Abstract：
:The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase longevity. However, fundamental questions remain unanswered, including the temporal requirements for β5 overexpression and whether β5 overexpression can extend lifespan in other species. To determine if adult-only overexpression of the β5 subunit can increase proteasome activity in a different model, we characterized phenotypes associated with β5 overexpression in Drosophila melanogaster adults. We find that adult-only overexpression of the β5 subunit does not result in transcriptional upregulation of the other subunits of the proteasome as they do in nematodes and human cell culture. Despite this lack of a regulatory role, boosting β5 expression increases the chymotrypsin-like activity associated with the proteasome, reduces both the size and number of ubiquitinated protein aggregates in aged flies, and increases longevity. Surprisingly, these phenotypes were not associated with increased resistance to acute proteotoxic insults or improved metabolic parameters.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nguyen NN,Rana A,Goldman C,Moore R,Tai J,Hong Y,Shen J,Walker DW,Hur JHdoi
10.1038/s41598-019-39508-4subject
Has Abstractpub_date
2019-02-28 00:00:00pages
3170issue
1issn
2045-2322pii
10.1038/s41598-019-39508-4journal_volume
9pub_type
杂志文章abstract：:Geographic variation in aridity determines environmental productivity patterns, including large-scale variability in pathogens, vectors and associated diseases. If disease risk decreases with increasing aridity and is matched by immune defense, we predict a decrease in innate immune function along a gradient of increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62806-1
更新日期：2020-04-03 00:00:00
abstract：:People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-64514-2
更新日期：2020-05-04 00:00:00
abstract：:During rescue operations related to the elimination of the effects of industrial accidents or natural disasters, extinguishing agents are used that affect the migration and transformation of contamination in the environment. Firefighting foam sprayed onto an oil spill slowly drains to an aqueous solution and penetrate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65660-3
更新日期：2020-06-01 00:00:00
abstract：:Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, the membrane potential across the inner membrane (ΔΨ) could also contribute to u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44152-z
更新日期：2019-05-21 00:00:00
abstract：:In insects, the transition from juvenile development to the adult stage is controlled by juvenile hormone (JH) synthesized from the corpora allata (CA) glands. Whereas a JH-free period during the last juvenile instar triggers metamorphosis and the end of the growth period, the reappearance of this hormone after the im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40234
更新日期：2017-01-11 00:00:00
abstract：:Polymerized ionic liquids (polyILs) combine the unique properties of ionic liquids (ILs) with macromolecular polymers. But anion diffusivities in polyILs can be three orders of magnitude lower than that in ILs. Endeavors to improve ion transport in polyILs urgently need in-depth insights of ion transport in polyILs. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64689-8
更新日期：2020-05-08 00:00:00
abstract：:Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78737-w
更新日期：2020-12-11 00:00:00
abstract：:The understanding of the relationship between topology and behaviour in interconnected networks would allow to charac- terise and predict behaviour in many real complex networks since both are usually not simultaneously known. Most previous studies have focused on the relationship between topology and synchronisation....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22617
更新日期：2016-03-04 00:00:00
abstract：:Recent successes in malaria control have been largely attributable to the deployment of insecticide-based vector control tools such as bed nets and indoor residual spraying. Pyrethroid-treated bed nets are acutely neurotoxic to mosquitoes, inducing symptoms such as loss of coordination, paralysis, and violent spasms. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46674
更新日期：2017-04-25 00:00:00
abstract：:We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43916-x
更新日期：2019-05-16 00:00:00
abstract：:Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N3O2) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investigate the inhibitory efficiency...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12379
更新日期：2015-07-23 00:00:00
abstract：:We demonstrate a method for the preparation of negative-index fibre Bragg gratings (FBGs) using 800 nm femtosecond laser overexposure and thermal regeneration. A positive-index type I-IR FBG was first inscribed in H2-free single-mode fibre using a femtosecond laser directed through a phase mask, and then a highly pola...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23379
更新日期：2016-03-16 00:00:00
abstract：:Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45609
更新日期：2017-04-03 00:00:00
abstract：:The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydrofolate, an essenti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38083
更新日期：2016-12-01 00:00:00
abstract：:This paper describes a Functional Electrical Stimulation (FES) standing system for rehabilitation of bone mineral density (BMD) in people with Spinal Cord Injury (SCI). BMD recovery offers an increased quality of life for people with SCI by reducing their risk of fractures. The standing system developed comprises an i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49237-3
更新日期：2019-09-10 00:00:00
abstract：:Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75747-6
更新日期：2020-10-29 00:00:00
abstract：:Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols. The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31855-y
更新日期：2018-09-11 00:00:00
abstract：:Gravity perception plays a key role in how plants develop and adapt to environmental changes. However, more than a century after the pioneering work of Darwin, little is known on the sensing mechanism. Using a centrifugal device combined with growth kinematics imaging, we show that shoot gravitropic responses to stead...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35431
更新日期：2016-10-14 00:00:00
abstract：:We assessed the relationship between the heterogeneity of HCC on preoperative non-contrast-enhanced CT and patient prognosis. The heterogeneity of CT images from 122 patients was assessed and texture feature parameters such as mean, standard deviation (SD), entropy, mean of the positive pixels (MPP), skewness, and kur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12688-7
更新日期：2017-10-04 00:00:00
abstract：:Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency of neonates. Epithelial tight junction (TJ) proteins, such as claudins, are essential for regulation and function of the intestinal barrier. Rho kinase (ROCK) affects cellular permeability and TJ regulation. We hypothesized that TJ protein cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41442-4
更新日期：2019-03-21 00:00:00
abstract：:Epsilon-Near-Zero materials exhibit a transition in the real part of the dielectric permittivity from positive to negative value as a function of wavelength. Here we study metal-dielectric layered metamaterials in the homogenised regime (each layer has strongly subwavelength thickness) with zero real part of the permi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27700
更新日期：2016-06-13 00:00:00
abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56820-1
更新日期：2020-01-09 00:00:00
abstract：:Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28729
更新日期：2016-06-29 00:00:00
abstract：:Actinidia arguta 'Tianyuanhong' is a new kiwifruit variety with an all-red pericarp and pulp, in contrast to the all-green pulp of A. arguta 'Yongfengyihao'. Transcriptome profile analysis of fruit color has been reported, however, the metabolic mechanisms producing red flesh remain unknown, and it is unclear why the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06074-6
更新日期：2017-07-18 00:00:00
abstract：:Stylopine is a protoberberine-type alkaloid that has potential biological activities. Based on the successful microbial production of (S)-reticuline, we attempted to produce stylopine from (S)-reticuline by the reaction of berberine bridge enzyme, cheilanthifoline synthase (CYP719A5), and stylopine synthase (CYP719A2)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22201
更新日期：2016-02-29 00:00:00
abstract：:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21247
更新日期：2016-02-16 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54609-w
更新日期：2019-11-27 00:00:00
abstract：:There is considerable interest in how early life experiences shape behavioural development. For example, the socialisation of unfamiliar pigs pre-weaning has been suggested to decrease aggression during later life. However, the behavioural mechanisms behind this socialisation effect remain unexplored. We allowed 12 li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40980-1
更新日期：2019-03-12 00:00:00
abstract：:Graphene, a two-dimensional structure of carbon, due to its structure has unique physico-chemical properties that can be used in numerous research and industry areas. Although this structure is already well known, there are still technological (and cost) barriers which do not allow to produce this material in large qu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67977-5
更新日期：2020-07-06 00:00:00
abstract：:Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15717-7
更新日期：2017-11-10 00:00:00
