Abstract:
:Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that is associated with the destruction of immune tolerance and activation of B cells. Interleukin (IL)-35 and IL-35-producing (IL-35+) regulatory B cells (Bregs) have been demonstrated to possess immunosuppressive functions, but their roles in the initiation and early development of SLE have not been explored. Here, we measured and compared the frequencies of blood regulatory B cell subsets and the concentrations of plasma IL-35, IL-10, IL-17A, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in 47 Chinese patients with newly diagnosed SLE and 20 matched healthy controls (HCs). The SLE patients had decreased percentages of IL-35+ B cells and IL-10+ B cells among the total blood B cells as well as decreased concentrations of plasma IL-35. In addition, higher levels of plasma IL-10, IFN-γ, TNF-α, and IL-17 along with higher frequencies of circulating plasma and memory B cells were observed in the SLE patients. The percentage of IL-35+ Bregs and the serum IL-35 level were inversely correlated with the SLE disease activity index and the erythrocyte sedimentation rate (ESR) levels. Our results indicate that IL-35+ Bregs and IL-35 may play protective roles in SLE initiation and progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ye Z,Jiang Y,Sun D,Zhong W,Zhao L,Jiang Zdoi
10.1038/s41598-019-49748-zsubject
Has Abstractpub_date
2019-09-13 00:00:00pages
13210issue
1issn
2045-2322pii
10.1038/s41598-019-49748-zjournal_volume
9pub_type
杂志文章abstract::Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13494
更新日期:2015-09-22 00:00:00
abstract::Recent severe European droughts raise the vital question: are we already experiencing measurable changes in drought likelihood that agree with climate change projections? The plethora of drought definitions compounds this question, requiring instead that we ask: how have various types of drought changed, how do these ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14283-2
更新日期:2017-10-25 00:00:00
abstract::Here we present a set of measurements using Differential Scanning Fluorimetry (DSF) as an inexpensive, high throughput screening method to investigate the folding of silk protein molecules as they abandon their first native melt conformation, dehydrate and denature into their final solid filament conformation. Our fir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05625
更新日期:2014-07-09 00:00:00
abstract::Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other prima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59110-3
更新日期:2020-02-12 00:00:00
abstract::Environmental contamination of arsenic (As) and its accumulation in rice (Oryza sativa L.) is of serious human health concern. In planta speciation of As is an important tool to understand As metabolism in plants. In the present study, we investigated root to shoot As translocation and speciation in rice exposed to in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40522
更新日期:2017-01-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-63129-x
更新日期:2020-04-16 00:00:00
abstract::Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21577
更新日期:2016-02-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65027-8
更新日期:2020-05-20 00:00:00
abstract::Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62343-x
更新日期:2020-03-24 00:00:00
abstract::Predators are an important ecological and evolutionary force shaping prey population dynamics. Ecologists have extensively assessed the lethal effects of invasive predators on prey populations. However, the role of non-lethal effects, such as physiological stress or behavioural responses like dispersal, has been compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20333-0
更新日期:2018-01-31 00:00:00
abstract::Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) is a prevalent pollen consumer in corn fields and is therefore exposed to insecticidal proteins contained in the pollen of insect-resistant transgenic corn cultivars expressing Cry proteins derived from Bacillus thuringiensis (Bt). In the present study, the pote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23507
更新日期:2016-03-23 00:00:00
abstract::Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06264-2
更新日期:2017-07-24 00:00:00
abstract::Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water sample...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45931
更新日期:2017-04-12 00:00:00
abstract::Bovine milk is vital for infant nutrition and is a major component of the human diet. Bovine mastitis is a common inflammatory disease of mammary gland in cattle. It alters the immune profile of the animal and lowers the quality and yield of milk causing huge economic losses to dairy industry. The incidence of sub-cli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66211-6
更新日期:2020-06-09 00:00:00
abstract::Previous trial evidence suggested potential risk of serious urinary tract infections (UTIs) and genital infections in type 2 diabetes patients using sodium glucose co-transporter-2 inhibitors (SGLT2) inhibitors. We conducted a systematic review and meta-analysis to assess the effects of SGLT2 inhibitors on UTIs and ge...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/s41598-017-02733-w
更新日期:2017-06-06 00:00:00
abstract::Lateral flow strip tests are a cost-effective method for detecting specific proteins in biological samples, which can be performed in the field without specialized expertise. While most recognizable in the pregnancy tests, there are many other applications for lateral flow strip technology. The pest control industry h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70200-0
更新日期:2020-08-07 00:00:00
abstract::The intermolt crustacean Y-organ (YO) maintains a basal state mediated by pulsatile release of molt inhibiting hormone (MIH), a neuropeptide produced in the eyestalk ganglia, inhibiting YO ecdysteroidogenesis. Reduction of MIH results in YO activation and the animal enters premolt. In the crab, Gecarcinus lateralis, m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25368-x
更新日期:2018-05-09 00:00:00
abstract::We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09501-w
更新日期:2017-08-21 00:00:00
abstract::This study was conducted to investigate prognosis and survival of patients undergoing distal subtotal gastrectomy with D2 and D2+ lymphadenectomy for patients with locally advanced gastric cancer. Overall survival rates of 416 patients with locally advanced gastric cancer were compared between D2 and D2+ lymphadenecto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17273
更新日期:2015-11-25 00:00:00
abstract::Salinity is a critical abiotic stress, which significantly impacts the agricultural yield worldwide. Identification of the molecular mechanisms underlying the salt tolerance in euhalophyte Suaeda salsa is conducive to the development of salt-resistant crops. In the present study, high-throughput RNA sequencing was per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61204-x
更新日期:2020-03-06 00:00:00
abstract::Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically defined medium containing two sugars (for example glucose and lactose). Typically, the two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phase. Diauxic growth is usually interpreted as an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25191
更新日期:2016-04-29 00:00:00
abstract::Genetic characterization of local breeds is essential to preserve their genomic variability, to advance conservation policies and to contribute to their promotion and sustainability. Genomic diversity of twenty European local pig breeds and a small sample of Spanish wild pigs was assessed using high density SNP chips....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49830-6
更新日期:2019-09-19 00:00:00
abstract::PageRank is arguably the most popular ranking algorithm which is being applied in real systems ranging from information to biological and infrastructure networks. Despite its outstanding popularity and broad use in different areas of science, the relation between the algorithm's efficacy and properties of the network ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16181
更新日期:2015-11-10 00:00:00
abstract::Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03928-x
更新日期:2017-06-16 00:00:00
abstract::Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80288-z
更新日期:2020-12-31 00:00:00
abstract::It is well known that the Gobi Desert is the dominant source area of the Badain Jaran Desert (BJD) and the Chinese Loess Plateau (CLP). However, due to the absence of quantitative analyses, there are nearly no exact assessments of its actual contribution. Combinations of field investigations, wind tunnel experiments, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37635-y
更新日期:2019-01-30 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44071-z
更新日期:2019-06-05 00:00:00
abstract::Listeria monocytogenes is an intracellular pathogen that causes listeriosis. Due to its intracellular niche, L. monocytogenes has evolved to limit immune recognition and response to infection. Antibodies that are slightly induced by listerial infection are completely unable to protect re-infection of L. monocytogenes....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39628
更新日期:2016-12-22 00:00:00
abstract::One fundamental question in prey luring systems is to understand how visual signals are interpreted by the receiver. Predators lure prey by falsely imitating the signal of a model, or may exploit sensory preferences of the receivers, which search for rewarding signals. Crab spiders reflect ultraviolet (UV) light, ambu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09456-y
更新日期:2017-08-23 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44437-3
更新日期:2019-06-05 00:00:00