Abstract:
:Diagnostic criteria for pathological gambling and alcohol dependence (AD) include repeated addictive behavior despite severe negative consequences. However, the concept of loss aversion (LA) as a facet of value-based decision making has not yet been used to directly compare these disorders. We hypothesized reduced LA in pathological gamblers (PG) and AD patients, correlation of LA with disorder severity, and reduced loss-related modulation of brain activity. 19 PG subjects, 15 AD patients and 17 healthy controls (HC) engaged in a LA task in a functional magnetic resonance imaging setting. Imaging analyses focused on neural gain and loss sensitivity in the meso-cortico-limbic network of the brain. Both PG and AD subjects showed reduced LA. AD subjects showed altered loss-related modulation of activity in lateral prefrontal regions. PG subjects showed indication of altered amygdala-prefrontal functional connectivity. Although we observed reduced LA in both a behavioral addiction and a substance-related disorder our neural findings might challenge the notion of complete neuro-behavioral congruence of substance-use disorders and behavioral addictions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Genauck A,Quester S,Wüstenberg T,Mörsen C,Heinz A,Romanczuk-Seiferth Ndoi
10.1038/s41598-017-16433-ysubject
Has Abstractpub_date
2017-11-24 00:00:00pages
16306issue
1issn
2045-2322pii
10.1038/s41598-017-16433-yjournal_volume
7pub_type
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