Abstract：
:Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metastasis have identified many new susceptibility MS genes. However, the comprehensive illustration of diverse cellular processes regulated by metastasis suppressors during the metastasis cascade is lacking. Thus, the relationship between MS genes and cancer risk is still unclear. To unveil the cellular complexity of MS genes, we have constructed MSGene (http://MSGene.bioinfo-minzhao.org/), the first literature-based gene resource for exploring human MS genes. In total, we manually curated 194 experimentally verified MS genes and mapped to 1448 homologous genes from 17 model species. Follow-up functional analyses associated 194 human MS genes with epithelium/tissue morphogenesis and epithelia cell proliferation. In addition, pathway analysis highlights the prominent role of MS genes in activation of platelets and coagulation system in tumor metastatic cascade. Moreover, global mutation pattern of MS genes across multiple cancers may reveal common cancer metastasis mechanisms. All these results illustrate the importance of MSGene to our understanding on cell development and cancer metastasis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao M,Li Z,Qu Hdoi
10.1038/srep15478subject
Has Abstractpub_date
2015-10-21 00:00:00pages
15478issn
2045-2322pii
srep15478journal_volume
5pub_type
杂志文章abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19658-7
更新日期：2018-02-05 00:00:00
abstract：:After active lengthening contractions, a given amount of force can be maintained with less muscle activation compared to pure isometric contractions at the same muscle length and intensity. This increase in neuromuscular efficiency is associated with mechanisms of stretch-induced residual force enhancement. We hypothe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39052
更新日期：2016-12-14 00:00:00
abstract：:Intense geomagnetic storms can cause severe damage to electrical systems and communications. This work proposes a counting process with Weibull inter-occurrence times in order to estimate the probability of extreme geomagnetic events. It is found that the scale parameter of the inter-occurrence time distribution grows...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38918-8
更新日期：2019-02-20 00:00:00
abstract：:The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57996-7
更新日期：2020-01-23 00:00:00
abstract：:IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08315-0
更新日期：2017-08-11 00:00:00
abstract：:Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPAR) to the postsynaptic membrane. PSD-95 disruption has recently been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45971-w
更新日期：2019-07-01 00:00:00
abstract：:Since its recent foundation, phase-coherent caloritronics has sparkled continuous interest giving rise to numerous concrete applications. This research field deals with the coherent manipulation of heat currents in mesoscopic superconducting devices by mastering the Josephson phase difference. Here, we introduce a new...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30268-1
更新日期：2018-08-16 00:00:00
abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73815-5
更新日期：2020-10-07 00:00:00
abstract：:Haloarchaea are unique microorganism's resistant to environmental and osmotic stresses and thrive in their habitats despite extreme fluctuating salinities. In the present study, haloarchaea were isolated from hypersaline thalossohaline salterns of Bhandup, Mumbai, India and were identified as Haloferax prahovense, Hal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25642
更新日期：2016-05-27 00:00:00
abstract：:We report the counterintuitive mechanism of increasing boiling heat transfer by incorporating low-conductivity materials at the interface between the surface and fluid. By embedding an array of non-conductive lines into a high-conductivity substrate, in-plane variations in the local surface temperature are created. Du...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13145
更新日期：2015-08-18 00:00:00
abstract：:Terrestrial arthropod fauna have been suggested as a key indicator of ecological integrity in forest systems. Because phenotypic identification is expert-limited, a shift towards DNA metabarcoding could improve scalability and democratize the use of forest floor arthropods for biomonitoring applications. The objective...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54532-0
更新日期：2019-12-03 00:00:00
abstract：:Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosis and portal hypertension and in experimental mouse fibrosis. We foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72172-7
更新日期：2020-09-23 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult-to-treat infection. Increasing efforts have been taken to mitigate the epidemics and to avoid potential outbreaks in low endemic settings. Understanding the population dynamics of MRSA is essential to identify the causal mechanisms driving the epidemics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66270-9
更新日期：2020-06-09 00:00:00
abstract：:In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36814
更新日期：2016-11-14 00:00:00
abstract：:Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plants found in the Pantanal, a unique and widely unexplored wetland in Br...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21400-2
更新日期：2018-02-15 00:00:00
abstract：:The early life stages represent a crucial period that can strongly influence population dynamics. We studied the development of foraging behaviour in the red-footed booby, a tropical seabird with an extensive post-fledging care period (3 to 6 months). Adults and juveniles were observed from shore and tracked at sea us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14478-7
更新日期：2017-10-24 00:00:00
abstract：:Spin-wave dynamics in full-Heusler Co2FeAl0.5Si0.5 films are studied using all-optical pump-probe magneto-optical polar Kerr spectroscopy. Backward volume magnetostatic spin-wave (BVMSW) mode is observed in films with thickness ranging from 20 to 100 nm besides perpendicular standing spin-wave (PSSW) mode, and found t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42513
更新日期：2017-02-14 00:00:00
abstract：:Greenhouse and field studies were conducted to provide a reference for pre-emergence (PRE) application of isoxaflutole on maize in China. In greenhouse study, the isoxaflutole PRE application at 30 g active ingredient (a.i.) ha-1 could effectively control large numbers of weeds, especially some large-seeded broadleave...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12696-7
更新日期：2017-10-04 00:00:00
abstract：:Examination of histological or immunohistochemically stained 2D sections of embedded tissue is one of the most frequently used tools in biomedical research and clinical routine. Since to date, targeted sectioning of specific regions of interest (ROI) in the sample is not possible, we aimed at developing a guided secti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26086-0
更新日期：2018-05-16 00:00:00
abstract：:We report a multi-channel optical frequency synthesizer developed to generate extremely stable continuous-wave lasers directly out of the optical comb of an Er-doped fiber oscillator. Being stabilized to a high-finesse cavity with a fractional frequency stability of 3.8 × 10-15 at 0.1 s, the comb-rooted synthesizer pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44122-5
更新日期：2019-05-21 00:00:00
abstract：:HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34539-9
更新日期：2018-11-02 00:00:00
abstract：:Since the 1990s the Mekong River delta has suffered a large decline in sediment supply causing coastal erosion, following catchment disturbance through hydropower dam construction and sand extraction. However, our new geological reconstruction of 2500-years of delta shoreline changes show that serious coastal erosion ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64630-z
更新日期：2020-05-15 00:00:00
abstract：:Grapevine (Vitis vinifera L.) is one of the classical fruits of the Old World. Among the thousands of domesticated grapevine varieties and variable wild sylvestris populations, the range of variation in pip morphology is very wide. In this study we scanned representative samples of grape pip populations, in an attempt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24738-9
更新日期：2018-04-25 00:00:00
abstract：:Cross-border equity and long-term debt securities portfolio investment networks are analysed from 2002 to 2012, covering the 2008 global financial crisis. They serve as network-proxies for measuring the robustness of the global financial system and the interdependence of financial markets, respectively. Two early-warn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03991
更新日期：2014-02-10 00:00:00
abstract：:Captive breeding programs and aquaculture production have commenced worldwide for the globally distributed yellowtail kingfish (Seriola lalandi), and captive bred fingerlings are being shipped from the Southern Hemisphere to be farmed in the Northern Hemisphere. It was recently proposed that Pacific S. lalandi compris...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07419-x
更新日期：2017-08-24 00:00:00
abstract：:In contrast to mammals, adult fish display a remarkable ability to fully regenerate central nervous system (CNS) axons, enabling functional recovery from CNS injury. Both fish and mammals normally undergo a developmental downregulation of axon growth activity as neurons mature. Fish are able to undergo damage-induced ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50485-6
更新日期：2019-10-02 00:00:00
abstract：:Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements produce conflicting results due to technical limitations whereby it is difficult to precisely determine molecular orientation, the nature of the mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39792
更新日期：2017-01-04 00:00:00
abstract：:Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47064-0
更新日期：2019-07-23 00:00:00
abstract：:Here, we characterized the basic properties of repetitive sequences in essential A and supernumerary B chromosomes of Festuca pratensis Huds. This was performed by comparative analysis of low-pass Illumina sequence reads of B chromosome lacking (-B) and B chromosome containing (+B) individuals of F. pratensis. 61% of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56383-1
更新日期：2019-12-27 00:00:00
abstract：:In fish, the fat content contributes to promoting the nutritional and organoleptic characteristics of the flesh, which is crucial for consumer acceptance. Methods to predict the fat in fish are important in nutritional and physiological research, where body content is traditionally determined by dissection followed by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67435-2
更新日期：2020-06-29 00:00:00
