Abstract：
:Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Methods of identifying BE patients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outcomes and identify who will benefit most from intensive surveillance or ablative therapy. Clinical predictors of BE progression to HGD or EAC are poorly understood, with multiple contradictory studies. We performed a retrospective study which included 460 patients at Johns Hopkins Hospital who underwent at least 2 upper endoscopies 6 months apart showing biopsy-documented BE between 1992 and 2013. Patients with EAC or HGD at the initial endoscopy were excluded. Demographic, clinicopathological, and endoscopic data were collected. Univariate and multivariate Cox proportional hazards analyses with time to progression to HGD and EAC were performed. Among 460 patients included in the study, 132 BE patients developed HGD and 62 developed EAC. Significant EAC risk factors included age, abdominal obesity, caffeine intake, and the presence of HGD. Risk factors for HGD or EAC included age, caffeine intake, and low-grade dysplasia while colonic adenomas trended towards significance. Notably, a history of statin or SSRI usage reduced the risk of EAC or HGD by 49% or 61%, respectively. Our study validated several known and identified several novel risk factors, including a history of colonic adenomas or caffeine usage. Low-grade dysplasia was a risk factor for progression but various endoscopic characteristics were not, suggesting that screening strategies should focus on histology instead. We identified SSRIs as a new potentially chemoprotective medication.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kambhampati S,Tieu AH,Luber B,Wang H,Meltzer SJdoi
10.1038/s41598-020-61874-7subject
Has Abstractpub_date
2020-03-17 00:00:00pages
4899issue
1issn
2045-2322pii
10.1038/s41598-020-61874-7journal_volume
10pub_type
杂志文章abstract：:Occlusion of the middle cerebral artery (MCA) by an intraluminal filament is widely used to study focal brain ischemia in male Sprague-Dawley rats. However, permanent occlusion goes along with a high fatality. To overcome this drawback we designed a new filament carrying a bowling pin-shaped tip (BP-tip) and compared ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28401
更新日期：2016-06-22 00:00:00
abstract：:Teleportation plays an important role in the communication of quantum information between the nodes of a quantum network and is viewed as an essential ingredient for long-distance Quantum Cryptography. We describe a method to teleport the quantum information carried by a photon in a superposition of a number d of ligh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03548
更新日期：2013-12-19 00:00:00
abstract：:Changes in the stability, hydrogen diffusion, and mechanical properties of the NbH phases from Ni-doping was studied by using first-principles methods. The calculation results reveal that the single H atom adsorption is energetically favorable at the tetrahedral interstitial site (TIS) and octahedral interstitial site...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06658-2
更新日期：2017-07-26 00:00:00
abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-56530-8
更新日期：2020-01-23 00:00:00
abstract：:A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32590-0
更新日期：2018-09-21 00:00:00
abstract：:Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06466-8
更新日期：2017-07-21 00:00:00
abstract：:During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01675-7
更新日期：2017-06-14 00:00:00
abstract：:Epilepsy, that comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups, is recognised as apasmara in the traditional medicinal system of Indian antiquity commonly known as Ayurveda. Towards exploring the molecular level complex regu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46715-6
更新日期：2019-07-22 00:00:00
abstract：:Mobile phone microscopes are a natural platform for point-of-care imaging, but current solutions require an externally powered illumination source, thereby adding bulk and cost. We present a mobile phone microscope that uses the internal flash or sunlight as the illumination source, thereby reducing complexity whilst ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21543-2
更新日期：2018-02-19 00:00:00
abstract：:Learning disability varies by month of conception. The underlying mechanism is unknown but vitamin D, necessary for normal brain development, is commonly deficient over winter in high latitude countries due to insufficient ultraviolet radiation. We linked the 2007-2016 Scottish School Pupil Censuses to Scottish matern...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45562-9
更新日期：2019-06-27 00:00:00
abstract：:In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tiss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08458-0
更新日期：2017-08-15 00:00:00
abstract：:Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15330-8
更新日期：2017-11-09 00:00:00
abstract：:Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67514-4
更新日期：2020-06-30 00:00:00
abstract：:There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45780
更新日期：2017-04-07 00:00:00
abstract：:Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09386-9
更新日期：2017-08-21 00:00:00
abstract：:Because of its novel physical properties, two-dimensional materials have attracted great attention. From first-principle calculations and vibration frequencies analysis, we predict a new family of two-dimensional materials based on the idea of octet stability: honeycomb lattices of pnictogens (N, P, As, Sb, Bi). The b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11512
更新日期：2015-06-30 00:00:00
abstract：:Nitrous oxide (N2O) is a potent greenhouse gas. In North China, vegetable fields are amended with high levels of N fertilizer and irrigation water, which causes massive N2O flux. The aim of this study was to determine the contribution of microbial processes to N2O production and characterize isotopic signature effects...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29257
更新日期：2016-07-08 00:00:00
abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67182-4
更新日期：2020-06-25 00:00:00
abstract：:Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09285-z
更新日期：2017-08-17 00:00:00
abstract：:Molecular dynamics (MD) simulations lasting 500 ns were performed in explicit water to investigate the effect of polarization on the binding of ligands to human α-thrombin based on the standard nonpolarizable AMBER force field and the quantum-derived polarized protein-specific charge (PPC). The PPC includes the electr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31488
更新日期：2016-08-10 00:00:00
abstract：:Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16064-3
更新日期：2017-11-20 00:00:00
abstract：:Lower corrected calcium (cCa) levels are associated with a better prognosis among incident dialysis patients. However, cCa frequently overestimates ionized calcium (iCa) levels. The prognostic importance of the true calcium status defined by iCa remains to be revealed. We conducted a retrospective cohort study of inci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61459-4
更新日期：2020-03-10 00:00:00
abstract：:CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30067
更新日期：2016-07-22 00:00:00
abstract：:This study aims to determine the prevalence of health personnel with normal weight central obesity and to investigate whether this group had higher cardiovascular disease (CVD) risk factors than those of the people with normal weight and without central obesity. A waist-to-height ratio was calculated as waist circumfe...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep37100
更新日期：2016-11-16 00:00:00
abstract：:Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and diffusion-based imaging can be used to characterize tissue microstructure. However, surprisingly few studies have examined the degree to which these MRI measures are related within and between various brain regions. Therefore, whole-brai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39199-x
更新日期：2019-02-21 00:00:00
abstract：:New treatments for oropharyngeal gonorrhoea are required to address rising antimicrobial resistance. We aimed to examine the efficacy of a 14-day course of mouthwash twice daily compared to standard treatment (antibiotic) for the treatment of oropharyngeal gonorrhoea. The OMEGA2 trial was a parallel-group and open-lab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76184-1
更新日期：2020-11-09 00:00:00
abstract：:The intensification of marine aquaculture raises multiple sustainability issues, namely the handling of nutrient-rich effluents that can adversely impact ecosystems. As integrated multi-trophic aquaculture (IMTA) gains momentum, the use of halophyte plants to phytoremediate aquaculture effluents has received growing a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66093-8
更新日期：2020-06-22 00:00:00
abstract：:Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36235-0
更新日期：2018-12-17 00:00:00
abstract：:The ZIC proteins are a family of transcription regulators with a well-defined zinc finger DNA-binding domain and there is evidence that they elicit functional DNA binding at a ZIC DNA binding site. Little is known, however, regarding domains within ZIC proteins that confer trans-activation or -repression. To address t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69917-9
更新日期：2020-08-04 00:00:00
abstract：:Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF1 plays a significa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11605-2
更新日期：2017-09-11 00:00:00
