncoding natural antisense transcripts (NATs) and their response to phosphate fluctuations.

    abstract：:Often ignored and regarded as mere transcriptional noise, long noncoding RNAs (lncRNAs) are starting to be considered key regulators of gene expression across the Eukarya domain of life. In the model diatom Phaeodactylum tricornutum, we have previously reported the occurrence of 1,510 intergenic lncRNAs (lincRNAs), ma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71002-0

    authors： Cruz de Carvalho MH,Bowler C

    更新日期：2020-08-24 00:00:00

  • Age, primary symptoms, and genotype characteristics of norovirus outbreaks in Shanghai schools in 2017.

    abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33724-0

    authors： Wang Y,Hao L,Pan L,Xue C,Liu Q,Zhao X,Zhu W

    更新日期：2018-10-15 00:00:00

  • Effects of Atmospheric-Pressure N2, He, Air, and O2 Microplasmas on Mung Bean Seed Germination and Seedling Growth.

    abstract：:Atmospheric-pressure N2, He, air, and O2 microplasma arrays have been used to investigate the effects of plasma treatment on seed germination and seedling growth of mung bean in aqueous solution. Seed germination and growth of mung bean were found to strongly depend on the feed gases used to generate plasma and plasma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32603

    authors： Zhou R,Zhou R,Zhang X,Zhuang J,Yang S,Bazaka K,Ken Ostrikov K

    更新日期：2016-09-01 00:00:00

  • The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia.

    abstract：:Multiple factors help shape the infant intestinal microbiota early in life. Environmental conditions such as the presence of bioactive molecules from breast milk dictate gut microbial growth and survival. Infants also receive distinct, personalized, bacterial exposures leading to differential colonization. Microbial e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40932

    authors： Lewis ZT,Sidamonidze K,Tsaturyan V,Tsereteli D,Khachidze N,Pepoyan A,Zhgenti E,Tevzadze L,Manvelyan A,Balayan M,Imnadze P,Torok T,Lemay DG,Mills DA

    更新日期：2017-02-02 00:00:00

  • Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction.

    abstract：:Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75747-6

    authors： Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

    更新日期：2020-10-29 00:00:00

  • Understanding turbulent free-surface vortex flows using a Taylor-Couette flow analogy.

    abstract：:Free-surface vortices have long been studied to develop an understanding of similar rotating flow phenomena observed in nature and technology. However, a complete description of its turbulent three-dimensional flow field still remains elusive. In contrast, the related Taylor-Couette flow system has been well explicate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16950-w

    authors： Mulligan S,De Cesare G,Casserly J,Sherlock R

    更新日期：2018-01-16 00:00:00

  • Enhanced thermoelectric performance of a chalcopyrite compound CuIn3Se5-xTex (x = 0~0.5) through crystal structure engineering.

    abstract：:In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40224

    authors： Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

    更新日期：2017-01-06 00:00:00

  • Atomistic study of the solid state inside graphene nanobubbles.

    abstract：:A two-dimensional (2D) material placed on an atomically flat substrate can lead to the formation of surface nanobubbles trapping different types of substances. In this paper graphene nanobubbles of the radius of 7-34 nm with argon atoms inside are studied using molecular dynamics (MD). All modeled graphene nanobubbles...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18226-9

    authors： Iakovlev E,Zhilyaev P,Akhatov I

    更新日期：2017-12-20 00:00:00

  • Effect of physical stimuli on hair follicle deposition of clobetasol-loaded Lipid Nanocarriers.

    abstract：:Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56760-w

    authors： Angelo T,El-Sayed N,Jurisic M,Koenneke A,Gelfuso GM,Cunha-Filho M,Taveira SF,Lemor R,Schneider M,Gratieri T

    更新日期：2020-01-13 00:00:00

  • Genetic barcoding of museum eggshell improves data integrity of avian biological collections.

    abstract：:Natural history collections are often plagued by missing or inaccurate metadata for collection items, particularly for specimens that are difficult to verify or rare. Avian eggshell in particular can be challenging to identify due to extensive morphological ambiguity among taxa. Species identifications can be improved...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79852-4

    authors： Grealy A,Langmore NE,Joseph L,Holleley CE

    更新日期：2021-01-15 00:00:00

  • Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor.

    abstract：:The human hepatoma-derived growth factor (HDGF), containing the chromatin-associated N-terminal PWWP domain capable of binding the SMYD1 promoter, participates in various cellular processes and is involved in human cancers. We report the first crystal structures of the human HDGF PWWP domain (residues 1-100) in a comp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18510-8

    authors： Chen LY,Huang YC,Huang ST,Hsieh YC,Guan HH,Chen NC,Chuankhayan P,Yoshimura M,Tai MH,Chen CJ

    更新日期：2018-01-10 00:00:00

  • Human pericentromeric tandemly repeated DNA is transcribed at the end of oocyte maturation and is associated with membraneless mitochondria-associated structures.

    abstract：:Most of the human genome is non-coding. However, some of the non-coding part is transcriptionally active. In humans, the tandemly repeated (TR) pericentromeric non-coding DNA-human satellites 2 and 3 (HS2, HS3)-are transcribed in somatic cells. These transcripts are also found in pre- and post-implantation embryos. Th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76628-8

    authors： Dobrynin MA,Korchagina NM,Prjibelski AD,Shafranskaya D,Ostromyshenskii DI,Shunkina K,Stepanova I,Kotova AV,Podgornaya OI,Enukashvily NI

    更新日期：2020-11-12 00:00:00

  • KvN mechanics approach to the time-dependent frequency harmonic oscillator.

    abstract：:Using the Ermakov-Lewis invariants appearing in KvN mechanics, the time-dependent frequency harmonic oscillator is studied. The analysis builds upon the operational dynamical model, from which it is possible to infer quantum or classical dynamics; thus, the mathematical structure governing the evolution will be the sa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26759-w

    authors： Ramos-Prieto I,Urzúa-Pineda AR,Soto-Eguibar F,Moya-Cessa HM

    更新日期：2018-05-30 00:00:00

  • Intrauterine exposure to low-dose DBP in the mice induces obesity in offspring via suppression of UCP1 mediated ER stress.

    abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73477-3

    authors： Li H,Li J,Qu Z,Qian H,Zhang J,Wang H,Xu X,Liu S

    更新日期：2020-10-01 00:00:00

  • Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer.

    abstract：:Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. Twenty-four patients were selected: ten with identified mutations (control set) and four...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37984

    authors： Feliubadaló L,Tonda R,Gausachs M,Trotta JR,Castellanos E,López-Doriga A,Teulé À,Tornero E,Del Valle J,Gel B,Gut M,Pineda M,González S,Menéndez M,Navarro M,Capellá G,Gut I,Serra E,Brunet J,Beltran S,Lázaro C

    更新日期：2017-01-04 00:00:00

  • Chinese olive extract ameliorates hepatic lipid accumulation in vitro and in vivo by regulating lipid metabolism.

    abstract：:Chinese olive contains plenty of polyphenols, which possess a wide range of biological actions. In this study, we aimed to investigate the role of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) in the modulation of lipid accumulation in vitro and in vivo. In cellular studies, CO-EtOAc attenuated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19553-1

    authors： Yeh YT,Cho YY,Hsieh SC,Chiang AN

    更新日期：2018-01-18 00:00:00

  • SDE5, a putative RNA export protein, participates in plant innate immunity through a flagellin-dependent signaling pathway in Arabidopsis.

    abstract：:In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and versatile silencing mechanism that plays an important role in various biological processes. Increasing evidences suggest that various components of RNA silencing pathway are involved in plant defense machinery against...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07918-x

    authors： Uddin MN,Akhter S,Chakraborty R,Baek JH,Cha JY,Park SJ,Kang H,Kim WY,Lee SY,Mackey D,Kim MG

    更新日期：2017-08-29 00:00:00

  • Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model.

    abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-018-31590-4

    authors： Naftalin CM,Verma R,Gurumurthy M,Hee KH,Lu Q,Yeo BCM,Tan KH,Lin W,Yu B,Seng KY,Lee LS,Paton NI

    更新日期：2018-09-10 00:00:00

  • The co-evolution of networks and prisoner's dilemma game by considering sensitivity and visibility.

    abstract：:Strategies adopted by individuals in a social network significantly impact the network, and they strongly affect relationships between individuals in the network. Links between individuals also heavily influence their levels of cooperation. Taking into account the evolution of each individual's connection, we explore ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45237

    authors： Li D,Ma J,Han D,Sun M,Tian L,Stanley HE

    更新日期：2017-03-24 00:00:00

  • Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes.

    abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28179

    authors： Webb CH,Nguyen D,Myszka M,Lupták A

    更新日期：2016-06-15 00:00:00

  • Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes.

    abstract：:Because of the scanty pipeline of antibiotics newly obtained from nature, chemical modification of established drugs is one of the major streams of current antibacterial research. Intuitive and easy-to-use assays are critical for identifying drug candidates with novel modes of action. In this study, we demonstrated th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01267-5

    authors： Sugimoto A,Maeda A,Itto K,Arimoto H

    更新日期：2017-04-25 00:00:00

  • Differential effects of socio-demographic factors on maternal haemoglobin concentration in three sub-Saharan African Countries.

    abstract：:Low Haemoglobin concentration (Hb) among women of reproductive age is a severe public health problem in sub-Saharan Africa. This study investigated the effects of putative socio-demographic factors on maternal Hb at different points of the conditional distribution of Hb concentration. We utilised quantile regression t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78617-3

    authors： Amugsi DA,Dimbuene ZT,Kyobutungi C

    更新日期：2020-12-07 00:00:00

  • The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.

    abstract：:The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. With CCL3 implicated as a potentially via...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32978-y

    authors： Staversky RJ,Byun DK,Georger MA,Zaffuto BJ,Goodman A,Becker MW,Calvi LM,Frisch BJ

    更新日期：2018-10-02 00:00:00

  • Prediction of spontaneous closure of traumatic macular hole with spectral domain optical coherence tomography.

    abstract：:It has been known that some traumatic macular holes can close spontaneously. However, knowledge about the types of macular hole that can close spontaneously is limited. In this retrospective study, we investigated patients with traumatic macular hole who were followed-up for at least 6 months without any surgical inte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12343

    authors： Chen H,Chen W,Zheng K,Peng K,Xia H,Zhu L

    更新日期：2015-07-21 00:00:00

  • A proteomic analysis of an in vitro knock-out of miR-200c.

    abstract：:Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out (KO) is of interest. In this study, we generated a TALENs KO of mi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25240-y

    authors： Ljepoja B,García-Roman J,Sommer AK,Fröhlich T,Arnold GJ,Wagner E,Roidl A

    更新日期：2018-05-02 00:00:00

  • Superconductor to resistive state switching by multiple fluctuation events in NbTiN nanostrips.

    abstract：:We report on measurements of the switching current distributions on two-dimensional superconducting NbTiN strips that are 5 nm thick and 80 nm wide. We observe that the width of the switching current distributions has a non-monotonous temperature dependence, where it is constant at the lowest temperatures up to about ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42736-3

    authors： Ejrnaes M,Salvoni D,Parlato L,Massarotti D,Caruso R,Tafuri F,Yang XY,You LX,Wang Z,Pepe GP,Cristiano R

    更新日期：2019-05-29 00:00:00

  • 'Candidatus Cochliophilus cryoturris' (Coxiellaceae), a symbiont of the testate amoeba Cochliopodium minus.

    abstract：:Free-living amoebae are well known for their role in controlling microbial community composition through grazing, but some groups, namely Acanthamoeba species, also frequently serve as hosts for bacterial symbionts. Here we report the first identification of a bacterial symbiont in the testate amoeba Cochliopodium. Th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03642-8

    authors： Tsao HF,Scheikl U,Volland JM,Köhsler M,Bright M,Walochnik J,Horn M

    更新日期：2017-06-13 00:00:00

  • Synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma: analysis of 41 cases treated in a single institution.

    abstract：:The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13335

    authors： Li X,Lin S,Zhang Y,Wang H

    更新日期：2015-08-20 00:00:00

  • Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study-Report No. 1.

    abstract：:We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity and clinical stages. A retrospective multicentre cross-sectional study was conducted in six tertiary hospitals in Korea ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73803-9

    authors： Kim YH,Chung YR,Oh J,Kim SW,Lee CS,Yun C,Lee B,Ahn SM,Choi EY,Jang S,Lee K

    更新日期：2020-10-06 00:00:00

  • Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration.

    abstract：:We present a novel, all-electric approach to record and to precisely control the activity of tens of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of multiple synapses and of the resulting dynamics of postsynaptic neurons in a cortical culture. For the measurements, we combine ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00981-4

    authors： Jäckel D,Bakkum DJ,Russell TL,Müller J,Radivojevic M,Frey U,Franke F,Hierlemann A

    更新日期：2017-04-20 00:00:00