Abstract：
:Graphene and related materials have come to the forefront of research in electrochemical sensors during recent years due to the promising properties of these nanomaterials. Further applications of these nanomaterials have been hampered by insufficient sensitivity offered by these nanohybrids for the type of molecules requiring lower detection ranges. Here, we report a signal amplification strategy based on magneto-electrochemical immunoassay which combines the advantages of carbon nanotube and reduced graphene oxide together with electrochemical bursting of magnetic nanoparticles into a large number of metal ions. Sensitive detection was achieved by precisely designing the nanohybrid and correlating the available metal ions with analyte concentration. We confirmed the ultrahigh sensitivity of this method for a new generation herbicide diuron and its analogues up to sub-picomolar concentration in standard water samples. The novel immune-detection platform showed the excellent potential applicability in rapid and sensitive screening of environmental pollutants or toxins in samples.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sharma P,Bhalla V,Dravid V,Shekhawat G,Jinsong-Wu,Prasad ES,Suri CRdoi
10.1038/srep00877subject
Has Abstractpub_date
2012-01-01 00:00:00pages
877issn
2045-2322journal_volume
2pub_type
杂志文章abstract：:PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20924
更新日期：2016-02-12 00:00:00
abstract：:Acute leukemia (AL) patients undergoing intensive induction chemotherapy develop severe gut dysbiosis, placing them at heightened risk for infectious complications. Some AL patients will undergo "repeat therapy" (re-induction or salvage) due to persistent or relapsed disease. We hypothesized that prior injury to the m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42652-6
更新日期：2019-04-15 00:00:00
abstract：:Here we construct mechanically flexible and optically transparent thin film solid state supercapacitors by assembling nano-engineered carbon electrodes, prepared in porous templates, with morphology of interconnected arrays of complex shapes and porosity. The highly textured graphitic films act as electrode and curren...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00773
更新日期：2012-01-01 00:00:00
abstract：:Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09795-w
更新日期：2017-08-24 00:00:00
abstract：:Hydrogels are being extensively used for three-dimensional immobilization and culture of cells in fundamental biological studies, biochemical processes, and clinical treatments. However, it is still a challenge to support viability and regulate phenotypic activities of cells in a structurally stable gel, because the g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08948
更新日期：2015-03-10 00:00:00
abstract：:Sharp increase in macromolecular crowding induces abnormal chromatin compaction in the cell nucleus, suggesting its non-negligible impact on chromatin structure and function. However, the details of the crowding-induced chromatin compaction remain poorly understood. In this work, we present a computer simulation study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23753-0
更新日期：2018-04-03 00:00:00
abstract：:That the human brain contains magnetite is well established; however, its spatial distribution in the brain has remained unknown. We present room temperature, remanent magnetization measurements on 822 specimens from seven dissected whole human brains in order to systematically map concentrations of magnetic remanence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29766-z
更新日期：2018-07-27 00:00:00
abstract：:Present study, for the first time, reports the development of a nanohybridized baculovirus based stent that can locally promote vascular re-endothelialization by efficient delivery of pro-angiogenic vascular endothelial growth factor (Vegf) genes. In vitro data demonstrated rapid expression of functionally active Vegf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02366
更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38498-7
更新日期：2019-03-12 00:00:00
abstract：:Hepatic stellate cells (HSCs) known as "master producers" and macrophages as "master regulators", are the key cell types that strongly contribute to the progression of liver fibrosis. Since Notch signaling regulates multiple cellular processes, we aimed to study the role of Notch signaling in HSCs differentiation and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18272
更新日期：2015-12-14 00:00:00
abstract：:Understanding cell-bubble interactions is crucial for preventing bubble related pathologies and harnessing their potential therapeutic benefits. Bubbles can occur in the body as a result of therapeutic intravenous administration, surgery, infections or decompression. Subsequent interactions with living cells, may resu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06678-y
更新日期：2017-07-24 00:00:00
abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09797-8
更新日期：2017-08-25 00:00:00
abstract：:Wind speed and variability are the most critical climatic factors affecting sand/dust storms, which have not been sufficiently studied in the middle reaches of the Yarlung Tsangpo River (MYR). In this study, wind speed variability was investigated using the moving average over shifting horizon method (MASH), combined ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69392-2
更新日期：2020-07-29 00:00:00
abstract：:The complex architecture of the cortical part of the bovine-femur was examined to develop potential tissue engineering (TE) scaffolds. Weight-change and X-ray diffraction (XRD) results show that significant phase transformation and morphology conversion of the bone occur at 500-750°C and 750-900°C, respectively. Anoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05843
更新日期：2014-07-28 00:00:00
abstract：:Animals thriving in hot deserts rely on extraordinary adaptations and thermoregulatory capacities to cope with heat. Uncovering such adaptations, and how they may be favoured by selection, is essential for predicting climate change impacts. Recently, the arid-adapted zebra finch was discovered to program their offspri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75909-6
更新日期：2020-11-03 00:00:00
abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77753-0
更新日期：2020-11-26 00:00:00
abstract：:The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral bl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66887-w
更新日期：2020-06-22 00:00:00
abstract：:High mobility channel thin-film-transistor (TFT) is crucial for both display and future generation integrated circuit. We report a new metal-oxide TFT that has an ultra-thin 4.5 nm SnO2 thickness for both active channel and source-drain regions, very high 147 cm(2)/Vs field-effect mobility, high ION/IOFF of 2.3 × 10(7...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19023
更新日期：2016-01-08 00:00:00
abstract：:Pre-clinical monitoring of tumor growth and identification of distal metastasis requires a balance between accuracy and expediency. Bioluminescence imaging (BLI) is often used to track tumor growth but is primarily limited to planar 2-dimensional (2D) imaging. Consistent subject placement within a standard top-mounted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21668-4
更新日期：2018-02-20 00:00:00
abstract：:We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67516-2
更新日期：2020-06-29 00:00:00
abstract：:The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75104-7
更新日期：2020-10-26 00:00:00
abstract：:Fine-motor impairment (FMI) is progressively expressed in early Parkinson's Disease (PD) patients and is now known to be evident in the immediate prodromal stage of the condition. The clinical techniques for detecting FMI may not be robust enough and here, we show that the subtle FMI of early PD patients can be effect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69369-1
更新日期：2020-07-28 00:00:00
abstract：:Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly decrease adenoviral tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00376-5
更新日期：2017-03-24 00:00:00
abstract：:The ongoing global intensification of wheat production will likely be accompanied by a rising pressure of Fusarium diseases. While utmost attention was given to Fusarium head blight (FHB) belowground plant infections of the pathogen have largely been ignored. The current knowledge about the impact of soil borne Fusari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31544-w
更新日期：2018-09-03 00:00:00
abstract：:CHF5633 is a novel synthetic clinical pulmonary surfactant preparation composed by two phospholipid species, dipalmitoyl phosphatidylcholine (DPPC) and palmitoyloleoyl phosphatidylglycerol (POPG), and synthetic analogues of the hydrophobic surfactant proteins SP-B and SP-C. In this study, the interfacial properties of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58248-4
更新日期：2020-01-28 00:00:00
abstract：:Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39872-1
更新日期：2019-03-07 00:00:00
abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72401-z
更新日期：2020-09-30 00:00:00
abstract：:Halobacteria, a class of Euryarchaeota are extremely halophilic archaea that can adapt to a wide range of salt concentration generally from 10% NaCl to saturated salt concentration of 32% NaCl. It consists of the orders: Halobacteriales, Haloferaciales and Natriabales. Pan-genome analysis of class Halobacteria was don...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77723-6
更新日期：2020-12-03 00:00:00
abstract：:Ergothioneine (ERG), a unique thiol compound, is suggested to function as an antioxidant and cytoprotectant. Despite several recent attempts to produce ERG using various organisms, its yield was still very low and the costs remained high. Since the level of ERG produced depends strictly on the availability of three di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38382-w
更新日期：2019-02-13 00:00:00
abstract：:Sand temperatures at nest depths and implications for hatchling sex ratios of hawksbill turtles (Eretmochelys imbricata) and green turtles (Chelonia mydas) nesting in the Chagos Archipelago, Indian Ocean are reported and compared to similar measurements at rookeries in the Atlantic and Caribbean. During 2012-2014, tem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20339
更新日期：2016-02-02 00:00:00
