Abstract:
:The human hepatoma-derived growth factor (HDGF), containing the chromatin-associated N-terminal PWWP domain capable of binding the SMYD1 promoter, participates in various cellular processes and is involved in human cancers. We report the first crystal structures of the human HDGF PWWP domain (residues 1-100) in a complex with SMYD1 of 10 bp at 2.84 Å resolution and its apo form at 3.3 Å, respectively. The structure of the apo PWWP domain comprises mainly four β-strands and two α-helices. The PWWP domain undergoes domain swapping to dramatically transform its secondary structures, altering the overall conformation from monomeric globular folding into an extended dimeric structure upon DNA binding. The flexible loop2, as a hinge loop with the partially built structure in the apo PWWP domain, notably refolds into a visible and stable α-helix in the DNA complex. The swapped PWWP domain interacts with the minor grooves of the DNA through residues Lys19, Gly22, Arg79 and Lys80 in varied ways on loops 1 and 4 of the two chains, and the structure becomes more rigid than the apo form. These novel structural findings, together with physiological and activity assays of HDGF and the PWWP domain, provide new insights into the DNA-binding mechanism of HDGF during nucleosomal functions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen LY,Huang YC,Huang ST,Hsieh YC,Guan HH,Chen NC,Chuankhayan P,Yoshimura M,Tai MH,Chen CJdoi
10.1038/s41598-017-18510-8subject
Has Abstractpub_date
2018-01-10 00:00:00pages
287issue
1issn
2045-2322pii
10.1038/s41598-017-18510-8journal_volume
8pub_type
杂志文章abstract::The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22197
更新日期:2016-02-23 00:00:00
abstract::In humans, oxytocin (OT) enhances prosocial behaviour. However, it is still unclear how the prosocial effects of OT are modulated by emotional features and/or individuals' characteristics. In a placebo-controlled design, we tested 20 healthy male volunteers to investigate these behavioural and neurophysiological modul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00384
更新日期:2012-01-01 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with stable angina pectoris (sAP) for F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48356-1
更新日期:2019-08-14 00:00:00
abstract::Dysregulation of specific microRNAs or Wnt/β-catenin signaling pathway is critically implicated in the pathogenesis of various renal diseases. However, the relationship between microRNAs and Wnt/β-catenin signaling in diabetes-induced glomerular sclerosis remains unknown. Here, we found that decreased miR-29a expressi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30575
更新日期:2016-07-27 00:00:00
abstract::In this report, we propose and demonstrate an air-mode photonic crystal ring resonator (PhCRR) on silicon-on-insulator platform. Air mode is utilized to confine the optical field into photonic crystal (PhC) air holes, which is confirmed by the three-dimensional finite-difference time-domain simulation. PhCRR structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19999
更新日期:2016-01-28 00:00:00
abstract::Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases, 10 controls) and fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71336-9
更新日期:2020-09-30 00:00:00
abstract::The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved therein. In this study, we employed a combination of MALDI imaging mass spectrometry (MALDI-IMS) and M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05515-6
更新日期:2017-07-17 00:00:00
abstract::The spatio-temporal distribution soil pH is critical for understanding the productivity and long-term sustainability of our agri-ecosystem. This study quantified the spatio-temporal distribution of paddy soil pH in Jiangxi province, China, and the potential driver of the change between 1980 and 2010. Data from the Soi...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-018-20873-5
更新日期:2018-02-09 00:00:00
abstract::Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40002
更新日期:2017-01-05 00:00:00
abstract::Recent studies have established that single nucleotide polymorphisms are sufficient to build accurate predictive models of gene expression. Gamazon, et al., found that gene expression values predicted from cis neighborhood SNPs show statistical association with disease status. In this work, we remove the cis neighborh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39360
更新日期:2016-12-20 00:00:00
abstract::Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR training program for the public in a Taiwanese setting. A total of 832 adults were randomized to either a tradi...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-67193-1
更新日期:2020-06-22 00:00:00
abstract::Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25183
更新日期:2016-05-12 00:00:00
abstract::Critically endangered sturgeons, having undergone three whole genome duplication events, represent an exceptional example of ploidy plasticity in vertebrates. Three extant ploidy groups, combined with autopolyploidization, interspecific hybridization and the fertility of hybrids are important issues in sturgeon conser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76680-4
更新日期:2020-11-12 00:00:00
abstract::A dual mode rare-earth based vanadate material (YVO4: Ho3+/Yb3+), prepared through ethylene glycol assisted hydrothermal method, demonstrating both downconversion and upconversion, along with systematic investigation of the luminescence spectroscopy within 12-300 K is presented herein. The energy transfer processes ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36342
更新日期:2016-11-02 00:00:00
abstract::Soil zinc (Zn) plays a crucial role in plant growth, but excessive accumulation in the environment may lead to air, water and soil pollution. It is affected by various chemical, environmental and spatial factors. Therefore, it is important to identify the factors influencing Zn content in the landscape. The main motiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33745-9
更新日期:2018-10-22 00:00:00
abstract::The Italian hare (Lepus corsicanus) is endemic to Central-Southern Italy and Sicily, classified as vulnerable due to habitat alterations, low density and fragmented populations and ecological competition with the sympatric European hare (Lepus europaeus). Despite this status, only few and local studies have explored i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70013-1
更新日期:2020-08-04 00:00:00
abstract::Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06542
更新日期:2014-10-13 00:00:00
abstract::Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to directly treat the diagnostic materials to cells, multiple steps to optimize dose concentration and treatment time are necessary due to diversity i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18497
更新日期:2015-12-18 00:00:00
abstract::Male moths use species-specific sex pheromones to identify and orientate toward conspecific females. Odorant receptors (ORs) for sex pheromone substances have been identified as sex pheromone receptors in various moth species. However, direct in vivo evidence linking the functional role of these ORs with behavioural r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11001
更新日期:2015-06-05 00:00:00
abstract::It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the therma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14710-4
更新日期:2017-10-31 00:00:00
abstract::Accurate and precise structural ensembles of proteins and macromolecular complexes can be obtained with metainference, a recently proposed Bayesian inference method that integrates experimental information with prior knowledge and deals with all sources of errors in the data as well as with sample heterogeneity. The s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31232
更新日期:2016-08-26 00:00:00
abstract::Changes associated with cognitive function in the high-fat high-carbohydrate diet-induced prediabetes animal model and effect of exercise remain unclear. Rats were randomly assigned to the following groups (n = 6): non-diabetic (ND), prediabetic (PD), intermittent exercising PD (PD + IE) and regular exercising PD (PD ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72098-0
更新日期:2020-09-14 00:00:00
abstract::The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous geneti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71066-y
更新日期:2020-09-02 00:00:00
abstract::The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in northeast Asia. The Changbai Mountains and the Korean peninsula (CM/KP) are usually considered to be the LGM refugia for P. koraiensis. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18608
更新日期:2015-12-22 00:00:00
abstract::Balloon whisk-like and flower-like SiOx tubes with well-dispersed Sn and joining countless SiOx loops together induce intense luminescence characteristics in substrate materials. Our synthetic technique called "direct substrate growth" is based on pre-contamination of the surroundings without the intended catalyst and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30901
更新日期:2016-08-01 00:00:00
abstract::A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12028
更新日期:2015-07-06 00:00:00
abstract::Depressive disorder (DD) is a mental illness affecting more than 300 million people worldwide, whereas social stigma and subtle, variant symptoms impede diagnosis. Psychomotor retardation is a common component of DD with a negative impact on motor function, usually reflected on patients' routine activities, including,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50002-9
更新日期:2019-09-16 00:00:00
abstract::Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39448-z
更新日期:2019-03-05 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62460-7
更新日期:2020-03-25 00:00:00
abstract::A brain-computer interface (BCI) is an advanced human-machine interaction technology. The BCI speller is a typical application that detects the stimulated source-induced EEG signal to identify the expected characters of the subjects. The current mainstream matrix-based BCI speller involves two problems that remain uns...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21717-y
更新日期:2018-02-20 00:00:00