Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis.

abstract：:The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the discovery of novel P2X receptor agonists, here we demonstrate the use of D...

journal_title：Scientific reports

authors： Grimes L,Griffiths J,Pasqualetto G,Brancale A,Kemp PJ,Young MT,van der Goes van Naters W

更新日期：2020-05-19 00:00:00

abstract：:Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...

journal_title：Scientific reports

authors： Billingsley KJ,Lättekivi F,Planken A,Reimann E,Kurvits L,Kadastik-Eerme L,Kasterpalu KM,Bubb VJ,Quinn JP,Kõks S,Taba P

更新日期：2019-03-13 00:00:00

abstract：:This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of five NLR family genes (NOD1, NOD2, NLRP1, NLRP3 and CIITA) are associated with Behcet's disease (BD) in a Chinese Han population. The study was carried out in 950 BD patients and 1440 controls for 19 SNPs in the selected NLR genes. In th...

journal_title：Scientific reports

authors： Li L,Yu H,Jiang Y,Deng B,Bai L,Kijlstra A,Yang P

更新日期：2016-02-01 00:00:00

abstract：:Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack of information, herein, we used next-generation sequencing methods for genome sequencing of two marine fungi,...

journal_title：Scientific reports

authors： Kumar A,Sørensen JL,Hansen FT,Arvas M,Syed MF,Hassan L,Benz JP,Record E,Henrissat B,Pöggeler S,Kempken F

更新日期：2018-07-05 00:00:00

abstract：:Knowing when, where, and how seizures are initiated in large-scale epileptic brain networks remains a widely unsolved problem. Seizure precursors - changes in brain dynamics predictive of an impending seizure - can now be identified well ahead of clinical manifestations, but either the seizure onset zone or remote bra...

journal_title：Scientific reports

authors： Rings T,von Wrede R,Lehnertz K

更新日期：2019-07-23 00:00:00

abstract：:Bone regeneration, following fracture, relies on autologous and allogenic bone grafts. However, majority of fracture population consists of older individuals with poor quality bone associated with loss and/or modification of matrix proteins critical for bone formation and mineralization. Allografts suffer from same li...

journal_title：Scientific reports

authors： Carvalho MS,Poundarik AA,Cabral JMS,da Silva CL,Vashishth D

更新日期：2018-09-26 00:00:00

abstract：:Experiments on the Ultimatum Game (UG) repeatedly show that people's behaviour is far from rational. In UG experiments, a subject proposes how to divide a pot and the other can accept or reject the proposal, in which case both lose everything. While rational people would offer and accept the minimum possible amount, i...

journal_title：Scientific reports

authors： Han X,Cao S,Bao JZ,Wang WX,Zhang B,Gao ZY,Sánchez A

更新日期：2018-01-19 00:00:00

abstract：:Histone methylation is thought to control the regulation of genetic program and the dysregulation of it has been found to be closely associated with cancer. JMJD3 has been identified as an H3K27 demethylase and its role in cancer development is context specific. The role of JMJD3 in gastric cancer (GC) has not been ex...

journal_title：Scientific reports

authors： Xu Z,Xia Y,Xiao Z,Jia Y,Li L,Jin Y,Zhao Q,Wan L,Yi T,Yu Y,Wen Q,Zhu Y,Qin B,Zhang F,Shen J

更新日期：2019-01-29 00:00:00

abstract：:We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (...

journal_title：Scientific reports

authors： Wang HW,Peng CY,Lai HC,Su WP,Lin CH,Chuang PH,Chen SH,Chen CH,Hsu WF,Huang GT

更新日期：2017-06-12 00:00:00

abstract：:Anxiety-related bias in the recognition memory based on trait anxiety has induced some studies. Their results, however, were conflicting. In fact, anxious differences not only differed from personality traits but also from different anxiety mood levels. We explored the emotional memory bias in both trait and state anx...

journal_title：Scientific reports

authors： Yu Q,Zhuang Q,Wang B,Liu X,Zhao G,Zhang M

更新日期：2018-11-01 00:00:00

abstract：:An isolated black yeast-like strain was obtained from radiation-polluted soil collected from Xinjiang province in northwest China. On the basis of ITS and LSU rDNA sequence analysis, in combination with the colony morphology and phenotypic properties, the isolated strain was revealed to represent a novel variety of Au...

journal_title：Scientific reports

authors： Liu T,Zhu L,Zhang Z,Huang H,Zhang Z,Jiang L

更新日期：2017-12-14 00:00:00

abstract：:Diabetic Retinopathy, the main cause of visual loss and blindness among working population, is a complication of Diabetes mellitus (DM), which has been described as a major public health challenge, so it is important to identify biomarkers to predict and to stratify patient´s possibility for developing DR. MicroRNAs (...

journal_title：Scientific reports

authors： Prado MSG,de Goes TC,de Jesus ML,Mendonça LSO,Nascimento JS,Kaneto CM

更新日期：2019-12-23 00:00:00

abstract：:We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss in diabetic mice. Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age. Non-dia...

journal_title：Scientific reports

authors： Ghosh A,Zhao S,Lo CS,Maachi H,Chenier I,Lateef MA,Abdo S,Filep JG,Ingelfinger JR,Zhang SL,Chan JSD

更新日期：2019-04-30 00:00:00

abstract：:The quantum Internet enables networking based on the fundamentals of quantum mechanics. Here, methods and procedures of resource prioritization and resource balancing are defined for the quantum Internet. We define a model for resource consumption optimization in quantum repeaters, and a strongly-entangled network str...

journal_title：Scientific reports

authors： Gyongyosi L,Imre S

更新日期：2020-12-28 00:00:00

abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...

journal_title：Scientific reports

authors： Luo Y,Qu T,Cui Y,Pan Y,Yu M,Luo H,Jia Y,Tan Z,Liu J,Zhang B

更新日期：2019-07-01 00:00:00

abstract：:The exploitation of surface plasmon polaritons has been mostly limited to the visible and near infrared range, due to the low frequency limit for coherent plasmon excitation and the reduction of confinement on the metal surface for lower energies. In this work we show that 3D--out of plane--nanostructures can consider...

journal_title：Scientific reports

authors： Malerba M,Alabastri A,Miele E,Zilio P,Patrini M,Bajoni D,Messina GC,Dipalo M,Toma A,Proietti Zaccaria R,De Angelis F

更新日期：2015-11-10 00:00:00

abstract：:To meet the demand for detection of foreign genes in genetically modified (GM) sugarcane necessary for regulation of gene technology, an efficient method with high specificity and rapidity was developed for the cry1Ac gene, based on loop-mediated isothermal amplification (LAMP). A set of four primers was designed usin...

journal_title：Scientific reports

authors： Zhou D,Guo J,Xu L,Gao S,Lin Q,Wu Q,Wu L,Que Y

更新日期：2014-05-09 00:00:00

abstract：:In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...

journal_title：Scientific reports

authors： Agoston-Coldea L,Lupu S,Mocan T

更新日期：2018-09-27 00:00:00

abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...

journal_title：Scientific reports

authors： Zheng D,Ye S,Wang X,Zhang Y,Yan D,Cai X,Gao W,Shan H,Gao Y,Chen J,Hu Z,Li H,Li J

更新日期：2017-06-06 00:00:00

abstract：:Previous results regarding the associations between esophageal squamous-cell carcinoma (ESCC) risk and smoking/alcohol drinking in high-risk areas are inconsistent. We performed a large population-based case-control study from 2010 to 2013 in a high-incidence area of China, and enrolled 1353 ESCC cases and 1961 contro...

journal_title：Scientific reports

authors： Yang X,Chen X,Zhuang M,Yuan Z,Nie S,Lu M,Jin L,Ye W

更新日期：2017-12-08 00:00:00

abstract：:The Mongol invasion of Eastern Europe, and especially its sudden withdrawal from Hungary in 1242 CE, has generated much speculation and an array of controversial theories. None of them, however, considered multifaceted environmental drivers and the coupled analysis of historical reports and natural archives. Here we i...

journal_title：Scientific reports

authors： Büntgen U,Di Cosmo N

更新日期：2016-05-26 00:00:00

abstract：:Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and ...

journal_title：Scientific reports

authors： Uchida G,Hirooka Y,Nakamura M,Watanabe O,Yamamura T,Matsushita M,Suhara H,Ishikawa T,Furukawa K,Funasaka K,Ohno E,Kawashima H,Miyahara R,Goto H

更新日期：2018-04-23 00:00:00

abstract：:Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution pat...

journal_title：Scientific reports

authors： Cunha RL,Assis JM,Madeira C,Seabra R,Lima FP,Lopes EP,Williams ST,Castilho R

更新日期：2017-02-02 00:00:00

abstract：:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood test...

journal_title：Scientific reports

authors： Yokota T,Kinugawa S,Hirabayashi K,Yamato M,Takada S,Suga T,Nakano I,Fukushima A,Matsushima S,Okita K,Tsutsui H

更新日期：2021-01-26 00:00:00

abstract：:Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in the fifth exon of pigs. As a reproductive performance-related gene, GSTM2 is involved in embryo implantation, whereas, functional deficiency ...

journal_title：Scientific reports

authors： Lv Y,Jin Y,Zhou Y,Jin J,Ma Z,Ren Z

更新日期：2016-12-01 00:00:00

abstract：:Stony corals form the foundation of coral reef ecosystems. Their phylogeny is characterized by a deep evolutionary divergence that separates corals into a robust and complex clade dating back to at least 245 mya. However, the genomic consequences and clade-specific evolution remain unexplored. In this study we have pr...

journal_title：Scientific reports

authors： Voolstra CR,Li Y,Liew YJ,Baumgarten S,Zoccola D,Flot JF,Tambutté S,Allemand D,Aranda M

更新日期：2017-12-14 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system. However, the mechanisms underlying its tumor initiation, progression, and metastasis are not yet fully understood. The annexin A4 (ANXA4) gene is highly expressed in GBC tissues and may play an important role in the initiation and progr...

journal_title：Scientific reports

authors： Yao HS,Sun C,Li XX,Wang Y,Jin KZ,Zhang XP,Hu ZQ

更新日期：2016-08-05 00:00:00

abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

journal_title：Scientific reports

authors： Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

更新日期：2019-10-16 00:00:00

abstract：:Although acute psychosocial stress can impact autobiographical memory retrieval, the nature of this effect is not entirely clear. One reason for this ambiguity is because stress can have opposing effects on the different stages of autobiographical memory retrieval. We addressed this issue by testing how acute stress a...

journal_title：Scientific reports

authors： Sheldon S,Chu S,Nitschke JP,Pruessner JC,Bartz JA

更新日期：2018-06-06 00:00:00

abstract：:Investigation of quantum spin Hall states in 1T' phase of the monolayer transition metal dichalcogenides has recently attracted the attention for its potential in nanoelectronic applications. While most of the theoretical findings in this regard deal with infinitely periodic crystal structures, here we employ density ...

journal_title：Scientific reports

authors： Das B,Sen D,Mahapatra S

更新日期：2020-04-21 00:00:00