Abstract：
:The current standard of care for head and neck cancer includes surgical resection of the tumor followed by targeted head and neck radiation. This radiotherapy results in a multitude of negative side effects in adjacent normal tissues. Autophagy is a cellular mechanism that could be targeted to ameliorate these side effects based on its role in cellular homeostasis. In this study, we utilized Atg5(f/f);Aqp5-Cre mice which harbor a conditional knockout of Atg5, in salivary acinar cells. These autophagy-deficient mice display increased radiosensitivity. Treatment of wild-type mice with radiation did not robustly induce autophagy following radiotherapy, however, using a model of preserved salivary gland function by IGF-1-treatment prior to irradiation, we demonstrate increased autophagosome formation 6-8 hours following radiation. Additionally, administration of IGF-1 to Atg5(f/f);Aqp5-Cre mice did not preserve physiological function. Thus, autophagy appears to play a beneficial role in salivary glands following radiation and pharmacological induction of autophagy could alleviate the negative side effects associated with therapy for head and neck cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Morgan-Bathke M,Hill GA,Harris ZI,Lin HH,Chibly AM,Klein RR,Burd R,Ann DK,Limesand KHdoi
10.1038/srep05206subject
Has Abstractpub_date
2014-06-06 00:00:00pages
5206issn
2045-2322pii
srep05206journal_volume
4pub_type
杂志文章abstract：:The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27989-8
更新日期：2018-06-28 00:00:00
abstract：:While considered an extracellular pathogen, Pseudomonas aeruginosa has been reported to be engulfed by macrophages in cellular and animal models. However, the role of macrophages in P. aeruginosa clearance in vivo remains poorly studied. The major outer membrane porin OprF has been recently shown to be involved in P. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79678-0
更新日期：2021-01-11 00:00:00
abstract：:Investigation of climatic conditions prior to the Sturtian glaciations is critical to understanding the trigger mechanism for the series of Neoproterozoic global glaciations. In this study, we report high-resolution chemical index of alteration (CIA) records in the sediments of South China prior to the Sturtian glacia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06868
更新日期：2014-10-31 00:00:00
abstract：:Antimicrobial peptides (AMPs) are peptide antibiotics with a broad spectrum of antimicrobial activities. Activity prediction of AMPs from their amino acid sequences is of great therapeutic importance but imposes challenges on prediction methods due to label interactions. In this paper we propose a novel multi-label le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01986-9
更新日期：2017-05-19 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep44797. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46843
更新日期：2017-06-16 00:00:00
abstract：:IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28290
更新日期：2016-06-16 00:00:00
abstract：:Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatechin-(epicatechin)7 gallate using electron-spray ionization time-of-flight mass sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48603-5
更新日期：2019-08-19 00:00:00
abstract：:A microwave domain characterization approach is proposed to determine the properties of high quality factor optical resonators. This approach features a very high precision in frequency and aims to acquire a full knowledge of the complex transfer function (amplitude and phase) characterizing an optical resonator using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27208
更新日期：2016-06-02 00:00:00
abstract：:Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31502
更新日期：2016-08-17 00:00:00
abstract：:Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20278-4
更新日期：2018-01-31 00:00:00
abstract：:In clinical translational research and molecular in vitro diagnostics, a major challenge in the detection of genetic mutations is overcoming artefactual results caused by the low-quality of formalin-fixed paraffin-embedded tissue (FFPET)-derived DNA (FFPET-DNA). Here, we propose the use of an 'internal quality control...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18642-x
更新日期：2018-01-11 00:00:00
abstract：:The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15005
更新日期：2015-10-07 00:00:00
abstract：:Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are used as attractants in tsetse fly traps to reduce the spread of the disease. Here we present an inexpensive production method for 3-ethylphenol (3-EP) and 3-prop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66997-5
更新日期：2020-06-19 00:00:00
abstract：:The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50128-w
更新日期：2019-09-24 00:00:00
abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52609-4
更新日期：2019-11-07 00:00:00
abstract：:Recent decades have experienced the discovery of numerous complex materials. At the root of the complexity underlying many of these materials lies a large number of contending atomic- and largerscale configurations. In order to obtain a more detailed understanding of such systems, we need tools that enable the detecti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00329
更新日期：2012-01-01 00:00:00
abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51783-9
更新日期：2019-10-25 00:00:00
abstract：:More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the autho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26036-w
更新日期：2018-05-17 00:00:00
abstract：:Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases; however, its function and therapeutic prospects with respect to kidney injury ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44241-z
更新日期：2019-05-24 00:00:00
abstract：:The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31114-0
更新日期：2018-08-24 00:00:00
abstract：:It has been shown that long-term stimulant consumption alters the biological and microbiological status of the oral cavity. We present a pilot study describing stimulant-specific oral immunomodulation in the oral cavity. Changes in salivary cytokine levels in response to long-term alcohol, tobacco and caffeine were id...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35094-z
更新日期：2018-11-12 00:00:00
abstract：:Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e.,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08547-0
更新日期：2017-08-14 00:00:00
abstract：:Bacteria swim in sequences of straight runs that are interrupted by turning events. They drive their swimming locomotion with the help of rotating helical flagella. Depending on the number of flagella and their arrangement across the cell body, different run-and-turn patterns can be observed. Here, we present fluoresc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16428-9
更新日期：2017-12-01 00:00:00
abstract：:Bisoprolol (B) exerts potential cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. Unfolded protein response (UPR) attenuates I/R injury induced apoptosis by reducing oxidative damage and inflammation response. The current study investigated whether the protective effects of bisoprolol resu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12366-8
更新日期：2017-09-19 00:00:00
abstract：:Assassin bugs (Reduvioidea) are one of the most diverse (>7,000 spp.) lineages of predatory animals and have evolved an astounding diversity of raptorial leg modifications for handling prey. The evolution of these modifications is not well understood due to the lack of a robust phylogeny, especially at deeper nodes. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22177
更新日期：2016-02-26 00:00:00
abstract：:Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02290
更新日期：2013-01-01 00:00:00
abstract：:Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18892
更新日期：2016-01-04 00:00:00
abstract：:Considering the significance of mast cells (MCs) in the course of various physiological and pathological processes, and the pivotal role of endogenous molecules, i.e., cathelicidins and defensins as multifunctional modulators, the study examines the constitutive and cathelicidin LL-37/defensin hBD-2-induced expression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30289-w
更新日期：2018-08-06 00:00:00
abstract：:The absorption spectra in array of Ge, Al and Ge/Al-shell nanoparticles immersed in alumina (Al2O3) matrix is calculated in framework of ab initio macroscopic dielectric model. It is demonstrated that absorption is strongly enhanced when germanium nanospheres are encapsulated by Al-shell. Two absorption peaks, appeari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56673-8
更新日期：2020-01-09 00:00:00
abstract：:Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves show...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07972-5
更新日期：2017-08-08 00:00:00
