Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors.

abstract：:Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as substrates for protein kinase CK2. Here, we have analysed the interplay of PDX-1...

journal_title：Scientific reports

authors： Spohrer S,Groß R,Nalbach L,Schwind L,Stumpf H,Menger MD,Ampofo E,Montenarh M,Götz C

更新日期：2017-11-27 00:00:00

abstract：:Spinal Muscular Atrophy (SMA) is a monogenic neurodegenerative disorder and the leading genetic cause of infantile mortality. While several functions have been ascribed to the SMN (survival motor neuron) protein, their specific contribution to the disease has yet to be fully elucidated. We hypothesized that some, but ...

journal_title：Scientific reports

authors： Osman EY,Bolding MR,Villalón E,Kaifer KA,Lorson ZC,Tisdale S,Hao Y,Conant GC,Pires JC,Pellizzoni L,Lorson CL

更新日期：2019-07-01 00:00:00

abstract：:Toxins are believed to play a crucial role in Burkholderia pseudomallei pathogenicity, however to date, only a few have been identified. The discovery of additional toxic molecules is limited by the lack of a sensitive indicator of B. pseudomallei toxicity. Previously, from a whole genome transcriptome analysis of B. ...

journal_title：Scientific reports

authors： Wong RR,Kong C,Lee SH,Nathan S

更新日期：2016-06-07 00:00:00

abstract：ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...

journal_title：Scientific reports

authors： Yang L,Zhou YJ,Zhang C,Xiao QX

更新日期：2017-10-27 00:00:00

abstract：:Sporadic outbreaks caused by coxsackievirus A4 (CV-A4) have been reported worldwide. To further elucidate the detailed genetic characteristics and evolutionary recombination events of CV-A4, virus samples from nationwide hand, foot and mouth disease (HFMD) surveillance, encompassing 27 out of the 31 provinces in China...

journal_title：Scientific reports

authors： Ji T,Guo Y,Lv L,Wang J,Shi Y,Yu Q,Zhang F,Tong W,Ma J,Zeng H,Zhao H,Zhang Y,Han T,Song Y,Yan D,Yang Q,Zhu S,Zhang Y,Xu W

更新日期：2019-09-20 00:00:00

abstract：:Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...

journal_title：Scientific reports

authors： Alberdi P,Cabezas-Cruz A,Prados PE,Rayo MV,Artigas-Jerónimo S,de la Fuente J

更新日期：2019-09-13 00:00:00

abstract：:Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. Little is known about flicker-induced changes of activity of retinal neurons themselves. We non-invasively investigated flicker-induc...

journal_title：Scientific reports

authors： Chou TH,Toft-Nielsen J,Porciatti V

更新日期：2019-12-05 00:00:00

abstract：:Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...

journal_title：Scientific reports

authors： Lai FY,Lympousi K,Been F,Benaglia L,Udrisard R,Delémont O,Esseiva P,Thomaidis NS,Covaci A,van Nuijs ALN

更新日期：2018-09-05 00:00:00

abstract：:Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty restenosis. A prospective, randomized, feasibility study was conducted to investigate the effect of ascorbic acid to...

journal_title：Scientific reports

authors： Yang CW,Wu CC,Luo CM,Chuang SY,Chen CH,Shen YF,Tarng DC

更新日期：2019-07-31 00:00:00

abstract：:The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) or conformation. The key issue in lignin-polymerization is to quantify the number of hydroxyl groups in the pristine molecules for subseque...

journal_title：Scientific reports

authors： Park IK,Sun H,Kim SH,Kim Y,Kim GE,Lee Y,Kim T,Choi HR,Suhr J,Nam JD

更新日期：2019-05-07 00:00:00

abstract：:Tendinopathy accounts for over 30% of primary care consultations and represents a growing healthcare challenge in an active and increasingly ageing population. Recognising critical cells involved in tendinopathy is essential in developing therapeutics to meet this challenge. Tendon cells are heterogenous and sparsely ...

journal_title：Scientific reports

authors： Kendal AR,Layton T,Al-Mossawi H,Appleton L,Dakin S,Brown R,Loizou C,Rogers M,Sharp R,Carr A

更新日期：2020-09-03 00:00:00

abstract：:Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import. We characterize the diffusion properties of individual Tom40 molecules fused to the photoconvertable fluorescent protein Dendra2 wi...

journal_title：Scientific reports

authors： Kuzmenko A,Tankov S,English BP,Tarassov I,Tenson T,Kamenski P,Elf J,Hauryliuk V

更新日期：2011-01-01 00:00:00

abstract：:Novel bioplastic films derived from wool keratins were prepared by protein solution in an alkaline mild oxidative method that splits disulphide (-S-S-) bonds. The native structure of the keratin macromolecules was partially modified upon extraction as revealed by the decrease of the β-sheet to α-helices/coils ratio bu...

journal_title：Scientific reports

authors： Fernández-d'Arlas B

更新日期：2019-10-15 00:00:00

abstract：:We present a study of precessional magnetization switching in orthogonal spin-torque spin-valve devices at low temperatures. The samples consist of a spin-polarizing layer that is magnetized out-of-the film plane and an in-plane magnetized free and reference magnetic layer separated by non-magnetic metallic layers. We...

journal_title：Scientific reports

authors： Rowlands GE,Ryan CA,Ye L,Rehm L,Pinna D,Kent AD,Ohki TA

更新日期：2019-01-28 00:00:00

abstract：:During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segrega...

journal_title：Scientific reports

authors： Mihajlović AI,Thamodaran V,Bruce AW

更新日期：2015-10-13 00:00:00

abstract：:Stored-product psocids (Psocoptera: Liposcelididae) are cosmopolitan storage pests that can damage stored products and cause serious economic loss. However, because of the body size (~1 mm) of eggs, nymphs, and adults, morphological identification of most stored-product psocids is difficult and hampers effective ident...

journal_title：Scientific reports

authors： Liu LJ,Pang AH,Feng SQ,Cui BY,Zhao ZH,Kučerová Z,Stejskal V,Opit G,Aulicky R,Cao Y,Li FJ,Wu Y,Zhang T,Li ZH

更新日期：2017-12-01 00:00:00

abstract：:Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later life. It is not clear whether there are individual differences in the effects of early life overfeeding and what the underlying mechanistic pathways are. We investigated the long-lasting effects of small litter size, an exp...

journal_title：Scientific reports

authors： Salari AA,Samadi H,Homberg JR,Kosari-Nasab M

更新日期：2018-07-26 00:00:00

abstract：:Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral...

journal_title：Scientific reports

authors： Cal L,Suarez-Bregua P,Comesaña P,Owen J,Braasch I,Kelsh R,Cerdá-Reverter JM,Rotllant J

更新日期：2019-03-05 00:00:00

abstract：:A bound state in the continuum (BIC) is an unusual localized state that is embedded in a continuum of extended states. Here, we present the general condition for BICs to arise from wave equation separability. Then we show that by exploiting perturbations of certain symmetry such BICs can be turned into resonances that...

journal_title：Scientific reports

authors： Rivera N,Hsu CW,Zhen B,Buljan H,Joannopoulos JD,Soljačić M

更新日期：2016-09-19 00:00:00

abstract：:Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...

journal_title：Scientific reports

authors： Basedow SL,McKee D,Lefering I,Gislason A,Daase M,Trudnowska E,Egeland ES,Choquet M,Falk-Petersen S

更新日期：2019-01-24 00:00:00

abstract：:Scaling evolutionary trees to time is essential for understanding the origins of clades. Recently developed methods allow including the entire fossil record known for the group of interest and eliminated the need for specifying prior distributions for node ages. Here we apply the fossilized birth-death (FBD) approach ...

journal_title：Scientific reports

authors： Šmíd J,Tolley KA

更新日期：2019-04-02 00:00:00

abstract：:Insects have evolved multiple mechanisms to adapt to variations in environmental temperatures, including postural control of solar input, variations in diurnal activity, external morphological structures and selecting/generating microhabitats. Foam produced by Mahanarva fimbriolata nymphs (also known as root spittlebu...

journal_title：Scientific reports

authors： Tonelli M,Gomes G,Silva WD,Magri NTC,Vieira DM,Aguiar CL,Bento JMS

更新日期：2018-03-16 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Saldaña L,Vallés G,Bensiamar F,Mancebo FJ,García-Rey E,Vilaboa N

更新日期：2018-03-06 00:00:00

abstract：:Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (MT1-AF7p) that bonded to the "MT-Loop" region of MT1-MMP was identified by using a phage-displayed peptide libr...

journal_title：Scientific reports

authors： Ren L,Wang Y,Zhu L,Shen L,Zhang J,Wang J,Li H,Zheng Q,Yu D,Fang X

更新日期：2018-07-09 00:00:00

abstract：:Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and func...

journal_title：Scientific reports

authors： Katchalski T,Case T,Kim KY,Ramachandra R,Bushong EA,Deerinck TJ,Haberl MG,Mackey MR,Peltier S,Castillon GA,Fujikawa N,Lawrence AR,Ellisman MH

更新日期：2018-05-15 00:00:00

abstract：:Fabric-based personal heating patches have small geometric profiles and can be attached to selected areas of garments for personal thermal management to enable significant energy savings in built environments. Scalable fabrication of such patches with high thermal performance at low applied voltage, high durability an...

journal_title：Scientific reports

authors： Hwang HJ,Devaraj H,Yang C,Gao Z,Chang CH,Lee H,Malhotra R

更新日期：2018-11-21 00:00:00

abstract：:The current standard of care for head and neck cancer includes surgical resection of the tumor followed by targeted head and neck radiation. This radiotherapy results in a multitude of negative side effects in adjacent normal tissues. Autophagy is a cellular mechanism that could be targeted to ameliorate these side ef...

journal_title：Scientific reports

authors： Morgan-Bathke M,Hill GA,Harris ZI,Lin HH,Chibly AM,Klein RR,Burd R,Ann DK,Limesand KH

更新日期：2014-06-06 00:00:00

abstract：:Polypyrrole complex nitrogen-doped porous carbon matrix (PPy/N-PCM) was synthesized by a simple two-step method. Firstly, graphene oxide was prepared by the modified Hummers method. Secondly, Polypyrrole was compounded on the graphene oxide substrate, and the carbon matrix with a high specific surface area was obtaine...

journal_title：Scientific reports

authors： Feng M,Lu W,Zhou Y,Zhen R,He H,Wang Y,Li C

更新日期：2020-09-21 00:00:00

abstract：:The exact mechanism of endometriosis is unknown. The recommendation system (RS) based on item similarities of machine learning has never been applied to the relationship between diseases. The study aim was to identify diseases associated with endometriosis by applying RS based on item similarities to insurance data in...

journal_title：Scientific reports

authors： Lee JH,Kwon SY,Chang J,Yuk JS

更新日期：2019-04-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

journal_title：Scientific reports

authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

更新日期：2019-01-23 00:00:00