Abstract：
:MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses during T1 relaxation. In this paper, we propose a method to simultaneously calibrate flip angles and measure T1 in vivo during a breath-hold time of less than 4 seconds. We demonstrate the accuracy, robustness and repeatability of this method and contrast it with traditional methods. By measuring the T1 of hyperpolarized gas, the oxygen pressure in vivo can be calibrated during the same breath hold. The results of the calibration have been applied in variable flip angle (VFA) scheme to obtain a stable steady-state transverse magnetization. Coupled with this method, the ultra-short TE (UTE) and constant VFA (CVFA) schemes are expected to give rise to new applications of hyperpolarized media.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhong J,Ruan W,Han Y,Sun X,Ye C,Zhou Xdoi
10.1038/srep25854subject
Has Abstractpub_date
2016-05-12 00:00:00pages
25854issn
2045-2322pii
srep25854journal_volume
6pub_type
杂志文章abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-30955-z
更新日期：2018-08-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-46785-6
更新日期：2019-07-17 00:00:00
abstract：:Chemical separation has great importance in industrial applications. Separation of xylene isomers still prevails to be one of the most important challenges in chemical industry, due to the large amount of commercial use of p-xylene in the production of beverage bottles, fibers and films. A novel Zn(II)-based dynamic c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05761
更新日期：2014-07-21 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-53737-7
更新日期：2019-11-13 00:00:00
abstract：:Cholinergic regulation of arterial luminal diameter involves intricate network of intercellular communication between the endothelial and smooth muscle cells that is highly dependent on the molecular mediators released by the endothelium. Albeit the well-recognized contribution of nitric oxide (NO) towards vasodilatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20322
更新日期：2016-02-02 00:00:00
abstract：:Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39204-3
更新日期：2019-02-22 00:00:00
abstract：:The freshwater snail Oncomelania hupensis is the unique intermediate host of the blood fluke Schistosoma japonicum, which is the major cause of schistosomiasis. The snail inhabits two contrasting environments: the hilly and marshland regions. The hilly snails are smaller in size and have the typical smooth shell, wher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16084-z
更新日期：2017-11-17 00:00:00
abstract：:In this report, spherical silver nanoparticle (AgNP-sp) and rod-shaped silver nanoparticle (AgNR) were prepared by chemical reduction method and their antibacterial activity against various Gram-positive and Gram-negative bacteria had been evaluated for their efficiency. Minimal inhibitory concentration (MIC) tests we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18590-6
更新日期：2018-01-09 00:00:00
abstract：:Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39557-9
更新日期：2019-02-27 00:00:00
abstract：:Spiral waves anchored to obstacles in cardiac tissues may cause lethal arrhythmia. To unpin these anchored spirals, comparing to high-voltage side-effect traditional therapies, wave emission from heterogeneities (WEH) induced by the uniform electric field (UEF) has provided a low-voltage alternative. Here we provide a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04831
更新日期：2014-04-29 00:00:00
abstract：:The effect of substitution of Nb by Mo in Nb40Ti30Ni30 was investigated with respect to microstructural features and hydrogen dissolution, diffusion and permeation. As-cast Nb40-xMoxTi30Ni30 (x = 0, 5, 10) alloys consist of primary bcc-Nb phase and binary eutectic (bcc-Nb + B2-TiNi). The substitution of Nb by Mo reduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00335-0
更新日期：2017-03-16 00:00:00
abstract：:Male Wistar rats were exposed to herbicide, pendimethalin (PND) at varying oral doses of 62.5, 125 and 250 mg/kg b.w. for 14 days. Toxiological effects were assessed in terms of oxidative stress, DNA damage, histopathological alterations and induction of anti-inflammatory and apoptotic responses linked Bax, Bcl-2, IFN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35484-3
更新日期：2018-11-20 00:00:00
abstract：:Phytoene desaturases catalyse from two to six desaturation reactions on phytoene, generating a large diversity of molecules that can then be cyclised and produce, depending on the organism, many different carotenoids. We constructed a phylogenetic tree of a subset of phytoene desaturases from the CrtI family for which...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77876-4
更新日期：2020-12-03 00:00:00
abstract：:Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35289
更新日期：2016-10-18 00:00:00
abstract：:Ergothioneine (ERG), a unique thiol compound, is suggested to function as an antioxidant and cytoprotectant. Despite several recent attempts to produce ERG using various organisms, its yield was still very low and the costs remained high. Since the level of ERG produced depends strictly on the availability of three di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38382-w
更新日期：2019-02-13 00:00:00
abstract：:A new fluorine-substituted ligand, compound 1 (CB251), with a very high affinity (Ki = 0.27 ± 0.09 nM) and selectivity for the 18-kDa translocator protein (TSPO), is presented as an attractive biomarker for the diagnosis of neuroinflammation, neurodegeneration and tumour progression. To test compound 1 as a TSPO PET i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20422
更新日期：2016-02-08 00:00:00
abstract：:This work highlights the possibility of using microstructured fibres with predefined doped regions to produce functional microstructures at a fibre facet with differential chemical etching. A specially designed silica microstructured fibre (MSF) that possesses specific boron-doped silica regions was fabricated for the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21279
更新日期：2016-02-19 00:00:00
abstract：:Plant responses to salinity have been extensively studied over the last decades. Despite the vast accumulated knowledge, the ways Arabidopsis lateral roots (LR) cope with lethal salinity has not been fully resolved. Here we compared the primary root (PR) and the LR responses during events leading to lethal salinity (N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60163-7
更新日期：2020-02-24 00:00:00
abstract：:Glial cell-derived neurotrophic factor (GDNF) has shown beneficial effects in models of Parkinson's disease. The mild results observed in the double-blind clinical trial by intraputamenal infusion of recombinant GDNF proteins warrant a search for alternative delivery methods. In this study, we investigated the functio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02786
更新日期：2013-09-27 00:00:00
abstract：:Volatile organic compounds (VOCs) represent a broad class of chemicals, many of which can be found in indoor air including residential indoor air. VOCs derive from a variety of sources including cleaning products, cooking practices, fragrances and fresheners, hobbies and at-home work behaviors. This study examined res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78756-7
更新日期：2020-12-10 00:00:00
abstract：:Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31668
更新日期：2016-08-23 00:00:00
abstract：:Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether individual differences in BMI control based on motor imagery (MI) are related to differences in MI ability. We assessed whether differences ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24076
更新日期：2016-04-07 00:00:00
abstract：:Gaze-following behaviour is considered crucial for social interactions which are influenced by social similarity. We investigated whether the degree of similarity, as indicated by the perceived age of another person, can modulate gaze following. Participants of three different age-groups (18-25; 35-45; over 65) perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04746
更新日期：2014-04-22 00:00:00
abstract：:Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53192-4
更新日期：2019-11-22 00:00:00
abstract：:The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40804-2
更新日期：2019-03-12 00:00:00
abstract：:Isopods of the genus Idotea have an unusual ability to feed on algae containing high amounts of chemical defense molecules, such as species of the genera Fucus and Ulva. In this study, we compared gene expression patterns of Idotea balthica individuals fed with Fucus vesiculosus to individuals fed with Ulva lactuca. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34937-z
更新日期：2018-11-14 00:00:00
abstract：:Three-dimensional (3D) bioprinting is driving major innovations in the area of cartilage tissue engineering. Extrusion-based 3D bioprinting necessitates a phase change from a liquid bioink to a semi-solid crosslinked network achieved by a photo-initiated free radical polymerization reaction that is known to be cytotox...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05699-x
更新日期：2017-07-19 00:00:00
abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34726-8
更新日期：2018-11-15 00:00:00
abstract：:Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14801
更新日期：2015-10-07 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-73944-x
更新日期：2020-10-09 00:00:00
