Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9.

Abstract:

:Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared with healthy donors (HD). Levels of VEGF (P < 0.005) and MMP-9 (P < 0.05) were significantly higher in COPD patients than HD. Compared to HD, a decrease in IL-8 (~8.1 folds; P < 0.0001) but an increase in MMP-9 (~1.6 folds; P < 0.05) levels were observed in the lung cancer patients. Cancer patients showed significantly (P < 0.005) lower levels of serum VEGF (1.9 folds) and IL-8 (~9 folds) than the COPD patients. VEGF level was significantly higher (2.6 folds; P < 0.0005) in metastatic than non-metastatic cancer patients. However, MMP-2 didn't show significant variation in these patients. The Youden's index (YI) values for lung cancer diagnosis in HD using IL-8 was 0.55 with 83.3% overall accuracy. VEGF was able to diagnose COPD in HD with better YI (0.38) and overall accuracy (70.6%). IL-8 was able to diagnose cancer in COPD patients and HD with YI values of 0.35, 0.55 with 71% and 83.3% overall accuracy, respectively.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Balla MM,Desai S,Purwar P,Kumar A,Bhandarkar P,Shejul YK,Pramesh CS,Laskar S,Pandey BN

doi

10.1038/srep36065

subject

Has Abstract

pub_date

2016-11-04 00:00:00

pages

36065

issn

2045-2322

pii

srep36065

journal_volume

6

pub_type

杂志文章
  • Whole genome sequencing for investigations of meningococcal outbreaks in the United States: a retrospective analysis.

    abstract::Although rare in the U.S., outbreaks due to Neisseria meningitidis do occur. Rapid, early outbreak detection is important for timely public health response. In this study, we characterized U.S. meningococcal isolates (N = 201) from 15 epidemiologically defined outbreaks (2009-2015) along with temporally and geographic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33622-5

    authors: Whaley MJ,Joseph SJ,Retchless AC,Kretz CB,Blain A,Hu F,Chang HY,Mbaeyi SA,MacNeil JR,Read TD,Wang X

    更新日期:2018-10-25 00:00:00

  • Evaluating phenotype-driven approaches for genetic diagnoses from exomes in a clinical setting.

    abstract::Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13841-y

    authors: Pengelly RJ,Alom T,Zhang Z,Hunt D,Ennis S,Collins A

    更新日期:2017-10-18 00:00:00

  • Evaluating and forecasting movement patterns of magnetically driven microbeads in complex geometries.

    abstract::The manipulation of superparamagnetic microbeads for lab-on-a-chip applications relies on the steering of microbeads across an altering stray field landscape on top of soft magnetic parent structures. Using ab initio principles, we show three-dimensional simulations forecasting the controlled movement of microbeads. S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65380-8

    authors: Klingbeil F,Block F,Sajjad U,Holländer RB,Deshpande S,McCord J

    更新日期:2020-05-29 00:00:00

  • Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata.

    abstract::Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50717-9

    authors: Wang W,Liu H,Zhang Y,Feng Y,Yuan F,Song X,Gao Z,Zhang J,Song Z,Jia L

    更新日期:2019-10-03 00:00:00

  • Effects of biotin on promoting anammox bacterial activity.

    abstract::Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81738-y

    authors: Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

    更新日期:2021-01-21 00:00:00

  • Reduced loss aversion in pathological gambling and alcohol dependence is associated with differential alterations in amygdala and prefrontal functioning.

    abstract::Diagnostic criteria for pathological gambling and alcohol dependence (AD) include repeated addictive behavior despite severe negative consequences. However, the concept of loss aversion (LA) as a facet of value-based decision making has not yet been used to directly compare these disorders. We hypothesized reduced LA ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16433-y

    authors: Genauck A,Quester S,Wüstenberg T,Mörsen C,Heinz A,Romanczuk-Seiferth N

    更新日期:2017-11-24 00:00:00

  • Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms.

    abstract::The delineation of the molecular pathology underlying amyotrophic lateral sclerosis (ALS) is being hampered by the lack of suitable biomarkers. We have previously reported that bromocriptine upregulates the endogenous antioxidative factor, neuronal apoptosis inhibitory protein (NAIP), sustains motor function and slows...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18627-w

    authors: Kano O,Tanaka K,Kanno T,Iwasaki Y,Ikeda JE

    更新日期:2018-01-08 00:00:00

  • Reversible Bending Behaviors of Photomechanical Soft Actuators Based on Graphene Nanocomposites.

    abstract::Photomechanical nanocomposites embedded with light-absorbing nanoparticles show promising applications in photoresponsive actuations. Near infrared (nIR)-responsive nanocomposites based photomechanical soft actuators can offer lightweight functional and underexploited entry into soft robotics, active optics, drug deli...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27366

    authors: Niu D,Jiang W,Liu H,Zhao T,Lei B,Li Y,Yin L,Shi Y,Chen B,Lu B

    更新日期:2016-06-06 00:00:00

  • Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.

    abstract::Oxaliplatin, a chemotherapy medication, causes severe peripheral neuropathy. Although oxaliplatin-induced peripheral neuropathy is a dose-limiting toxicity, a therapeutic strategy against its effects has not been established. We previously reported the involvement of N-methyl-D-aspartate receptors and their intracellu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08891-1

    authors: Yamamoto S,Ushio S,Egashira N,Kawashiri T,Mitsuyasu S,Higuchi H,Ozawa N,Masuguchi K,Ono Y,Masuda S

    更新日期:2017-08-29 00:00:00

  • Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers.

    abstract::The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics, and chemotherapeutic agents. Devising an adroit delivery method to cross the BBB is essential to unlocking widespread application of peptide therapeutics. Presented here is an engin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12497

    authors: Anand P,O'Neil A,Lin E,Douglas T,Holford M

    更新日期:2015-08-03 00:00:00

  • Fluorescence Polarization Switching from a Single Silicon Vacancy Colour Centre in Diamond.

    abstract::Single-photon emitters with stable and uniform photoluminescence properties are important for quantum technology. However, in many cases, colour centres in diamond exhibit spectral diffusion and photoluminescence intensity fluctuation. It is therefore essential to investigate the dynamics of colour centres at the sing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12244

    authors: Liu Y,Chen G,Rong Y,McGuinness LP,Jelezko F,Tamura S,Tanii T,Teraji T,Onoda S,Ohshima T,Isoya J,Shinada T,Wu E,Zeng H

    更新日期:2015-07-23 00:00:00

  • Characterization of photocatalytic TiO2 powder under varied environments using near ambient pressure X-ray photoelectron spectroscopy.

    abstract::Consecutive eight study phases under the successive presence and absence of UV irradiation, water vapor, and oxygen were conducted to characterize surface changes in the photocatalytic TiO2 powder using near-ambient-pressure X-ray photoelectron spectroscopy (XPS). Both Ti 2p and O 1s spectra show hysteresis through th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43298

    authors: Krishnan P,Liu M,Itty PA,Liu Z,Rheinheimer V,Zhang MH,Monteiro PJ,Yu LE

    更新日期:2017-02-27 00:00:00

  • Enhancing Morphology and Separation Performance of Polyamide 6,6 Membranes By Minimal Incorporation of Silver Decorated Graphene Oxide Nanoparticles.

    abstract::Nanomaterials can be incorporated in the synthesis of membrane to obtain mixed-matrix membrane with marked improvement in properties and performance. However, stability and dispersion of the nanomaterials in the membrane matrix, as well as the need to use high ratio of nanomaterials for obvious improvement of membrane...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38060-x

    authors: Mahmoudi E,Ng LY,Ang WL,Chung YT,Rohani R,Mohammad AW

    更新日期:2019-02-04 00:00:00

  • A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome.

    abstract::A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10179

    authors: Wong KL,Lai YM,Li KW,Lee KF,Ng TB,Cheung HP,Zhang YB,Lao L,Wong RN,Shaw PC,Wong JH,Zhang ZJ,Lam JK,Ye WC,Sze SC

    更新日期:2015-07-10 00:00:00

  • Comprehensive profiling of lysine ubiquitome reveals diverse functions of lysine ubiquitination in common wheat.

    abstract::Protein ubiquitination, which is a major post-translational modifications that occurs in eukaryotic cells, is involved in diverse biological processes. To date, large-scale profiling of the ubiquitome in common wheat has not been reported, despite its status as the major cereal crop in the world. Here, we performed th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13992-y

    authors: Zhang N,Zhang L,Shi C,Tian Q,Lv G,Wang Y,Cui D,Chen F

    更新日期:2017-10-19 00:00:00

  • Altering Compliance of a Load Carriage Device in the Medial-Lateral Direction Reduces Peak Forces While Walking.

    abstract::Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32175-x

    authors: Martin JP,Li Q

    更新日期:2018-09-13 00:00:00

  • Influence of deposition rate on the structural properties of plasma-enhanced CVD epitaxial silicon.

    abstract::Solar cells based on epitaxial silicon layers as the absorber attract increasing attention because of the potential cost reduction. In this work, we studied the influence of the deposition rate on the structural properties of epitaxial silicon layers produced by plasma-enhanced chemical vapor deposition (epi-PECVD) us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43968

    authors: Chen W,Cariou R,Hamon G,Léal R,Maurice JL,Cabarrocas PR

    更新日期:2017-03-06 00:00:00

  • Leaf selection by two Bornean colobine monkeys in relation to plant chemistry and abundance.

    abstract::Focusing on the chemical basis of dietary selection while investigating the nutritional ecology of animals helps understand their feeding biology. It is also important to consider food abundance/biomass while studying the mechanism of animal food selection. We studied leaf selection in two Bornean folivorous primates ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01873

    authors: Matsuda I,Tuuga A,Bernard H,Sugau J,Hanya G

    更新日期:2013-01-01 00:00:00

  • Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses.

    abstract::Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49386-5

    authors: Kato S,Shirai Y,Sakamoto M,Mori S,Kodama T

    更新日期:2019-09-13 00:00:00

  • Diagnostic value of digital clock drawing test in comparison with CERAD neuropsychological battery total score for discrimination of patients in the early course of Alzheimer's disease from healthy individuals.

    abstract::The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40010-0

    authors: Müller S,Herde L,Preische O,Zeller A,Heymann P,Robens S,Elbing U,Laske C

    更新日期:2019-03-05 00:00:00

  • Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model.

    abstract::The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28057

    authors: Xu S,Tian Y,Hu Y,Zhang N,Hu S,Song D,Wu Z,Wang Y,Cui Y,Tang H

    更新日期:2016-06-22 00:00:00

  • Selective binding of facial features reveals dynamic expression fragments.

    abstract::The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27242-2

    authors: Harrison C,Binetti N,Mareschal I,Johnston A

    更新日期:2018-06-13 00:00:00

  • Effective Hamiltonian for surface states of topological insulator nanotubes.

    abstract::In this work we derive an effective Hamiltonian for the surface states of a hollow topological insulator (TI) nanotube with finite width walls. Unlike a solid TI cylinder, a TI nanotube possesses both an inner as well as outer surface on which the states localized at each surface are coupled together. The curvature al...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45350

    authors: Siu ZB,Tan SG,Jalil MB

    更新日期:2017-04-03 00:00:00

  • Fabrication of low cost soft tissue prostheses with the desktop 3D printer.

    abstract::Soft tissue prostheses such as artificial ear, eye and nose are widely used in the maxillofacial rehabilitation. In this report we demonstrate how to fabricate soft prostheses mold with a low cost desktop 3D printer. The fabrication method used is referred to as Scanning Printing Polishing Casting (SPPC). Firstly the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06973

    authors: He Y,Xue GH,Fu JZ

    更新日期:2014-11-27 00:00:00

  • Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model.

    abstract::Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18490-9

    authors: Kim SR,Yi HJ,Lee YN,Park JY,Hoffman RM,Okano T,Shim IK,Kim SC

    更新日期:2018-01-10 00:00:00

  • Dense Ge nanocrystals embedded in TiO2 with exponentially increased photoconduction by field effect.

    abstract::Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23316-3

    authors: Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

    更新日期:2018-03-20 00:00:00

  • Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.

    abstract::Activation of TLR4 by lipopolysaccharide (LPS) induces both pro-inflammatory and anti-inflammatory cytokine production in macrophages. Type 4 phosphodiesterases (PDE4) are key cAMP-hydrolyzing enzymes, and PDE4 inhibitors are considered as immunosuppressors to various inflammatory responses. We demonstrate here that P...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46165

    authors: Yang JX,Hsieh KC,Chen YL,Lee CK,Conti M,Chuang TH,Wu CP,Jin SC

    更新日期:2017-04-06 00:00:00

  • Stable solid and aqueous H2CO3 from CO2 and H2O at high pressure and high temperature.

    abstract::Carbonic acid (H2CO3) forms in small amounts when CO2 dissolves in H2O, yet decomposes rapidly under ambient conditions of temperature and pressure. Despite its fleeting existence, H2CO3 plays an important role in the global carbon cycle and in biological carbonate-containing systems. The short lifetime in water and p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19902

    authors: Wang H,Zeuschner J,Eremets M,Troyan I,Willams J

    更新日期:2016-01-27 00:00:00

  • Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

    abstract::Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35909-z

    authors: Bang CH,Yoon JW,Lee HJ,Lee JY,Park YM,Lee SJ,Lee JH

    更新日期:2018-12-14 00:00:00

  • Chronic oral exposure to field-realistic pesticide combinations via pollen and nectar: effects on feeding and thermal performance in a solitary bee.

    abstract::Pesticide use is one of the main causes of pollinator declines in agricultural ecosystems. Traditionally, most laboratory studies on bee ecotoxicology test acute exposure to single compounds. However, under field conditions, bees are often chronically exposed to a variety of chemicals, with potential synergistic effec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50255-4

    authors: Azpiazu C,Bosch J,Viñuela E,Medrzycki P,Teper D,Sgolastra F

    更新日期:2019-09-24 00:00:00