In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography.

abstract：:Angiosperm mitochondrial genomes (mtDNA) exhibit variable quantities of alien sequences. Many of these sequences are acquired by intracellular gene transfer (IGT) from the plastid. In addition, frequent events of horizontal gene transfer (HGT) between mitochondria of different species also contribute to their expanded...

journal_title：Scientific reports

authors： Gandini CL,Sanchez-Puerta MV

更新日期：2017-03-06 00:00:00

abstract：:We report on a wavelet based space-scale decomposition method for analyzing the response of living muscle precursor cells (C2C12 myoblasts and myotubes) upon sharp indentation with an AFM cantilever and quantifying their aptitude to sustain such a local shear strain. Beyond global mechanical parameters which are curre...

journal_title：Scientific reports

authors： Streppa L,Ratti F,Goillot E,Devin A,Schaeffer L,Arneodo A,Argoul F

更新日期：2018-06-05 00:00:00

abstract：:Practical application of superhydrophobic surfaces is limited by the fragility of nanoscale asperities. Combining chemical etching and anodization, microscale pits and nanoscale pores, instead of the micro and nano protrusions on traditional superhydrophobic surfaces mimicking Lutos leaves, were fabricated on commerci...

journal_title：Scientific reports

authors： Wang G,Liu S,Wei S,Liu Y,Lian J,Jiang Q

更新日期：2016-02-08 00:00:00

abstract：:Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580) to investigate the genetic basis for brain weights, activi...

journal_title：Scientific reports

authors： Janecka M,Marzi SJ,Parsons MJ,Liu L,Paya-Cano JL,Smith RG,Fernandes C,Schalkwyk LC

更新日期：2017-02-01 00:00:00

abstract：:Parametric analysis of Cerebellar Ataxia (CA) could be of immense value compared to its subjective clinical assessments. This study focuses on a comprehensive scheme for objective assessment of CA through the instrumented versions of 9 commonly used neurological tests in 5 domains- speech, upper limb, lower limb, gait...

journal_title：Scientific reports

authors： Kashyap B,Phan D,Pathirana PN,Horne M,Power L,Szmulewicz D

更新日期：2020-06-11 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...

journal_title：Scientific reports

authors： Fu XL,Liu DJ,Yan TT,Yang JY,Yang MW,Li J,Huo YM,Liu W,Zhang JF,Hong J,Hua R,Chen HY,Sun YW

更新日期：2016-09-15 00:00:00

abstract：:Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a relatively large number of photons, hence slowing down total acquis...

journal_title：Scientific reports

authors： Zickus V,Wu ML,Morimoto K,Kapitany V,Fatima A,Turpin A,Insall R,Whitelaw J,Machesky L,Bruschini C,Faccio D,Charbon E

更新日期：2020-12-02 00:00:00

abstract：:Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during th...

journal_title：Scientific reports

authors： Porphyre T,Correia-Gomes C,Chase-Topping ME,Gamado K,Auty HK,Hutchinson I,Reeves A,Gunn GJ,Woolhouse ME

更新日期：2017-02-22 00:00:00

abstract：:Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC). To date, various phenotypic defects such as cortical lamination irregularity, subependymal nodule formation, dysmorphic astrocyte differentiation and dendritic malformati...

journal_title：Scientific reports

authors： Shin J,Kim M,Jung HJ,Cha HL,Suh-Kim H,Ahn S,Jung J,Kim Y,Jun Y,Lee S,Hwang D,Kim J

更新日期：2017-06-06 00:00:00

abstract：:The present research relates to a fusion protein comprising a chromogenic blue ultramarine protein (UM) bound to a keratin-based peptide (KP). The KP-UM fusion protein explores UM chromogenic nature together with KP affinity towards hair. For the first time a fusion protein with a chromogenic nature is explored as a h...

journal_title：Scientific reports

authors： Tinoco A,Antunes E,Martins M,Gonçalves F,Gomes AC,Silva C,Cavaco-Paulo A,Ribeiro A

更新日期：2019-10-01 00:00:00

abstract：:In Eastern Boundary Current systems, wind-driven upwelling drives nutrient-rich water to the ocean surface, making these regions among the most productive on Earth. Regulation of productivity by changing wind and/or nutrient conditions can dramatically impact ecosystem functioning, though the mechanisms are not well u...

journal_title：Scientific reports

authors： Jacox MG,Hazen EL,Bograd SJ

更新日期：2016-06-09 00:00:00

abstract：:Modern Computed Tomography (CT) scanners are capable of acquiring contrast dynamics of the whole brain, adding functional to anatomical information. Soft tissue segmentation is important for subsequent applications such as tissue dependent perfusion analysis and automated detection and quantification of cerebral patho...

journal_title：Scientific reports

authors： Manniesing R,Oei MTH,Oostveen LJ,Melendez J,Smit EJ,Platel B,Sánchez CI,Meijer FJA,Prokop M,van Ginneken B

更新日期：2017-03-09 00:00:00

abstract：:The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...

journal_title：Scientific reports

authors： Okamoto F,Moriya Y,Sugiura Y,Murakami T,Morikawa S,Hoshi S,Hiraoka T,Oshika T

更新日期：2020-11-11 00:00:00

abstract：:In long-lived species, the age-, stage- and/or sex-dependent patterns of survival and reproduction determine the evolution of life history strategies, the shape of the reproductive value, and ultimately population dynamics. We evaluate the combined effects of age and sex in recruitment, breeder survival and breeding s...

journal_title：Scientific reports

authors： Sanz-Aguilar A,Cortés-Avizanda A,Serrano D,Blanco G,Ceballos O,Grande JM,Tella JL,Donázar JA

更新日期：2017-01-11 00:00:00

abstract：:Taraxacum kok-saghyz (TKS) carries great potential as alternative natural rubber source. To better inform future breeding efforts with TKS and gain a deeper understanding of its genetic diversity, we utilized de novo sequencing to generate novel genomic simple sequence repeats markers (gSSRs). We utilized 25 gSSRs on ...

journal_title：Scientific reports

authors： Nowicki M,Zhao Y,Boggess SL,Fluess H,Payá-Milans M,Staton ME,Houston LC,Hadziabdic D,Trigiano RN

更新日期：2019-02-13 00:00:00

abstract：:Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gene transfer efficiency, low immunogenicity, stable long-term expressio...

journal_title：Scientific reports

authors： Kimura T,Ferran B,Tsukahara Y,Shang Q,Desai S,Fedoce A,Pimentel DR,Luptak I,Adachi T,Ido Y,Matsui R,Bachschmid MM

更新日期：2019-09-19 00:00:00

abstract：:Warburg effect or aerobic glycolysis provides selective growth advantage to aggressive cancers. However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude of cells. In this study, we present ADP-dependent glucokinase (ADPGK)...

journal_title：Scientific reports

authors： Tandon A,Birkenhagen J,Nagalla D,Kölker S,Sauer SW

更新日期：2020-08-12 00:00:00

abstract：:Heterostructures consisting of two-dimensional materials have shown new physical phenomena, novel electronic and optical properties, and new device concepts not observed in bulk material systems or purely three dimensional heterostructures. These new effects originated mostly from the van der Waals interaction between...

journal_title：Scientific reports

authors： Park J,Back T,Mitchel WC,Kim SS,Elhamri S,Boeckl J,Fairchild SB,Naik R,Voevodin AA

更新日期：2015-09-23 00:00:00

abstract：:Here, we report results on systematic analysis of DNA substrate preferences of three N6-adenine β-class DNA methyltransferases that are part of the type II restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII and M.LlaCI, which although found in phylogenetically distant bacteria (γ-proteoba...

journal_title：Scientific reports

authors： Wons E,Mruk I,Kaczorowski T

更新日期：2018-05-29 00:00:00

abstract：:As a fundamental property of pressure-induced amorphization (PIA) in ice and ice-like materials (notably α-quartz), the occurrence of mechanical instability can be related to violation of Born criteria for elasticity. The most outstanding elastic feature of α-quartz before PIA has been experimentally reported to be th...

journal_title：Scientific reports

authors： Dong J,Zhu H,Chen D

更新日期：2015-06-23 00:00:00

abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

journal_title：Scientific reports

authors： Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

更新日期：2017-04-24 00:00:00

abstract：:Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several e...

journal_title：Scientific reports

authors： Brendle C,Stefan N,Stef I,Ripkens S,Soekler M,la Fougère C,Nikolaou K,Pfannenberg C

更新日期：2019-02-13 00:00:00

abstract：:In eye movement perimetry (EMP), the saccadic reaction time (SRT) to 'seen' visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 he...

journal_title：Scientific reports

authors： Mazumdar D,Meethal NSK,George R,Pel JJM

更新日期：2021-01-29 00:00:00

abstract：:High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...

journal_title：Scientific reports

authors： Efremova MV,Naumenko VA,Spasova M,Garanina AS,Abakumov MA,Blokhina AD,Melnikov PA,Prelovskaya AO,Heidelmann M,Li ZA,Ma Z,Shchetinin IV,Golovin YI,Kireev II,Savchenko AG,Chekhonin VP,Klyachko NL,Farle M,Majouga AG,Wi

更新日期：2018-07-26 00:00:00

abstract：:Catharanthus roseus is a commercial source for anti-cancer terpenoid indole alkaloids (TIAs: vincristine and vinblastine). Inherent levels of these TIAs are very low, hence research studies need to focus on enhancing their levels in planta. Since primary metabolism provides precursors for specialized-metabolism, eleva...

journal_title：Scientific reports

authors： Nishanth MJ,Sheshadri SA,Rathore SS,Srinidhi S,Simon B

更新日期：2018-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Santra M,Sharma M,Katoch D,Jain S,Saikia UN,Dogra MR,Luthra-Guptasarma M

更新日期：2020-07-16 00:00:00

abstract：:Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically...

journal_title：Scientific reports

authors： Shirmanova MV,Druzhkova IN,Lukina MM,Dudenkova VV,Ignatova NI,Snopova LB,Shcheslavskiy VI,Belousov VV,Zagaynova EV

更新日期：2017-08-21 00:00:00

abstract：:Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical ch...

journal_title：Scientific reports

authors： Mak ADP,Northoff G,Yeung DKW,Chu WCW,Hui SCN,Cheung C,Ching J,Lam L,Lee S,Wu J

更新日期：2017-06-20 00:00:00

abstract：:Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-d...

journal_title：Scientific reports

authors： Morokuma S,Tsukimori K,Hori T,Kato K,Furue M

更新日期：2017-04-07 00:00:00

abstract：:Ciliate Mesodinium species are commonly distributed in diverse aquatic systems worldwide. Among Mesodinium species, M. rubrum is closely associated with microbial food webs and red tide formation and is known to acquire chloroplasts from its cryptophyte prey for use in photosynthesis. For these reasons, Mesodinium has...

journal_title：Scientific reports

authors： Kim M,Park MG

更新日期：2019-10-01 00:00:00