Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia.

abstract：:A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA...

journal_title：Scientific reports

authors： Wilks TR,O'Reilly RK

更新日期：2016-12-16 00:00:00

abstract：:The Plasmodium life cycle within the mosquito involves the gamete, zygote, motile ookinete, and the oocyst stage that supports sporogony and sporozoite formation. We mapped the P. falciparum transcriptome as the parasite progresses through the oocyst stage of development on days 2, 4, 6, and 8 post-P. falciparum infec...

journal_title：Scientific reports

authors： Oakley MS,Verma N,Myers TG,Zheng H,Locke E,Morin MJ,Tripathi AK,Mlambo G,Kumar S

更新日期：2018-08-01 00:00:00

abstract：:High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...

journal_title：Scientific reports

authors： Roehling JD,Baran D,Sit J,Kassar T,Ameri T,Unruh T,Brabec CJ,Moulé AJ

更新日期：2016-08-08 00:00:00

abstract：:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine en...

journal_title：Scientific reports

authors： Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosens

更新日期：2017-10-03 00:00:00

abstract：:Acute kidney disease (AKD), or renal dysfunction persisting >7 days after an initiating event of acute kidney injury, is a rising concern. This study aimed to elucidate the clinical course of AKD after cardiac surgery with data on post-cardiac surgery patients admitted to intensive care units (ICU) at 18 Japanese hosp...

journal_title：Scientific reports

authors： Matsuura R,Iwagami M,Moriya H,Ohtake T,Hamasaki Y,Nangaku M,Doi K,Kobayashi S,Noiri E

更新日期：2020-04-16 00:00:00

abstract：:Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+)  T cells that are activated by MHC I-mediated presen...

journal_title：Scientific reports

authors： Keller IE,Vosyka O,Takenaka S,Kloß A,Dahlmann B,Willems LI,Verdoes M,Overkleeft HS,Marcos E,Adnot S,Hauck SM,Ruppert C,Günther A,Herold S,Ohno S,Adler H,Eickelberg O,Meiners S

更新日期：2015-05-19 00:00:00

abstract：:Urothelial cells play essential roles in protection of urine exudation and bacterial invasion at the urothelial mucosa, so that defect or damage of urothelial cells associated with urinary tract diseases may cause serious problems. If a sufficient number of functional urothelial cells are prepared in culture and trans...

journal_title：Scientific reports

authors： Inoue Y,Kishida T,Kotani SI,Akiyoshi M,Taga H,Seki M,Ukimura O,Mazda O

更新日期：2019-09-25 00:00:00

abstract：:We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze a total of 1238 facial and masseteric nerve biopsies. The technique was validated by comparing manual and semi-automated quantification ...

journal_title：Scientific reports

authors： Engelmann S,Ruewe M,Geis S,Taeger CD,Kehrer M,Tamm ER,Bleys RLAW,Zeman F,Prantl L,Kehrer A

更新日期：2020-02-06 00:00:00

abstract：:While researches have focused on drag reduction of various coated surfaces such as superhydrophobic structures and polymer brushes, the insights tso understand the fundamental physics of the laminar skin friction coefficient and the related drag reduction due to the formation of finite velocity at porous surfaces is s...

journal_title：Scientific reports

authors： Mirbod P,Wu Z,Ahmadi G

更新日期：2017-12-08 00:00:00

abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...

journal_title：Scientific reports

authors： Arima M,Tsukamoto S,Fujiwara K,Murayama M,Fujikawa K,Sonoda KH

更新日期：2017-06-20 00:00:00

abstract：:Exosomes contain cell-specific collections of bioactive materials including proteins, lipids, and RNAs that are transported to recipient cells to exert their impacts. MicroRNAs (miRNAs) can function as tumor suppressor or oncogenic genes and miR-21 is one of the most frequently up-regulated miRNAs in solid tumors incl...

journal_title：Scientific reports

authors： Sun LH,Tian D,Yang ZC,Li JL

更新日期：2020-05-19 00:00:00

abstract：:Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO2 satellite measurements from the Ozone Monitoring Instrument (OMI) and groun...

journal_title：Scientific reports

authors： Jia Y,Yu G,Gao Y,He N,Wang Q,Jiao C,Zuo Y

更新日期：2016-01-27 00:00:00

abstract：:Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-re...

journal_title：Scientific reports

authors： Lochab V,Jones TH,Dusane DH,Peters CW,Stoodley P,Wozniak DJ,Subramaniam VV,Prakash S

更新日期：2020-06-18 00:00:00

abstract：:Despite phages' ubiquitous presence and great importance in shaping microbial communities, little is known about the diversity of specific phages in different ecological niches. Here, we isolated, sequenced, and characterized 38 Escherichia coli-infecting phages (coliphages) from poultry faeces to gain a better unders...

journal_title：Scientific reports

authors： Sørensen PE,Van Den Broeck W,Kiil K,Jasinskyte D,Moodley A,Garmyn A,Ingmer H,Butaye P

更新日期：2020-09-16 00:00:00

abstract：:In photosynthesis Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the often rate limiting CO2-fixation step in the Calvin cycle. This makes Rubisco both the gatekeeper for carbon entry into the biosphere and a target for functional improvement to enhance photosynthesis and plant growth. Encumbering...

journal_title：Scientific reports

authors： Wilson RH,Alonso H,Whitney SM

更新日期：2016-03-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Golkar A,Olsson A

更新日期：2018-07-18 00:00:00

abstract：:Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye has been characterized, the more recently described pathways of NO generation by nitrate (NO3-) and nitrite (NO2-) ions reduction has rec...

journal_title：Scientific reports

authors： Park JW,Piknova B,Jenkins A,Hellinga D,Parver LM,Schechter AN

更新日期：2020-08-05 00:00:00

abstract：:Metformin is used to treat type 2 diabetes. Metformin activates AMP-activated kinase (AMPK), which may contribute to the action of metformin. Metformin also shows anti-proliferation activity. However, the mechanism is remained unknown. We found that treatment of MCF-7 cells with metformin induced the demethylase activ...

journal_title：Scientific reports

authors： Tanaka Y,Konishi A,Obinata H,Tsuneoka M

更新日期：2019-12-10 00:00:00

abstract：:It has been known that some traumatic macular holes can close spontaneously. However, knowledge about the types of macular hole that can close spontaneously is limited. In this retrospective study, we investigated patients with traumatic macular hole who were followed-up for at least 6 months without any surgical inte...

journal_title：Scientific reports

authors： Chen H,Chen W,Zheng K,Peng K,Xia H,Zhu L

更新日期：2015-07-21 00:00:00

abstract：:The mouse (Mus musculus) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g. CDKN1A, MDM2, BBC3, and CCNG1) or down-r...

journal_title：Scientific reports

authors： Ghandhi SA,Smilenov L,Shuryak I,Pujol-Canadell M,Amundson SA

更新日期：2019-12-19 00:00:00

abstract：:The connection between structure and stability of ecological networks has been widely studied in the last fifty years. A challenge that scientists continue to face is that in-depth mathematical model analysis is often difficult, unless the considered systems are specifically constrained. This makes it challenging to g...

journal_title：Scientific reports

authors： Fischer SM,Huth A

更新日期：2019-10-01 00:00:00

abstract：:We introduce a compact, fast large area multiphoton exoscope (FLAME) system with enhanced molecular contrast for macroscopic imaging of human skin with microscopic resolution. A versatile imaging platform, FLAME combines optical and mechanical scanning mechanisms with deep learning image restoration to produce depth-r...

journal_title：Scientific reports

authors： Fast A,Lal A,Durkin AF,Lentsch G,Harris RM,Zachary CB,Ganesan AK,Balu M

更新日期：2020-10-22 00:00:00

abstract：:To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the therma...

journal_title：Scientific reports

authors： Vaillon R,Dupré O,Cal RB,Calaf M

更新日期：2018-09-03 00:00:00

abstract：:In this work, four water-soluble polythiophene derivatives (PT, PT-DDA, PT-ADA, and PT-ADA-PPR) with different pendant moieties were synthesized via oxidative copolymerization by FeCl3. By increasing the hydrophobic ability of side chain moieties, there is a gradually blue shift for the maximum absorption wavelength a...

journal_title：Scientific reports

authors： Wang F,Li M,Wang B,Zhang J,Cheng Y,Liu L,Lv F,Wang S

更新日期：2015-01-05 00:00:00

abstract：:Nickel-titanium-oxide (Ni-Ti-O) nanotube arrays (NTAs) prepared on nearly equiatomic NiTi alloy shall have broad application potential such as for energy storage and biomedicine, but their precise structure control is a great challenge because of the high content of alloying element of Ni, a non-valve metal that canno...

journal_title：Scientific reports

authors： Hang R,Liu Y,Zhao L,Gao A,Bai L,Huang X,Zhang X,Tang B,Chu PK

更新日期：2014-12-18 00:00:00

abstract：:Diagnostic criteria for pathological gambling and alcohol dependence (AD) include repeated addictive behavior despite severe negative consequences. However, the concept of loss aversion (LA) as a facet of value-based decision making has not yet been used to directly compare these disorders. We hypothesized reduced LA ...

journal_title：Scientific reports

authors： Genauck A,Quester S,Wüstenberg T,Mörsen C,Heinz A,Romanczuk-Seiferth N

更新日期：2017-11-24 00:00:00

abstract：:Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet resulted in limited therapeutic benefit. Here, we explore a novel ...

journal_title：Scientific reports

authors： Damo M,Wilson DS,Simeoni E,Hubbell JA

更新日期：2015-12-03 00:00:00

abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...

journal_title：Scientific reports

authors： Huang K,Li YF,Li DZ,Chen LM,Tao MZ,Ma Y,Zhao JR,Li MH,Chen M,Mirzaie M,Hafz N,Sokollik T,Sheng ZM,Zhang J

更新日期：2016-06-08 00:00:00

abstract：:Recruitment via settlement of pelagic larvae is critical for the persistence of benthic marine populations. For many benthic invertebrates, larval settlement occurs in response to surface microbial films. Larvae of the serpulid polychaete Hydroides elegans can be induced to settle by single bacterial species. Until no...

journal_title：Scientific reports

authors： Freckelton ML,Nedved BT,Hadfield MG

更新日期：2017-02-14 00:00:00

abstract：:The sex-determining gene SRY induces SOX9 expression in the testes of eutherian mammals via two pathways. SRY binds to testis-specific enhancer of Sox9 (TESCO) with SF1 to activate SOX9 transcription. SRY also up-regulates ER71 expression, and ER71 activates Sox9 transcription. After the initiation of testis different...

journal_title：Scientific reports

authors： Otake T,Kuroiwa A

更新日期：2016-09-09 00:00:00