Abstract：
:In recent years, texture analysis of medical images has become increasingly popular in studies investigating diagnosis, classification and treatment response assessment of cancerous disease. Despite numerous applications in oncology and medical imaging in general, there is no consensus regarding texture analysis workflow, or reporting of parameter settings crucial for replication of results. The aim of this study was to assess how sensitive Haralick texture features of apparent diffusion coefficient (ADC) MR images are to changes in five parameters related to image acquisition and pre-processing: noise, resolution, how the ADC map is constructed, the choice of quantization method, and the number of gray levels in the quantized image. We found that noise, resolution, choice of quantization method and the number of gray levels in the quantized images had a significant influence on most texture features, and that the effect size varied between different features. Different methods for constructing the ADC maps did not have an impact on any texture feature. Based on our results, we recommend using images with similar resolutions and noise levels, using one quantization method, and the same number of gray levels in all quantized images, to make meaningful comparisons of texture feature results between different subjects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Brynolfsson P,Nilsson D,Torheim T,Asklund T,Karlsson CT,Trygg J,Nyholm T,Garpebring Adoi
10.1038/s41598-017-04151-4subject
Has Abstractpub_date
2017-06-22 00:00:00pages
4041issue
1issn
2045-2322pii
10.1038/s41598-017-04151-4journal_volume
7pub_type
杂志文章abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21317-w
更新日期：2018-02-12 00:00:00
abstract：:Based on the geological conditions of overburden rock, the dynamic development law of overburden breakage was investigated by theoretical analysis and similarity model experiments in this paper. The formula of the compressive strength and No. ratio was obtained by testing the compressive strength of cylinder samples o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63526-2
更新日期：2020-04-16 00:00:00
abstract：:A variety of animals use Earth's magnetic field as a reference for their orientation behaviour. Although distinctive magnetoreception mechanisms have been postulated for many migrating or homing animals, the molecular mechanisms are still undefined. In this study, we found that zebrafish, a model organism suitable for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00727
更新日期：2012-01-01 00:00:00
abstract：:The molecular mechanisms behind aneurysmal subarachnoid haemorrhage (aSAH) are still poorly understood. Expression patterns of miRNAs may help elucidate the post-transcriptional gene expression in aSAH. Here, we evaluate the global miRNAs expression profile (miRnome) of patients with aSAH to identify potential biomark...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27078-w
更新日期：2018-06-08 00:00:00
abstract：:The ability to predict others' behaviour represents a crucial mechanism which allows individuals to react faster and more appropriately. To date, several studies have investigated humans' ability to predict conspecifics' behaviour, but little is known on our ability to predict behaviour in other species. Here, we aime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78275-5
更新日期：2020-12-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62994-w
更新日期：2020-04-24 00:00:00
abstract：:Nicotine is the psychoactive agent involved in nicotine dependence. However, nicotine as a drug, and its effects on human psychology are largely under-investigated in genetic studies. In this study, we recruited 208 current non-smokers to evaluate the effect of nicotine and its relationship to genetic risks to nicotin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09521
更新日期：2015-03-31 00:00:00
abstract：:Methylacetoin (3-hydroxy-3-methylbutan-2-one) and 2-methyl-2,3-butanediol are currently obtained exclusively via chemical synthesis. Here, we report, to the best of our knowledge, the first alternative route, using engineered Escherichia coli. The biological synthesis of methylacetoin was first accomplished by reversi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02445
更新日期：2013-01-01 00:00:00
abstract：:L-R (left and right) symmetry breaking during embryogenesis and the establishment of asymmetric body plan are key issues in developmental biology, but the onset including the handedness-determining gene locus still remains unknown. Using pure dextral (DD) and sinistral (dd) strains of the pond snail Lymnaea stagnalis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34809
更新日期：2016-10-06 00:00:00
abstract：:Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR am...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42250
更新日期：2017-02-10 00:00:00
abstract：:In recent years, microbial cholesterol oxidases have gained great attention due to its widespread use in medical applications for serum cholesterol determination. Streptomyces aegyptia strain NEAE-102 exhibited high level of extracellular cholesterol oxidase production using a minimum medium containing cholesterol as ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20786-3
更新日期：2018-02-09 00:00:00
abstract：:Huanglongbing (HLB) (citrus greening disease) is one of the most serious bacterial diseases of citrus. It is caused by (1) Candidatus Liberibacter africanus, transmitted by Trioza erytreae and (2) C.L. asiaticus and C.L. americanus, transmitted by Diaphorina citri. As part of a multidisciplinary project on D. citri (w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64132-y
更新日期：2020-04-28 00:00:00
abstract：:Science, being a social enterprise, is subject to fragmentation into groups that focus on specialized areas or topics. Often new advances occur through cross-fertilization of ideas between sub-fields that otherwise have little overlap as they study dissimilar phenomena using different techniques. Thus to explore the n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00551
更新日期：2012-01-01 00:00:00
abstract：:All-spin logic device (ASLD) has attracted increasing interests as one of the most promising post-CMOS device candidates, thanks to its low power, non-volatility and logic-in-memory structure. Here we investigate the key current-limiting factors and develop a physics-based model of ASLD through nano-magnet switching, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14905
更新日期：2015-10-09 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-24103-w
更新日期：2018-04-13 00:00:00
abstract：:Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03424-2
更新日期：2017-06-19 00:00:00
abstract：:Great Indian Bustard (GIB) is listed as Critically Endangered, with less than 250 individuals surviving in three fragmented populations. The species is under tremendous threat due to various anthropogenic pressures. Effective management and conservation of GIB requires a proper monitoring protocol, which we propose us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48193-2
更新日期：2019-08-12 00:00:00
abstract：:Asymmetric transmission (AT) devices are fundamental elements for optical computing and information processing. We here propose an AT device consisting of a pair of coupled complementary subwavelength gratings. Different from previous works, asymmetric dielectric environment is employed for unidirectional excitation o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53586-4
更新日期：2019-11-19 00:00:00
abstract：:In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70137-4
更新日期：2020-08-12 00:00:00
abstract：:Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) and inhibited with Dickkopf-related protein 1 (DKK1). Treatment of bovine embryos with AMBMP at da...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01266
更新日期：2013-01-01 00:00:00
abstract：:CRISPR/Cas9-derived RNA-guided nucleases (RGNs) are DNA targeting systems, which are rapidly being harnessed for gene regulation and gene editing purposes in model organisms and cell lines. As bona fide gene delivery vehicles, viral vectors may be particularly fit to broaden the applicability of RGNs to other cell typ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05105
更新日期：2014-05-29 00:00:00
abstract：:Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06856
更新日期：2014-10-31 00:00:00
abstract：:Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31604
更新日期：2016-08-17 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-49306-7
更新日期：2019-09-03 00:00:00
abstract：:Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macu...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-60674-3
更新日期：2020-03-02 00:00:00
abstract：:We evaluated the effect of separately adding two sources of lanthanum (La), LaCl3 and La(NO3)3 × 6H2O at a concentration of 40 µM each, to the preservative solution of 15 cut tulip flower varieties. Ascorbic acid (AsA; 0.2 g/L) was used as a reference solution, while distilled water was used as control. The variety La...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61200-1
更新日期：2020-03-06 00:00:00
abstract：:Pinus pinaster bark, an abundant by-product from the timber industry, has been studied as a potential low-cost adsorbent for the removal of Congo red (CR) dye from wastewaters. Surface morphological and physico-chemical characteristics of pine bark were analysed using Fourier transform infrared (FTIR) spectroscopy, sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53046-z
更新日期：2019-11-11 00:00:00
abstract：:The lateral movement of soil carbon has a profound effect on the carbon budget of terrestrial ecosystems; however, it has never been quantified in China, which is one of the strongest soil erosion areas in the world. In this study, we estimated that the overall soil erosion in China varies from 11.27 to 18.17 Pg yr(-1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07247
更新日期：2014-11-28 00:00:00
abstract：:We propose and demonstrate an on-chip optofluidic device allowing active oscillatory microrheological measurements with sub-μL sample volume, low cost and high flexibility. Thanks to the use of this optofluidic microrheometer it is possible to measure the viscoelastic properties of complex fluids in the frequency rang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62628-1
更新日期：2020-04-02 00:00:00
abstract：:Production of reactive nitrogen species (NO) is a key step in the immune response following infections. NO induces lesions to bacterial DNA, thus limiting bacterial growth within hosts. Using two pathogenic bacteria, Bacillus cereus and Shigella flexneri, we show that the DNA-repair protein Mfd (Mutation-Frequency-Dec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29349
更新日期：2016-07-20 00:00:00
