Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast.

abstract：:Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly fo...

journal_title：Scientific reports

authors： Shirasawa H,Matsumura N,Shimoda M,Oki S,Yoda M,Tohmonda T,Kanai Y,Matsumoto M,Nakamura M,Horiuchi K

更新日期：2017-01-31 00:00:00

abstract：:The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversi...

journal_title：Scientific reports

authors： Zhang Y,Liu C,Liu J,Guo R,Yan Z,Liu W,Lau WB,Jiao X,Cao J,Xu K,Jia Y,Ma X,Wang Y

更新日期：2020-01-21 00:00:00

abstract：:Saccharomyces cerevisiae is a robust host for heterologous protein expression. The efficient expression of cellulases in S. cerevisiae is important for the consolidated bioprocess that directly converts lignocellulose into valuable products. However, heterologous proteins are often N-hyperglycosylated in S. cerevisiae...

journal_title：Scientific reports

authors： Tang H,Wang S,Wang J,Song M,Xu M,Zhang M,Shen Y,Hou J,Bao X

更新日期：2016-05-09 00:00:00

abstract：:Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV...

journal_title：Scientific reports

authors： Hsu HL,Millet JK,Costello DA,Whittaker GR,Daniel S

更新日期：2016-10-18 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Qiao Y,Berg AL,Wang P,Ge Y,Quan S,Zhou S,Wang H,Liu Z,Gong R

更新日期：2020-09-21 00:00:00

abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...

journal_title：Scientific reports

authors： Tzeng YC,Dai L,Chung MC,Amico L,Kwek LC

更新日期：2016-05-24 00:00:00

abstract：:A relation exists between network proximity of molecular entities in interaction networks, functional similarity and association with diseases. The identification of network regions associated with biological functions and pathologies is a major goal in systems biology. We describe a network diffusion-based pipeline f...

journal_title：Scientific reports

authors： Bersanelli M,Mosca E,Remondini D,Castellani G,Milanesi L

更新日期：2016-10-12 00:00:00

abstract：:Little is known of how fungal distribution ranges vary with elevation. We studied fungal diversity and community composition from 740 to 2940 m above sea level on Mt. Norikura, Japan, sequencing the ITS2 region. There was a clear trend, repeated across each of the fungal phyla (Basidiomycota, Ascomycota, Zygomycota, C...

journal_title：Scientific reports

authors： Ogwu MC,Takahashi K,Dong K,Song HK,Moroenyane I,Waldman B,Adams JM

更新日期：2019-04-25 00:00:00

abstract：:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...

journal_title：Scientific reports

authors： Zhang L,Xue X,Yan J,Yan LY,Jin XH,Zhu XH,He ZZ,Liu J,Li R,Qiao J

更新日期：2016-07-14 00:00:00

abstract：:Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and a leading cause of nosocomial infections. P. aerug...

journal_title：Scientific reports

authors： Lloyd MG,Vossler JL,Nomura CT,Moffat JF

更新日期：2019-04-30 00:00:00

abstract：:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal med...

journal_title：Scientific reports

authors： Bauer J,Klingelhöfer D,Maier W,Schwettmann L,Groneberg DA

更新日期：2020-11-05 00:00:00

abstract：:Fibrous scaffolds are used for bone tissue engineering purposes with great success across a variety of polymers with different physical and chemical properties. It is now evident that the correct degree of curvature promotes increased cytoskeletal tension on osteoprogenitors leading to osteogenic differentiation. Howe...

journal_title：Scientific reports

authors： Ozdemir T,Bowers DT,Zhan X,Ghosh D,Brown JL

更新日期：2019-01-30 00:00:00

abstract：:Lnc2Catlas ( http://lnc2catlas.bioinfotech.org/ ) is an atlas of long noncoding RNAs (lncRNAs) associated with cancer risk. LncRNAs are a class of functional noncoding RNAs with lengths over 200 nt and play a vital role in diverse biological processes. Increasing evidence shows that lncRNA dysfunction is associated wi...

journal_title：Scientific reports

authors： Ren C,An G,Zhao C,Ouyang Z,Bo X,Shu W

更新日期：2018-01-30 00:00:00

abstract：:Intermediate level radioactive waste (ILW) generally contains a heterogeneous range of organic and inorganic materials, of which some are encapsulated in cement. Of particular concern are cellulosic waste items, which will chemically degrade under the conditions predicted during waste disposal, forming significant qua...

journal_title：Scientific reports

authors： Kuippers G,Boothman C,Bagshaw H,Ward M,Beard R,Bryan N,Lloyd JR

更新日期：2018-06-08 00:00:00

abstract：:Parthenocarpy is the development of an ovary into a seedless fruit without pollination. The ubiquitous downregulation of SlIAA9 induces not only parthenocarpic fruit formation but also an abnormal vegetative phenotype. To make parthenocarpic transgenic tomato plants without unwanted phenotypes, we found two genes, nam...

journal_title：Scientific reports

authors： Kim JS,Ezura K,Lee J,Ariizumi T,Ezura H

更新日期：2019-12-11 00:00:00

abstract：:Present study, for the first time, reports the development of a nanohybridized baculovirus based stent that can locally promote vascular re-endothelialization by efficient delivery of pro-angiogenic vascular endothelial growth factor (Vegf) genes. In vitro data demonstrated rapid expression of functionally active Vegf...

journal_title：Scientific reports

authors： Paul A,Elias CB,Shum-Tim D,Prakash S

更新日期：2013-01-01 00:00:00

abstract：:Cancer cachexia is a complex multi-organ syndrome characterized by body weight loss, weakness, muscle atrophy and fat depletion. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. Our latest results highlighted microb...

journal_title：Scientific reports

authors： Pötgens SA,Brossel H,Sboarina M,Catry E,Cani PD,Neyrinck AM,Delzenne NM,Bindels LB

更新日期：2018-08-17 00:00:00

abstract：:This study was to evaluate the effectiveness of oral hygiene care in improving oral health- and health-related quality of life (OHRQoL and HRQoL) among patients receiving outpatient stroke rehabilitation. Subjects were randomized to: (1) a conventional oral hygiene care programme (COHCP) comprising a manual toothbrush...

journal_title：Scientific reports

authors： Dai R,Lam OLT,Lo ECM,Li LSW,McGrath C

更新日期：2017-08-09 00:00:00

abstract：:Rubber-filler composites are a key component in the manufacture of tyres. The filler provides mechanical reinforcement and additional wear resistance to the rubber, but it in turn introduces non-linear mechanical behaviour to the material which most likely arises from interactions between the filler particles, mediate...

journal_title：Scientific reports

authors： Staniewicz L,Vaudey T,Degrandcourt C,Couty M,Gaboriaud F,Midgley P

更新日期：2014-12-09 00:00:00

abstract：:Lower cervical dislocation with facet interlocking is one of the most drastic injuries to the cervical spine. The early reduction is thought critical in preventing progressive secondary spinal cord injury. The authors report a new surgical procedure in the management of lower cervical dislocation with facet interlocki...

journal_title：Scientific reports

authors： Li Y,Zhou P,Cui W,Li C,Xiao W,Wen Y,Wang H,Wang H

更新日期：2019-02-04 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:Hundreds of cellular host factors are required to support dengue virus infection, but their identity and roles are incompletely characterized. Here, we identify human host dependency factors required for efficient dengue virus-2 (DENV2) infection of human cells. We focused on two, TTC35 and TMEM111, which we previousl...

journal_title：Scientific reports

authors： Barrows NJ,Anglero-Rodriguez Y,Kim B,Jamison SF,Le Sommer C,McGee CE,Pearson JL,Dimopoulos G,Ascano M,Bradrick SS,Garcia-Blanco MA

更新日期：2019-07-04 00:00:00

abstract：:The Ebola filovirus causes severe hemorrhagic fever with a high fatality rate in humans. The primary structural matrix protein VP40 displays transformer-protein characteristics and exists in different conformational and oligomeric states. VP40 plays crucial roles in viral assembly and budding at the plasma membrane of...

journal_title：Scientific reports

authors： Pavadai E,Gerstman BS,Chapagain PP

更新日期：2018-06-27 00:00:00

abstract：:Animal models are extensively used to evaluate the in vivo functionality of novel drug delivery systems (DDS). However, many variations likely exist in vivo between the animals and human physiological environment that significantly alter results obtained with animal models relative to human system. To date, it is not ...

journal_title：Scientific reports

authors： Namdee K,Carrasco-Teja M,Fish MB,Charoenphol P,Eniola-Adefeso O

更新日期：2015-06-26 00:00:00

abstract：:Small ruminant lentiviruses (SRLVs) are found in sheep in Germany and Iran. SRLVs have been classified into four genotypes: A-C and E. Genotype A has been subdivided into 20 subtypes. Previous studies suggested that, first, the ancestors of genotype A are those SRLVs found in Turkey, second, the evolution of SRLVs is ...

journal_title：Scientific reports

authors： Molaee V,Bazzucchi M,De Mia GM,Otarod V,Abdollahi D,Rosati S,Lühken G

更新日期：2020-02-10 00:00:00

abstract：:Ultrasound has significantly increased safety and effectiveness in regional anesthesia. However, little is known about its clinical use. We studied clinical approaches currently used by anesthesiologists, conducted a nationwide survey, and analyzed data collected in ordered logistic regression models. All active membe...

journal_title：Scientific reports

authors： Luedi MM,Upadek V,Vogt AP,Steinfeldt T,Eichenberger U,Sauter AR

更新日期：2019-06-24 00:00:00

abstract：:Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, ...

journal_title：Scientific reports

authors： Jiang F,Peng P

更新日期：2016-09-07 00:00:00

abstract：:Detailed measurements of physical, chemical and biological dynamics in groundwater are key to understanding the important processes in place and their influence on water quality - particularly when used for drinking water. Measuring temporal bacterial dynamics at high frequency is challenging due to the limitations in...

journal_title：Scientific reports

authors： Besmer MD,Epting J,Page RM,Sigrist JA,Huggenberger P,Hammes F

更新日期：2016-12-07 00:00:00

abstract：:Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...

journal_title：Scientific reports

authors： Chen R,Cui Y,Tian H,Yao R,Liu Z,Shu Y,Li C,Yang Y,Ren T,Zhang G,Zou R

更新日期：2015-03-09 00:00:00