Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.

abstract：:Epstein-Barr virus-encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs consistently expressed in all EBV infected cells, but their function remains poorly understood. Conventional in situ hybridization studies have indicated that these RNAs are present exclusively in the nucleus. We have re...

journal_title：Scientific reports

authors： Ahmed W,Tariq S,Khan G

更新日期：2018-10-18 00:00:00

abstract：:Visual reasoning is critical in many complex visual tasks in medicine such as radiology or pathology. It is challenging to explicitly explain reasoning processes due to the dynamic nature of real-time human cognition. A deeper understanding of such reasoning processes is necessary for improving diagnostic accuracy and...

journal_title：Scientific reports

authors： Li Y,Cao H,Allen CM,Wang X,Erdelez S,Shyu CR

更新日期：2020-12-10 00:00:00

abstract：:We introduce a simple method to characterize the topological charge associated with the orbital angular momentum of a m-order elliptic light beam. This method consists in the observation of the far field pattern of the beam carrying orbital angular momentum, diffracted from a triangular aperture. We show numerically a...

journal_title：Scientific reports

authors： Melo LA,Jesus-Silva AJ,Chávez-Cerda S,Ribeiro PHS,Soares WC

更新日期：2018-04-23 00:00:00

abstract：:Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced BMP-2-induced bone formation. Since IL-17 is known to induce ost...

journal_title：Scientific reports

authors： Croes M,Kruyt MC,Groen WM,van Dorenmalen KMA,Dhert WJA,Öner FC,Alblas J

更新日期：2018-05-08 00:00:00

abstract：:Caragana korshinskii Kom. has a significant function in desert-grassland revegetation in arid regions. Plant reproduction in arid regions can be restricted due to inadequate pollen receipt and reduced pollen transfer. An assessment of pollination success as a result of pollen limitation and pollinator visitation in va...

journal_title：Scientific reports

authors： Chen M,Zhao XY

更新日期：2019-07-05 00:00:00

abstract：:Male Wistar rats were exposed to herbicide, pendimethalin (PND) at varying oral doses of 62.5, 125 and 250 mg/kg b.w. for 14 days. Toxiological effects were assessed in terms of oxidative stress, DNA damage, histopathological alterations and induction of anti-inflammatory and apoptotic responses linked Bax, Bcl-2, IFN...

journal_title：Scientific reports

authors： Ahmad MI,Zafeer MF,Javed M,Ahmad M

更新日期：2018-11-20 00:00:00

abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...

journal_title：Scientific reports

authors： Shiba K,Tsuchiya K,Komiya C,Miyachi Y,Mori K,Shimazu N,Yamaguchi S,Ogasawara N,Katoh M,Itoh M,Suganami T,Ogawa Y

更新日期：2018-02-05 00:00:00

abstract：:In recent years, texture analysis of medical images has become increasingly popular in studies investigating diagnosis, classification and treatment response assessment of cancerous disease. Despite numerous applications in oncology and medical imaging in general, there is no consensus regarding texture analysis workf...

journal_title：Scientific reports

authors： Brynolfsson P,Nilsson D,Torheim T,Asklund T,Karlsson CT,Trygg J,Nyholm T,Garpebring A

更新日期：2017-06-22 00:00:00

abstract：:The current standard of care for head and neck cancer includes surgical resection of the tumor followed by targeted head and neck radiation. This radiotherapy results in a multitude of negative side effects in adjacent normal tissues. Autophagy is a cellular mechanism that could be targeted to ameliorate these side ef...

journal_title：Scientific reports

authors： Morgan-Bathke M,Hill GA,Harris ZI,Lin HH,Chibly AM,Klein RR,Burd R,Ann DK,Limesand KH

更新日期：2014-06-06 00:00:00

abstract：:Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, howev...

journal_title：Scientific reports

authors： He D,Jin D,Chen Z,Zhang W

更新日期：2015-03-02 00:00:00

abstract：:N-α-acetyltransferase 10 (Naa10) displays alpha (N-terminal) acetyltransferase activity. It functions as a major modulator of cell growth and differentiation. Until now, a few downstream targets were found, but no studies have concerned about which gene is the early event of Naa10 downstream target. As we know, the ea...

journal_title：Scientific reports

authors： Xu H,Han Y,Liu B,Li R

更新日期：2016-12-02 00:00:00

abstract：:APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization ...

journal_title：Scientific reports

authors： Pan Y,Zagorski K,Shlyakhtenko LS,Lyubchenko YL

更新日期：2018-12-18 00:00:00

abstract：:The vertebrate gut is host to large communities of bacteria, and one of the beneficial contributions of this commensal gut microbiota is the increased nutritional gain from feed components that the host cannot degrade on its own. Fish larvae of similar age and under the same rearing conditions often diverge with regar...

journal_title：Scientific reports

authors： Forberg T,Sjulstad EB,Bakke I,Olsen Y,Hagiwara A,Sakakura Y,Vadstein O

更新日期：2016-02-15 00:00:00

abstract：:Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...

journal_title：Scientific reports

authors： Lau WC,Li Y,Zhang Q,Huen MS

更新日期：2015-10-27 00:00:00

abstract：:PCGEM1 is a long non-coding RNA (lncRNA) that is often upregulated in prostate cancer. However, little is known how PCGEM1 is regulated. In the present study, we show transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. While ectopic expression of p54/nrb increases, suppression of p54/n...

journal_title：Scientific reports

authors： Ho TT,Huang J,Zhou N,Zhang Z,Koirala P,Zhou X,Wu F,Ding X,Mo YY

更新日期：2016-09-29 00:00:00

abstract：:Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...

journal_title：Scientific reports

authors： Zhao M,Li Z,Qu H

更新日期：2015-10-21 00:00:00

abstract：:Present-day terrestrial analogue sites are crucial ground truth proxies for studying life in geochemical conditions close to those assumed to be present on early Earth or inferred to exist on other celestial bodies (e.g. Mars, Europa). Although hypersaline sapropels are border-of-life habitats with moderate occurrence...

journal_title：Scientific reports

authors： Andrei AŞ,Baricz A,Robeson MS 2nd,Păuşan MR,Tămaş T,Chiriac C,Szekeres E,Barbu-Tudoran L,Levei EA,Coman C,Podar M,Banciu HL

更新日期：2017-07-21 00:00:00

abstract：:Stem cells are promising for the treatment of myocardial infarction (MI) and large animal models should be used to better understand the full spectrum of stem cell actions and preclinical evidences. In this study, bone marrow mesenchymal stem cells (BM-MSCs) were transplanted into swine heart ischemia model. To detect...

journal_title：Scientific reports

authors： Cai M,Shen R,Song L,Lu M,Wang J,Zhao S,Tang Y,Meng X,Li Z,He ZX

更新日期：2016-06-20 00:00:00

abstract：:Many systems biology studies lack context-relevant data and as a consequence the predictive capabilities can be limited in developing targeted cancer therapeutics. Production of colon crypt in vitro is ideal for studying colon systems biology. This report presents the first production of, to our knowledge, physiologic...

journal_title：Scientific reports

authors： Tan CW,Hirokawa Y,Burgess AW

更新日期：2015-06-18 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...

journal_title：Scientific reports

authors： Li R,Zhang Y,Zheng X,Peng S,Yuan K,Zhang X,Min W

更新日期：2017-02-23 00:00:00

abstract：:Motivational, cognitive and action goals are processed by distinct, topographically organized, corticostriatal circuits. We aimed to test whether processing in the striatum is under causal control by cortical regions in the human brain by investigating the effects of offline transcranial magnetic stimulation (TMS) ove...

journal_title：Scientific reports

authors： van Holstein M,Froböse MI,O'Shea J,Aarts E,Cools R

更新日期：2018-02-19 00:00:00

abstract：:We present new evidence that shows magma mingling can be a key process during highly explosive eruptions. Using fractal analysis of the size distribution of trachybasaltic fragments found on the inner walls of bubbles in trachytic pumices, we show that the more mafic component underwent fracturing during quenching aga...

journal_title：Scientific reports

authors： Paredes-Mariño J,Dobson KJ,Ortenzi G,Kueppers U,Morgavi D,Petrelli M,Hess KU,Laeger K,Porreca M,Pimentel A,Perugini D

更新日期：2017-12-04 00:00:00

abstract：:The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc -/- and Optc +/+ mice. Ten weeks post-surgery, cartilage was processed for histology and immu...

journal_title：Scientific reports

authors： Farrán A,Valverde-Franco G,Tío L,Lussier B,Fahmi H,Pelletier JP,Bishop PN,Monfort J,Martel-Pelletier J

更新日期：2018-01-11 00:00:00

abstract：:The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...

journal_title：Scientific reports

authors： Lum FM,Couderc T,Chia BS,Ong RY,Her Z,Chow A,Leo YS,Kam YW,Rénia L,Lecuit M,Ng LFP

更新日期：2018-01-30 00:00:00

abstract：:Recently, the use of a liquid biopsy has shown promise in monitoring tumor burden. While point mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tumor specificity. Such rearrangements can be identified in the tumor and subsequently detected in the plasma of patients using qu...

journal_title：Scientific reports

authors： Harris FR,Kovtun IV,Smadbeck J,Multinu F,Jatoi A,Kosari F,Kalli KR,Murphy SJ,Halling GC,Johnson SH,Liu MC,Mariani A,Vasmatzis G

更新日期：2016-07-20 00:00:00

abstract：:Multi-wavelength lasers have widespread applications (e.g. fiber telecommunications, pump-probe measurements, terahertz generation). Here, we report a nanotube-mode-locked all-fiber ultrafast oscillator emitting three wavelengths at the central wavelengths of about 1540, 1550, and 1560 nm, which are tunable by stretch...

journal_title：Scientific reports

authors： Liu X,Han D,Sun Z,Zeng C,Lu H,Mao D,Cui Y,Wang F

更新日期：2013-01-01 00:00:00

abstract：:Glomerular filtration rate (GFR) assessment is indicated before every administration of cisplatin. The optimal modality for this purpose [GFR measurement by urinary Creatinine Clearance (uCrCl) versus GFR estimation (eGFR) by the CKD-EPI formula versus both] is unclear. We investigated whether eGFR only is safe in thi...

journal_title：Scientific reports

authors： Klöckl MC,Kasparek AK,Riedl JM,Moik F,Mollnar S,Stotz M,Szkandera J,Terbuch A,Gerger A,Niedrist T,Pichler M,Bauernhofer T,Schilcher G,Zitta S,Rosenkranz AR,Friedl C,Stöger H,Posch F

更新日期：2020-07-08 00:00:00

abstract：:It was hypothesized that supplementation of omega-3 fatty acids could increase physical activity (PA) levels, where traditional interventions often fail. The aim of this double-blind, randomized, placebo-controlled trail was to evaluate the effects of 15-week administration of omega-3 fatty acids on objectively measur...

journal_title：Scientific reports

authors： Svensson V,Johansson E,Fischer M,Deng SL,Hagströmer M,Danielsson P

更新日期：2018-08-24 00:00:00

abstract：:The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ([Formula: see text]) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor depositio...

journal_title：Scientific reports

authors： Wang X,Gao D,Li M,Li H,Li C,Wu X,Yang B

更新日期：2017-08-01 00:00:00

abstract：:Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infan...

journal_title：Scientific reports

authors： Kim YH,Shin HJ,Sol IS,Kim SY,Kim JD,Yoon H,Kim KW,Kim MJ,Lee MJ,Sohn MH

更新日期：2017-11-09 00:00:00