X-ray based virtual histology allows guided sectioning of heavy ion stained murine lungs for histological analysis.

abstract：:We propose a novel stochastic global optimization algorithm with applications to the refinement stage of protein docking prediction methods. Our approach can process conformations sampled from multiple clusters, each roughly corresponding to a different binding energy funnel. These clusters are obtained using a densit...

journal_title：Scientific reports

authors： Zarbafian S,Moghadasi M,Roshandelpoor A,Nan F,Li K,Vakli P,Vajda S,Kozakov D,Paschalidis IC

更新日期：2018-04-12 00:00:00

abstract：:The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, accurate POC diagnostic assays play a crucial role in developing countries, where there are limit...

journal_title：Scientific reports

authors： Shafiee H,Asghar W,Inci F,Yuksekkaya M,Jahangir M,Zhang MH,Durmus NG,Gurkan UA,Kuritzkes DR,Demirci U

更新日期：2015-03-06 00:00:00

abstract：:Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...

journal_title：Scientific reports

authors： Feng MX,Hong JX,Wang Q,Fan YY,Yuan CT,Lei XH,Zhu M,Qin A,Chen HX,Hong D

更新日期：2016-01-08 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep45235. ...

journal_title：Scientific reports

authors： Wu J,Hu S,Chen Y,Li Z,Zhang J,Yuan H,Shi Q,Shao N,Ying X

更新日期：2017-12-22 00:00:00

abstract：:We aimed to develop a brief, preclinical test to screen the reduced hippocampal volume that is a marker of early dementia [Cognitive Quotient (CQ) test]. We performed an observational study of adult subjects who underwent brain MRI in seven institutions from February 2018 to May 2019. The CQ test consists of five comp...

journal_title：Scientific reports

authors： Kasai W,Goto T,Aoyama Y,Sato K

更新日期：2020-10-07 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative treatment option, but it remains unclear which patients benefit most from liver surgery, highlighting the need for new preoperative strat...

journal_title：Scientific reports

authors： Loosen SH,Roderburg C,Kauertz KL,Koch A,Vucur M,Schneider AT,Binnebösel M,Ulmer TF,Lurje G,Schoening W,Tacke F,Trautwein C,Longerich T,Dejong CH,Neumann UP,Luedde T

更新日期：2017-12-05 00:00:00

abstract：:The mammalian central nervous system (CNS) contains various types of neurons with different neuronal functions. In contrast to established roles of cell type-specific transcription factors on neuronal specification and maintenance, whether ubiquitous transcription factors have conserved or differential neuronal functi...

journal_title：Scientific reports

authors： Yamanaka T,Tosaki A,Miyazaki H,Kurosawa M,Koike M,Uchiyama Y,Maity SN,Misawa H,Takahashi R,Shimogori T,Hattori N,Nukina N

更新日期：2016-09-30 00:00:00

abstract：:Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...

journal_title：Scientific reports

authors： Chen X,Chen X,Pedone A,Apperley D,Hill RG,Karpukhina N

更新日期：2018-01-22 00:00:00

abstract：:The effects of surface treatment combining corona discharge and hydrogen peroxide (H2O2) on the electrochemical performance of carbon felt electrodes for vanadium redox flow batteries (VRFBs) have been thoroughly investigated. A high concentration of oxygen functional groups has been successfully introduced onto the s...

journal_title：Scientific reports

authors： Kim KJ,Lee SW,Yim T,Kim JG,Choi JW,Kim JH,Park MS,Kim YJ

更新日期：2014-11-04 00:00:00

abstract：:Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry into the CNS of hamsters. NiV initially predominantly targeted the olfactory epithelium in the nasal turbinat...

journal_title：Scientific reports

authors： Munster VJ,Prescott JB,Bushmaker T,Long D,Rosenke R,Thomas T,Scott D,Fischer ER,Feldmann H,de Wit E

更新日期：2012-01-01 00:00:00

abstract：:17α-ethynilestradiol (EE2) and tamoxifen (Tmx) are pollutants world-wide distributed in aquatic environments. Gilthead seabream, Sparus aurata L., is highlighted as a species model of intensively culture in anthropogenic disturbed environments. The effects of these pollutants on gilthead seabream reproduction and some...

journal_title：Scientific reports

authors： Valero Y,López-Cánovas AE,Rodenas MC,Cabas I,García-Hernández P,Arizcun M,García-Ayala A,Chaves-Pozo E

更新日期：2020-05-14 00:00:00

abstract：:X-linked Alport syndrome (XLAS) is a congenital renal disease caused by mutations in COL4A5. In XLAS cases suspected of being caused by aberrant splicing, transcript analysis needs to be conducted to determine splicing patterns and assess the pathogenicity. However, such analysis is not always available. We conducted ...

journal_title：Scientific reports

authors： Horinouchi T,Nozu K,Yamamura T,Minamikawa S,Nagano C,Sakakibara N,Nakanishi K,Shima Y,Morisada N,Ishiko S,Aoto Y,Nagase H,Takeda H,Rossanti R,Kaito H,Matsuo M,Iijima K

更新日期：2019-09-03 00:00:00

abstract：:Phase distribution of emerging organic contaminants is highly influential in their presence, fate and transport in surface water. Therefore, it is crucial to determine their state, partitioning behaviour and tendencies in water environments. In this study, Bisphenol A was investigated in both colloidal and soluble pha...

journal_title：Scientific reports

authors： Shehab ZN,Jamil NR,Aris AZ

更新日期：2020-11-23 00:00:00

abstract：:A simple and scalable approach has been reported for V2O5 encapsulation over interconnected multi-walled carbon nanotubes (MWCNTs) network using chemical bath deposition method. Chemically synthesized V2O5/MWCNTs electrode exhibited excellent charge-discharge capability with extraordinary cycling retention of 93% over...

journal_title：Scientific reports

authors： Pandit B,Dubal DP,Gómez-Romero P,Kale BB,Sankapal BR

更新日期：2017-03-03 00:00:00

abstract：:Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis genome and displays a high degree of polymorphism with respect to copy number and insertion sites. Therefore, IS6110 is considered to be a useful molecular marker for diagnosis and strain typing of M. tuberculosis. Generally IS61...

journal_title：Scientific reports

authors： Roychowdhury T,Mandal S,Bhattacharya A

更新日期：2015-07-28 00:00:00

abstract：:Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variabi...

journal_title：Scientific reports

authors： Sharma A,Osato N,Liu H,Asthana S,Dakal TC,Ambrosini G,Bucher P,Schmitt I,Wüllner U

更新日期：2019-12-05 00:00:00

abstract：:Fractal behavior is scale-invariant and widely characterized by fractal dimension. However, the cor-respondence between them is that fractal behavior uniquely determines a fractal dimension while a fractal dimension can be related to many possible fractal behaviors. Therefore, fractal behavior is independent of the fr...

journal_title：Scientific reports

authors： Jin Y,Wu Y,Li H,Zhao M,Pan J

更新日期：2017-04-24 00:00:00

abstract：:Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Her...

journal_title：Scientific reports

authors： He J,Wang W,Lu L,Tian Y,Niu D,Ren J,Dong L,Sun S,Zhao Y,Chen L,Shen J,Li X

更新日期：2016-06-08 00:00:00

abstract：:Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The...

journal_title：Scientific reports

authors： Yu M,Jia HM,Zhou C,Yang Y,Sun LL,Zou ZM

更新日期：2017-04-20 00:00:00

abstract：:Circulation through cerebral collaterals can maintain tissue viability until reperfusion is achieved. However, collateral circulation is time limited, and failure of collaterals is accelerated in the aged. Remote ischemic perconditioning (RIPerC), which involves inducing a series of repetitive, transient peripheral cy...

journal_title：Scientific reports

authors： Ma J,Ma Y,Shuaib A,Winship IR

更新日期：2020-07-24 00:00:00

abstract：:The purpose of this study is to investigate whether implementing a myofascial release (MFR) protocol designed to restore the myofascial properties of the diaphragm has any effect on the symptoms, quality of life, and consumption of proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal reflux...

journal_title：Scientific reports

authors： Martínez-Hurtado I,Arguisuelas MD,Almela-Notari P,Cortés X,Barrasa-Shaw A,Campos-González JC,Lisón JF

更新日期：2019-05-13 00:00:00

abstract：:Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a standardised approach to compare the UK HIV Drug Resistance Database and the Swiss HIV Cohort Study while maintaining data-protection requirement...

journal_title：Scientific reports

authors： Ragonnet-Cronin ML,Shilaih M,Günthard HF,Hodcroft EB,Böni J,Fearnhill E,Dunn D,Yerly S,Klimkait T,Aubert V,Yang WL,Brown AE,Lycett SJ,Kouyos R,Brown AJ

更新日期：2016-09-19 00:00:00

abstract：:As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhes...

journal_title：Scientific reports

authors： Jaillet C,Morelle W,Slomianny MC,Paget V,Tarlet G,Buard V,Selbonne S,Caffin F,Rannou E,Martinez P,François A,Foulquier F,Allain F,Milliat F,Guipaud O

更新日期：2017-07-13 00:00:00

abstract：:Cells spontaneously emit photons in the UV to visible/near-infrared range (ultra-weak photon emission, UPE). Perturbations of the cells' state cause changes in UPE (evoked UPE). The aim of the present study was to analyze the evoked UPE dynamics of cells caused by two types of cell perturbations (stressors): (i) a cel...

journal_title：Scientific reports

authors： Madl P,Verwanger T,Geppert M,Scholkmann F

更新日期：2017-09-12 00:00:00

abstract：:MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...

journal_title：Scientific reports

authors： Zhong J,Ruan W,Han Y,Sun X,Ye C,Zhou X

更新日期：2016-05-12 00:00:00

abstract：:Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated i...

journal_title：Scientific reports

authors： Bernhart SH,Kretzmer H,Holdt LM,Jühling F,Ammerpohl O,Bergmann AK,Northoff BH,Doose G,Siebert R,Stadler PF,Hoffmann S

更新日期：2016-11-23 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00

abstract：:Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N(9)-(2...

journal_title：Scientific reports

authors： Wang J,Bonnesen PV,Rangel E,Vallejo E,Sanchez-Castillo A,James Cleaves Ii H,Baddorf AP,Sumpter BG,Pan M,Maksymovych P,Fuentes-Cabrera M

更新日期：2016-01-04 00:00:00

abstract：:The exploration of intrinsically disordered proteins in isolation is a crucial step to understand their complex dynamical behavior. In particular, the emergence of partially ordered states has not been explored in depth. The experimental characterization of such partially ordered states remains elusive due to their tr...

journal_title：Scientific reports

authors： Herrera-Nieto P,Pérez A,De Fabritiis G

更新日期：2020-07-24 00:00:00