Abstract：
:We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocytes and inflammatory cell infiltration in the liver, while only the HFD group had collagen deposition in the perivascular space of the liver. UT treatment significantly reduced liver steatosis and inflammation in both obese mouse models. Furthermore, serine phosphorylation of IRS-1 was reduced by 25% in the HFD mice treated with UT. Overall, UT treated animals exhibited higher insulin sensitivity as compared to vehicle administration. In conclusion, Uncaria tomentosa extract improved glucose homeostasis and reverted NAFLD to a benign hepatic steatosis condition and these effects were associated with the attenuation of liver inflammation in obese mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Araujo LCC,Feitosa KB,Murata GM,Furigo IC,Teixeira SA,Lucena CF,Ribeiro LM,Muscará MN,Costa SKP,Donato J Jr,Bordin S,Curi R,Carvalho CROdoi
10.1038/s41598-018-29044-ysubject
Has Abstractpub_date
2018-07-20 00:00:00pages
11013issue
1issn
2045-2322pii
10.1038/s41598-018-29044-yjournal_volume
8pub_type
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