Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.

abstract：:Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implica...

journal_title：Scientific reports

authors： Kalli M,Minia A,Pliaka V,Fotis C,Alexopoulos LG,Stylianopoulos T

更新日期：2019-01-30 00:00:00

abstract：:It is frequently assumed that in the limit of vanishing cooling rate, the glass transition phenomenon becomes a thermodynamic transition at a temperature TK. However, with any finite cooling rate, the system falls out of equilibrium at temperatures near Tg(>TK), implying that the very existence of the putative thermod...

journal_title：Scientific reports

authors： Chakrabarty S,Karmakar S,Dasgupta C

更新日期：2015-07-24 00:00:00

abstract：:Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by mass spectrometry a...

journal_title：Scientific reports

authors： Roncal C,Martínez-Aguilar E,Orbe J,Ravassa S,Fernandez-Montero A,Saenz-Pipaon G,Ugarte A,Estella-Hermoso de Mendoza A,Rodriguez JA,Fernández-Alonso S,Fernández-Alonso L,Oyarzabal J,Paramo JA

更新日期：2019-10-30 00:00:00

abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...

journal_title：Scientific reports

authors： Petursdottir Maack H,Skalkidou A,Sjöholm A,Eurenius-Orre K,Mulic-Lutvica A,Wikström AK,Sundström Poromaa I

更新日期：2019-04-17 00:00:00

abstract：:Defect engineering is a promising route for controlling the electronic properties of monolayer transition-metal dichalcogenide (TMD) materials. Here, we demonstrate that the electronic structure of MoS2 depends sensitively on the defect charge, both its sign and magnitude. In particular, we study shallow bound states ...

journal_title：Scientific reports

authors： Aghajanian M,Mostofi AA,Lischner J

更新日期：2018-09-11 00:00:00

abstract：:Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard treatment of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due to a limited peritoneal exposure time of chemotherapeutics. Paclitaxel-loaded genipin-crosslinked gelatin microspheres (PTX-GP-MS) a...

journal_title：Scientific reports

authors： De Clercq K,Xie F,De Wever O,Descamps B,Hoorens A,Vermeulen A,Ceelen W,Vervaet C

更新日期：2019-10-16 00:00:00

abstract：:After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...

journal_title：Scientific reports

authors： Chen S,Qiu G

更新日期：2020-10-14 00:00:00

abstract：:It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number of RNA sequencing studies have considerably improved our understanding of transcriptome complexity. However, it still remain...

journal_title：Scientific reports

authors： Chen SY,Deng F,Jia X,Li C,Lai SJ

更新日期：2017-08-09 00:00:00

abstract：:Human parainfluenza type-3 virus (hPIV-3) is one of the principal aetiological agents of acute respiratory illness in infants worldwide and also shows high disease severity in the elderly and immunocompromised, but neither therapies nor vaccines are available to treat or prevent infection, respectively. Using a multid...

journal_title：Scientific reports

authors： Bailly B,Dirr L,El-Deeb IM,Altmeyer R,Guillon P,von Itzstein M

更新日期：2016-04-07 00:00:00

abstract：:This work demonstrates an anisotropic increase in resistivity with decreasing width in single crystal tungsten (W) nanowires having a height of 21 nm. Nanowire-widths were in the range of 15-451 nm, with the anisotropy observed for widths below 50 nm. The longitudinal directions of the nanowires coincided with the <10...

journal_title：Scientific reports

authors： Choi D,Moneck M,Liu X,Oh SJ,Kagan CR,Coffey KR,Barmak K

更新日期：2013-01-01 00:00:00

abstract：:Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...

journal_title：Scientific reports

authors： Yao Y,Wang H,Wang R,Chai Y

更新日期：2019-02-04 00:00:00

abstract：:Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging ...

journal_title：Scientific reports

authors： Sim K,Chen S,Li Y,Kammoun M,Peng Y,Xu M,Gao Y,Song J,Zhang Y,Ardebili H,Yu C

更新日期：2015-11-10 00:00:00

abstract：:Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts the HCV life cycle are not fully understood. We assessed the effect of quercetin on different steps of the HCV life cycle in Huh-7.5 cells and primary human he...

journal_title：Scientific reports

authors： Rojas Á,Del Campo JA,Clement S,Lemasson M,García-Valdecasas M,Gil-Gómez A,Ranchal I,Bartosch B,Bautista JD,Rosenberg AR,Negro F,Romero-Gómez M

更新日期：2016-08-22 00:00:00

abstract：:The American mink (Neovison vison) is a semiaquatic species of mustelid native to North America. It's an important animal for the fur industry. Many efforts have been made to locate genes influencing fur quality and color, but this search has been impeded by the lack of a reference genome. Here we present the first dr...

journal_title：Scientific reports

authors： Cai Z,Petersen B,Sahana G,Madsen LB,Larsen K,Thomsen B,Bendixen C,Lund MS,Guldbrandtsen B,Panitz F

更新日期：2017-11-06 00:00:00

abstract：:Kefir peptides, generated by kefir grain fermentation of milk proteins, showed positive antioxidant effects, lowered blood pressure and modulated the immune response. In this study, kefir peptide was evaluated regarding their anti-inflammatory effects on particulate matter <4 μm (PM4.0)-induced lung inflammation in NF...

journal_title：Scientific reports

authors： Chen HL,Hung KF,Yen CC,Laio CH,Wang JL,Lan YW,Chong KY,Fan HC,Chen CM

更新日期：2019-08-08 00:00:00

abstract：:The lateral movement of soil carbon has a profound effect on the carbon budget of terrestrial ecosystems; however, it has never been quantified in China, which is one of the strongest soil erosion areas in the world. In this study, we estimated that the overall soil erosion in China varies from 11.27 to 18.17 Pg yr(-1...

journal_title：Scientific reports

authors： Zhang H,Liu S,Yuan W,Dong W,Ye A,Xie X,Chen Y,Liu D,Cai W,Mao Y

更新日期：2014-11-28 00:00:00

abstract：:Mitochondria increase in number by the fission of existing mitochondria. Mitochondrial fission is needed to provide mitochondria to daughter cells during cell division. In Arabidopsis thaliana, four kinds of genes have been reported to be involved in mitochondrial fission. Two of them, DRP3 (dynamin-related protein3) ...

journal_title：Scientific reports

authors： Nagaoka N,Yamashita A,Kurisu R,Watari Y,Ishizuna F,Tsutsumi N,Ishizaki K,Kohchi T,Arimura SI

更新日期：2017-07-04 00:00:00

abstract：:Ceramide is one of the most important intercellular components responsible for the barrier and moisture retention functions of the skin. Because of the risks involved with using products of animal origin and the low productivity of plants, the availability of ceramides is currently limited. In this study, we successfu...

journal_title：Scientific reports

authors： Murakami S,Shimamoto T,Nagano H,Tsuruno M,Okuhara H,Hatanaka H,Tojo H,Kodama Y,Funato K

更新日期：2015-11-17 00:00:00

abstract：:Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. An NHD-associated mutation, c.482 + 2 T > C, disrupts the splice donor site of intron 3 and causes aberrant skipping of exon 3, resulting in the los...

journal_title：Scientific reports

authors： Yanaizu M,Sakai K,Tosaki Y,Kino Y,Satoh JI

更新日期：2018-05-02 00:00:00

abstract：:There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable and binding of ADPR occurs N-terminally. Zebrafish TRPM2 needs both, the N-termin...

journal_title：Scientific reports

authors： Kühn FJP,Ehrlich W,Barth D,Kühn C,Lückhoff A

更新日期：2019-12-16 00:00:00

abstract：:Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...

journal_title：Scientific reports

authors： Tsou LK,Yeh SH,Ueng SH,Chang CP,Song JS,Wu MH,Chang HF,Chen SR,Shih C,Chen CT,Ke YY

更新日期：2020-10-08 00:00:00

abstract：:Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty restenosis. A prospective, randomized, feasibility study was conducted to investigate the effect of ascorbic acid to...

journal_title：Scientific reports

authors： Yang CW,Wu CC,Luo CM,Chuang SY,Chen CH,Shen YF,Tarng DC

更新日期：2019-07-31 00:00:00

abstract：:The function of most long noncoding RNAs (lncRNAs) is unknown. However, recent studies reveal important roles of lncRNAs in regulating cancer-related pathways. Human antisense lncRNA-NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3. Amplification of this region and/or differential e...

journal_title：Scientific reports

authors： Kathuria H,Millien G,McNally L,Gower AC,Tagne JB,Cao Y,Ramirez MI

更新日期：2018-09-26 00:00:00

abstract：:Podocyte loss is the initial event in the development of glomerulosclerosis, the structural hallmark of progressive proteinuric nephropathies. Understanding mechanisms underlying glomerular injury is the key challenge for identifying novel therapeutic targets. In mice with protein-overload induced by bovine serum albu...

journal_title：Scientific reports

authors： Morigi M,Locatelli M,Rota C,Buelli S,Corna D,Rizzo P,Abbate M,Conti D,Perico L,Longaretti L,Benigni A,Zoja C,Remuzzi G

更新日期：2016-06-27 00:00:00

abstract：:Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Methods of identifying BE patients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outcomes and identify who will benefit most from intensive surveillance or ablative therapy. Clinical predi...

journal_title：Scientific reports

authors： Kambhampati S,Tieu AH,Luber B,Wang H,Meltzer SJ

更新日期：2020-03-17 00:00:00

abstract：:Tissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity ...

journal_title：Scientific reports

authors： Houseright RA,Rosowski EE,Lam PY,Tauzin SJM,Mulvaney O,Dewey CN,Huttenlocher A

更新日期：2020-09-24 00:00:00

abstract：:Lactose intolerance is a major concern driving the growth of lactose-free foods including lactose-free infant formula. It is unknown what the metabolic consequence is of consumption of a formula where lactose has been replaced with corn syrup solids (CSS). Here, a randomized double-blinded intervention study was condu...

journal_title：Scientific reports

authors： Slupsky CM,He X,Hernell O,Andersson Y,Rudolph C,Lönnerdal B,West CE

更新日期：2017-06-16 00:00:00

abstract：:Polarimetric imaging has proved its value in medical diagnostics, bionics, remote sensing, astronomy, and in many other wide fields. Pixel-level solid monolithically integrated polarimetric imaging photo-detectors are the trend for infrared polarimetric imaging devices. For better polarimetric imaging performance the ...

journal_title：Scientific reports

authors： Li Q,Li Z,Li N,Chen X,Chen P,Shen X,Lu W

更新日期：2014-09-11 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...

journal_title：Scientific reports

authors： Bernardes-Oliveira E,de Freitas DLD,de Morais CLM,Cornetta MDCM,Camargo JDAS,de Lima KMG,Crispim JCO

更新日期：2020-11-06 00:00:00

abstract：:Due to the high CO2-footprint of ordinary Portland cement (OPC), the search for alternative binders is now in a full swing. Rankinite-which is a hydraulically inactive material and low in calcium, is a real alternative to OPC, as it absorbs the harmful greenhouse gas from the air through carbonation hardening. Neverth...

journal_title：Scientific reports

authors： Smigelskyte A,Siauciunas R,Hilbig H,Decker M,Urbonas L,Skripkiunas G

更新日期：2020-09-02 00:00:00