Abstract:
:We describe a high resolution laser polarimeter built from commodity optical components. The optical rotation angle is determined by measuring the phase difference between two harmonically modulated polarised laser beams - an 'object beam' that passes through the sample under test and a 'reference beam' that bypasses the sample. The complete polarimeter may be assembled from low cost off-the-shelf parts for less than £300 (UK Sterling). Data acquisition and analysis are carried out on a microcontroller running an efficient algorithm based on the sliding Discrete Fourier Transform. Despite its low cost, the polarimeter is a fully automatic, research-grade instrument with an accuracy of ±0.0013° and a precision of ±0.0028° - comparable to far costlier commercial instruments. The polarimeter's ease of use, compact size, fast measurement times and high angular resolution make it a capable and versatile tool for analytical science, while its low cost means it is ideally suited for use in resource-constrained environments and process monitoring. The polarimeter is released here as open hardware, with technical diagrams, a full parts list, and source code for its firmware included as Supplementary Information.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Harvie AJ,Phillips TW,deMello JCdoi
10.1038/s41598-020-61715-7subject
Has Abstractpub_date
2020-03-25 00:00:00pages
5448issue
1issn
2045-2322pii
10.1038/s41598-020-61715-7journal_volume
10pub_type
杂志文章abstract::Muscular dystrophy-dystroglycanopathies comprise a heterogeneous and complex group of disorders caused by loss-of-function mutations in a multitude of genes that disrupt the glycobiology of α-dystroglycan, thereby affecting its ability to function as a receptor for extracellular matrix proteins. Of the various genes i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46431-1
更新日期:2019-07-11 00:00:00
abstract::Metallic glasses are disordered materials that offer the unique ability to perform thermoplastic forming operations at low thermal budget while preserving excellent mechanical properties such as high strength, large elastic strain limits, and wear resistance owing to the metallic nature of bonding and lack of internal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19530
更新日期:2016-01-20 00:00:00
abstract::Landscape's spatial structure has vast implications for the dynamics and distribution of species populations and ecological communities. However, the characterization of the structure of spatial networks has not received nearly as much attention as networks of species interactions counterparts. Recent experiments show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65669-8
更新日期:2020-05-26 00:00:00
abstract::Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in Cannabis, which is studied extensively for its medicinal value. A central gap in the science is the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profiles. Using a mass-spectrometry based metabolomic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46478-0
更新日期:2019-07-19 00:00:00
abstract::Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis. We aimed to analyze the CD4+ T cell anergy profile and their phenotypic and functional features through differential expression of cellu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49421-5
更新日期:2019-09-11 00:00:00
abstract::Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury on FBLN5 content, elastic fibers, b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63031-6
更新日期:2020-04-14 00:00:00
abstract::Male infertility is a worldwide medical problem. Asthenozoospermia is a common cause of infertility. Epigenetic modifications of DNA and histones have been shown to influence human infertility, but no research has explored whether N(6)-methyladenosine (m(6)A) level in RNA is associated with asthenozoospermia. Here, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24345
更新日期:2016-04-13 00:00:00
abstract::To develop an effective, safe, and convenient vaccine for the prevention of highly pathogenic avian influenza (HPAI) H5N1, we have constructed a recombinant Bacillus subtilis strain (B.S.-HA) expressing the hemagglutinin (HA) protein. Then we evaluated the immune function in chicken bone marrow derived dendritic cells...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38403
更新日期:2016-12-16 00:00:00
abstract::Macrophage infiltration and recruitment in breast tumors has been correlated with poor prognosis in breast cancer patients and has been linked to tumor cell dissemination. Much of our understanding comes from animal models in which macrophages are labeled by expression of an extrinsic fluorophore. However, conventiona...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25086
更新日期:2016-05-25 00:00:00
abstract::OVGP1 is the major non-serum glycoprotein in the oviduct fluid at the time of fertilization and early embryo development. Its activity differs among species. Here, we show that the C-terminal region of recombinant OVGP1 regulates its binding to the extracellular zona pellucida and affects its activity during fertiliza...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32556
更新日期:2016-09-07 00:00:00
abstract::Mechanochemical synthesis of Si/Cu3Si-based composite as negative electrode materials for lithium ion battery is investigated. Results indicate that CuO is decomposed and alloyed with Si forming amorphous Cu-Si solid solution due to high energy impacting during high energy mechanical milling (HEMM). Upon carbonization...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30703-3
更新日期:2018-08-23 00:00:00
abstract::The methyl farnesoate receptor (MfR) orchestrates aspects of reproduction and development such as male sex determination in branchiopod crustaceans. Phenotypic endpoints regulated by the receptor have been well-documented, but molecular interactions involved in receptor activation remain elusive. We hypothesized that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45071
更新日期:2017-03-21 00:00:00
abstract::In sugarcane (Saccharum spp. hybrid) breeding, introgression of useful genes via intergeneric hybridization is a powerful strategy for improving the crop productivity. Erianthus arundinaceus shows great potential in terms of useful traits; however, little is known about the cytogenetic and agronomic characteristics of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38316-6
更新日期:2019-02-11 00:00:00
abstract::The Acoustic Complexity Index (ACI) is increasingly applied to the study of biodiversity in aquatic habitats. However, it remains unknown which types of acoustic information are highlighted by this index in underwater environments. This study explored the robustness of the ACI to fine variations in fish sound abundanc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28771-6
更新日期:2018-07-12 00:00:00
abstract::Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29127-w
更新日期:2018-07-24 00:00:00
abstract::Glycan-protein lateral interactions have gained increased attention as important modulators of receptor function, by regulating surface residence time and endocytosis of membrane glycoproteins. The pathogen-recognition receptor DC-SIGN is highly expressed at the membrane of antigen-presenting dendritic cells, where it...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07220-w
更新日期:2017-07-27 00:00:00
abstract::The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19495-8
更新日期:2018-01-22 00:00:00
abstract::Reef coral assemblages are highly dynamic and subject to repeated disturbances, which are predicted to increase in response to climate change. Consequently there is an urgent need to improve our understanding of the mechanisms underlying different recovery scenarios. Recent work has demonstrated that reef structural c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02402-y
更新日期:2017-05-22 00:00:00
abstract::Coastal ecosystems play significant ecological and economic roles but are threatened and facing decline. Microbes drive various biogeochemical processes in coastal ecosystems. Tidal flats are critical components of coastal ecosystems; however, the structure and function of microbial communities in tidal flats are poor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36550
更新日期:2016-11-08 00:00:00
abstract::Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1β and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15282
更新日期:2015-10-26 00:00:00
abstract::Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03972-7
更新日期:2017-06-15 00:00:00
abstract::K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48029-z
更新日期:2019-08-13 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23329-y
更新日期:2018-03-19 00:00:00
abstract::Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52332-0
更新日期:2019-11-04 00:00:00
abstract::Metabolic disorders in T2DM generate multiple sources of free radicals and oxidative stress that accelerate nonenzymatic degenerative protein modifications (DPMs) such as protein oxidation, disrupt redox signaling and physiological function, and remain a major risk factor for clinical diabetic vascular complications. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62341-z
更新日期:2020-04-15 00:00:00
abstract::Efficient control of magnetism with electric means is a central issue of current spintronics research, which opens an opportunity to design integrated spintronic devices. However, recent well-studied methods are mostly based on electric-current injection, and they are inevitably accompanied by considerable energy loss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46009-x
更新日期:2019-07-02 00:00:00
abstract::Many neurological diseases present with substantial genetic and phenotypic heterogeneity, making assessment of these diseases challenging. This has led to ineffective treatments, significant morbidity, and high mortality rates for patients with neurological diseases, including brain cancers and neurodegenerative disor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74459-1
更新日期:2020-10-14 00:00:00
abstract::Oxidative stress is one of the strongest toxic factors in nature: it can harm or even kill cells. Cellular means of subverting the toxicity of oxidative stress are important for the success of infectious diseases. Many types of bacterium inhabit the intestine, where they can encounter pathogens. During oxidative stres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27086-w
更新日期:2018-06-13 00:00:00
abstract::Soft ferromagnetic Fe-based bulk metallic glass key-shaped specimens with a maximum and minimum width of 25.4 and 5 mm, respectively, were successfully produced using a high pressure die casting (HPDC) method, The influence of die material, alloy temperature and flow rate on the microstructure, thermal stability and s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35258
更新日期:2016-10-11 00:00:00
abstract::We sequenced coding regions of the cluster of differentiation 36 (CD36) gene in 184 French individuals of European ancestry presenting simultaneously with type 2 diabetes (T2D), arterial hypertension, dyslipidemia, and coronary heart disease. We identified rare missense mutations (p.Pro191Leu/rs143150225 and p.Ala252V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53388-8
更新日期:2019-11-20 00:00:00