Abstract:
:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined the preventive effects of an SGLT2 inhibitor canagliflozin (CANA) in Western diet (WD)-fed melanocortin 4 receptor-deficient (MC4R-KO) mice, a mouse model of human NASH. An eight-week CANA treatment attenuated hepatic steatosis in WD-fed MC4R-KO mice, with increased epididymal fat mass without inflammatory changes. CANA treatment for 20 weeks inhibited the development of hepatic fibrosis in WD-fed MC4R-KO mice. After one year of CANA treatment, the number of liver tumors was significantly reduced in WD-fed MC4R-KO mice. In adipose tissue, CANA suppressed the ratio of oxidative to reduced forms of glutathiones (GSSG/GSH) in WD-fed MC4R-KO mice. Treatment with GSH significantly attenuated the H2O2-induced upregulation of genes related to NADPH oxidase in 3T3-L1 adipocytes, and that of Il6, Tgfb, and Pdgfb in RAW264.7 cells. This study provides evidence that SGLT2 inhibitors represent the unique class of drugs that can attenuate or delay the onset of NASH and eventually hepatocellular carcinoma, at least partly, through "healthy adipose expansion".
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shiba K,Tsuchiya K,Komiya C,Miyachi Y,Mori K,Shimazu N,Yamaguchi S,Ogasawara N,Katoh M,Itoh M,Suganami T,Ogawa Ydoi
10.1038/s41598-018-19658-7subject
Has Abstractpub_date
2018-02-05 00:00:00pages
2362issue
1issn
2045-2322pii
10.1038/s41598-018-19658-7journal_volume
8pub_type
杂志文章abstract::Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19787
更新日期:2016-01-25 00:00:00
abstract::Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79748-3
更新日期:2021-01-08 00:00:00
abstract::Dual terahertz (THz) comb spectroscopy enables high spectral resolution, high spectral accuracy, and broad spectral coverage; however, the requirement for dual stabilized femtosecond lasers hampers its versatility. We here report the first demonstration of dual THz comb spectroscopy using a single free-running fibre l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29403-9
更新日期:2018-07-24 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44657-7
更新日期:2019-06-05 00:00:00
abstract::This paper reports on 3D phase field simulations of IMC growth in Co/Sn and Cu/Sn solder systems. In agreement with experimental micrographs, we obtain uniform growth of the CoSn3 phase in Co/Sn solder joints and a non-uniform wavy morphology for the Cu6Sn5 phase in Cu/Sn solder joints. Furthermore, simulations were p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51179-9
更新日期:2019-10-16 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63150-0
更新日期:2020-04-09 00:00:00
abstract::High-performance locally resonant metamaterials represent the next frontier in materials technology due to their extraordinary properties obtained through materials design, enabling a variety of potential applications. The most exceptional feature of locally resonant metamaterials is the subwavelength size of their un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68894-3
更新日期:2020-07-21 00:00:00
abstract::The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43500
更新日期:2017-02-27 00:00:00
abstract::Excess Phosphorus (P) in agriculture is causing serious environmental problems like eutrophication of lakes and rivers. Unlike the enormous information available for phosphate starvation response (P0), very few information is available for the effect of excess phosphate Pi on plants. Characterization of Excess Phospha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03061-9
更新日期:2017-06-08 00:00:00
abstract::Optical imaging and photolithography promise broad applications in nano-electronics, metrologies, and single-molecule biology. Light diffraction however sets a fundamental limit on optical resolution, and it poses a critical challenge to the down-scaling of nano-scale manufacturing. Surface plasmons have been used to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00175
更新日期:2011-01-01 00:00:00
abstract::Metal sulfides are of great interest for future electrode materials in supercapacitor and solar cell applications owing to their superior electrochemical activity and excellent electrical conductivity. With this scope, a binary transition metal sulfide (CoS) is prepared via one-step hydrothermal synthesis. Hexagonal p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37463-0
更新日期:2019-02-04 00:00:00
abstract::Recent work reveals that the extinction of conditioned fear depends upon the interval between conditioning and extinction. Extinction training that takes place within minutes to hours after fear conditioning fails to produce a long-term extinction memory, a phenomenon known as the immediate extinction deficit (IED). N...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46010-4
更新日期:2019-07-01 00:00:00
abstract::Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regulates receptor trafficking in two ways. We found GPCR/14-3-3 interact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47478-w
更新日期:2019-08-01 00:00:00
abstract::Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26978
更新日期:2016-06-01 00:00:00
abstract::Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18406
更新日期:2015-12-18 00:00:00
abstract::Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg1MDW), which overexpress this neurosensory-specific miRNA cluster in the inner ear, were developed as...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21811-1
更新日期:2018-02-23 00:00:00
abstract::Coxsackievirus A24 variant (CVA24v) is a major causative agent of acute hemorrhagic conjunctivitis outbreaks worldwide, yet the evolutionary and transmission dynamics of the virus remain unclear. To address this, we analyzed and compared the 3C and partial VP1 gene regions of CVA24v isolates obtained from five outbrea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70436-w
更新日期:2020-08-13 00:00:00
abstract::Insecticide-treated nets (ITNs) remain major components for vector control despite the spread of resistance mechanisms among mosquito populations. Multiple exposures to pyrethroids may induce physiological and behavioral changes in mosquitoes, possibly reducing efficacy of control tools. Despite epidemiological releva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44633-1
更新日期:2019-06-03 00:00:00
abstract::The patterns of evolution and expression of tissue-specific genes are poorly understood beyond sex-specific genes. Accordingly, we identified 3,191 tissue-specific genes and 38,745 common genes using 22 RNA-seq datasets from cultivated peanut. The expression levels of tissue-specific genes were significantly lower tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09905-8
更新日期:2017-08-21 00:00:00
abstract::Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-11852-3
更新日期:2017-11-10 00:00:00
abstract::Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10738
更新日期:2015-06-04 00:00:00
abstract::Among patients with non-small cell lung cancer (NSCLC), best supportive care (BSC) is well-known to improve patient's quality of life and prolong survival. This study aimed to clarify (1) the decision-making factors of BSC alone and (2) the prognostic factors after selection of no further anticancer therapies. We retr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56431-w
更新日期:2019-12-27 00:00:00
abstract::Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12355-x
更新日期:2017-09-28 00:00:00
abstract::A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12028
更新日期:2015-07-06 00:00:00
abstract::Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30033-4
更新日期:2018-08-02 00:00:00
abstract::Efficient control of magnetism with electric means is a central issue of current spintronics research, which opens an opportunity to design integrated spintronic devices. However, recent well-studied methods are mostly based on electric-current injection, and they are inevitably accompanied by considerable energy loss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46009-x
更新日期:2019-07-02 00:00:00
abstract::The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18104
更新日期:2015-12-08 00:00:00
abstract::The function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a tissue microarray containing more than 600 esophageal cancers was analyzed. In non-neoplastic esophageal mucos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35459-4
更新日期:2018-11-26 00:00:00
abstract::In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33180
更新日期:2016-09-12 00:00:00
abstract::Cas13 endonuclease activity depends on the RNA local secondary structure with strong preference for single-stranded (SS) regions. Hence, it becomes indispensable to identify the SS regions for effective Cas13 mediated RNA knockdown. We herein present rational gRNA design by integrating experimental structure-seq data ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68459-4
更新日期:2020-07-14 00:00:00