Chronic unpredictable stress induces anxiety-like behaviors in young zebrafish.

Abstract:

:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vertebrate model in neuroscience research. We exposed zebrafish to a series of intermittent and unpredictable mild stressors from day 10 to 17 post-fertilization. The stressed fish showed a reduced exploration of a novel environment one day post-stress and an increased responsiveness to dark-light transition two days post-stress, indicative of heightened anxiety-related behaviors. The stress-induced decrease in exploration lasted for at least three days and returned to control levels within one week. Moreover, stressed fish were on average 8% smaller than their control siblings two days post-stress and returned to control levels within one week. All together, our results demonstrate that young zebrafish exposed to chronic unpredictable stress develop growth and behavioral alterations akin to those observed in rodent models.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Golla A,Østby H,Kermen F

doi

10.1038/s41598-020-67182-4

subject

Has Abstract

pub_date

2020-06-25 00:00:00

pages

10339

issue

1

issn

2045-2322

pii

10.1038/s41598-020-67182-4

journal_volume

10

pub_type

杂志文章
  • Work extraction from heat-powered quantized optomechanical setups.

    abstract::We analyze work extraction from an autonomous (self-contained) heat-powered optomechanical setup. The initial state of the quantized mechanical oscillator plays a key role. As the initial mean amplitude of the oscillator decreases, the resulting efficiency increases. In contrast to laser-powered self-induced oscillati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07809

    authors: Gelbwaser-Klimovsky D,Kurizki G

    更新日期:2015-01-15 00:00:00

  • The coupling of leaf, litter, and soil nutrients in warm temperate forests in northwestern China.

    abstract::The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12199-5

    authors: Zhang G,Zhang P,Peng S,Chen Y,Cao Y

    更新日期:2017-09-18 00:00:00

  • Switching of magnetic easy-axis using crystal orientation for large perpendicular coercivity in CoFe2O4 thin film.

    abstract::Perpendicular magnetization and precise control over the magnetic easy axis in magnetic thin film is necessary for a variety of applications, particularly in magnetic recording media. A strong (111) orientation is successfully achieved in the CoFe2O4 (CFO) thin film at relatively low substrate temperature of 100 °C, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30074

    authors: Shirsath SE,Liu X,Yasukawa Y,Li S,Morisako A

    更新日期:2016-07-20 00:00:00

  • Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons.

    abstract::PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20924

    authors: Xu J,Wang N,Luo JH,Xia J

    更新日期:2016-02-12 00:00:00

  • Joining Chemical Pressure and Epitaxial Strain to Yield Y-doped BiFeO3 Thin Films with High Dielectric Response.

    abstract::BiFeO3 is one of the most promising multiferroic materials but undergoes two major drawbacks: low dielectric susceptibility and high dielectric loss. Here we report high in-plane dielectric permittivity (ε' ∼2500) and low dielectric loss (tan δ < 0.01) obtained on Bi0.95Y0.05FeO3 films epitaxially grown on SrTiO3 (001...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25535

    authors: Scarisoreanu ND,Craciun F,Birjega R,Ion V,Teodorescu VS,Ghica C,Negrea R,Dinescu M

    更新日期:2016-05-09 00:00:00

  • Cell wall integrity signaling regulates cell wall-related gene expression in Chlamydomonas reinhardtii.

    abstract::An intact cell wall is critical for cellular interactions with the environment and protecting the cell from environmental challenges. Signaling mechanisms are necessary to monitor cell wall integrity and to regulate cell wall production and remodeling during growth and division cycles. The green alga, Chlamydomonas, h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48523-4

    authors: Cronmiller E,Toor D,Shao NC,Kariyawasam T,Wang MH,Lee JH

    更新日期:2019-08-21 00:00:00

  • A dynamically reconfigurable Fano metamaterial through graphene tuning for switching and sensing applications.

    abstract::We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02105

    authors: Amin M,Farhat M,Baǧcı H

    更新日期:2013-01-01 00:00:00

  • Droplet Controlled Growth Dynamics in Molecular Beam Epitaxy of Nitride Semiconductors.

    abstract::The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28984-9

    authors: Azadmand M,Barabani L,Bietti S,Chrastina D,Bonera E,Acciarri M,Fedorov A,Tsukamoto S,Nötzel R,Sanguinetti S

    更新日期:2018-07-26 00:00:00

  • UPLC-Tandem Mass Spectrometry for Quantification of Busulfan in Human Plasma: Application to Therapeutic Drug Monitoring.

    abstract::Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65919-9

    authors: Matar KM,Alshemmari SH,Refaat S,Anwar A

    更新日期:2020-06-02 00:00:00

  • Genomic Characterization of Diverse Gyroviruses Identified in the Feces of Domestic Cats.

    abstract::Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus, which consists of the chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported in chickens, humans, mice, and companion animals. To date, CAV has been identified in the f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49955-8

    authors: Niu JT,Yi SS,Dong GY,Guo YB,Zhao YL,Huang HL,Wang K,Hu GX,Dong H

    更新日期:2019-09-16 00:00:00

  • Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury.

    abstract::Platelet transfusions can cause adverse reactions in their recipients, including transfusion-related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of signaling pathways and the inflammatory role played by blood platelets remains controversial. Platelets are important in inflammation, part...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49040-0

    authors: Tariket S,Hamzeh-Cognasse H,Laradi S,Arthaud CA,Eyraud MA,Bourlet T,Berthelot P,Garraud O,Cognasse F

    更新日期:2019-08-29 00:00:00

  • Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

    abstract::The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40783

    authors: Chen R,Zhao X,Wang Y,Xie Y,Liu J

    更新日期:2017-01-18 00:00:00

  • Crotoxin promotes macrophage reprogramming towards an antiangiogenic phenotype.

    abstract::Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels. Angiogenesis has a key role in tumour growth and progression and is regulated by macrophage secret...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40903-0

    authors: de Araújo Pimenta L,de Almeida MES,Bretones ML,Cirillo MC,Curi R,Sampaio SC

    更新日期:2019-03-12 00:00:00

  • A new type of power energy for accelerating chemical reactions: the nature of a microwave-driving force for accelerating chemical reactions.

    abstract::The use of microwave (MW) irradiation to increase the rate of chemical reactions has attracted much attention recently in nearly all fields of chemistry due to substantial enhancements in reaction rates. However, the intrinsic nature of the effects of MW irradiation on chemical reactions remains unclear. Herein, the h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25149

    authors: Zhou J,Xu W,You Z,Wang Z,Luo Y,Gao L,Yin C,Peng R,Lan L

    更新日期:2016-04-27 00:00:00

  • Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.

    abstract::Alternative splicing of cancer-related genes is a common cellular mechanism accounting for cancer cell transcriptome complexity and affecting cell cycle control, proliferation, apoptosis, angiogenesis, invasion, and metastasis. In this study, we describe the discovery and molecular cloning of thirty novel transcripts ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16269-6

    authors: Adamopoulos PG,Kontos CK,Scorilas A

    更新日期:2017-12-11 00:00:00

  • Helical organization of microtubules occurs in a minority of tunneling membrane nanotubes in normal and cancer urothelial cells.

    abstract::Tunneling membrane nanotubes (TnTs) are membrane protrusions connecting nearby or distant cells in vitro and in vivo. Functions of TnTs in cellular processes are various and rely on TnT structure, which also depends on cytoskeletal composition. In the present study, we focused on the organization of microtubules (MTs)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35370-y

    authors: Resnik N,Prezelj T,De Luca GMR,Manders E,Polishchuk R,Veranič P,Kreft ME

    更新日期:2018-11-20 00:00:00

  • Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation.

    abstract::Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiologi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31656

    authors: Chen L,Li B,Chen B,Shao Y,Luo Q,Shi X,Chen Y

    更新日期:2016-08-22 00:00:00

  • A Sustainable Nanocomposite Au(Salen)@CC for Catalytic Degradation of Eosin Y and Chromotrope 2R Dyes.

    abstract::Up to now, a very few catalysts have been developed approaching the heterogeneous catalytic degradation of Eosin Y and Chromotrope 2R dyes (Acid Red 29). The present study provides a complete perspective of recyclable nanocomposite Au(Salen)@CC for catalytic degradation of hazardous water pollutant dyes viz., Eosin Y ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07707-6

    authors: Mayani VJ,Mayani SV,Kim SW

    更新日期:2017-08-03 00:00:00

  • Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells.

    abstract::Decitabine has been found to have anti-metabolic and anti-tumor activities in various tumor cells. Recently, the use of decitabine in combination with other conventional therapies reportedly resulted in improved anti-tumor activity against various tumors. Ionizing radiation (IR) is widely used as a cancer treatment. D...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32470

    authors: Son CH,Lee HR,Koh EK,Shin DY,Bae JH,Yang K,Park YS

    更新日期:2016-09-27 00:00:00

  • Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.

    abstract::Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-017-11852-3

    authors: Rietschel L,Streit F,Zhu G,McAloney K,Frank J,Couvy-Duchesne B,Witt SH,Binz TM,CORtisolNETwork (CORNET) Consortium.,Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC).,McGrath J,Hickie IB,Hansell

    更新日期:2017-11-10 00:00:00

  • A High Throughput Ambient Mass Spectrometric Approach to Species Identification and Classification from Chemical Fingerprint Signatures.

    abstract::A high throughput method for species identification and classification through chemometric processing of direct analysis in real time (DART) mass spectrometry-derived fingerprint signatures has been developed. The method entails introduction of samples to the open air space between the DART ion source and the mass spe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11520

    authors: Musah RA,Espinoza EO,Cody RB,Lesiak AD,Christensen ED,Moore HE,Maleknia S,Drijfhout FP

    更新日期:2015-07-09 00:00:00

  • The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin.

    abstract::Defective hepatic autophagy is observed in obesity and diabetes, whereas autophagy is inhibited by insulin in hepatocytes. Insulin-induced anti-autophagy is mediated by non-canonical Gαi3 signaling via an unknown mechanism. Previously, we identified the anti-autophagic activity of Tnfaip8 via activation of mammalian t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06576-3

    authors: Kim JS,Park J,Kim MS,Ha JY,Jang YW,Shin DH,Son JH

    更新日期:2017-07-24 00:00:00

  • Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis.

    abstract::Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-langua...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-020-68082-3

    authors: Kotepui M,Kotepui KU,De Jesus Milanez G,Masangkay FR

    更新日期:2020-07-06 00:00:00

  • Effect of the phenoxy groups on PDIB and its derivatives.

    abstract::The anisotropic hole and electron mobilities in N,N'-3,4,9,10-perylenediimide-1,7-phenoxy (PDIB-2OPh) and N,N'-3,4,9,10-perylenediimide (PDIB) were theoretically predicted using the Marcus-Hush theory. The substituent effect of phenoxy on their mobility rates, absorption spectra, electron affinities, and ionization po...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35555

    authors: Song P,Guan B,Zhou Q,Zhao M,Huang J,Ma F

    更新日期:2016-10-19 00:00:00

  • Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and ...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41598-019-39998-2

    authors: Pelusi S,Baselli G,Pietrelli A,Dongiovanni P,Donati B,McCain MV,Meroni M,Fracanzani AL,Romagnoli R,Petta S,Grieco A,Miele L,Soardo G,Bugianesi E,Fargion S,Aghemo A,D'Ambrosio R,Xing C,Romeo S,De Francesco R,Reeves

    更新日期:2019-03-06 00:00:00

  • Machine-learning techniques for geochemical discrimination of 2011 Tohoku tsunami deposits.

    abstract::Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07077

    authors: Kuwatani T,Nagata K,Okada M,Watanabe T,Ogawa Y,Komai T,Tsuchiya N

    更新日期:2014-11-17 00:00:00

  • A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions.

    abstract::NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer r...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41598-017-11709-9

    authors: Rodrigo JP,Villaronga MÁ,Menéndez ST,Hermida-Prado F,Quer M,Vilaseca I,Allonca E,Pedregal Mallo D,Astudillo A,García-Pedrero JM

    更新日期:2017-09-11 00:00:00

  • Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson.

    abstract::Channelrhodopsins are light-gated ion channels of green algae used for the precise temporal and spatial control of transmembrane ion fluxes. The channelrhodopsin Chrimson from Chlamydomonas noctigama allows unprecedented deep tissue penetration due to peak absorption at 590 nm. We demonstrate by electrophysiological r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09600-8

    authors: Vierock J,Grimm C,Nitzan N,Hegemann P

    更新日期:2017-08-30 00:00:00

  • A study on mechanism of resistance distribution characteristics of oxide-based resistive memory.

    abstract::Although oxide-based resistive switching memory (OxRAM) is one of the strong next-generation high capacity memory candidates, it has the critical disadvantage that deviations of resistance levels is too severe to be adopted as a high capacity memory device. More specifically, it is known that the larger on/off current...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35838-x

    authors: Hur JH,Kim DK

    更新日期:2019-01-22 00:00:00

  • Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.

    abstract::Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with clinicopathologic parameters are used to classify breast cancer and to predict disease outcome. Triple-negative breast cancer (TNBC) is a particular typ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44414

    authors: Manica GC,Ribeiro CF,Oliveira MA,Pereira IT,Chequin A,Ramos EA,Klassen LM,Sebastião AP,Alvarenga LM,Zanata SM,Noronha L,Rabinovich I,Costa FF,Souza EM,Klassen G

    更新日期:2017-03-15 00:00:00