Protein-Protein Affinity Determination by Quantitative FRET Quenching.

abstract：:Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....

journal_title：Scientific reports

authors： Mei C,Wang H,Zhu W,Wang H,Cheng G,Qu K,Guang X,Li A,Zhao C,Yang W,Wang C,Xin Y,Zan L

更新日期：2016-01-25 00:00:00

abstract：:Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...

journal_title：Scientific reports

authors： He Y,Wu L,Liu X,Zhang X,Jiang P,Ma H

更新日期：2019-10-29 00:00:00

abstract：:We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocyte...

journal_title：Scientific reports

authors： Araujo LCC,Feitosa KB,Murata GM,Furigo IC,Teixeira SA,Lucena CF,Ribeiro LM,Muscará MN,Costa SKP,Donato J Jr,Bordin S,Curi R,Carvalho CRO

更新日期：2018-07-20 00:00:00

abstract：:Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer...

journal_title：Scientific reports

authors： Lee J,Song B,Subbiah R,Chung JJ,Choi UH,Park K,Kim SH,Oh SJ

更新日期：2019-02-21 00:00:00

abstract：:Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

journal_title：Scientific reports

authors： Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

更新日期：2015-03-17 00:00:00

abstract：:There is widespread transcriptional dysregulation in Huntington's disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem changes. However, mutant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available and contains cells that are dysfunctional i...

journal_title：Scientific reports

authors： Hensman Moss DJ,Flower MD,Lo KK,Miller JR,van Ommen GB,'t Hoen PA,Stone TC,Guinee A,Langbehn DR,Jones L,Plagnol V,van Roon-Mom WM,Holmans P,Tabrizi SJ

更新日期：2017-03-21 00:00:00

abstract：:Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been...

journal_title：Scientific reports

authors： Zhao X,Cui Q,Fu Q,Song X,Jia R,Yang Y,Zou Y,Li L,He C,Liang X,Yin L,Lin J,Ye G,Shu G,Zhao L,Shi F,Lv C,Yin Z

更新日期：2017-08-18 00:00:00

abstract：:Two hundred and six strains of avian infectious bronchitis virus (IBV) were isolated from chickens showing signs of disease in southern China during the period from 2013-2015. The nucleotide and amino acid sequences from the isolated field strains were compared to 42 published references. Nucleotide homologies ranged ...

journal_title：Scientific reports

authors： Feng K,Wang F,Xue Y,Zhou Q,Chen F,Bi Y,Xie Q

更新日期：2017-07-26 00:00:00

abstract：:Neurovascular unit (NVU) is a basic unit in the brain, including neurons, glial cells, blood vessels and extracellular matrix. This concept implies the importance of a three-dimensional (3D) culture model including these cell types for investigating brain functions. However, little is known about the construction of a...

journal_title：Scientific reports

authors： Uwamori H,Higuchi T,Arai K,Sudo R

更新日期：2017-12-11 00:00:00

abstract：:We report the counterintuitive mechanism of increasing boiling heat transfer by incorporating low-conductivity materials at the interface between the surface and fluid. By embedding an array of non-conductive lines into a high-conductivity substrate, in-plane variations in the local surface temperature are created. Du...

journal_title：Scientific reports

authors： Rahman MM,Pollack J,McCarthy M

更新日期：2015-08-18 00:00:00

abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...

journal_title：Scientific reports

authors： Schelleckes K,Schmitz B,Lenders M,Mewes M,Brand SM,Brand E

更新日期：2018-03-09 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Acerbi A,van Leeuwen EJC,Haun DBM,Tennie C

更新日期：2019-04-17 00:00:00

abstract：:The entire recrystallisation sequence and associated crystallographic texture evolution of Mg-0.8Zn-0.2Ca (wt.%) alloy was tracked using a quasi-in-situ electron backscatter diffraction (EBSD) method. Characteristic "Rare Earth" (RE) texture was formed, originating mainly from double twins and twinning-related shear b...

journal_title：Scientific reports

authors： Guan D,Liu X,Gao J,Ma L,Wynne BP,Rainforth WM

更新日期：2019-05-09 00:00:00

abstract：:To master linguistic communication, humans must acquire large vocabularies quickly and effortlessly. Efficient word learning might be facilitated by the ability to rapidly acquire novel word forms even outside the focus of attention, occurring within minutes of repetitive exposure and suggesting fast and automatic lex...

journal_title：Scientific reports

authors： Partanen EJ,Leminen A,Cook C,Shtyrov Y

更新日期：2018-10-25 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared ...

journal_title：Scientific reports

authors： Balla MM,Desai S,Purwar P,Kumar A,Bhandarkar P,Shejul YK,Pramesh CS,Laskar S,Pandey BN

更新日期：2016-11-04 00:00:00

abstract：:In this study, we report a metallogel developed based on metal-phenolic coordination of natural low-cost polyphenolic molecule and metal ions. Gelation occurs by mixing tannic acid (TA) and group (IV) titanium ions (TiIV) to form TA-TiIV gel. The TA-TiIV gel exhibits good capability to incorporate diverse metal ions b...

journal_title：Scientific reports

authors： Anh HTP,Huang CM,Huang CJ

更新日期：2019-08-09 00:00:00

abstract：:The higher-order architecture observed in biological systems, like viruses, is very effective in nucleic acid transport. The replications of this system has been attempted with both synthetic and naturally occurring polymers with mixed results. Here we describe a peptide/siRNA quaternary complex that functions as an s...

journal_title：Scientific reports

authors： Gamboa A,Urfano SF,Hernandez K,Fraser DA,Ayalew L,Slowinska K

更新日期：2019-11-14 00:00:00

abstract：:Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with broad antimicrobial activities in the low µM range against Gram-positive and -negative bacteria, including antibiotic resistant strains, and fungi. Allicin reacts with thiol groups and can inactivate essential enzymes. However, a...

journal_title：Scientific reports

authors： Leontiev R,Hohaus N,Jacob C,Gruhlke MCH,Slusarenko AJ

更新日期：2018-04-30 00:00:00

abstract：:This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcriptio...

journal_title：Scientific reports

authors： Al Bkhetan Z,Plewczynski D

更新日期：2018-03-26 00:00:00

abstract：:Macro- and micro-environmental factors modulate parasite loads in fish, determining parasitic abundances, diversity, and interaction dynamics. In this study, seasonal variations in larval ectoparasites on fish larvae in the northern Humboldt Current System (HCS) were evaluated using a delta-gamma generalized linear mo...

journal_title：Scientific reports

authors： Paredes LD,Landaeta MF,Molinet C,González MT

更新日期：2021-01-12 00:00:00

abstract：:Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson's disease pathology. However, the significance of PREP protein for aSyn aggregation and toxicity is not known. We studied this in vivo by using PREP knock-out mice with viral ve...

journal_title：Scientific reports

authors： Svarcbahs R,Julku UH,Norrbacka S,Myöhänen TT

更新日期：2018-01-24 00:00:00

abstract：:This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum assisted breast biopsy (DBT-VABB) of screening detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions and spiculated masses. In this institutionally ap...

journal_title：Scientific reports

authors： Bohan S,Ramli Hamid MT,Chan WY,Vijayananthan A,Ramli N,Kaur S,Rahmat K

更新日期：2021-01-08 00:00:00

abstract：:Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...

journal_title：Scientific reports

authors： Sharma P,Diergaarde B,Ferrone S,Kirkwood JM,Whiteside TL

更新日期：2020-01-09 00:00:00

abstract：:The honeybee's drinking process has generally been simplified because of its high speed and small scale. In this study, we clearly observed the drinking cycle of the Italian honeybee using a specially designed high-speed camera system. We analysed the pattern of glossal hair erection and the movement kinematics of the...

journal_title：Scientific reports

authors： Wu J,Yang H,Yan S

更新日期：2015-10-08 00:00:00

abstract：:Ultrasound imaging is affected by coherent noise or speckle, which reduces contrast and overall image quality and degrades the diagnostic precision of the collected images. Elevational angular compounding (EAC) is an attractive means of addressing this limitation, since it reduces speckle noise while operating in real...

journal_title：Scientific reports

authors： Afshari P,Zakian C,Ntziachristos V

更新日期：2020-10-23 00:00:00

abstract：:The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...

journal_title：Scientific reports

authors： Thompson WH,Fransson P

更新日期：2016-12-19 00:00:00

abstract：:With limited success achieved in bladder cancer patient management, novel agents are in urgent need for the purpose of therapy and prevention. As a sesquiterpenoid dimmer isolated from Gochnatia pomculat, (-)-gochnatiolide B has been bio-mimetically synthesized in multiple steps with a poor yield, which heavily limite...

journal_title：Scientific reports

authors： Chen Y,Li W,Zeng Z,Tang Y

更新日期：2018-06-11 00:00:00

abstract：:Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...

journal_title：Scientific reports

authors： Zheng M,Qu D,Wang H,Sun Z,Liu X,Chen J,Li C,Li X,Chen Z

更新日期：2016-06-29 00:00:00

abstract：:Assembly of metagenomic samples is a very complex process, with algorithms designed to address sequencing platform-specific issues, (read length, data volume, and/or community complexity), while also faced with genomes that differ greatly in nucleotide compositional biases and in abundance. To address these issues, we...

journal_title：Scientific reports

authors： Scholz M,Lo CC,Chain PS

更新日期：2014-10-01 00:00:00

abstract：:We introduce a compact, fast large area multiphoton exoscope (FLAME) system with enhanced molecular contrast for macroscopic imaging of human skin with microscopic resolution. A versatile imaging platform, FLAME combines optical and mechanical scanning mechanisms with deep learning image restoration to produce depth-r...

journal_title：Scientific reports

authors： Fast A,Lal A,Durkin AF,Lentsch G,Harris RM,Zachary CB,Ganesan AK,Balu M

更新日期：2020-10-22 00:00:00