Abstract:
:Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols. The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese animals placed under different photoperiods. Non-obese and diet-induced obese male Fischer 344 rats were placed under either a short-day (SD) or long-day (LD) photoperiod and were supplemented with either 100 mg/kg of lyophilized red grapes or cherries. In non-obese animals, both fruits reduced energy balance independent of the photoperiod to which they were placed. However, the hypothalamic gene expression of Pomc was significantly up-regulated only in the SD photoperiod. In contrast, in obese animals only cherry significantly decreased the energy balance, although both fruits were able to counteract the diet-induced increase in hypothalamic AgRP mRNA levels when consumed during the SD photoperiod. In conclusion, the consumption of rich-polyphenol fruits may increase leptin sensitivity through the modulation of the hypothalamic leptin signal pathway mainly when consumed in the SD photoperiod. Therefore, fruit seasonality should be considered, as it can influence energy homeostasis and obesity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ibars M,Aragonès G,Ardid-Ruiz A,Gibert-Ramos A,Arola-Arnal A,Suárez M,Bladé Cdoi
10.1038/s41598-018-31855-ysubject
Has Abstractpub_date
2018-09-11 00:00:00pages
13572issue
1issn
2045-2322pii
10.1038/s41598-018-31855-yjournal_volume
8pub_type
杂志文章abstract::Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43446
更新日期:2017-03-06 00:00:00
abstract::The intricate molecular processes underlying photosynthesis have long been studied using various analytic approaches. However, the three-dimensional (3D) dynamics of such photosynthetic processes remain unexplored due to technological limitations related to investigating intraorganellar mechanisms in vivo. By developi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29940
更新日期:2016-07-15 00:00:00
abstract::Sleep, in addition to its brain restorative processes, plays an important role in memory transfer from its temporary store in the hippocampus to the more permanent storage in the neocortex. Alzheimer's disease (AD) affects memory and sleep. The aim of this study was to explore disturbances in global and local synchron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41851-5
更新日期:2019-03-29 00:00:00
abstract::Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30630
更新日期:2016-07-29 00:00:00
abstract::The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43187-6
更新日期:2019-04-30 00:00:00
abstract::This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46499-9
更新日期:2019-07-11 00:00:00
abstract::High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11401-y
更新日期:2017-09-11 00:00:00
abstract::The role of intraspecific variation in the magnitude and direction of plastic responses in ecology and evolution is increasingly recognized. However, the factors underlying intraspecific variation in plastic responses remain largely unexplored, particularly for the hypothesis that the herbivores' phenotypic response t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45220-0
更新日期:2019-06-21 00:00:00
abstract::Continuous gas-phase synthesis of nanoparticles is associated with rapid agglomeration, which can be a limiting factor for numerous applications. In this report, we challenge this paradigm by providing experimental evidence to support that gas-phase methods can be used to produce ultrapure non-agglomerated "singlet" n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15788
更新日期:2015-10-29 00:00:00
abstract::Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31906-4
更新日期:2018-09-10 00:00:00
abstract::The presence of non-poplar extracts, cutin, and wax layer in the wheat straw outer surface (WOS) greatly limit its application in bio-composite preparation. In this study, a dielectric-barrier-discharge plasma using water vapor as feeding gas was used to fast modify the WOS. The morphology, free radical concentrations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20285-5
更新日期:2018-02-02 00:00:00
abstract::The shape of fragments generated by the breakup of solids is central to a wide variety of problems ranging from the geomorphic evolution of boulders to the accumulation of space debris orbiting Earth. Although the statistics of the mass of fragments has been found to show a universal scaling behavior, the comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09147
更新日期:2015-03-16 00:00:00
abstract::We aimed to develop and validate a multiparametric MR radiomics model using conventional, diffusion-, and perfusion-weighted MR imaging for better prognostication in patients with newly diagnosed glioblastoma. A total of 216 patients with newly diagnosed glioblastoma were enrolled from two tertiary medical centers and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61178-w
更新日期:2020-03-06 00:00:00
abstract::Strongly interacting one-dimensional quantum systems often behave in a manner that is distinctly different from their higher-dimensional counterparts. When a particle attempts to move in a one-dimensional environment it will unavoidably have to interact and 'push' other particles in order to execute a pattern of motio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10675
更新日期:2015-06-15 00:00:00
abstract::Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09253
更新日期:2015-03-19 00:00:00
abstract::In vertebrates, growth hormone/insulin-like growth factor (GH/IGF) axis signaling plays a critical role in regulating somatic growth. Understanding the direct upstream regulators of GH/IGF axis remains a major challenge. Our studies of the zebrafish reveal that the conserved miR-200 family members are critical regulat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15906
更新日期:2015-10-28 00:00:00
abstract::Nuclear magnetic resonance (NMR) is a fundamental research tool that is widely used in many fields. Despite its powerful applications, unfortunately the low sensitivity of conventional NMR makes it difficult to study thin film or nano-sized samples. In this work, we report the first NMR spectrum obtained from general ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03189
更新日期:2013-11-12 00:00:00
abstract::Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76415-5
更新日期:2020-11-20 00:00:00
abstract::Multifocal multiphoton microscopy (MMM) achieves fast imaging by simultaneously scanning multiple foci across different regions of specimen. The use of imaging detectors in MMM, such as CCD or CMOS, results in degradation of image signal-to-noise-ratio (SNR) due to the scattering of emitted photons. SNR can be partly ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05153
更新日期:2014-06-05 00:00:00
abstract::Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right pari...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24831
更新日期:2016-04-20 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia characterized by the formation of amyloid plaques (Aβ). Over the last decade, the important role of the innate immune system for the disease development has been established. Chronic activation of microglial cells creates a proinflammatory environment, which...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19699-y
更新日期:2018-01-24 00:00:00
abstract::Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic diversity is expressed in brain function still remains unclear. Functional connectivity has been shown to be a valuable approach in characterizing t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21697
更新日期:2016-02-22 00:00:00
abstract::Antiretroviral therapy containing an integrase strand transfer inhibitor (INSTI) plus two NRTIs has become the recommended treatment for antiretroviral-naive HIV-1-infected patients in the updated guidelines. We aimed to determine the prevalence of INSTI-related mutations in Taiwan. Genotypic resistance assays were pe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35779
更新日期:2016-10-25 00:00:00
abstract::PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28890
更新日期:2016-07-04 00:00:00
abstract::Sweet sorghum bagasse (SSB) is a promising raw material for silage fermentation due to its high residual nutritive, but the efficient fermentation strategy of SSB has not been reported yet. This study evaluated the effects of microbial inoculant on the fermentation quality, chemical composition and microbial community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57628-0
更新日期:2020-01-21 00:00:00
abstract::Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18302-0
更新日期:2017-12-22 00:00:00
abstract::Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18921-7
更新日期:2018-01-12 00:00:00
abstract::Ideal sillenite type Bi12FeO20 (BFO) micron sized single crystals have been successfully grown via inexpensive hydrothermal method. The refined single crystal X-ray diffraction data reveals cubic Bi12FeO20 structure with single crystal parameters. Occurrence of rare Fe4+ state is identified via X-ray photoelectron spe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78598-3
更新日期:2020-12-16 00:00:00
abstract::Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play a crucial role in growth and development, as well as metabolic processes. However, knowledge of the function of LBD proteins in Camellia sinensis is limited, and no systematic investigations of the LBD family have been re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52027-6
更新日期:2019-10-30 00:00:00
abstract::During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16868
更新日期:2015-11-20 00:00:00