Abstract：
:Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is shown to be associated with lithium response in Han Chinese BPI patients. In this study, we demonstrated for the first time the relationship among lithium, GADL1, and KCTD12. In circulating CD11b+ macrophage cells, BPI patients showed a significantly higher percentage of KCTD12 expression than healthy controls. Among BPI patients, carriers of the 'T' allele (i.e., CT or TT) at site rs17026688 were found to secrete lower amounts of GADL1 but higher amounts of GABA b receptor 2 (GABBR2) in the plasma. In human SH-SY5Y neuroblastoma cells, lithium treatment increased the percentage of KCTD12 expression. Through inhibition of glycogen synthase kinase-3 (GSK-3), lithium induced cyclic AMP-response element binding protein (CREB)-mediated KCTD12 promoter activation. On the other hand, GADL1 overexpression enhanced GSK-3 activation and inhibited KCTD12 expression. We found that lithium induced, whereas GADL1 inhibited, KCTD12 expression. These findings suggested that KCTD12 may be an important gene with respect to neuron excitability and lithium response in BPI patients. Therefore, targeting GSK-3 activity and/or KCTD12 expression may constitute a possible therapeutic strategy for treating patients with BPI disorder.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu TN,Chen CK,Lee CS,Wu BJ,Sun HJ,Chang CH,Chen CY,Wu LS,Cheng ATdoi
10.1038/s41598-019-46655-1subject
Has Abstractpub_date
2019-07-16 00:00:00pages
10255issue
1issn
2045-2322pii
10.1038/s41598-019-46655-1journal_volume
9pub_type
杂志文章abstract：:Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19937
更新日期：2016-01-28 00:00:00
abstract：:To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study included 47 patients with COVID-19 admitted to three hospitals in Quanzhou City, Fujian Province, China, between January 21, 2020 and March 6, 2020. Univariate and multiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81010-3
更新日期：2021-01-13 00:00:00
abstract：:Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanical loading. We know from clinical experience that malrotation of surgical nasoseptal cartilage grafts can lead to increased graft absorption. Other studies have al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48578-3
更新日期：2019-08-28 00:00:00
abstract：:This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27319-y
更新日期：2018-06-12 00:00:00
abstract：:Spintronic devices currently rely on magnetic switching or controlled motion of domain walls by an external magnetic field or spin-polarized current. Achieving the same degree of magnetic controllability using an electric field has potential advantages including enhanced functionality and low power consumption. Here w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00258
更新日期：2012-01-01 00:00:00
abstract：:One of the most exciting areas in lithium ion batteries is engineering structured silicon anodes. These new materials promise to lead the next generation of batteries with significantly higher reversible charge capacity than current technologies. One drawback of these materials is that their production involves costly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00795
更新日期：2012-01-01 00:00:00
abstract：:Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes and can be employed t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05260
更新日期：2014-06-11 00:00:00
abstract：:Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76789-6
更新日期：2020-11-16 00:00:00
abstract：:Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14358-0
更新日期：2017-11-08 00:00:00
abstract：:The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13335
更新日期：2015-08-20 00:00:00
abstract：:2-Bromo-5-(2-bromo-2-nitrovinyl)furan (G1 or Furvina) is an antimicrobial with a direct reactivity against thiol groups. It is active against Gram-positive and Gram-negative bacteria, yeasts and filamentous fungi. By reacting with thiol groups it causes direct damage to proteins but, as a result, is very short-living ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36844
更新日期：2016-11-10 00:00:00
abstract：:We previously reported that induction of the adipocyte-specific gene adiponectin (Adipoq) during 3T3-L1 adipocyte differentiation is closely associated with epigenetic memory histone H3 acetylation on the transcribed region of the gene. We used 3T3-L1 adipocytes and Brd4 heterozygous mice to investigate whether the in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12342-2
更新日期：2017-09-20 00:00:00
abstract：:The MADS-box transcription factors play essential roles in many physiological and biochemical processes of plants, especially in fruit ripening. Here, a tomato MADS-box gene, SlCMB1, was isolated. SlCMB1 expression declined with the fruit ripening from immature green to B + 7 (7 days after Breaker) fruits in the wild ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21672-8
更新日期：2018-02-21 00:00:00
abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31763-1
更新日期：2018-09-14 00:00:00
abstract：:This study demonstrates significant visible light photo-detection capability of pristine ZnO nanostructure thin films possessing substantially high percentage of oxygen vacancies [Formula: see text] and zinc interstitials [Formula: see text], introduced by simple tuning of economical solution method. The demonstrated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15125-x
更新日期：2017-11-08 00:00:00
abstract：:Here we report a high efficiency photocatalyst, i.e., Mn(2+)-doped and N-decorated ZnO nanofibers (NFs) enriched with vacancy defects, fabricated via electrospinning and a subsequent controlled annealing process. This nanocatalyst exhibits excellent visible-light photocatalytic activity and an apparent quantum efficie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32711
更新日期：2016-09-07 00:00:00
abstract：:Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five clinically used PD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47910-1
更新日期：2019-08-07 00:00:00
abstract：:Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00553-6
更新日期：2017-04-04 00:00:00
abstract：:The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40302-5
更新日期：2019-03-04 00:00:00
abstract：:The theoretical optimal olfactory search strategy is to move cross-wind. Empirical evidence supporting wind-associated directionality among carnivores, however, is sparse. We examined satellite-linked telemetry movement data of adult female polar bears (Ursus maritimus) from Hudson Bay, Canada, in relation to modelled...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46332
更新日期：2017-04-12 00:00:00
abstract：:One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40467
更新日期：2017-01-11 00:00:00
abstract：:The regulatory transcriptional factor PATZ1 is constantly downregulated in human thyroid cancer where it acts as a tumour suppressor by targeting p53-dependent genes involved in Epithelial-Mesenchymal Transition and cell migration. The aim of the present work was to elucidate the upstream signalling mechanisms regulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25268
更新日期：2016-04-29 00:00:00
abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29918-1
更新日期：2018-08-02 00:00:00
abstract：:Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18629
更新日期：2015-12-21 00:00:00
abstract：:Common estimates of external training intensity for resistance exercise do not incorporate inter-set recovery duration, and might not reflect the overall demands of training. This study aimed to assess novel metrics of exercise density (ED) during resistance exercise, and how these related to a physiological marker of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05953-2
更新日期：2017-07-17 00:00:00
abstract：:This study assessed the efficacy and tolerability of intravenous ibuprofen in the improvement of post-operative pain control and the reduction of opioid usage. Patients were randomly divided into placebo, ibuprofen 400 mg and ibuprofen 800 mg groups. All patients received patient-controlled intravenous morphine analge...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-28428-4
更新日期：2018-07-05 00:00:00
abstract：:Reliable P wave detection is necessary for accurate and automatic electrocardiogram (ECG) analysis. Currently, methods for P wave detection in physiological conditions are well-described and efficient. However, methods for P wave detection during pathology are not generally found in the literature, or their performanc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55323-3
更新日期：2019-12-13 00:00:00
abstract：:Diatoms are known for their intricate, silicified cell walls (frustules). Silica polymerization occurs in a compartment called the silica deposition vesicle (SDV) and it was proposed that the cytoskeleton influences silica patterning through the SDV membrane (silicalemma) via interactions with transmembrane proteins. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13613-8
更新日期：2017-10-18 00:00:00
abstract：:Proteins are highly dynamic entities attaining a myriad of different conformations. Protein side chains change their states during dynamics, causing clashes that are propagated at distal sites. A convenient formalism to analyze protein dynamics is based on network theory using Protein Structure Networks (PSNs). Despit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01498-6
更新日期：2017-06-06 00:00:00
abstract：:microRNAs are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landscape of a cell. Similar to mRNA, they often exhibit cell type enriched expression and serve to reinforce cellular identity. In tissue with high cellular complexity, such as the central nervous system (CNS), it ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61307-5
更新日期：2020-03-18 00:00:00
