Predicting protein-peptide interaction sites using distant protein complexes as structural templates.

abstract：:Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be indu...

journal_title：Scientific reports

authors： Mandel Y,Manivanh R,Dalal R,Huie P,Wang J,Brinton M,Palanker D

更新日期：2013-01-01 00:00:00

abstract：:Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...

journal_title：Scientific reports

authors： Nayak S,Sridhara A,Melo R,Richer L,Chee NH,Kim J,Linder V,Steinmiller D,Sia SK,Gomes-Solecki M

更新日期：2016-10-11 00:00:00

abstract：:This study presents analysis of four chimney samples in terms of glycerol dialkyl glycerol tetraether lipids (GDGTs), representing different growing stages of sulfide chimneys at the Deyin hydrothermal field, the southern mid-Atlantic ridge. The modified Bligh-Dyer method was used for lipid extraction and purification...

journal_title：Scientific reports

authors： Li H,Lü X,Tao C,Han T,Hu P,Zhang G,Yu Z,Dong C,Shao Z

更新日期：2018-05-23 00:00:00

abstract：:Recent studies have revealed the systematic altering of gene expression in human peripheral blood during the early stages of ischemic stroke, which suggests a new potential approach for the rapid diagnosis or prediction of stroke onset. Nevertheless, due to the difficulties of collecting human samples during proper di...

journal_title：Scientific reports

authors： Wang Y,Cai Y

更新日期：2016-07-13 00:00:00

abstract：:Due to their unique properties, Weyl semimetals (WSMs) are promising materials for the future electronics. Currently, the two types (I and II) of WSMs are discovered experimentally. These types of WSMs differ from each other in their topological properties. In this paper we showed that a coexistence of types I and II ...

journal_title：Scientific reports

authors： Alisultanov ZZ

更新日期：2018-09-12 00:00:00

abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...

journal_title：Scientific reports

authors： Andresen L,Tenson T,Hauryliuk V

更新日期：2016-11-07 00:00:00

abstract：:Nowadays Field Emission Gun-Scanning Electron Microscopes provide detailed crystallographic information with high spatial and angular resolutions, and allow direct observation of crystalline defects, such as dislocations, through an attractive technique called Electron Channeling Contrast Imaging (ECCI). Dislocations ...

journal_title：Scientific reports

authors： Kriaa H,Guitton A,Maloufi N

更新日期：2017-08-29 00:00:00

abstract：:Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis (Bt) are spore-forming members of the Bacillus cereus group. Spores of B. cereus group species are encircled by exosporium, which is composed of an external hair-like nap and a paracrystalline basal layer. Despite the extensive studies on the structure of...

journal_title：Scientific reports

authors： Peng Q,Kao G,Qu N,Zhang J,Li J,Song F

更新日期：2016-01-25 00:00:00

abstract：:Flavonoids, due to their pharmacological attributes, have recently become target molecules for metabolic engineering in commonly consumed food crops. Strategies including expression of single genes and gene pyramiding have provided only limited success, due principally to the highly branched and complex biosynthetic p...

journal_title：Scientific reports

authors： Pandey A,Misra P,Bhambhani S,Bhatia C,Trivedi PK

更新日期：2014-05-21 00:00:00

abstract：:Direct growth of MoS2 nanowalls on vapor grown carbon nanofibers (VGCNFs) has been achieved using a microwave-assisted hydrothermal (MAH) method under an acidic condition. The acidic condition was obtained through the addition of an HCl aqueous solution. We demonstrate that the HCl not only modifies the pH value for l...

journal_title：Scientific reports

authors： Sari FNI,Ting JM

更新日期：2017-07-20 00:00:00

abstract：:Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...

journal_title：Scientific reports

authors： Condamine FL,Clapham ME,Kergoat GJ

更新日期：2016-01-18 00:00:00

abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

journal_title：Scientific reports

authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

更新日期：2017-11-02 00:00:00

abstract：:During our research, we explored a novel way to represent subwavelength imaging and derived a transmission equation to explicate the FP (Fabry-Pérot) resonance phenomena. Subsequently, using analysis and observation, we performed deep-subwavelength imaging. Both numerically and experimentally, imaging with super-resol...

journal_title：Scientific reports

authors： Anzan-Uz-Zaman M,Song K,Lee DG,Hur S

更新日期：2020-07-01 00:00:00

abstract：:The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...

journal_title：Scientific reports

authors： Yan J,Dong J,Wu J,Zhu R,Wang Z,Wang B,Wang L,Wang Z,Zhang H,Wu H,Yu B,Kong W,Yu X

更新日期：2016-03-03 00:00:00

abstract：:The purpose of this paper is to develop a lightweight apron that will be used for shielding low intensity radiation in medical imaging radiography room and to apply it to a custom-made effective shielding. The quality of existing aprons made for protecting our bodies from direct radiation are improved so that they are...

journal_title：Scientific reports

authors： Kim SC,Choi JR,Jeon BK

更新日期：2016-07-27 00:00:00

abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...

journal_title：Scientific reports

authors： Katayama N,Yamamori S,Fukaya M,Kobayashi S,Watanabe M,Takahashi M,Manabe T

更新日期：2017-08-11 00:00:00

abstract：:Charge density wave (CDW), the periodic modulation of the electronic charge density, will open a gap on the Fermi surface that commonly leads to decreased or vanishing conductivity. On the other hand superconductivity, a commonly believed competing order, features a Fermi surface gap that results in infinite conductiv...

journal_title：Scientific reports

authors： Zhu X,Ning W,Li L,Ling L,Zhang R,Zhang J,Wang K,Liu Y,Pi L,Ma Y,Du H,Tian M,Sun Y,Petrovic C,Zhang Y

更新日期：2016-06-02 00:00:00

abstract：:Identification of patients with early stage non-small cell lung cancer (NSCLC) with high risk of recurrence could help identify patients who would receive additional benefit from adjuvant therapy. In this work, we present a computational histomorphometric image classifier using nuclear orientation, texture, shape, and...

journal_title：Scientific reports

authors： Wang X,Janowczyk A,Zhou Y,Thawani R,Fu P,Schalper K,Velcheti V,Madabhushi A

更新日期：2017-10-19 00:00:00

abstract：:The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a role in lipid metabolism and inflammation, we investigated the e...

journal_title：Scientific reports

authors： Bae CR,Hino J,Hosoda H,Arai Y,Son C,Makino H,Tokudome T,Tomita T,Kimura T,Nojiri T,Hosoda K,Miyazato M,Kangawa K

更新日期：2017-08-29 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarker...

journal_title：Scientific reports

authors： Ando Y,Yamazaki M,Yamada H,Munetsuna E,Fujii R,Mizuno G,Ichino N,Osakabe K,Sugimoto K,Ishikawa H,Ohashi K,Teradaira R,Ohta Y,Hamajima N,Hashimoto S,Suzuki K

更新日期：2019-12-11 00:00:00

abstract：:An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occu...

journal_title：Scientific reports

authors： Katigbak A,Cencic R,Robert F,Sénécha P,Scuoppo C,Pelletier J

更新日期：2016-12-16 00:00:00

abstract：:The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

journal_title：Scientific reports

authors： Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

更新日期：2020-03-09 00:00:00

abstract：:Six selected weedy Amaranthus genotypes (three accessions from each species of A. viridis and A. spinosus) were evaluated in terms of nutrients, minerals, antioxidant constituents and antioxidant activity for the possibilities of weedy species as a vegetable cultivar in a randomized complete block design with three re...

journal_title：Scientific reports

authors： Sarker U,Oba S

更新日期：2019-12-31 00:00:00

abstract：:Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to overcome tyrosine kinase inhibitor (TKI) resistance in epithelial growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) cells in vivo and in vitro. However, little is known about the putative induction of no...

journal_title：Scientific reports

authors： Otahal A,Aydemir D,Tomasich E,Minichsdorfer C

更新日期：2020-01-22 00:00:00

abstract：:The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...

journal_title：Scientific reports

authors： Scheinpflug K,Wenzel M,Krylova O,Bandow JE,Dathe M,Strahl H

更新日期：2017-03-09 00:00:00

abstract：:Single-cell RNA-seq has been established as a reliable and accessible technique enabling new types of analyses, such as identifying cell types and studying spatial and temporal gene expression variation and change at single-cell resolution. Recently, single-cell RNA-seq has been applied to developing embryos, which of...

journal_title：Scientific reports

authors： Ilsley GR,Suyama R,Noda T,Satoh N,Luscombe NM

更新日期：2020-03-18 00:00:00

abstract：:Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclea...

journal_title：Scientific reports

authors： Sambandam Y,Baird KL,Stroebel M,Kowal E,Balasubramanian S,Reddy SV

更新日期：2016-05-04 00:00:00

abstract：:Cancer vaccines are less effective at old than at young age because of immunosenescence. Besides, in preliminary observations we showed that the immunization with HER-2/neu DNA plasmid in transgenic young mice (standard immunization, SI) delays but not abrogate spontaneous mammary tumours progressively appearing durin...

journal_title：Scientific reports

authors： Provinciali M,Barucca A,Orlando F,Pierpaoli E

更新日期：2017-06-08 00:00:00

abstract：:MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...

journal_title：Scientific reports

authors： Tscherner A,Brown AC,Stalker L,Kao J,Dufort I,Sirard MA,LaMarre J

更新日期：2018-08-01 00:00:00

abstract：:The brew temperature is widely considered a key parameter affecting the final quality of coffee, with a temperature near 93 °C often described as optimal. In particular, drip brewers that do not achieve a minimum brew temperature of 92 °C within a prescribed time period fail their certification. There is little empiri...

journal_title：Scientific reports

authors： Batali ME,Ristenpart WD,Guinard JX

更新日期：2020-10-05 00:00:00