Abstract：
:Emerging infectious pathogens that threaten blood transfusions are known to be present in blood samples from healthy/qualified donors. The objective of this study was to investigate the microbiome of blood from healthy donors from the Luzhou area in southwestern China. Potential pathogens and cytomegalovirus (CMV) infection in the donor blood were identified. Total plasma nucleic acids were extracted from one pool of 5734 samples and were constructed for metagenomics analysis using Illumina sequencing. The microbiome and potential emerging/re-emerging pathogens were identified using bioinformatics analysis. Moreover, CMV antigen was measured via an enzyme-linked immunosorbent assay, and the CMV DNA level was assessed by quantitative RT-PCR. A total of 132 bacterial reads, 65 viral reads and 165 parasitic reads were obtained. The most frequent bacterium was Escherichia coli (95/132, 72%) with 95 reads in 132 bacterial reads, and the most prevalent parasite was Toxoplasma gondii (131/165, 79%). Among the viruses, cytomegalovirus (44/65, 68%) accounted for the highest frequency, followed by Hepatitis E Virus (10/65, 15%). Moreover, the positive rate of CMV-IgG was 46.25% (2652/5734), and the positive rate of CMV-IgM was 5.82% (334/5734). The positive rate of dual positive (IgG+ and IgM+) CMV was 0.07% (4/5734). Twenty-one (0.37%) specimens from 5734 donated blood samples were positive for CMV DNA. The CMV DNA levels ranged from 7.56 × 102 to 3.58 × 103 copies/mL. The current study elucidated the microbiome structure in blood from healthy/qualified donors in the Luzhou area and identified emerging/re-emerging pathogens. This preliminary study contributes to information regarding blood transfusion safety in China.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu M,Gao J,Li S,Zeng M,Wu J,Luo Mdoi
10.1038/s41598-020-72808-8subject
Has Abstractpub_date
2020-09-25 00:00:00pages
15809issue
1issn
2045-2322pii
10.1038/s41598-020-72808-8journal_volume
10pub_type
杂志文章abstract：:Chaotic time series prediction based on nonlinear systems showed a superior performance in prediction field. We studied prenatal exposure to polychlorinated biphenyls (PCBs) by chaotic time series prediction using the least squares self-exciting threshold autoregressive (SEATR) model in umbilical cord blood in an elec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25005
更新日期：2016-04-27 00:00:00
abstract：:Millimeter wave (MMW)-induced heating represents a promising alternative for non-invasive hyperthermia of superficial skin cancer, such as melanoma. Pulsed MMW-induced heating of tumors allows for reaching high peak temperatures without overheating surrounding tissues. Herein, for the first time, we evaluate apoptotic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51731-7
更新日期：2019-10-24 00:00:00
abstract：:Macular edema due to neovascular age-related macular degeneration, diabetes or retinal vein occlusion can cause central vision loss. Intravitreal treatment with antibody-based biopharmaceutical compounds designed to neutralize vascular endothelial growth factor (VEGF) has proven to be an efficient strategy to ameliora...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20525-8
更新日期：2018-02-01 00:00:00
abstract：:While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58877-9
更新日期：2020-02-07 00:00:00
abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50281-2
更新日期：2019-10-10 00:00:00
abstract：:Here, we demonstrated the expression of the N-glycosylated extracellular ligand binding domain of receptor for advanced glycation end products (sRAGE) in middle silk glands (MSGs) of transgenic silkworms using the GAL4/UAS system. Over 1 mg of sRAGE was obtained from one transgenic silkworm. sRAGE purified from the si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00420-4
更新日期：2017-03-23 00:00:00
abstract：:Bloodstain Pattern Analysis is a forensic discipline in which, among others, the position of victims can be determined at crime scenes on which blood has been shed. To determine where the blood source was investigators use a straight-line approximation for the trajectory, ignoring effects of gravity and drag and thus ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11461
更新日期：2015-06-22 00:00:00
abstract：:MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-45570-9
更新日期：2019-07-01 00:00:00
abstract：:Unlike the constant nature of elastic coefficients of isotropic bulk materials, the Young's (E) and shear (μ) moduli of nano-structured (NS) gyroid metamaterials change with relative density (ρ), but at different rates depending on the cell size of the structure. These elastic behaviors displayed by E and μ cause cros...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10978-8
更新日期：2017-09-05 00:00:00
abstract：:Microalgae identification is extremely difficult. The efficiency of DNA barcoding in microalgae identification involves ideal gene markers and approaches employed, which however, is still under the way. Although Scenedesmus has obtained much research in producing lipids its identification is difficult. Here we present...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36822
更新日期：2016-11-09 00:00:00
abstract：:Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19549
更新日期：2016-01-19 00:00:00
abstract：:The real time detection of quantitative oxygen release from the cathode is performed by in-situ Gas Chromatography as a tool to not only determine the amount of oxygen release from a lithium-ion cell but also to address the safety concerns. This in-situ gas chromatography technique monitoring the gas evolution during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23394
更新日期：2016-03-22 00:00:00
abstract：:Nitric oxide synthase like enzyme (NOS-like enzyme), which produces nitric oxide, participates in many biological processes. However it remains unidentified and highly controversial that plants do possess a NOS-like enzyme. In this paper, a novel arginine analogue NP1 was designed and developed for the direct identifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32630
更新日期：2016-09-02 00:00:00
abstract：:Six selected weedy Amaranthus genotypes (three accessions from each species of A. viridis and A. spinosus) were evaluated in terms of nutrients, minerals, antioxidant constituents and antioxidant activity for the possibilities of weedy species as a vegetable cultivar in a randomized complete block design with three re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50977-5
更新日期：2019-12-31 00:00:00
abstract：:TP53 mutation (i.e., loss of normal-p53) may evoke epithelial-mesenchymal transition (EMT), which was previously attributed to loss of certain miRNAs. However, not all epithelial cells undergo EMT upon TP53 mutation, and the p53-miRNA axis may not fully explain p53 function in epithelial integrity. We here show two mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20043-7
更新日期：2018-01-25 00:00:00
abstract：:Ultrathin transmission metasurface devices are designed on the basis of the Yang-Gu amplitude-phase retrieval algorithm for focusing the terahertz (THz) radiation into four or nine spots with focal spacing of 2 or 3 mm at a frequency of 0.8 THz. The focal properties are experimentally investigated in detail, and the r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28800
更新日期：2016-06-27 00:00:00
abstract：:Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16823-2
更新日期：2017-11-28 00:00:00
abstract：:Finding strategies to preserve quantum resources in open systems is nowadays a main requirement for reliable quantum-enhanced technologies. We address this issue by considering structured cavities embedding qubits driven by a control technique known as frequency modulation. We first study a single qubit in a lossy cav...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32661-2
更新日期：2018-09-24 00:00:00
abstract：:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53705-1
更新日期：2019-11-27 00:00:00
abstract：:Most pollination in large-scale agriculture is dependent on managed colonies of a single species, the honey bee Apis mellifera. More than 1 million hives are transported to California each year just to pollinate the almonds, and bees are trucked across the country for various cropping systems. Concerns have been raise...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32023
更新日期：2016-08-24 00:00:00
abstract：:Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39757-3
更新日期：2019-03-01 00:00:00
abstract：:Mitochondrial dysfunction is implicated in many human diseases and occurs in normal aging. Mitochondrial health is maintained through organelle biogenesis and repair or turnover of existing mitochondria. Mitochondrial turnover is principally mediated by mitophagy, the trafficking of damaged mitochondria to lysosomes v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12397
更新日期：2015-07-28 00:00:00
abstract：:We are reporting a 3D printable composite paste having strong thixotropic rheology. The composite has been designed and investigated with highly conductive silver nanowires. The optimized electrical percolation threshold from both simulation and experiment is shown from 0.7 vol. % of silver nanowires which is signific...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03365-w
更新日期：2017-06-12 00:00:00
abstract：:Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of pheromones in the crop plants. This has now been achieved by genetically engineering a hexaploid variety of wheat to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11183
更新日期：2015-06-25 00:00:00
abstract：:We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11420
更新日期：2015-06-19 00:00:00
abstract：:Multisensory interactions are essential to make sense of the environment by transforming the mosaic of sensory inputs received by the organism into a unified perception. Brain rhythms allow coherent processing within areas or between distant brain regions and could thus be instrumental in functionally connecting remot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47503-y
更新日期：2019-08-02 00:00:00
abstract：:Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11923
更新日期：2015-07-06 00:00:00
abstract：:Biomaterial development for tissue engineering applications is rapidly increasing but necessitates efficacy and safety testing prior to clinical application. Current in vitro and in vivo models hold a number of limitations, including expense, lack of correlation between animal models and human outcomes and the need to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32168
更新日期：2016-08-31 00:00:00
abstract：:There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable and binding of ADPR occurs N-terminally. Zebrafish TRPM2 needs both, the N-termin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55232-5
更新日期：2019-12-16 00:00:00
abstract：:Diverse communities can adjust their trait composition to altered environmental conditions, which may strongly influence their dynamics. Previous studies of trait-based models mainly considered only one or two trophic levels, whereas most natural system are at least tritrophic. Therefore, we investigated how the addit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43974-1
更新日期：2019-05-17 00:00:00
