Abstract:
:Male moths use species-specific sex pheromones to identify and orientate toward conspecific females. Odorant receptors (ORs) for sex pheromone substances have been identified as sex pheromone receptors in various moth species. However, direct in vivo evidence linking the functional role of these ORs with behavioural responses is lacking. In the silkmoth, Bombyx mori, female moths emit two sex pheromone components, bombykol and bombykal, but only bombykol elicits sexual behaviour in male moths. A sex pheromone receptor BmOR1 is specifically tuned to bombykol and is expressed in specialized olfactory receptor neurons (ORNs) in the pheromone sensitive long sensilla trichodea of male silkmoth antennae. Here, we show that disruption of the BmOR1 gene, mediated by transcription activator-like effector nucleases (TALENs), completely removes ORN sensitivity to bombykol and corresponding pheromone-source searching behaviour in male moths. Furthermore, transgenic rescue of BmOR1 restored normal behavioural responses to bombykol. Our results demonstrate that BmOR1 is required for the physiological and behavioural response to bombykol, demonstrating that it is the receptor that mediates sex pheromone responses in male silkmoths. This study provides the first direct evidence that a member of the sex pheromone receptor family in moth species mediates conspecific sex pheromone information for sexual behaviour.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sakurai T,Mitsuno H,Mikami A,Uchino K,Tabuchi M,Zhang F,Sezutsu H,Kanzaki Rdoi
10.1038/srep11001subject
Has Abstractpub_date
2015-06-05 00:00:00pages
11001issn
2045-2322pii
srep11001journal_volume
5pub_type
杂志文章abstract::We evaluated the best methods for predicting various infarct core thresholds for endovascular treatment of ischemic stroke using parameters obtained by multiphase computed tomographic angiography (mCTA). Consecutive patients evaluated for endovascular treatment who concomitantly underwent mCTA and stroke magnetic reso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51708-6
更新日期:2019-10-23 00:00:00
abstract::Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02579
更新日期:2013-01-01 00:00:00
abstract::Inter-digital capacitors (IDCs) with aerosol-deposition (AD) high-k dielectric layer were compared via simulation and measurements of bare IDCs and AD IDCs at room temperature and subjected to a post-annealing process for realizing capacitive super-sensing applications. IDCs with thin AD films can provide higher capac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37416-7
更新日期:2019-01-24 00:00:00
abstract::Under specific reaction conditions, levansucrase from Bacillus subtilis (SacB) catalyzes the synthesis of a low molecular weight levan through the non-processive elongation of a great number of intermediates. To deepen understanding of the polymer elongation mechanism, we conducted a meticulous examination of the fruc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32872-7
更新日期:2018-10-09 00:00:00
abstract::Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-dependent cellular c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46347
更新日期:2017-04-11 00:00:00
abstract::Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15660
更新日期:2015-10-22 00:00:00
abstract::Thirty-nine UK adapted wheat cultivars dating from between 1790 and 2012 were grown in replicated randomised field trials for three years, milled, and white flour analysed for the contents of dietary fibre components (arabinoxylan and β-glucan) and polar metabolites (sugars, amino acids, organic acids, choline and bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62777-3
更新日期:2020-04-03 00:00:00
abstract::Mechanosensitive ion channels are pore-forming transmembrane proteins that allow ions to move down their electrochemical gradient in response to mechanical stimuli. They participate in many plant developmental processes including the maintenance of plastid shape, pollen tube growth, etc. Herein, a total of 11, 10, 6, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73627-7
更新日期:2020-10-06 00:00:00
abstract::Cold environments dominate the Earth's biosphere and the resident microorganisms play critical roles in fulfilling global biogeochemical cycles. However, only few studies have examined the molecular basis of thermosensing; an ability that microorganisms must possess in order to respond to environmental temperature and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24278
更新日期:2016-04-07 00:00:00
abstract::Uncertainty in the form of risk or ambiguity can arise from the interaction with nature and other players, while strategic uncertainty arises only in interactions with others. Here, we systematically compare binary decisions between a safe option and a potentially higher paying but uncertain option in four experimenta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21962-1
更新日期:2018-02-23 00:00:00
abstract::Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50711-1
更新日期:2019-10-04 00:00:00
abstract::Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45504-5
更新日期:2019-06-24 00:00:00
abstract::Successful communication is critical to the fitness of individuals and maintenance of populations, but less is known regarding the social contexts and reactions to scent marking by other individuals in solitary carnivores, including pumas. We evaluated the responses of resident male pumas to visitation and scent marki...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27257
更新日期:2016-06-02 00:00:00
abstract::Light chain (AL) amyloidosis, caused by deposition of amyloidogenic immunoglobulin light chains (LCs), is the most common systemic form in industrialized countries. Still open questions, and premises for developing targeted therapies, concern the mechanisms of amyloid formation in vivo and the bases of organ targeting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29096
更新日期:2016-07-04 00:00:00
abstract::Predicting the occurrence of ventricular tachyarrhythmia (VTA) in advance is a matter of utmost importance for saving the lives of cardiac arrhythmia patients. Machine learning algorithms have been used to predict the occurrence of imminent VTA. In this study, we used a one-dimensional convolutional neural network (1-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63566-8
更新日期:2020-04-21 00:00:00
abstract::Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70598-7
更新日期:2020-08-12 00:00:00
abstract::Natal habitat preference induction (NHPI) occurs when characteristics of the natal habitat influence the future habitat selection of an animal. However, the influence of NHPI after the dispersal phase has received remarkably little attention. We tested whether exposure to humans in the natal habitat helps understand w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42835-1
更新日期:2019-04-25 00:00:00
abstract::Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are important facilitators of intercellular communication by transporting contents, such as protein, mRNA, and microRNAs, between neighboring cells, such as in the tumor microenvironment. The purpose of this study was to understand the mechani...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30110
更新日期:2016-07-22 00:00:00
abstract::Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26754-1
更新日期:2018-06-04 00:00:00
abstract::It is rigorously proved that ideal memcapacitors and meminductors are not passive or cyclo-passive devices. Equivalently, this implies that there exist excitation profiles that allow to extract more energy from the device than it is supplied with; so that their energy conversion efficiency exceeds 100%. This means tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73833-3
更新日期:2020-10-07 00:00:00
abstract::Constrained layer dampers (CLD) are in widespread use for passive vibration damping, in applications including aerospace structures. However, the introducing of the damping layer can reduce the stiffness of the sandwich structures. A viscoelastic material filling (VMF) is chosen to balance structural and vibrational p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27963-4
更新日期:2018-06-25 00:00:00
abstract::To characterize the molecular mechanisms underlying life-stage transitions in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhibitor of morphological development from microbial culture extracts prepared mostly from actinomycetes from soil in Japan. Of the more tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79326-7
更新日期:2020-12-18 00:00:00
abstract::Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37051-2
更新日期:2019-01-24 00:00:00
abstract::Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic dr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03195-w
更新日期:2017-06-23 00:00:00
abstract::The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67965-9
更新日期:2020-07-06 00:00:00
abstract::Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42859-7
更新日期:2019-04-23 00:00:00
abstract::Muscle damage and loss of muscle mass are triggered by immobilization, loss of appetite, dystrophies and chronic wasting diseases. In addition, physical exercise causes muscle damage. In damaged muscle, the N-terminal and C-terminal regions of titin, a giant sarcomere protein, are cleaved by calpain-3, and the resulti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39375
更新日期:2016-12-19 00:00:00
abstract::Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57496-8
更新日期:2020-01-20 00:00:00
abstract::Cenozoic climate cooling at the advent of the Eocene-Oligocene transition (EOT), ~33.7 Ma ago, was stamped in the ocean by a series of climatic events albeit the impact of this global climatic transition on terrestrial environments is still fragmentary. Yet archival constraints on Late Eocene atmospheric circulation a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07766-9
更新日期:2017-08-10 00:00:00
abstract::This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive funct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49054-8
更新日期:2019-08-29 00:00:00