Abstract：
:The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral blood vessels has been controversial. While recent work has shown clear evidence of directional flow of CSF in the PVS in anesthetized mice, the driving force for the observed fluid flow remains elusive. The heartbeat-driven peristaltic pulsation of arteries has been proposed as a probable driver of directed CSF flow. In this study, we use rigorous fluid dynamic simulations to provide a physical interpretation for peristaltic pumping of fluids. Our simulations match the experimental results and show that arterial pulsations only drive oscillatory motion of CSF in the PVS. The observed directional CSF flow can be explained by naturally occurring and/or experimenter-generated pressure differences.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kedarasetti RT,Drew PJ,Costanzo Fdoi
10.1038/s41598-020-66887-wsubject
Has Abstractpub_date
2020-06-22 00:00:00pages
10102issue
1issn
2045-2322pii
10.1038/s41598-020-66887-wjournal_volume
10pub_type
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