Monoamine and genome-wide DNA methylation investigation in behavioral addiction.

abstract：:The sulfur-selenium doped carbon quantum dots (S,Se-CQDs) were synthesized by one-step through hydrothermal method in this study, which have high fluorescence quantum yield (43%) and advanced ability to scavenge reactive oxygen species (ROS). They were characterized by transmission electron microscope (TEM), nuclear m...

journal_title：Scientific reports

authors： Huang G,Lin Y,Zhang L,Yan Z,Wang Y,Liu Y

更新日期：2019-12-23 00:00:00

abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...

journal_title：Scientific reports

authors： Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA

更新日期：2019-06-20 00:00:00

abstract：:The role of marginal populations for the long-term maintenance of species' genetic diversity and evolutionary potential is particularly timely in view of the range shifts caused by climate change. The Centre-Periphery hypothesis predicts that marginal populations should bear reduced genetic diversity and have low evol...

journal_title：Scientific reports

authors： Ciborowski K,Jordan WC,Garcia de Leaniz C,Consuegra S

更新日期：2017-02-10 00:00:00

abstract：:α-synuclein (aS) is a natively unfolded pre-synaptic protein found in all Parkinson's disease patients as the major component of fibrillar plaques. Metal ions, and especially Cu(II), have been demonstrated to accelerate aggregation of aS into fibrillar plaques, the precursors to Lewy bodies. In this work, copper bindi...

journal_title：Scientific reports

authors： Rose F,Hodak M,Bernholc J

更新日期：2011-01-01 00:00:00

abstract：:The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...

journal_title：Scientific reports

authors： Hijazi K,Malyszko B,Steiling K,Xiao X,Liu G,Alekseyev YO,Dumas YM,Hertsgaard L,Jensen J,Hatsukami D,Brooks DR,O'Connor G,Beane J,Lenburg ME,Spira A

更新日期：2019-05-06 00:00:00

abstract：:Contemporary improvements in the type II clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system offer a convenient way for genome editing in zebrafish. However, the low efficiencies of genome editing and germline transmission require a time-intensive and laborious sc...

journal_title：Scientific reports

authors： Xie SL,Bian WP,Wang C,Junaid M,Zou JX,Pei DS

更新日期：2016-09-29 00:00:00

abstract：:Repeated blood pressure (BP) measurements allow better control of hypertension. Current measurements rely on cuff-based devices. The aim of the present study was to compare BP measurements using a novel cuff-less photoplethysmography-based device to a standard sphygmomanometer device. Males and females were recruited ...

journal_title：Scientific reports

authors： Nachman D,Gepner Y,Goldstein N,Kabakov E,Ishay AB,Littman R,Azmon Y,Jaffe E,Eisenkraft A

更新日期：2020-09-30 00:00:00

abstract：:Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...

journal_title：Scientific reports

authors： Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

更新日期：2018-12-17 00:00:00

abstract：:Piwi-like proteins are essential for stem-cell maintenance and self-renewal in multicellular organisms. We analyzed the expression of Piwi-like 1 and Piwi-like 2 by immunohistochemistry (IHC) in 95 muscle invasive bladder cancer (MIBC) samples using tissue microarray. Application of an immunoreactive score (IRS) revea...

journal_title：Scientific reports

authors： Eckstein M,Jung R,Weigelt K,Sikic D,Stöhr R,Geppert C,Agaimy A,Lieb V,Hartmann A,Wullich B,Wach S,Taubert H

更新日期：2018-12-06 00:00:00

abstract：:Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and p...

journal_title：Scientific reports

authors： Wang T,Xia L,Ma S,Qi X,Li Q,Xia Y,Tang X,Cui D,Wang Z,Chi J,Li P,Feng YX,Xia Q,Zhai B

更新日期：2016-05-12 00:00:00

abstract：:Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and ev...

journal_title：Scientific reports

authors： Guo Q,Lu X,Gao Y,Zhang J,Yan B,Su D,Song A,Zhao X,Wang G

更新日期：2017-03-07 00:00:00

abstract：:Artificial interface anisotropy is demonstrated in alternating Co/Pt and Co/Pd stripe patterns, providing a means of forming magnetic anisotropy using lithography. In-plane hysteresis loops measured along two principal directions are explained in depth by two competing shape and interface anisotropies, thus confirming...

journal_title：Scientific reports

authors： Kim SN,Nam YJ,Kim YD,Choi JW,Lee H,Lim SH

更新日期：2016-05-24 00:00:00

abstract：:In recent and future synchrotron radiation facilities, relativistic electron bunches with increasingly high charge density are needed for producing brilliant light at various wavelengths, from X-rays to terahertz. In such conditions, interaction of electron bunches with their own emitted electromagnetic fields leads t...

journal_title：Scientific reports

authors： Bielawski S,Blomley E,Brosi M,Bründermann E,Burkard E,Evain C,Funkner S,Hiller N,Nasse MJ,Niehues G,Roussel E,Schedler M,Schönfeldt P,Steinmann JL,Szwaj C,Walther S,Müller AS

更新日期：2019-07-17 00:00:00

abstract：:SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. UbL modification of proteins occurs via a specific enzymatic cascade formed by the crosstalk b...

journal_title：Scientific reports

authors： Liu B,Lois LM,Reverter D

更新日期：2017-02-06 00:00:00

abstract：:Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged ...

journal_title：Scientific reports

authors： Gao W,Xia W,Gao X,Zhang P

更新日期：2016-11-11 00:00:00

abstract：:Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...

journal_title：Scientific reports

authors： Chakraborty P,Cao L,Wang Y

更新日期：2017-08-15 00:00:00

abstract：:Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is sh...

journal_title：Scientific reports

authors： Wu TN,Chen CK,Lee CS,Wu BJ,Sun HJ,Chang CH,Chen CY,Wu LS,Cheng AT

更新日期：2019-07-16 00:00:00

abstract：:The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...

journal_title：Scientific reports

authors： Takagaki N,Kitaguchi T,Iwayama M,Shinoda A,Kumamaru H,Honda I

更新日期：2019-12-27 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrob...

journal_title：Scientific reports

authors： Shi J,Liu Y,Wang Y,Zhang J,Zhao S,Yang G

更新日期：2015-11-09 00:00:00

abstract：:This paper has been retracted. ...

journal_title：Scientific reports

authors： Magar S,Nayak D,Mahajan UB,Patil KR,Shinde SD,Goyal SN,Swaminarayan S,Patil CR,Ojha S,Kundu CN

更新日期：2019-06-11 00:00:00

abstract：:The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To ...

journal_title：Scientific reports

authors： Mao XW,Nishiyama NC,Byrum SD,Stanbouly S,Jones T,Drew A,Sridharan V,Boerma M,Tackett AJ,Zawieja D,Willey JS,Delp M,Pecaut MJ

更新日期：2019-06-03 00:00:00

abstract：:The symmetrically stable craniofacial bony structure supports the complex functions and delicate contour of the face. Congenital craniofacial deformities are often accompanied by bony defects and have been repetitively correlated with compromised dento-maxillary stability, but neither the extent nor the pattern of cle...

journal_title：Scientific reports

authors： Luo X,Huang H,Yin X,Shi B,Li J

更新日期：2019-03-12 00:00:00

abstract：:L-arginine:glycine amidinotransferase (AGAT) and its metabolites creatine and homoarginine (HA) have been linked to cardiovascular pathologies in both human and murine studies, but the underlying molecular mechanisms are poorly understood. Here, we report the first analysis of heart transcriptome variation using micro...

journal_title：Scientific reports

authors： Jensen M,Müller C,Choe CU,Schwedhelm E,Zeller T

更新日期：2020-03-16 00:00:00

abstract：:Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out (KO) is of interest. In this study, we generated a TALENs KO of mi...

journal_title：Scientific reports

authors： Ljepoja B,García-Roman J,Sommer AK,Fröhlich T,Arnold GJ,Wagner E,Roidl A

更新日期：2018-05-02 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:The patterns of life exhibited by large populations have been described and modeled both as a basic science exercise and for a range of applied goals such as reducing automotive congestion, improving disaster response, and even predicting the location of individuals. However, these studies have had limited access to c...

journal_title：Scientific reports

authors： Frank MR,Mitchell L,Dodds PS,Danforth CM

更新日期：2013-01-01 00:00:00

abstract：:Fear, anxiety, and preference in fish are generally evaluated by video-based behavioural analyses. We previously proposed a system that can measure bioelectrical signals, called ventilatory signals, using a 126-electrode array placed at the bottom of an aquarium and achieved cameraless real-time analysis of motion and...

journal_title：Scientific reports

authors： Soh Z,Matsuno M,Yoshida M,Furui A,Tsuji T

更新日期：2021-01-08 00:00:00

abstract：:The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial dysfunction. Furthermore, it can be activated in the cytosol by mitochondrial oxidative str...

journal_title：Scientific reports

authors： Blignaut M,Loos B,Botchway SW,Parker AW,Huisamen B

更新日期：2019-03-18 00:00:00

abstract：:Spin-orbit coupling (SOC) plays an essential role in many exotic and interesting phenomena in condensed matter physics. In neutral-atom-based quantum simulations, synthetic SOC constitutes a key enabling element. The strength of SOC realized so far is limited by various reasons or constraints. This work reports tunabl...

journal_title：Scientific reports

authors： Wu LN,Luo XY,Xu ZF,Ueda M,Wang R,You L

更新日期：2017-04-27 00:00:00