Abstract：
:Dysregulation of specific microRNAs or Wnt/β-catenin signaling pathway is critically implicated in the pathogenesis of various renal diseases. However, the relationship between microRNAs and Wnt/β-catenin signaling in diabetes-induced glomerular sclerosis remains unknown. Here, we found that decreased miR-29a expression and attenuated Wnt/β-catenin signaling were concomitantly detected in glomeruli of streptozotocin-induced diabetic mice. Gain of miR-29a function in diabetic mice substantially increased the expression of β-catenin and blocked the expressions of profibrotic gene markers, including DKK1 (a Wnt antagonist), TGF-β1 and fibronectin, in glomerular mesangium. Moreover, in the normal mice treated with miR-29a inhibitor, renal fibrosis was induced with an attenuated Wnt/β-catenin signaling activity. Consistently, the constructed miR-29a transgenic mice that supported sustained Wnt/β-catenin signaling had the ability to block the expressions of profibrotic genes after induction of diabetes. We also demonstrated that miR-29a acts as a positive regulator of Wnt/β-catenin signaling in cultured mesangial cells and functions to protect cell apoptosis and fibrosis. Importantly, we showed that activation of Wnt/β-catenin signaling in cultured mesangial cells by transfecting the β-catenin (Δ45) mutant or by a GSK-3β inhibitor reversely upregulated miR29a. Our findings suggest that the reciprocal relationship between miR-29a and DKK1/Wnt/β-catenin signaling may play an important part in protecting renal fibrogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hsu YC,Chang PJ,Ho C,Huang YT,Shih YH,Wang CJ,Lin CLdoi
10.1038/srep30575subject
Has Abstractpub_date
2016-07-27 00:00:00pages
30575issn
2045-2322pii
srep30575journal_volume
6pub_type
杂志文章abstract：:The 70-kD heat shock proteins (Hsp70s) are highly conserved molecular chaperones that play essential roles in cellular processes including abiotic stress responses. Physcomitrella patens serves as a representative of the first terrestrial plants and can recover from serious dehydration. To assess the possible relation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33650
更新日期：2016-09-20 00:00:00
abstract：:Microfluidic paper-based analytical devices (µPADs) have provided a breakthrough in portable and low-cost point-of-care diagnostics. Despite their significant scope, the complexity of fabrication and reliance on expensive and sophisticated tools, have limited their outreach and possibility of commercialization. Herein...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44455-1
更新日期：2019-05-27 00:00:00
abstract：:The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05340
更新日期：2014-06-18 00:00:00
abstract：:We propose a new method to extend the path length tunability of rotary delay-lines. This method was shown to achieve a duty cycle of >80% and repetition rates of over 40 kHz. The new method relies on a new multi-segmented micro-machined mirror and serial injection of a single reflection onto separate segments of this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09576-5
更新日期：2017-08-24 00:00:00
abstract：:Calcium oxalate monohydrate (COM) crystals cause kidney stone disease by still unclear mechanisms. The present study aimed to characterize changes in secretion of proteins from basolateral compartment of renal tubular epithelial cells after exposure to COM crystals and then correlated them with the stone pathogenesis....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24064
更新日期：2016-04-05 00:00:00
abstract：:Predators are an important ecological and evolutionary force shaping prey population dynamics. Ecologists have extensively assessed the lethal effects of invasive predators on prey populations. However, the role of non-lethal effects, such as physiological stress or behavioural responses like dispersal, has been compa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20333-0
更新日期：2018-01-31 00:00:00
abstract：:Maintaining energy balance over a wide range of temperatures is critical for an active pelagic fish species such as the mahi-mahi (Coryphaena hippurus), which can experience rapid changes in temperature during vertical migrations. Due to the profound effect of temperature on mitochondrial function, this study was desi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71741-0
更新日期：2020-09-10 00:00:00
abstract：:It is known that ribosomal RNA (rRNA) synthesis is regulated by cellular energy and proliferation status. In this study, we investigated rRNA gene transcription in response to cytoskeletal stress. Our data revealed that the cell shape constrained by isotropic but not elongated micropatterns in HeLa cells led to a sign...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28685
更新日期：2016-06-28 00:00:00
abstract：:In this study, novel ZnS@In2S3 core@shell hollow nanospheres were fabricated by a facile refluxing method for the first time, and the formation mechanism of hollow structure with interior architecture was discussed based on ion-exchange Ostwald ripening. As the photocatalytic material for degradation of gaseous o-Dich...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16732-4
更新日期：2017-11-27 00:00:00
abstract：:Graphene and related materials have come to the forefront of research in electrochemical sensors during recent years due to the promising properties of these nanomaterials. Further applications of these nanomaterials have been hampered by insufficient sensitivity offered by these nanohybrids for the type of molecules ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00877
更新日期：2012-01-01 00:00:00
abstract：:Emerging infectious pathogens that threaten blood transfusions are known to be present in blood samples from healthy/qualified donors. The objective of this study was to investigate the microbiome of blood from healthy donors from the Luzhou area in southwestern China. Potential pathogens and cytomegalovirus (CMV) inf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72808-8
更新日期：2020-09-25 00:00:00
abstract：:Muscle damage and loss of muscle mass are triggered by immobilization, loss of appetite, dystrophies and chronic wasting diseases. In addition, physical exercise causes muscle damage. In damaged muscle, the N-terminal and C-terminal regions of titin, a giant sarcomere protein, are cleaved by calpain-3, and the resulti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39375
更新日期：2016-12-19 00:00:00
abstract：:Although the reversible wettability transition between hydrophobic and hydrophilic graphene under ultraviolet (UV) irradiation has been observed, the mechanism for this phenomenon remains unclear. In this work, experimental and theoretical investigations demonstrate that the H2O molecules are split into hydrogen and h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06450
更新日期：2014-09-23 00:00:00
abstract：:Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24630-6
更新日期：2018-04-27 00:00:00
abstract：:Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06525
更新日期：2014-10-06 00:00:00
abstract：:Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00933-y
更新日期：2017-04-07 00:00:00
abstract：:Submillimetre-sized plastic particles (microplastics and nanoplastics) of waste origin in the environment have been repeatedly suggested in recent years to have severe impact on living organisms. While the uptake of these materials has been unequivocally evidenced for animals, so far no adverse effects have been obser...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52495-w
更新日期：2019-11-05 00:00:00
abstract：:Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03737-2
更新日期：2017-06-15 00:00:00
abstract：:The renal sodium chloride cotransporter, NCC, in the distal convoluted tubule is important for maintaining body Na+ and K+ homeostasis. Endogenous NCC is highly ubiquitylated, but the role of individual ubiquitylation sites is not established. Here, we assessed the role of 10 ubiquitylation sites for NCC function. Tra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12819-0
更新日期：2017-10-11 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-26716-7
更新日期：2018-06-18 00:00:00
abstract：:The nucleotides guanosine tetraphosphate and pentaphosphate (together known as (p)ppGpp or magic spot) are produced in plant plastids from GDP/GTP and ATP by RelA-SpoT homologue (RSH) enzymes. In the model plant Arabidopsis (p)ppGpp regulates chloroplast transcription and translation to affect growth, and is also impl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54207-w
更新日期：2019-11-27 00:00:00
abstract：:This work provides new insights into the dynamics of silica nanoparticle-based removal of organic fluids (here oil) from naturally occurring porous media. We have used 4D (time-resolved 3D) imaging at pore-scale using X-ray computed micro-tomography (μCT) technique. The captured 3D tomographic time-series data reveal ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29569-2
更新日期：2018-07-24 00:00:00
abstract：:Pitch is a complex hearing phenomenon that results from elicited and self-generated cochlear vibrations. Read-off vibrational information is relayed higher up the auditory pathway, where it is then condensed into pitch sensation. How this can adequately be described in terms of physics has largely remained an open que...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02676
更新日期：2013-01-01 00:00:00
abstract：:Analyzing the cytotoxic functions of effector cells, such as NK cells against target cancer cells, is thought to be necessary for predicting the clinical efficacy of antibody-dependent cellular cytotoxicity (ADCC) -dependent antibody therapy. The (51)Cr release assay has long been the most widely used method for quant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19772
更新日期：2016-01-27 00:00:00
abstract：:Two important theories in spatial modelling relate to structural and spatial dependence. Structural dependence refers to environmental state-factor models, where an environmental property is modelled as a function of the states and interactions of environmental predictors, such as climate, parent material or relief. C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73773-y
更新日期：2020-10-07 00:00:00
abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28291-3
更新日期：2018-07-05 00:00:00
abstract：:To elude the strength-electrical conductivity trade-off dilemma, a nanostructuring strategy was achieved in microalloyed Al-0.1wt.% Zr conductor by optimizing the processing route, leading to enhanced strength and simultaneously improved electrical conductivity. The nanostructural design involved ultrafine grains with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24527-4
更新日期：2018-04-18 00:00:00
abstract：:It has been a long-standing puzzle why buckled dimers of the Si(001) surface appeared symmetric below ~20 K in scanning tunneling microscopy (STM) experiments. Although such symmetric dimer images were concluded to be due to an artifact induced by STM measurements, its underlying mechanism is still veiled. Here, we de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27868
更新日期：2016-06-13 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that is associated with the destruction of immune tolerance and activation of B cells. Interleukin (IL)-35 and IL-35-producing (IL-35+) regulatory B cells (Bregs) have been demonstrated to possess immunosuppressive functions, but their roles in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49748-z
更新日期：2019-09-13 00:00:00
abstract：:The adaptation of herbivorous insects to various host plants facilitates the spread and outbreak of many important invasive pests, however, the molecular mechanisms that underneath this process are poorly understood. In the past three decades, two species of the whitefly Bemisia tabaci complex, Middle East-Asia Minor ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12387-3
更新日期：2017-09-21 00:00:00
