Abstract：
:As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhesion molecules, but also by other as yet unknown mechanisms. Since protein glycosylation is an important determinant of cell adhesion, we hypothesized that radiation could alter the glycosylation pattern of endothelial cells and thereby impact adhesion of circulating cells. Herein, we show that ionizing radiation increases high mannose-type N-glycans and decreases glycosaminoglycans. These changes stimulate interactions measured under flow conditions between irradiated endothelial cells and monocytes. Targeted transcriptomic approaches in vitro in endothelial cells and in vivo in a radiation enteropathy mouse model confirm that genes involved in N- and O-glycosylation are modulated by radiation, and in silico analyses give insight into the mechanism by which radiation modifies glycosylation. The endothelium glycome may therefore be considered as a key therapeutic target for modulating the chronic inflammatory response observed in healthy tissues or for participating in tumor control by radiation therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jaillet C,Morelle W,Slomianny MC,Paget V,Tarlet G,Buard V,Selbonne S,Caffin F,Rannou E,Martinez P,François A,Foulquier F,Allain F,Milliat F,Guipaud Odoi
10.1038/s41598-017-05563-ysubject
Has Abstractpub_date
2017-07-13 00:00:00pages
5290issue
1issn
2045-2322pii
10.1038/s41598-017-05563-yjournal_volume
7pub_type
杂志文章abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...
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pub_type： 杂志文章,多中心研究
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