Abstract：
:Using a free boundary approach based on an analogy with ice melting models, we propose a deterministic PDE framework to describe the dynamics of fitness distributions in the presence of beneficial mutations with non-epistatic effects on fitness. Contrarily to most approaches based on deterministic models, our framework does not rely on an infinite population size assumption, and successfully captures the transient as well as the long time dynamics of fitness distributions. In particular, consistently with stochastic individual-based approaches or stochastic PDE approaches, it leads to a constant asymptotic rate of adaptation at large times, that most deterministic approaches failed to describe. We derive analytic formulas for the asymptotic rate of adaptation and the full asymptotic distribution of fitness. These formulas depend explicitly on the population size, and are shown to be accurate for a wide range of population sizes and mutation rates, compared to individual-based simulations. Although we were not able to derive an analytic description for the transient dynamics, numerical computations lead to accurate predictions and are computationally efficient compared to stochastic simulations. These computations show that the fitness distribution converges towards a travelling wave with constant speed, and whose profile can be computed analytically.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Roques L,Garnier J,Martin Gdoi
10.1038/s41598-017-17212-5subject
Has Abstractpub_date
2017-12-19 00:00:00pages
17838issue
1issn
2045-2322pii
10.1038/s41598-017-17212-5journal_volume
7pub_type
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