Abstract:
:Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure of berberine (the major active compound) in the Coptidis Rhizoma extract were much better than those of pure berberine. Scanning electron microscopy, laser scanning confocal microscopy (LSCM), and dynamic light scattering experiments confirmed that nanoparticles attached to very fine precipitates existed in the aqueous extract solution. The LSCM experiment showed that the precipitates were absorbed with the particles by the mouse intestine. High-speed centrifugation of the extract could not remove the nanoparticles and did not influence plasma exposure or acute oral toxicity. However, after extract dilution, the attached precipitates vanished, although the nanoparticles were preserved, and there were no differences in the acute oral toxicity and plasma exposure between the extract and pure berberine. The nanoparticles were then purified and identified as proteinaceous. Furthermore, they could absorb co-dissolved berberine. Our results indicate that naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption. These findings should inspire related studies in other natural products.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ma BL,Yin C,Zhang BK,Dai Y,Jia YQ,Yang Y,Li Q,Shi R,Wang TM,Wu JS,Li YY,Lin G,Ma YMdoi
10.1038/srep20110subject
Has Abstractpub_date
2016-01-29 00:00:00pages
20110issn
2045-2322pii
srep20110journal_volume
6pub_type
杂志文章abstract::Plastic degradation rates in the marine environment are essential to understand. This study demonstrates that in plastic-microbial interaction experiments, residual monomeric and oligomeric content of PA6 significantly influences the development of dissolved organic carbon. While it is well recognized that additives i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38685-6
更新日期:2019-02-14 00:00:00
abstract::Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10492-x
更新日期:2017-09-06 00:00:00
abstract::State of the art clinical hand prostheses are controlled in a simple and limited way that allows the activation of one function at a time. More advanced laboratory approaches, based on machine learning, offer a significant increase in functionality, but their clinical impact is limited, mainly due to lack of reliabili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04255-x
更新日期:2017-06-30 00:00:00
abstract::Previous studies showed that better adherence to the Mediterranean diet (MD) is associated with lower risk of chronic diseases, but limited data are available on bone health. We investigated the association of the MD with bone mineral density (BMD) in Chinese adults. We included 2371 participants aged 40-75 years in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25662
更新日期:2016-05-09 00:00:00
abstract::Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20254
更新日期:2016-02-04 00:00:00
abstract::Dirt and microorganisms are the major problems in textiles which can generate unpleasant odor during their growth. Here, zinc oxide (ZnO) nanoparticles prepared by sol-gel method were loaded on the cotton fabrics using spin coating technique to enhance their antimicrobial properties and water repellency. The effects o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22324-7
更新日期:2018-03-02 00:00:00
abstract::Several carbon dots doping with diferent elements (Ca, Ag, Au) were fabricated and their catalytic properties had been investigated in this paper. It was found that the Ag-doped carbon dots (CDAg) had played a role of mimic enzyme on the reaction of HAuCl4-H2O2 and generated nanogold particles with surface enhanced Ra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46426-y
更新日期:2019-07-10 00:00:00
abstract::Toward the increasing demands of portable energy storage and electric vehicle applications, the widely used graphite anodes with significant drawbacks become more and more unsuitable. Herein, we report a novel scaffold of hierarchical silicon nanowires-carbon textiles anodes fabricated via a facile method. Further, co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01622
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05110
更新日期:2014-06-05 00:00:00
abstract::Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35496-z
更新日期:2018-11-21 00:00:00
abstract::Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17669
更新日期:2015-12-04 00:00:00
abstract::We propose a virtual sound barrier system that blocks sound transmission through openings without affecting access, light and air circulation. The proposed system applies active control technique to cancel sound transmission with a double layered loudspeaker array at the edge of the opening. Unlike traditional transpa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13546-2
更新日期:2017-10-17 00:00:00
abstract::Accurate species identification is fundamental when recording ecological data. However, the ability to correctly identify organisms visually is rarely questioned. We investigated how experts and non-experts compared in the identification of bumblebees, a group of insects of considerable conservation concern. Experts a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33634
更新日期:2016-09-20 00:00:00
abstract::Wss1 is a DNA-protein crosslinks (DPCs) repair protein, which is responsible for degradation of the protein components in DPCs. In this investigation, crystal structure of the protease domain from saccharomyces cerevisiae Wss1 (ScWss1) was solved and was compared with the known crystal structure of Schizosaccharomyces...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08834-w
更新日期:2017-08-15 00:00:00
abstract::Daily life stress is an omnipresent phenomenon in modern society. Research has linked prolonged activation of the hypothalamic-pituitary-adrenal axis to psychiatric and somatic diseases. Everyday stressors substantially contribute to these health risks. Despite the notion that the physiological stress response is high...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33708-0
更新日期:2018-10-18 00:00:00
abstract::Empirical yield estimation from satellite data has long lacked suitable combinations of spatial and temporal resolutions. Consequently, the selection of metrics, i.e., temporal descriptors that predict grain yield, has likely been driven by practicality and data availability rather than by systematic targetting of cri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51715-7
更新日期:2019-10-31 00:00:00
abstract::Micronutrients are essential for survival and growth for all the organisms including pathogens. In this manuscript, we report that zinc (Zn) chelator N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethylenediamine (TPEN) affects growth and viability of intracellular pathogen Leishmania donovani (LD) by a concentration and t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10041-6
更新日期:2017-09-05 00:00:00
abstract::Convergent-margin basins (CMBs) are commonly associated with active arcs, and hence are rich in detrital zircon (DZ) whose ages closely reflect the timing of deposition. Consequently, maximum depositional ages (MDA) from DZ geochronology can be employed to resolve the stratigraphy and evolution of CMBs. Herein, we use...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51795-5
更新日期:2019-10-25 00:00:00
abstract::Drugs of abuse represent a growing public health crisis. Accumulating evidence indicates that gabapentin (GBP), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence. Commonly, drugs of abuse modulate the dopaminergic system to induce addiction. In this study, we used the conditioned place prefere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67318-6
更新日期:2020-06-26 00:00:00
abstract::Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36087-8
更新日期:2018-12-12 00:00:00
abstract::Nutrient inputs and ultraviolet radiation (UVR) are global factors affecting the structure and functioning of aquatic ecosystems, particularly clear-water ecosystems. We performed experiments in two model lakes highly exposed to UVR fluxes in order to test the effect that future increases in mineral nutrients transpor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06279-9
更新日期:2017-07-24 00:00:00
abstract::Severe sepsis and septic shock are life-threatening conditions, with Gram-negative organisms responsible for most sepsis mortality. Systemic administration of compounds that block the action of lipopolysaccharide (LPS), a constituent of the Gram-negative outer cell membrane, is hampered by their hydrophobicity and cat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29739
更新日期:2016-07-14 00:00:00
abstract::Since their first appearance, organic-inorganic perovskite absorbers have been capturing the attention of the scientific community. While high efficiency devices highlight the importance of band level alignment, very little is known on the origin of the strong n-doping character observed in the perovskite. Here, by me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50108-0
更新日期:2019-10-22 00:00:00
abstract::A highly effective method for the research and development of a novel macroscopic hydrogel sensor and bilayer hydrogel is reported. Based on Rhodamine 6G, an Hg2+ sensitive fluorescent functional monomer was synthesized, then the monomer was utilized to synthesize hydrogel sensors and bilayer hydrogels. Hydrogel senso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64549-5
更新日期:2020-05-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65025-w
更新日期:2020-05-27 00:00:00
abstract::Integrated photonics promises solutions to questions of stability, complexity, and size in quantum optics. Advances in tunable and non-planar integrated platforms, such as laser-inscribed photonics, continue to bring the realisation of quantum advantages in computation and metrology ever closer, perhaps most easily se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09601
更新日期:2015-04-27 00:00:00
abstract::We provide an explicit model for a spin-1/2 quasi-particle, based on the superposition of plasmon excitations in a quantum plasmas with intrinsic orbital angular momentum. Such quasi-particle solutions can show remarkable similarities with single electrons moving in vacuum: they have spin-1/2, a finite rest mass, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26196-9
更新日期:2018-05-18 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29235-7
更新日期:2018-07-18 00:00:00
abstract::Fitness-related costs of evolving insecticide resistance have been reported in a number of insect species, but the interplay between evolutionary adaptation to insecticide pressure and variable environmental conditions has received little attention. We provisioned nymphs from three German cockroach (Blattella germanic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28731
更新日期:2016-06-27 00:00:00
abstract::Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36138-0
更新日期:2018-12-24 00:00:00