Abstract:
:The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ([Formula: see text]) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor deposition (CVD) method. CVD graphene, which here served as a sensing platform, provided a highly sensitive and selective option, with detection limits of AA, DA, UA, Trp, and [Formula: see text] of 1.58, 0.06, 0.09, 0.10, and 6.45 μM (S/N = 3), respectively. The high selectivity of the electrode is here explained by a relationship between the bandgap energy of analyte and the Fermi level of graphene. The high sensitivity in the oxidation current was determined by analyzing the influence of the high surface area and chemical structure of free-standing graphene nanosheets on analyte adsorption capacity. This finding strongly indicates that the CVD graphene electrode can be used as a biosensor to detect five analytes in human serum.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang X,Gao D,Li M,Li H,Li C,Wu X,Yang Bdoi
10.1038/s41598-017-07646-2subject
Has Abstractpub_date
2017-08-01 00:00:00pages
7044issue
1issn
2045-2322pii
10.1038/s41598-017-07646-2journal_volume
7pub_type
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