Urinary and Fecal Metabonomics Study of the Protective Effect of Chaihu-Shu-Gan-San on Antibiotic-Induced Gut Microbiota Dysbiosis in Rats.

abstract：:Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector T-cells (Teff). To...

journal_title：Scientific reports

authors： Kumar P,Alharshawi K,Bhattacharya P,Marinelarena A,Haddad C,Sun Z,Chiba S,Epstein AL,Prabhakar BS

更新日期：2017-01-03 00:00:00

abstract：:We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...

journal_title：Scientific reports

authors： Amin M,Farhat M,Baǧcı H

更新日期：2013-01-01 00:00:00

abstract：:There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subje...

journal_title：Scientific reports

authors： Chu X,Zhou Y,Hu Z,Lou J,Song W,Li J,Liang X,Chen C,Wang S,Yang B,Chen L,Zhang X,Song J,Dong Y,Chen S,He L,Xie Q,Chen X,Li W

更新日期：2016-09-09 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Plant cells are covered with rigid cell walls, yet tip-growing cells can elongate by providing new cell wall material to their apical regions. Studies of the mechanical properties of tip-growing plant cells typically involve measurement of the turgor pressure and stiffness of the cells' apical regions. These experimen...

journal_title：Scientific reports

authors： Yanagisawa N,Sugimoto N,Arata H,Higashiyama T,Sato Y

更新日期：2017-05-03 00:00:00

abstract：:We have prepared and studied a family of cyanobiphenyl dimers with varying linking groups with a view to exploring how molecular structure dictates the stability of the nematic and twist-bend nematic mesophases. Using molecular modelling and 1D 1H NOESY NMR spectroscopy, we determine the angle between the two aromatic...

journal_title：Scientific reports

authors： Mandle RJ,Archbold CT,Sarju JP,Andrews JL,Goodby JW

更新日期：2016-11-07 00:00:00

abstract：:The nuclear factor κB (NF-κB) pathway plays a key role in innate and adaptive immunity, cell proliferation and survival, inflammation and tumors development. MiR-146a is an immune system regulator that has anti-inflammatory function in multiple cell types and conditions. Here we demonstrate activation of canonical NF-...

journal_title：Scientific reports

authors： Venuti A,Musarra-Pizzo M,Pennisi R,Tankov S,Medici MA,Mastino A,Rebane A,Sciortino MT

更新日期：2019-03-26 00:00:00

abstract：:Traditional radiomics models mainly rely on explicitly-designed handcrafted features from medical images. This paper aimed to investigate if deep features extracted via transfer learning can generate radiomics signatures for prediction of overall survival (OS) in patients with Glioblastoma Multiforme (GBM). This study...

journal_title：Scientific reports

authors： Lao J,Chen Y,Li ZC,Li Q,Zhang J,Liu J,Zhai G

更新日期：2017-09-04 00:00:00

abstract：:Recombination is crucial for biological evolution, which provides many new combinations of genetic diversity. Accurate identification of recombination spots is useful for DNA function study. To improve the prediction accuracy, researchers have proposed several computational methods for recombination spot identificatio...

journal_title：Scientific reports

authors： Wang R,Xu Y,Liu B

更新日期：2016-03-31 00:00:00

abstract：:The focus of this study is to evaluate the efficacy of Machine Learning (ML) algorithms in the long-lead prediction of El Niño (La Niña) Modoki (ENSO Modoki) index (EMI). We evaluated two widely used non-linear ML algorithms namely Support Vector Regression (SVR) and Random Forest (RF) to forecast the EMI at various l...

journal_title：Scientific reports

authors： Pal M,Maity R,Ratnam JV,Nonaka M,Behera SK

更新日期：2020-01-15 00:00:00

abstract：:Sacrospinous ligament fixation (SSLF) is one of the most utilized surgeries in the management of pelvic organ prolapse (POP). We conducted a large-series study of SSLF in a tertiary center by an experienced urogynecologic team. The 453 women with POP who underwent SSLF at National Taiwan University Hospital in the per...

journal_title：Scientific reports

authors： Wu CJ,Chang WC,Huang KJ,Hsieh YC,Wei LH,Sheu BC

更新日期：2020-03-19 00:00:00

abstract：:Mosquito larvae continuously encounter microbes in their aquatic environment, which serve as food and play a critical role in successful development. In previous work, we isolated a Chromobacterium sp. (C.sp_P) with larvicidal activity from the midgut of dengue vector Aedes mosquitoes in Panama. In this study, we foun...

journal_title：Scientific reports

authors： Short SM,van Tol S,MacLeod HJ,Dimopoulos G

更新日期：2018-05-29 00:00:00

abstract：:Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by initiating oxidative stress and/or an inflammatory response. In addition, cerebral endothelial dysfunction (particularly at the lev...

journal_title：Scientific reports

authors： Bernard A,Ku JM,Vlahos R,Miller AA

更新日期：2019-10-30 00:00:00

abstract：:There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...

journal_title：Scientific reports

authors： Barker J,Atxitia U,Ostler TA,Hovorka O,Chubykalo-Fesenko O,Chantrell RW

更新日期：2013-11-20 00:00:00

abstract：:The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C4-chair, (2)SO-skew boat, and less frequently, in (4)C1-chair conformations. Here, we analyzed the conformation of IdoA residue ...

journal_title：Scientific reports

authors： Hsieh PH,Thieker DF,Guerrini M,Woods RJ,Liu J

更新日期：2016-07-14 00:00:00

abstract：:Heating on the microscale using focused lasers gave rise to recent applications, e.g., in biomedicine, biology and microfluidics, especially using gold nanoparticles as efficient nanoabsorbers of light. However, such an approach naturally leads to nonuniform, Gaussian-like temperature distributions due to the diffusiv...

journal_title：Scientific reports

authors： Durdevic L,Robert HML,Wattellier B,Monneret S,Baffou G

更新日期：2019-03-15 00:00:00

abstract：:Unlike MoS2 ultra-thin films, where solution-based single source precursor synthesis for electronic applications has been widely studied, growing uniform and large area few-layer WS2 films using this approach has been more challenging. Here, we report a method for growth of few-layer WS2 that results in continuous and...

journal_title：Scientific reports

authors： Abbas OA,Zeimpekis I,Wang H,Lewis AH,Sessions NP,Ebert M,Aspiotis N,Huang CC,Hewak D,Mailis S,Sazio P

更新日期：2020-02-03 00:00:00

abstract：:Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...

journal_title：Scientific reports

authors： Sharma P,Diergaarde B,Ferrone S,Kirkwood JM,Whiteside TL

更新日期：2020-01-09 00:00:00

abstract：:Monitoring one's actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These error(-related) negativity (Ne/ERN) amplitudes are often found to be attenuated in patients with Parkinson's disease (PD) compared to health...

journal_title：Scientific reports

authors： Seer C,Lange F,Loens S,Wegner F,Schrader C,Dressler D,Dengler R,Kopp B

更新日期：2017-01-24 00:00:00

abstract：:Several mosquito species have been described as vectors for the Zika virus (ZIKV), such as those in the Aedes, Anopheles, Mansonia and Culex genera. Our previous survey studies were found the ZIKV RNA positive in both male, female and larvae of Culex quinquefasciatus Say and Aedes aegypti (L.) mosquitoes collected fro...

journal_title：Scientific reports

authors： Phumee A,Chompoosri J,Intayot P,Boonserm R,Boonyasuppayakorn S,Buathong R,Thavara U,Tawatsin A,Joyjinda Y,Wacharapluesadee S,Siriyasatien P

更新日期：2019-03-27 00:00:00

abstract：:The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) or conformation. The key issue in lignin-polymerization is to quantify the number of hydroxyl groups in the pristine molecules for subseque...

journal_title：Scientific reports

authors： Park IK,Sun H,Kim SH,Kim Y,Kim GE,Lee Y,Kim T,Choi HR,Suhr J,Nam JD

更新日期：2019-05-07 00:00:00

abstract：:Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value < 5 × 10-8) with diabetic albuminuria, in Finnish individuals with t...

journal_title：Scientific reports

authors： Sandholm N,Haukka JK,Toppila I,Valo E,Harjutsalo V,Forsblom C,Groop PH

更新日期：2018-08-17 00:00:00

abstract：:The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data...

journal_title：Scientific reports

authors： Magi A,Masselli M,Sala C,Guerriero A,Laise P,Puccini B,Rigacci L,Breschi C,Crociani O,Pillozzi S,Arcangeli A

更新日期：2019-06-13 00:00:00

abstract：:In this report, we propose and demonstrate an air-mode photonic crystal ring resonator (PhCRR) on silicon-on-insulator platform. Air mode is utilized to confine the optical field into photonic crystal (PhC) air holes, which is confirmed by the three-dimensional finite-difference time-domain simulation. PhCRR structure...

journal_title：Scientific reports

authors： Gao G,Zhang Y,Zhang H,Wang Y,Huang Q,Xia J

更新日期：2016-01-28 00:00:00

abstract：:Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...

journal_title：Scientific reports

authors： Li W,Wu Y,Kong D,Yang H,Wang Y,Shao J,Feng Y,Chen W,Ma L,Ying T,Dimitrov DS

更新日期：2017-08-22 00:00:00

abstract：:We present a two-step technique for the synthesis of superconducting CuxBi2Se3. Cu0.15Bi2Se3 single crystals were synthesized using the melt-growth method. Although these samples are non-superconducting, they can be employed to generate high quality superconducting samples if used as precursors in the following electr...

journal_title：Scientific reports

authors： Wang M,Song Y,You L,Li Z,Gao B,Xie X,Jiang M

更新日期：2016-03-03 00:00:00

abstract：:The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...

journal_title：Scientific reports

authors： Harbers H,Zanolli C,Cazenave M,Theil JC,Ortiz K,Blanc B,Locatelli Y,Schafberg R,Lecompte F,Baly I,Laurens F,Callou C,Herrel A,Puymerail L,Cucchi T

更新日期：2020-11-04 00:00:00

abstract：:Contrast-induced nephropathy (CIN) has become the third-leading cause of hospital-acquired acute renal injury. Although alprostadil has been proposed as an effective preventative measure, this conclusion remains inconsistent. Thus, we performed a meta-analysis of the published studies on this topic to evaluate the pre...

journal_title：Scientific reports

authors： Zhang JZ,Kang XJ,Gao Y,Zheng YY,Wu TT,Li L,Liu F,Yang YN,Li XM,Ma YT,Xie X

更新日期：2017-04-21 00:00:00

abstract：:Anopheles gambiae and Aedes aegypti are perhaps the best studied mosquito species and important carriers of human malaria and arbovirus, respectively. Mosquitoes have daily rhythms in behaviors and show a wide range of activity patterns. Although Anopheles is known to be principally nocturnal and Aedes principally diu...

journal_title：Scientific reports

authors： Araujo MDS,Guo F,Rosbash M

更新日期：2020-03-19 00:00:00

abstract：:Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...

journal_title：Scientific reports

authors： Xu X,Xu L,Yuan G,Wang Y,Qu Y,Zhou M

更新日期：2018-05-08 00:00:00