Abstract：
:Flavonoids, due to their pharmacological attributes, have recently become target molecules for metabolic engineering in commonly consumed food crops. Strategies including expression of single genes and gene pyramiding have provided only limited success, due principally to the highly branched and complex biosynthetic pathway of the flavonoids. Transcription factors have been demonstrated as an efficient tool for metabolic engineering of this pathway, but often exhibit variation in heterologous systems relative to that in the homologous system. In the present work, Arabidopsis MYB transcription factor, AtMYB111, has been expressed in tobacco to study whether this can enhance flavonoid biosynthesis in heterologous system. The results suggest that AtMYB111 expression in transgenic tobacco enhances expression of genes of the phenylpropanoid pathway leading to an elevated content of flavonols. However, dark incubation of transgenic and wild type (WT) plants down-regulated both the expression of genes as well as flavonoid content as compared to light grown plants. The study concludes that AtMYB111 can be effectively used in heterologous systems, however, light is required for its action in modulating biosynthetic pathway.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pandey A,Misra P,Bhambhani S,Bhatia C,Trivedi PKdoi
10.1038/srep05018subject
Has Abstractpub_date
2014-05-21 00:00:00pages
5018issn
2045-2322pii
srep05018journal_volume
4pub_type
杂志文章abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07685
更新日期：2015-01-08 00:00:00
abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72062-y
更新日期：2020-09-16 00:00:00
abstract：:The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell sur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66554-0
更新日期：2020-06-15 00:00:00
abstract：:An important property of spin-torque nano-oscillators (STNOs) is their ability to produce a frequency modulated (FM) signal, which is very critical for communication applications. We here demonstrate a novel single sideband (SSB) modulation phenomenon using a magnetic tunnel junction (MTJ)-based STNO, which saves tran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13551-5
更新日期：2017-10-18 00:00:00
abstract：:Rice stripe virus-infected females of the small brown planthopper (SBPH, Laodelphax striatellus) usually lay fewer eggs with a longer hatch period, low hatchability, malformation and retarded or defective development compared with healthy females. To explore the molecular mechanism of those phenomena, we analyzed the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27216
更新日期：2016-06-09 00:00:00
abstract：:Although cooperation is central to the organisation of many social systems, relatively little is known about cooperation in situations of collective emergency. When groups of people flee from a danger such as a burning building or a terrorist attack, the collective benefit of cooperation is important, but the cost of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33417
更新日期：2016-09-15 00:00:00
abstract：:We investigated high-efficiency two-terminal tandem photovoltaic (PV) devices consisting of a p/i/n thin film silicon top sub-cell (p/i/n-TFS) and a heterojunction with an intrinsic thin-layer (HIT) bottom sub-cell. We used computer simulations and experimentation. The short-circuit current density (Jsc) of the top su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33734-y
更新日期：2018-10-18 00:00:00
abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26770-1
更新日期：2018-06-07 00:00:00
abstract：:LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-017-15712-y
更新日期：2017-11-10 00:00:00
abstract：:Coleoid cephalopods have an elaborate camera eye whereas nautiloids have primitive pinhole eye without lens and cornea. The Nautilus pinhole eye provides a unique example to explore the module of lens formation and its evolutionary mechanism. Here, we conducted an RNA-seq study of developing eyes of Nautilus and pygmy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01432
更新日期：2013-01-01 00:00:00
abstract：:Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since obesity leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation leads to early-onset o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24168
更新日期：2016-04-18 00:00:00
abstract：:To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant Hp antigens by ELISA and immunoblotting in 139...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07801-9
更新日期：2017-08-11 00:00:00
abstract：:Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19765-5
更新日期：2018-01-24 00:00:00
abstract：:Dental caries is an important public health problem worldwide. This study aims to prove how preventive therapies reduce the onset of caries in adult patients, and to identify patients with high or low risk of caries by using Classification and Regression Trees based survival analysis (survival CART). A clinical data s...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/srep29190
更新日期：2016-07-06 00:00:00
abstract：:Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25258
更新日期：2016-04-29 00:00:00
abstract：:The Lesotho guidelines for the management of drug-resistant tuberculosis (TB) recommend initiation of patients diagnosed with rifampicin resistant (RR)-TB on a standardized drug resistant regimen while awaiting confirmation of rifampicin resistant TB (RR-TB) and complete drug susceptibility test results. Review of dia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58690-4
更新日期：2020-02-05 00:00:00
abstract：:The cumulative effects of hepatic injury due to hepatitis B virus (HBV) infections and aflatoxin-B1 (AFB1) exposure are the major risk factors of HCC. Understanding early metabolic changes involving these risk factors in an animal model closely resembling human hepatocellular carcinoma (HCC) is critical for biomarker ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20299
更新日期：2016-02-02 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep46667. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46924
更新日期：2017-12-22 00:00:00
abstract：:Accumulated evidence suggests that activated pancreatic stellate cells (PSCs) serve as the main source of the extracellular matrix proteins accumulated under the pathological conditions leading to pancreatic fibrosis in chronic pancreatitis (CP). However, little is known about the mechanisms of PSC activation. PSCs ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76095-1
更新日期：2020-11-05 00:00:00
abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42360-1
更新日期：2019-04-17 00:00:00
abstract：:Male moths use species-specific sex pheromones to identify and orientate toward conspecific females. Odorant receptors (ORs) for sex pheromone substances have been identified as sex pheromone receptors in various moth species. However, direct in vivo evidence linking the functional role of these ORs with behavioural r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11001
更新日期：2015-06-05 00:00:00
abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51654-3
更新日期：2019-10-22 00:00:00
abstract：:The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance. Phthalates are commonly used in industrial applications. Widespread exposure to phthalates has been evidenced by their presence in human...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79932-5
更新日期：2021-01-18 00:00:00
abstract：:Nano-flowers reported so far were mostly constituted of inorganic or hybrid materials. We have synthesized and crystallized a new organic compound, 1, 2-bis(tritylthio)ethane forming an organic nano-flower consisting of single crystalline petals. Crystal structure at nano and micro level indicates that π-π stacking in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17538-0
更新日期：2017-12-11 00:00:00
abstract：:Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48028-0
更新日期：2019-08-12 00:00:00
abstract：:Digital phase shifters have been applied in traditional phased array antennas to realize beam steering. However, the phase shifter deals with the phase of the induced current; hence, it has to be in the path of each element of the antenna array, making the phased array antennas very expensive. Metamaterials and/or met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20663
更新日期：2016-02-10 00:00:00
abstract：:The synthesis of ordered monolayers of gold nano-urchin (Au-NU) nanostructures with controlled size, directly on thin films using a simple electrochemical method is reported in this study. In order to demonstrate one of the vast potential applications, the developed Au-NUs were formed on the electrodes of transducers ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24625
更新日期：2016-04-19 00:00:00
abstract：:Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the results of 53 studies, we examined temporal and spatial variation in C: N ratios and in N-C scaling relationships of both the organic and the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19117
更新日期：2016-01-08 00:00:00
abstract：:Beaver have been referred to as ecosystem engineers because of the large impacts their dam building activities have on the landscape; however, the benefits they may provide to fluvial fish species has been debated. We conducted a watershed-scale experiment to test how increasing beaver dam and colony persistence in a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28581
更新日期：2016-07-04 00:00:00
abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42480
更新日期：2017-02-16 00:00:00
