Abstract:
:Plant cells are covered with rigid cell walls, yet tip-growing cells can elongate by providing new cell wall material to their apical regions. Studies of the mechanical properties of tip-growing plant cells typically involve measurement of the turgor pressure and stiffness of the cells' apical regions. These experiments, however, do not address how living tip-growing cells react when they encounter physical obstacles that are not substantially altered by turgor pressure. To investigate this issue, we constructed microfabricated platforms with a series of artificial gaps as small as 1 μm, and examined the capability of tip-growing plant cells, including pollen tubes, root hairs, and moss protonemata, to penetrate into these gaps. The cells were grown inside microfluidic chambers and guided towards the gaps using microdevices customized for each cell type. All types of tip-growing cells could grow through the microgaps with their organelles intact, even though the gaps were much smaller than the cylindrical cell diameter. Our findings reveal the dramatic physiological and developmental flexibility of tip-growing plant cells. The microfluidic platforms designed in this study provide novel tools for the elucidation of the mechanical properties of tip-growing plant cells in extremely small spaces.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yanagisawa N,Sugimoto N,Arata H,Higashiyama T,Sato Ydoi
10.1038/s41598-017-01610-wsubject
Has Abstractpub_date
2017-05-03 00:00:00pages
1403issue
1issn
2045-2322pii
10.1038/s41598-017-01610-wjournal_volume
7pub_type
杂志文章abstract::CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41485
更新日期:2017-02-02 00:00:00
abstract::Gold nanoparticles (GNP) have been intensively investigated for applications in cancer imaging and therapy. Most imaging studies focused on microscopic imaging. Their potential as optical imaging probes for whole body small animal imaging has rarely been explored. Taking advantage of their surface plasmon resonance (S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27624-6
更新日期:2018-06-19 00:00:00
abstract::The epidermal growth factor receptor (EGFR) inhibitors such as erlotinib and gefitinib are widely used for treatment of non-small cell lung cancer (NSCLC), but they have shown limited efficacy in an unselected population of patients. The KRAS mutations, which are identified in approximately 20% of NSCLC patients, have...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37059-8
更新日期:2019-01-24 00:00:00
abstract::Despite important progress, uncertainty persists regarding the ecological forces driving microbial community assembly. Here, we present the first study to use phylogenetic information to interpret the structure and diversity of diatom communities. We examined local phylogenetic divergence and beta- phylogenetic divers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48125-0
更新日期:2019-08-12 00:00:00
abstract::Streptococcus anginosus is increasingly recognized as an opportunistic pathogen. However, our knowledge about virulence determinants in this species is scarce. One exception is the streptolysin-S (SLS) homologue responsible for the β-hemolytic phenotype of the S. anginosus type strain. In S. anginosus the expression o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27334-z
更新日期:2018-06-13 00:00:00
abstract::In southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30112-6
更新日期:2018-08-17 00:00:00
abstract::Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02843-5
更新日期:2017-06-02 00:00:00
abstract::The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76594-1
更新日期:2020-11-11 00:00:00
abstract::Owing to the growing infectious diseases caused by eukaryotic and prokaryotic pathogens, it is urgent to develop novel antimicrobial agents against clinical pathogenic infections. Biofilm formation and invasion into the host cells are vital processes during pathogenic colonization and infection. In this study, we test...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26667
更新日期:2016-05-25 00:00:00
abstract::This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56153-z
更新日期:2020-01-08 00:00:00
abstract::We present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36111-x
更新日期:2018-12-13 00:00:00
abstract::The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39005-8
更新日期:2019-02-21 00:00:00
abstract::The search for green and sustainable modification method to produce durable bamboo materials remains a challenge in industry. Here, heat treatment in tung oil at 100-200 °C was employed to modify bamboo materials. Oil permeation and distribution in the structure of bamboo samples during heat treatment were explored. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49240-8
更新日期:2019-09-06 00:00:00
abstract::Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00863-9
更新日期:2017-04-07 00:00:00
abstract::In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47077-9
更新日期:2019-07-24 00:00:00
abstract::The knowledge of the metallization of warm dense helium has important implications for understanding the thermal histories, stellar structure and magnetic field environment of giant planets. However, it is also a pendent scientific topic. For a revisiting into the properties of warm dense helium, we performed extensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41885
更新日期:2017-02-03 00:00:00
abstract::Anatomical features of first maxillary premolars may greatly affect endodontic and following restorative treatments. The aim of this study was to evaluate root canal configuration and root wall thickness of first maxillary premolars using a preexisting CBCT database. A CBCT database of 400 first maxillary premolar was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56957-z
更新日期:2020-01-16 00:00:00
abstract::Increased biosynthesis of abscisic acid (ABA) occurs in plants in response to water deficit, which is mediated by changes in the levels of reactive oxygen species such as H2O2. Water deficit and ABA induce expression of some RD22-like proteins. This study aimed to evaluate the effect of water deficit and exogenous ABA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08976-x
更新日期:2017-08-18 00:00:00
abstract::Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their chemical composition is unknown. As a case study, we analyzed the metabolite profiles of 17 plant species and 45 biomass samples from agricultural grasslands in Eng...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20091-z
更新日期:2018-01-26 00:00:00
abstract::Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65919-9
更新日期:2020-06-02 00:00:00
abstract::The Gulf of California, Mexico is home to many cetacean species, including a presumed resident population of fin whales, Balaenoptera physalus. Past studies reported very low levels of genetic diversity among Gulf of California fin whales and a significant level of genetic differentiation from con-specifics in the eas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48700-5
更新日期:2019-08-27 00:00:00
abstract::Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Clinical trials have ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30841-8
更新日期:2018-08-17 00:00:00
abstract::This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72401-z
更新日期:2020-09-30 00:00:00
abstract::Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06785
更新日期:2014-10-30 00:00:00
abstract::Constitutive expression of Odorant-Binding Proteins (OBPs) in antennae and other body parts has been examined mainly to infer their involvement in insect olfaction, while their regulation in response to semiochemical stimuli has remained poorly known. Previous studies of semiochemical response were basically done usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24297-z
更新日期:2018-04-16 00:00:00
abstract::Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and granulocytes. This complex process is regulated by various extracellular a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24203-7
更新日期:2018-05-08 00:00:00
abstract::In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36814
更新日期:2016-11-14 00:00:00
abstract::A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-37591-7
更新日期:2019-01-22 00:00:00
abstract::The morphological and topochemical changes in wood tissues in compression wood of Japanese cedar (Cryptomeria japonica) upon treated with two types of ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C2mim][Cl]) and 1-ethylpyridinium bromide ([EtPy][Br]) were investigated. Compression wood tracheids were swollen ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30147
更新日期:2016-07-18 00:00:00
abstract::Aerosols impact clear-sky surface irradiance () through the effects of scattering and absorption. Linear or nonlinear relationships between aerosol optical depth (τa) and have been established to describe the aerosol direct radiative effect on (ADRE). However, considerable uncertainties remain associated with ADRE due...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14376
更新日期:2015-09-23 00:00:00