Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis.

abstract：:The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental procedure for Kd determination using a quantitative FRET method. Here we report a new development of Kd de...

journal_title：Scientific reports

authors： Jiang L,Xiong Z,Song Y,Lu Y,Chen Y,Schultz JS,Li J,Liao J

更新日期：2019-02-14 00:00:00

abstract：:The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase longevity. However, fu...

journal_title：Scientific reports

authors： Nguyen NN,Rana A,Goldman C,Moore R,Tai J,Hong Y,Shen J,Walker DW,Hur JH

更新日期：2019-02-28 00:00:00

abstract：:Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. In the present study, reduced mechanical thresholds for hindpaw-withdrawal reflex were found in mice after transient hindpaw ischemia, which was produced by a high pressu...

journal_title：Scientific reports

authors： Watanabe T,Sasaki M,Komagata S,Tsukano H,Hishida R,Kohno T,Baba H,Shibuki K

更新日期：2015-07-13 00:00:00

abstract：:CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-depende...

journal_title：Scientific reports

authors： Zhang R,Zhang G,Xiang B,Chen X,Tang L,Shi S,Liu Y,Ai X,Xie P,Li Z

更新日期：2017-12-07 00:00:00

abstract：:Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor may be a possible solutio...

journal_title：Scientific reports

authors： Joshi N,Shirsath N,Singh A,Joshi KS,Banerjee R

更新日期：2014-11-18 00:00:00

abstract：:Ciliate Mesodinium species are commonly distributed in diverse aquatic systems worldwide. Among Mesodinium species, M. rubrum is closely associated with microbial food webs and red tide formation and is known to acquire chloroplasts from its cryptophyte prey for use in photosynthesis. For these reasons, Mesodinium has...

journal_title：Scientific reports

authors： Kim M,Park MG

更新日期：2019-10-01 00:00:00

abstract：:Macro-fungi play important roles in the soil elemental cycle in terrestrial ecosystems. Many researchers have focused on the interactions between mycorrhizal fungi and host plants, whilst comparatively few studies aim to characterise the relationships between macro-fungi and bacteria in situ. In this study, we detecte...

journal_title：Scientific reports

authors： Liu Y,Sun Q,Li J,Lian B

更新日期：2018-08-03 00:00:00

abstract：:In 2017-2019 a surge of Shispare Glacier, a former tributary of the once larger Hasanabad Glacier (Hunza region), dammed the proglacial river of Muchuhar Glacier, which formed an ice-dammed lake and generated a small Glacial Lake Outburst Flood (GLOF). Surge movement produced the highest recorded Karakoram glacier sur...

journal_title：Scientific reports

authors： Bhambri R,Watson CS,Hewitt K,Haritashya UK,Kargel JS,Pratap Shahi A,Chand P,Kumar A,Verma A,Govil H

更新日期：2020-03-13 00:00:00

abstract：:Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure of berberine (the m...

journal_title：Scientific reports

authors： Ma BL,Yin C,Zhang BK,Dai Y,Jia YQ,Yang Y,Li Q,Shi R,Wang TM,Wu JS,Li YY,Lin G,Ma YM

更新日期：2016-01-29 00:00:00

abstract：:This study aims to identify a panel of blood-cell neuroplasticity-related genes expressed following environmental enrichment stimulation (EE). The Drug detection (DD) training course was an excellent model for the study of EE in the working dog. This research is divided into two experimental trials. In the First Trial...

journal_title：Scientific reports

authors： Guelfi G,Casano AB,Menchetti L,Bellicci M,Suvieri C,Moscati L,Carotenuto P,Santoro MM,Diverio S

更新日期：2019-05-06 00:00:00

abstract：:Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye has been characterized, the more recently described pathways of NO generation by nitrate (NO3-) and nitrite (NO2-) ions reduction has rec...

journal_title：Scientific reports

authors： Park JW,Piknova B,Jenkins A,Hellinga D,Parver LM,Schechter AN

更新日期：2020-08-05 00:00:00

abstract：:Spreading broadly refers to the notion of an entity propagating throughout a networked system via its interacting components. Evidence of its ubiquity and severity can be seen in a range of phenomena, from disease epidemics to financial systemic risk. In order to understand the dynamics of these critical phenomena, co...

journal_title：Scientific reports

authors： Ellinas C

更新日期：2018-03-12 00:00:00

abstract：:Term preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11-1...

journal_title：Scientific reports

authors： Bahado-Singh R,Poon LC,Yilmaz A,Syngelaki A,Turkoglu O,Kumar P,Kirma J,Allos M,Accurti V,Li J,Zhao P,Graham SF,Cool DR,Nicolaides K

更新日期：2017-11-23 00:00:00

abstract：:Variability in the x-ray tube current used in computed tomography may affect quantitative features extracted from the images. To investigate these effects, we scanned the Credence Cartridge Radiomics phantom 12 times, varying the tube current from 25 to 300 mA∙s while keeping the other acquisition parameters constant....

journal_title：Scientific reports

authors： Mackin D,Ger R,Dodge C,Fave X,Chi PC,Zhang L,Yang J,Bache S,Dodge C,Jones AK,Court L

更新日期：2018-02-05 00:00:00

abstract：:Plant cells are covered with rigid cell walls, yet tip-growing cells can elongate by providing new cell wall material to their apical regions. Studies of the mechanical properties of tip-growing plant cells typically involve measurement of the turgor pressure and stiffness of the cells' apical regions. These experimen...

journal_title：Scientific reports

authors： Yanagisawa N,Sugimoto N,Arata H,Higashiyama T,Sato Y

更新日期：2017-05-03 00:00:00

abstract：:Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...

journal_title：Scientific reports

authors： Nomura R,Kadota T,Ogaya Y,Matayoshi S,Iwashita N,Okawa R,Nakano K

更新日期：2020-07-27 00:00:00

abstract：:Alzheimer's disease is a debilitating neurodegenerative condition that progressively causes synaptic loss and major neuronal damage. Immunotherapy utilising Aβ as an active immunogen or via passive treatment utilising antibodies raised to amyloid have shown therapeutic promise. The migratory properties of peripheral b...

journal_title：Scientific reports

authors： Mold M,Kumar M,Mirza A,Shardlow E,Exley C

更新日期：2018-02-05 00:00:00

abstract：:Metastatic colorectal cancer is the fourth most common cause of cancer death. Current options in palliation such as hyperthermic intraperitoneal chemotherapy (HIPEC) present severe side effects. Recent research efforts suggested the therapeutic use of oxidant-enriched liquid using cold physical plasma. To investigate ...

journal_title：Scientific reports

authors： Freund E,Liedtke KR,van der Linde J,Metelmann HR,Heidecke CD,Partecke LI,Bekeschus S

更新日期：2019-01-24 00:00:00

abstract：:Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosoci...

journal_title：Scientific reports

authors： Nijjar PS,Connett JE,Lindquist R,Brown R,Burt M,Pergolski A,Wolfe A,Balaji P,Chandiramani N,Yu X,Kreitzer MJ,Everson-Rose SA

更新日期：2019-12-05 00:00:00

abstract：:Photoswitchable fluorescent proteins (PFPs) that can change fluorescence color upon excitation have revolutionized many applications of light such as tracking protein movement, super-resolution imaging, identification of circulating cells, and optical data storage. Nevertheless, the relatively weak fluorescence of PFP...

journal_title：Scientific reports

authors： Harrington WN,Novoselova MV,Bratashov DN,Khlebtsov BN,Gorin DA,Galanzha EI,Zharov VP

更新日期：2019-08-27 00:00:00

abstract：:The prognostic value and staging category of parotid lymph node (PLN) metastasis in nasopharyngeal carcinoma (NPC) remain unknown. We retrospectively reviewed MRI scans and medical records for 1811 NPC patients who received intensity-modulated radiotherapy. The diagnosis of PLN metastasis was mainly based on MRI follo...

journal_title：Scientific reports

authors： Zhang Y,Li WF,Chen L,Mao YP,Guo R,Zhang F,Peng H,Liu LZ,Li L,Liu Q,Ma J

更新日期：2015-09-08 00:00:00

abstract：:The study of organic/inorganic molecules with activity against intracellular fungi of the phylum Microsporidia is of critical importance. Here, for the first time, the inactivation of these parasitic fungi by porphyrins is reported. The biological effects of porphyrins (10 µM and 100 µM) on the microsporidian Nosema c...

journal_title：Scientific reports

authors： Ptaszyńska AA,Trytek M,Borsuk G,Buczek K,Rybicka-Jasińska K,Gryko D

更新日期：2018-04-03 00:00:00

abstract：:The conservation of plant and animal genetic heritage is not a purpose in itself, but it represents the sine qua non condition for practicing a sustainable agriculture and to ensure nutrition and food security on long-term. Our research focused on identifying the areas with the richest genetic diversity of vegetables ...

journal_title：Scientific reports

authors： Maxim A,Străjeru S,Albu C,Sandor M,Mihalescu L,Pauliuc SE

更新日期：2020-10-28 00:00:00

abstract：:Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy), exerts better anti-breast cancer efficacy and lower side effects than Cos or Dehy alone in vivo, however, their anti-cancer molecular mech...

journal_title：Scientific reports

authors： Peng Z,Wang Y,Fan J,Lin X,Liu C,Xu Y,Ji W,Yan C,Su C

更新日期：2017-01-24 00:00:00

abstract：:The activation energy of the β → α/ω phase transformation increased monotonously with the application of a continuous heating process to a Ti-15Mo-2.7Nb-3Al-0.2Si alloy. Precipitation behaviour of the alloy aged at different temperatures were analysed with scanning electron microscopy, electron backscattered diffracti...

journal_title：Scientific reports

authors： Xu T,Zhang S,Liang S,Cui N,Cao L,Wan Y

更新日期：2019-11-26 00:00:00

abstract：:Recently, the organic functionalization of polyoxometalates (POMs) has drawn increasing interest, and an easy and effective route to achieve organic derivatives is of great importance. Herein, the first reported synthesis of a tosyl ester derivative of the polyoxometalate (Bu4N)2[V6O13{(OCH2)3CCH2SO3C7H4}2]·2.5CH3CN (...

journal_title：Scientific reports

authors： Jia H,Li Q,Bayaguud A,She S,Huang Y,Chen K,Wei Y

更新日期：2017-10-02 00:00:00

abstract：:The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...

journal_title：Scientific reports

authors： Iyer RS,Chatham L,Sleigh R,Meek DW

更新日期：2017-06-15 00:00:00

abstract：:We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3- effector T-cells (Teff), when CD4+ T-cells are co-cultured with GM-CSF derived bone marrow dendritic cells (G-BMDCs). Events downstream of OX40L/OX40 interaction in Tregs respons...

journal_title：Scientific reports

authors： Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Bhattacharya P,Sun Z,Epstein AL,Maker AV,Prabhakar BS

更新日期：2017-07-26 00:00:00

abstract：:This study used resting-state functional MRI (r-fMRI) to evaluate intrinsic brain activity in drug-naive patients with essential tremor (ET) with and without head tremor. We enrolled 20 patients with ET with hand and head tremor (h-ET), 27 patients with ET without head tremor (a-ET), and 27 healthy controls (HCs). All...

journal_title：Scientific reports

authors： Wang L,Lei D,Suo X,Li N,Lu Z,Li J,Peng J,Gong Q,Peng R

更新日期：2018-07-12 00:00:00

abstract：:Size shifts may be a by-product of alterations in life history traits driven by natural selection. Although this approach has been proposed for islands, it has not yet been explored in continental faunas. The trends towards size decrease experienced by some hipparionins constitute a good case study for the application...

journal_title：Scientific reports

authors： Orlandi-Oliveras G,Nacarino-Meneses C,Koufos GD,Köhler M

更新日期：2018-11-21 00:00:00